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PROSITE entry PS50027


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General information about the entry

Entry name [info] EGF_LAM_2
Accession [info] PS50027
Entry type [info] MATRIX
Date [info] 01-MAY-2005 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00961
Associated ProRule [info] PRU00460

Name and characterization of the entry

Description [info] Laminin-type EGF-like (LE) domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=50;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=50;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.6474471; R2=0.0190416; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=439; N_SCORE=12.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=124; N_SCORE=6.0; MODE=1; TEXT='R?';
/DEFAULT: B1=*; E1=*; MM=*; II=*;

...
 
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=-85; E0=*; BD=-50;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='N';  M=-23,-38, 17,  8, -5,-18,  6,-39, -4,-19,-29, 20, -8, 18, -7,  2, -7,-34,-40, -1; M0=-9;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-50; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='N';  M=-34,-48, 20,-22, -7,-39, 28,-49,-27,-48,-40, 29,  2,-25,-33,  7,-33,-44,-46, -5; M0=-22;
/I:         MM=-2; MI=-101; MD=-28; IM=-9; II=-11; DM=-14; DD=-7;
/M: SY='P';  M=-21,-34,-20, -7,-37,  5,  6,-10,-14,-20,-25, -2, 31,  0,  1,  0,-21,  3,-36,-30; M0=-10;
/I:         MM=-1; MI=-48; MD=-109; IM=-10; II=-10; DM=-19; DD=-5;
/M: SY='H';  M=-22,-34,  9,-16, -7,-32, 22,  2,  2, -1,-25,  8, -4, 11, -9, -3, -5,  9,-36,  9; M0=-5;
/I:         MM=0; MI=-99; MD=-110; IM=-9; II=-11; DM=-1; DD=-34;
/M: SY='G';  M=-53,-56,-61,-64,-76, 38,-66,-81,-72,-80,-74, -6,-63,-68,-71,-56,-58,-70,-70,-76; M0=-57;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=  8,-36, -6,-19,-39,-35, 25,-16,-19,-37,-28,  4,-36,-18,-23, 26,  5,-16,-39,-33; M0=-15;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M=  3,-30,-29,  3,  3,-36,  8,  3, -9,  8,-22,-25, -8,  9, -7,  6, -1,  3,-34, 10; M0=-5;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M=-10,-38,  2,  5, -6,  5, 17,-39, -5,-38,-29,  2, -2, -5, -5, 23, -9,-34,-40,-33; M0=-10;
/I:         MM=-1; MI=-102; MD=-44; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='E';  M=  0,-37,  5, 12, -9,  6,-19,-12,  5, -7,-28, -1, -6, -1,  6, 10, -6,-11,-39,-33; M0=-4;
/I:         MM=-2; MI=-101; MD=-29; IM=-9; II=-11; DM=-17; DD=-5;
/M: SY='T';  M= -3,-36,  2, -3,-39,  2,-17, -4, -7, -7,-27, 11,-32,  5,  7, -4, 16,  5,-37, -1; M0=-5;
/I:         MM=-4; MI=-20; MD=-109; IM=-10; II=-10; DM=-1; DD=-36;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-53; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M= -4,-42, 27,  4, -9,-36, 19,-43,-20,-42,-33, 26,-37,-19,-25,-12,-27,-11,-44,-37; M0=-18;
/I:         MM=-3; MI=-40; MD=-29; IM=-26; II=-3; DM=-13; DD=-7;
/M: SY='P';  M=-21,-36,-20, -3,-39,-31, -3,-36,  7, -5, 16, -2, 22, 10,  6, -4,  4,  4,-38,-31; M0=-8;
/I:         MM=0; MI=-99; MD=-110; IM=-9; II=-11; DM=-3; DD=-23;
/M: SY='E';  M= -5,-38,  5, 15,-41,-10, 11,-17,  2, -8,-29, 11,-34, -1, -6,  2,  2,  6,-40,  5; M0=-5;
/I:         MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-4; DD=-20;
/M: SY='T';  M=-26,-26,-46,-40,-26,  1,  4, -7,-37,-25,-19,-37,-42,-34,-37, 18, 29, -1,-31,  4; M0=-18;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=-54,-56,-61,-65,-77, 38,-66,-81,-72,-80,-74, -8,-63,-68,-71,-56,-58,-70,-70,-76; M0=-58;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M= -4,-38, -6,-17,  3,-33, 11,-38, -4, -6,-29, -5,-34, 37,  0,-11,-23,-34,-40, -6; M0=-13;
/I:         MM=-2; MI=-33; MD=-112; IM=-17; II=-5; DM=-7; DD=-14;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-11,-37, -4, 13, -6,-33,  1,-11, -8, -8, 17,-20,  6, 17,  6,  3, -3,  2,  7,-33; M0=-5;
/I:         MM=-3; MI=-25; MD=-112; IM=0; II=-54; DM=-7; DD=-14;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-40,-50,-42,-11,-57,-47,-29,-52, 29,-16,-41,-34, -9, 18, 24,-12,-38,-48,-49,-46; M0=-25;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=-10,-38,  9, 12,-41,-33, 20,-39, -5,-38,-29, -1, 29,-15,  2,-22, -6,-13,-40,-33; M0=-14;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=-49,-53,-38,-41,-26, 30, 23,-57,-47,-18,-51, 26,-56,-44,-49,-48,-50,-55,-33, -5; M0=-33;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=  0,-30,-55,-50, 10,-46,-35,-22,-46,-28,-23,-43,-47,-42,-44,-37, 20, 30,-33,  8; M0=-25;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='T';  M=-10,-37, -7, 12,-39,  4,-20,-12, -4,-19, -1,-20,-34, 11,-21,-23, 27, -2,-39,-32; M0=-10;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=-78,-68,-78,-82,-84, 39,-75,-94,-84,-88,-87,-80,-73,-82,-78,-82,-81,-89,-71,-84; M0=-74;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M= -1,-38, -8, -4,  4,-33,-20,-22,  0,  7,-29,-20, 14, 15, 18,-10,  3,-34,-40,-33; M0=-8;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M= -3,-40,-25,-19,-44,-36, 24,-41, 12,-40,  0,  9,-37, 23, 22,-25,  5,-37,-42,-35; M0=-18;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=-47,-69, 32, 21,-69,-44,-39,-69,-43,-68,-62, 18,-50,  5,-54,-43,-48,-64,-70,-58; M0=-40;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-18,-38, -8,  1,-41,-33,-20,-19,  5, -2,-29,-20,-34, 21, 28,-11,  5,-23,-40,-33; M0=-12;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 17,-38,  9,  3,-41,-33,-20,-12, 14,  6,-29,-20,-34, 15, -5, -5,-23,-34,-40,-33; M0=-11;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=-10,-38,  9,  1,-41,-33,  8,-39, -4,-16,-29,  7, 31,-15,  1, -1,-12,-34,-40,-33; M0=-13;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=-36,-41,-32,-11, -3, 34,  3,-39,-36,-41,-35,-34, -2,-34,-40,-37,-11,-38,-36,  5; M0=-24;
/I:         MM=-2; MI=-29; MD=-112; IM=-7; II=-15; DM=-7; DD=-14;
/M: SY='Y';  M=-67,-57,-71,-75, 36,-70, 11,-57,-70,-50,-51,-57,-69,-58,-64,-21, -4,-58,-25, 37; M0=-47;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M= -5,-25,-43,-37, 21,-13, 17,-20,-34,-24,-17,-35,-41,  5,-12,-31, -6, -9, 27, 35; M0=-17;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='G';  M=-10,-38, -5, -1,-41, 28, -2,-39,-16, -8,  3, 11,-34,  7,  1,-22,-23,-34,-40,-33; M0=-13;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-26,  0, 17,-40, 20,-41,-30, -8,-37, 13,-16, 12,-41, -7,-36, -2,-15, -2,-29, 11; M0=-13;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=  6,-38, -4, -5,-41,  6,-20,-39,-16,-38,-29, -4, 23,  7,  7,  1,  8,-15,-40, -3; M0=-9;
/I:         MM=-1; MI=-102; MD=-36; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='T';  M= -5,-37, -4, -6,-12,-11,-19,-10, -4, -8,-28, -3,  4, 11, 10, 14, 14,-33, 12, -8; M0=-5;
/I:         MM=-1; MI=-100; MD=-44; IM=-9; II=-11; DM=-22; DD=-4;
/M: SY='N';  M=  4,-36, -1,  1,-40,  3,  4,  3,  7,-16,-27, 15,-10,-14,  7,  5,  4,-33,-38, -2; M0=-5;
/I:         MM=-6; MI=-100; MD=-16; IM=-9; II=-11; DM=-26; DD=-3;
/M: SY='G';  M=  3,-23,-24,-19,  2, 18,  4, -4,-17,-11,-15, 15,  8,  3, -2,-20,-18,  7,-27,-22; M0=-6;
/I:         MM=-2; MI=-94; MD=-28; IM=-9; II=-11; DM=-40; DD=-1;
/M: SY='T';  M=  9,-31,-15, -9,-34, 16,  1,-31, 10,-31,-22,-12, 10,  6, -5,-15, 16,-27,-32,-26; M0=-9;
/I:         MM=-12; MI=-8; MD=-102; IM=-10; II=-10; DM=-3; DD=-24;
/M: SY='G';  M= -3,-37,  5,-15,-40, 26,-19,-37,  2,-16,-28, -2,  3,-14, -9, -1, -6, -6,-39,-32; M0=-9;
/I:         MM=0; MI=-100; MD=-111; IM=-9; II=-11; DM=-2; DD=-28;
/M: SY='C';  M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M= -9,-38,-11,  0, -6,-33,  6,  4, 11,-10,-29,-20,-34, 23, 11,-11, 13,-13,-40, -5; M0=-8;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=  1,-38,-12,-17,-41,-33,-20,-38, 13,-18,-29, -9, 32, -6,  3, -9,-23,  1,-40,-33; M0=-13;
/I:         B0=*; E1=-10;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.


Total number of hits 610 in 92 different sequences
Number of true positive hits 586 in 89 different sequences
Number of 'unknown' hits 0
Number of false positive hits 24 in 3 different sequences
Number of false negative sequences 6
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 96.07 %
Recall (true positives / (true positives + false negatives)) 98.99 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 22
Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] N_Hulo
Feature key [info] DOMAIN
Feature description [info] Laminin EGF-like
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 89 sequences 

AGRIN_CHICK (P31696), AGRIN_DIPOM (Q90404), AGRIN_HUMAN (O00468), 

AGRIN_MOUSE (A2ASQ1), AGRIN_RAT   (P25304), ATRN1_HUMAN (Q5VV63), 
ATRN1_MOUSE (Q6A051), ATRN_HUMAN  (O75882), ATRN_MOUSE  (Q9WU60), 
ATRN_RAT(Q99J86), CELR1_HUMAN (Q9NYQ6), CELR1_MOUSE (O35161), 
CELR2_HUMAN (Q9HCU4), CELR2_MOUSE (Q9R0M0), CELR2_RAT   (Q9QYP2), 
CELR3_HUMAN (Q9NYQ7), CELR3_MOUSE (Q91ZI0), CELR3_RAT   (O88278), 
EPI1_CAEEL  (Q21313), LAM2_CAEEL  (Q18823), LAM3_CAEEL  (G5ECE3), 
LAMA1_HUMAN (P25391), LAMA1_MOUSE (P19137), LAMA2_HUMAN (P24043), 
LAMA2_MOUSE (Q60675), LAMA3_HUMAN (Q16787), LAMA3_MOUSE (Q61789), 
LAMA4_HUMAN (Q16363), LAMA4_MOUSE (P97927), LAMA5_HUMAN (O15230), 
LAMA5_MOUSE (Q61001), LAMA_DROME  (Q00174), LAMB1_CHICK (Q01635), 
LAMB1_DROME (P11046), LAMB1_HUMAN (P07942), LAMB1_HYDVU (Q27262), 
LAMB1_MOUSE (P02469), LAMB2_HUMAN (P55268), LAMB2_MOUSE (Q61292), 
LAMB2_RAT   (P15800), LAMB3_HUMAN (Q13751), LAMB3_MOUSE (Q61087), 
LAMB4_DANRE (Q8JHV6), LAMB4_HUMAN (A4D0S4), LAMB_HIRME  (Q25092), 
LAMC1_DANRE (Q1LVF0), LAMC1_DROME (P15215), LAMC1_HUMAN (P11047), 
LAMC1_MOUSE (P02468), LAMC1_XENTR (A0JP86), LAMC2_HORSE (Q8HZI9), 
LAMC2_HUMAN (Q13753), LAMC2_MOUSE (Q61092), LAMC3_HUMAN (Q9Y6N6), 
LAMC3_MOUSE (Q9R0B6), MEGF8_HUMAN (Q7Z7M0), MEGF8_MOUSE (P60882), 
MEGF8_RAT   (Q9QYP0), MEGF9_HUMAN (Q9H1U4), MEGF9_MOUSE (Q8BH27), 
NET1_CHICK  (Q90922), NET1_HUMAN  (O95631), NET1_MOUSE  (O09118), 
NET1_PIG(Q2HXW4), NET1_RAT(Q924Z9), NET3_CHICK  (Q90923), 
NET3_HUMAN  (O00634), NET3_MOUSE  (Q9R1A3), NET4_HUMAN  (Q9HB63), 
NET4_MOUSE  (Q9JI33), NET4_PONAB  (Q5RB89), NET5_HUMAN  (Q8WTR8), 
NET5_MOUSE  (Q3UQ22), NET5_RAT(D3ZT86), NETA_DROME  (Q24567), 
NETB_DROME  (Q24568), NTNG1_HUMAN (Q9Y2I2), NTNG1_MOUSE (Q8R4G0), 
NTNG2_HUMAN (Q96CW9), NTNG2_MOUSE (Q8R4F1), PGBM_HUMAN  (P98160), 
PGBM_MOUSE  (Q05793), STAN_DROME  (Q9V5N8), TAG53_CAEEL (Q19981), 
UNC52_CAEEL (Q06561), UNC6_CAEEL  (P34710), USH2A_HUMAN (O75445), 
USH2A_MOUSE (Q2QI47), USH2A_RAT   (Q8K3K1)
» more

UniProtKB/Swiss-Prot
False negative sequences		 6 sequences 

SIGK_DICDI  (Q6TMJ6), STAB1_HUMAN (Q9NY15), STAB1_MOUSE (Q8R4Y4), 

STAB2_HUMAN (Q8WWQ8), STAB2_MOUSE (Q8R4U0), STAB2_RAT   (Q8CFM6)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

LAMBV_CHICK (Q01636)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			3 sequences
			


			
MEG10_DANRE (E9QJQ6), MEG11_HUMAN (A6BM72), MEG11_MOUSE (Q80T91)


				
	

	

		PDB
[Detailed view]		
		
			27 PDB
			


			1KLO; 1NPE; 1TLE; 2Y38; 3TBD; 3ZYG; 3ZYI; 3ZYJ; 4AQS; 4AQT; 4OVE; 4PLM; 
			
				4PLN; 4PLO; 4URT; 4WNX; 5LF2; 6FKQ; 7LER; 7LRF; 7NDG; 7NE0; 7NE1; 8DMK; 
				8EDK; 8S9P; 8SNP
			
			

			» more