 |
|
| Entry: PS50027 |
General information about the entry
| Entry name [info] | EGF_LAM_2 |
| Accession [info] | PS50027 |
| Entry type [info] | MATRIX |
| Date [info] |
01-MAY-2005 CREATED;
01-OCT-2013 DATA UPDATE; 02-JUN-2021 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00961 |
| Associated ProRule [info] | PRU00460 |
Name and characterization of the entry
| Description [info] | Laminin-type EGF-like (LE) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=50; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=50; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.6474471; R2=0.0190416; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=439; N_SCORE=12.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=124; N_SCORE=6.0; MODE=1; TEXT='R?'; /DEFAULT: B1=*; E1=*; MM=*; II=*; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=-85; E0=*; BD=-50; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='N'; M=-23,-38, 17, 8, -5,-18, 6,-39, -4,-19,-29, 20, -8, 18, -7, 2, -7,-34,-40, -1; M0=-9; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-50; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='N'; M=-34,-48, 20,-22, -7,-39, 28,-49,-27,-48,-40, 29, 2,-25,-33, 7,-33,-44,-46, -5; M0=-22; /I: MM=-2; MI=-101; MD=-28; IM=-9; II=-11; DM=-14; DD=-7; /M: SY='P'; M=-21,-34,-20, -7,-37, 5, 6,-10,-14,-20,-25, -2, 31, 0, 1, 0,-21, 3,-36,-30; M0=-10; /I: MM=-1; MI=-48; MD=-109; IM=-10; II=-10; DM=-19; DD=-5; /M: SY='H'; M=-22,-34, 9,-16, -7,-32, 22, 2, 2, -1,-25, 8, -4, 11, -9, -3, -5, 9,-36, 9; M0=-5; /I: MM=0; MI=-99; MD=-110; IM=-9; II=-11; DM=-1; DD=-34; /M: SY='G'; M=-53,-56,-61,-64,-76, 38,-66,-81,-72,-80,-74, -6,-63,-68,-71,-56,-58,-70,-70,-76; M0=-57; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='S'; M= 8,-36, -6,-19,-39,-35, 25,-16,-19,-37,-28, 4,-36,-18,-23, 26, 5,-16,-39,-33; M0=-15; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Y'; M= 3,-30,-29, 3, 3,-36, 8, 3, -9, 8,-22,-25, -8, 9, -7, 6, -1, 3,-34, 10; M0=-5; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='S'; M=-10,-38, 2, 5, -6, 5, 17,-39, -5,-38,-29, 2, -2, -5, -5, 23, -9,-34,-40,-33; M0=-10; /I: MM=-1; MI=-102; MD=-44; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='E'; M= 0,-37, 5, 12, -9, 6,-19,-12, 5, -7,-28, -1, -6, -1, 6, 10, -6,-11,-39,-33; M0=-4; /I: MM=-2; MI=-101; MD=-29; IM=-9; II=-11; DM=-17; DD=-5; /M: SY='T'; M= -3,-36, 2, -3,-39, 2,-17, -4, -7, -7,-27, 11,-32, 5, 7, -4, 16, 5,-37, -1; M0=-5; /I: MM=-4; MI=-20; MD=-109; IM=-10; II=-10; DM=-1; DD=-36; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-53; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='D'; M= -4,-42, 27, 4, -9,-36, 19,-43,-20,-42,-33, 26,-37,-19,-25,-12,-27,-11,-44,-37; M0=-18; /I: MM=-3; MI=-40; MD=-29; IM=-26; II=-3; DM=-13; DD=-7; /M: SY='P'; M=-21,-36,-20, -3,-39,-31, -3,-36, 7, -5, 16, -2, 22, 10, 6, -4, 4, 4,-38,-31; M0=-8; /I: MM=0; MI=-99; MD=-110; IM=-9; II=-11; DM=-3; DD=-23; /M: SY='E'; M= -5,-38, 5, 15,-41,-10, 11,-17, 2, -8,-29, 11,-34, -1, -6, 2, 2, 6,-40, 5; M0=-5; /I: MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-4; DD=-20; /M: SY='T'; M=-26,-26,-46,-40,-26, 1, 4, -7,-37,-25,-19,-37,-42,-34,-37, 18, 29, -1,-31, 4; M0=-18; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='G'; M=-54,-56,-61,-65,-77, 38,-66,-81,-72,-80,-74, -8,-63,-68,-71,-56,-58,-70,-70,-76; M0=-58; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= -4,-38, -6,-17, 3,-33, 11,-38, -4, -6,-29, -5,-34, 37, 0,-11,-23,-34,-40, -6; M0=-13; /I: MM=-2; MI=-33; MD=-112; IM=-17; II=-5; DM=-7; DD=-14; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M=-11,-37, -4, 13, -6,-33, 1,-11, -8, -8, 17,-20, 6, 17, 6, 3, -3, 2, 7,-33; M0=-5; /I: MM=-3; MI=-25; MD=-112; IM=0; II=-54; DM=-7; DD=-14; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='K'; M=-40,-50,-42,-11,-57,-47,-29,-52, 29,-16,-41,-34, -9, 18, 24,-12,-38,-48,-49,-46; M0=-25; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M=-10,-38, 9, 12,-41,-33, 20,-39, -5,-38,-29, -1, 29,-15, 2,-22, -6,-13,-40,-33; M0=-14; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='G'; M=-49,-53,-38,-41,-26, 30, 23,-57,-47,-18,-51, 26,-56,-44,-49,-48,-50,-55,-33, -5; M0=-33; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='V'; M= 0,-30,-55,-50, 10,-46,-35,-22,-46,-28,-23,-43,-47,-42,-44,-37, 20, 30,-33, 8; M0=-25; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='T'; M=-10,-37, -7, 12,-39, 4,-20,-12, -4,-19, -1,-20,-34, 11,-21,-23, 27, -2,-39,-32; M0=-10; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='G'; M=-78,-68,-78,-82,-84, 39,-75,-94,-84,-88,-87,-80,-73,-82,-78,-82,-81,-89,-71,-84; M0=-74; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='R'; M= -1,-38, -8, -4, 4,-33,-20,-22, 0, 7,-29,-20, 14, 15, 18,-10, 3,-34,-40,-33; M0=-8; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='H'; M= -3,-40,-25,-19,-44,-36, 24,-41, 12,-40, 0, 9,-37, 23, 22,-25, 5,-37,-42,-35; M0=-18; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='D'; M=-47,-69, 32, 21,-69,-44,-39,-69,-43,-68,-62, 18,-50, 5,-54,-43,-48,-64,-70,-58; M0=-40; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='R'; M=-18,-38, -8, 1,-41,-33,-20,-19, 5, -2,-29,-20,-34, 21, 28,-11, 5,-23,-40,-33; M0=-12; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='A'; M= 17,-38, 9, 3,-41,-33,-20,-12, 14, 6,-29,-20,-34, 15, -5, -5,-23,-34,-40,-33; M0=-11; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M=-10,-38, 9, 1,-41,-33, 8,-39, -4,-16,-29, 7, 31,-15, 1, -1,-12,-34,-40,-33; M0=-13; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='G'; M=-36,-41,-32,-11, -3, 34, 3,-39,-36,-41,-35,-34, -2,-34,-40,-37,-11,-38,-36, 5; M0=-24; /I: MM=-2; MI=-29; MD=-112; IM=-7; II=-15; DM=-7; DD=-14; /M: SY='Y'; M=-67,-57,-71,-75, 36,-70, 11,-57,-70,-50,-51,-57,-69,-58,-64,-21, -4,-58,-25, 37; M0=-47; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Y'; M= -5,-25,-43,-37, 21,-13, 17,-20,-34,-24,-17,-35,-41, 5,-12,-31, -6, -9, 27, 35; M0=-17; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='G'; M=-10,-38, -5, -1,-41, 28, -2,-39,-16, -8, 3, 11,-34, 7, 1,-22,-23,-34,-40,-33; M0=-13; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='F'; M=-26, 0, 17,-40, 20,-41,-30, -8,-37, 13,-16, 12,-41, -7,-36, -2,-15, -2,-29, 11; M0=-13; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M= 6,-38, -4, -5,-41, 6,-20,-39,-16,-38,-29, -4, 23, 7, 7, 1, 8,-15,-40, -3; M0=-9; /I: MM=-1; MI=-102; MD=-36; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='T'; M= -5,-37, -4, -6,-12,-11,-19,-10, -4, -8,-28, -3, 4, 11, 10, 14, 14,-33, 12, -8; M0=-5; /I: MM=-1; MI=-100; MD=-44; IM=-9; II=-11; DM=-22; DD=-4; /M: SY='N'; M= 4,-36, -1, 1,-40, 3, 4, 3, 7,-16,-27, 15,-10,-14, 7, 5, 4,-33,-38, -2; M0=-5; /I: MM=-6; MI=-100; MD=-16; IM=-9; II=-11; DM=-26; DD=-3; /M: SY='G'; M= 3,-23,-24,-19, 2, 18, 4, -4,-17,-11,-15, 15, 8, 3, -2,-20,-18, 7,-27,-22; M0=-6; /I: MM=-2; MI=-94; MD=-28; IM=-9; II=-11; DM=-40; DD=-1; /M: SY='T'; M= 9,-31,-15, -9,-34, 16, 1,-31, 10,-31,-22,-12, 10, 6, -5,-15, 16,-27,-32,-26; M0=-9; /I: MM=-12; MI=-8; MD=-102; IM=-10; II=-10; DM=-3; DD=-24; /M: SY='G'; M= -3,-37, 5,-15,-40, 26,-19,-37, 2,-16,-28, -2, 3,-14, -9, -1, -6, -6,-39,-32; M0=-9; /I: MM=0; MI=-100; MD=-111; IM=-9; II=-11; DM=-2; DD=-28; /M: SY='C'; M=-78, 59,-79,-83,-83,-68,-75,-93,-84,-88,-87,-81,-73,-83,-78,-83,-81,-89,-71,-83; M0=-79; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='Q'; M= -9,-38,-11, 0, -6,-33, 6, 4, 11,-10,-29,-20,-34, 23, 11,-11, 13,-13,-40, -5; M0=-8; /I: MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14; /M: SY='P'; M= 1,-38,-12,-17,-41,-33,-20,-38, 13,-18,-29, -9, 32, -6, 3, -9,-23, 1,-40,-33; M0=-13; /I: B0=*; E1=-10;» more |
Numerical results [info]
| Total number of hits | 593 in 91 different sequences |
| Number of true positive hits | 569 in 88 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 24 in 3 different sequences |
| Number of false negative sequences | 6 |
| Number of 'partial' sequences | 1 |
| Precision (true positives / (true positives + false positives)) | 95.95 % |
| Recall (true positives / (true positives + false negatives)) | 98.96 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | window20 |
| Author [info] | N_Hulo |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 22 |
| Feature key [info] | DOMAIN |
| Feature description [info] | Laminin EGF-like |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
88 sequences
AGRIN_CHICK (P31696 ), AGRIN_DIPOM (Q90404 ), AGRIN_HUMAN (O00468 ), AGRIN_MOUSE (A2ASQ1 ), AGRIN_RAT (P25304 ), ATRN1_HUMAN (Q5VV63 ), ATRN1_MOUSE (Q6A051 ), ATRN_HUMAN (O75882 ), ATRN_MOUSE (Q9WU60 ), ATRN_RAT (Q99J86 ), CELR1_HUMAN (Q9NYQ6 ), CELR1_MOUSE (O35161 ), CELR2_HUMAN (Q9HCU4 ), CELR2_MOUSE (Q9R0M0 ), CELR2_RAT (Q9QYP2 ), CELR3_HUMAN (Q9NYQ7 ), CELR3_MOUSE (Q91ZI0 ), CELR3_RAT (O88278 ), EPI1_CAEEL (Q21313 ), LAM2_CAEEL (Q18823 ), LAMA1_HUMAN (P25391 ), LAMA1_MOUSE (P19137 ), LAMA2_HUMAN (P24043 ), LAMA2_MOUSE (Q60675 ), LAMA3_HUMAN (Q16787 ), LAMA3_MOUSE (Q61789 ), LAMA4_HUMAN (Q16363 ), LAMA4_MOUSE (P97927 ), LAMA5_HUMAN (O15230 ), LAMA5_MOUSE (Q61001 ), LAMA_DROME (Q00174 ), LAMB1_CHICK (Q01635 ), LAMB1_DROME (P11046 ), LAMB1_HUMAN (P07942 ), LAMB1_HYDVU (Q27262 ), LAMB1_MOUSE (P02469 ), LAMB2_HUMAN (P55268 ), LAMB2_MOUSE (Q61292 ), LAMB2_RAT (P15800 ), LAMB3_HUMAN (Q13751 ), LAMB3_MOUSE (Q61087 ), LAMB4_DANRE (Q8JHV6 ), LAMB4_HUMAN (A4D0S4 ), LAMB_HIRME (Q25092 ), LAMC1_DANRE (Q1LVF0 ), LAMC1_DROME (P15215 ), LAMC1_HUMAN (P11047 ), LAMC1_MOUSE (P02468 ), LAMC1_XENTR (A0JP86 ), LAMC2_HORSE (Q8HZI9 ), LAMC2_HUMAN (Q13753 ), LAMC2_MOUSE (Q61092 ), LAMC3_HUMAN (Q9Y6N6 ), LAMC3_MOUSE (Q9R0B6 ), MEGF8_HUMAN (Q7Z7M0 ), MEGF8_MOUSE (P60882 ), MEGF8_RAT (Q9QYP0 ), MEGF9_HUMAN (Q9H1U4 ), MEGF9_MOUSE (Q8BH27 ), NET1_CHICK (Q90922 ), NET1_HUMAN (O95631 ), NET1_MOUSE (O09118 ), NET1_PIG (Q2HXW4 ), NET1_RAT (Q924Z9 ), NET3_CHICK (Q90923 ), NET3_HUMAN (O00634 ), NET3_MOUSE (Q9R1A3 ), NET4_HUMAN (Q9HB63 ), NET4_MOUSE (Q9JI33 ), NET4_PONAB (Q5RB89 ), NET5_HUMAN (Q8WTR8 ), NET5_MOUSE (Q3UQ22 ), NET5_RAT (D3ZT86 ), NETA_DROME (Q24567 ), NETB_DROME (Q24568 ), NTNG1_HUMAN (Q9Y2I2 ), NTNG1_MOUSE (Q8R4G0 ), NTNG2_HUMAN (Q96CW9 ), NTNG2_MOUSE (Q8R4F1 ), PGBM_HUMAN (P98160 ), PGBM_MOUSE (Q05793 ), STAN_DROME (Q9V5N8 ), TAG53_CAEEL (Q19981 ), UNC52_CAEEL (Q06561 ), UNC6_CAEEL (P34710 ), USH2A_HUMAN (O75445 ), USH2A_MOUSE (Q2QI47 ), USH2A_RAT (Q8K3K1 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
6 sequences
SIGK_DICDI (Q6TMJ6 ), STAB1_HUMAN (Q9NY15 ), STAB1_MOUSE (Q8R4Y4 ), STAB2_HUMAN (Q8WWQ8 ), STAB2_MOUSE (Q8R4U0 ), STAB2_RAT (Q8CFM6 )» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
1 sequence
LAMBV_CHICK (Q01636 ) |
| UniProtKB/Swiss-Prot False positive sequences |
3 sequences
MEG10_DANRE (E9QJQ6 ), MEG11_HUMAN (A6BM72 ), MEG11_MOUSE (Q80T91 ) |
| PDB [Detailed view] |
18 PDB
1KLO; 1NPE; 1TLE; 2Y38; 3TBD; 3ZYG; 3ZYI; 3ZYJ; 4AQS; 4AQT; 4OVE; 4PLM; 4PLN; 4PLO; 4URT; 4WNX; 5LF2; 6FKQ » more |
View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission