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PROSITE entry PS50056


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General information about the entry

Entry name [info] TYR_PHOSPHATASE_2
Accession [info] PS50056
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00323

Name and characterization of the entry

Description [info] Tyrosine specific protein phosphatases domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=68;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=63;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7969000; R2=0.0165700; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2939.9223633; R2=3.8252428; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=465; H_SCORE=4719; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=345; H_SCORE=4260; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=-50; MI=-105; MD=-105; IM=-105; DM=-105; MM=1; M0=-1;

...
 
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -9, -3,-21,  0,  5,-18,-20, -6,-15,  1, -6, -7, -6,-13,  1,  2, -8, -7,-13,-25,-10,  2;
/M: SY='D';  M= -9, 10,-25, 13, 10,-22,-12,  0,-24,  5,-20,-15,  8,-12,  3,  2,  2, -4,-20,-28,-11,  6;
/M: SY='F';  M=-14,-27,-24,-34,-26, 39,-27,-18,  6,-25,  9,  2,-21,-25,-28,-20,-19,-10,  2, 10, 19,-25;
/M: SY='L';  M= -6,-22,-21,-24,-16,  2,-26,-18, 13,-19, 14,  8,-19,-20,-15,-16,-14, -6, 11,-20, -3,-16;
/M: SY='E';  M= -7,  5,-26,  7, 10,-24,-10, -2,-24,  7,-22,-13,  5, -8,  8,  6,  1, -5,-21,-27,-14,  8;
/M: SY='M';  M= -4,-13,-21,-15, -5, -2,-19,-12, -4, -7,  1,  3,-12,-17, -6, -6, -9, -6, -3,-19, -4, -5;
/M: SY='V';  M=  1,-24,-12,-27,-23, -2,-27,-24, 19,-19, 11,  8,-22,-24,-21,-19,-10, -1, 24,-25, -7,-22;
/M: SY='R';  M=-10,  5,-25,  4,  7,-23,-17,  2,-22, 13,-20, -9,  6,-14,  9, 14, -2, -6,-19,-26,-10,  7;
/M: SY='E';  M= -4,  1,-22, -2,  3,-12,-17, -3,-14, -2,-13, -7,  2,-13,  2, -4,  2,  3,-12,-23, -6,  2;
/I:         MD=-15;
/M: SY='I';  M= -6,-19,-13,-23,-17,  4,-24,-14,  7,-15,  5,  4,-16,-21,-15,-13,-10, -4,  7,-16,  1,-16; D=-2;
/I:         MD=-15;
/M: SY='Y';  M=-10, -7,-22, -9, -6, -4,-19, -5, -5, -5, -3, -2, -5,-17, -5, -2, -8, -4, -5,-18,  1, -7; D=-2;
/I:         MD=-15;
/M: SY='E';  M= -6,  3,-19,  4,  9,-22,-12, -5,-20,  6,-19,-12,  2, -1,  5,  4,  0, -4,-18,-24,-15,  6; D=-2;
/I:         MD=-15;
/M: SY='E';  M= -3, -3,-19, -3,  5,-16,-14, -3,-13,  4,-12, -6, -4, -7,  4,  0, -2, -5,-10,-19, -9,  4; D=-2;
/I:         I=-4; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='K';  M= -3, -2,-14, -2,  2,-11, -6, -4,-12,  3, -9, -5, -2, -5,  1,  2, -1, -2, -9,-13, -7,  1; D=-2;
/I:         DM=-15;
/M: SY='S';  M= -4,  2,-19,  1,  3,-21, -9, -1,-21, -1,-19,-11,  3,-12,  4, -2,  5, -1,-17,-28,-11,  3;
/M: SY='E';  M= -4, -1,-25,  0,  5,-24,-14, -3,-20,  5,-21,-12,  1,  4,  4,  2,  0, -4,-19,-27,-15,  3;
/M: SY='G';  M= -3,  0,-27,  0,-10,-27, 40,-11,-34,-13,-28,-19,  7,-18,-11,-13,  4,-12,-27,-24,-23,-11;
/M: SY='P';  M= -5,-10,-14,-10, -5,-24,  0,-13,-24, -4,-22,-14, -6,  4, -7, -5, -3, -8,-19,-28,-21, -8;
/I:         MD=-21;
/M: SY='P';  M= -6, -7,-17, -6,  0,-17,-10, -9,-14,  2,-14, -8, -6,  8, -2,  1, -5, -6,-13,-20,-13, -3; D=-4;
/I:         I=-5; MI=0; IM=0; DM=-21;
/M: SY='I';  M= -4,-27,-18,-32,-26, -1,-32,-27, 30,-24, 15, 13,-22,-21,-22,-23,-14, -3, 28,-24, -5,-26;
/M: SY='V';  M= -2,-25,-13,-28,-23,  0,-24,-22, 18,-23, 17,  9,-23,-26,-22,-21,-14, -3, 21,-24, -6,-23;
/M: SY='V';  M= -1,-29,-14,-31,-29,  1,-31,-29, 32,-22, 12, 11,-28,-28,-28,-22,-11, -1, 44,-28, -8,-29;
/M: SY='H';  M=-19, -1,-29, -1, -1,-19,-20, 94,-28,-10,-20,  0,  9,-20,  9, -1, -9,-18,-28,-29, 19, -1;
/M: SY='C';  M=-10,-20,117,-30,-30,-20,-28,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-49,-30,-30;
/M: SY='S';  M=  3, -6,-15, -8, -4,-15, -9,-11,-12, -7,-15, -9,  0,-15, -1, -4, 16,  8, -6,-31,-13, -3;
/M: SY='A';  M= 30, -4,-11,-11, -8,-20, -1,-13,-13,-10,-12, -9, -4,-13, -9,-17,  6, -2, -5,-24,-18, -9;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='V';  M= -3,-24,-14,-28,-22, -4,-27,-21, 19,-20, 10,  8,-20,-24,-18,-18,-12, -4, 21,-25, -6,-22;
/M: SY='G';  M=  1, -4,-25, -5,-13,-27, 46,-15,-34,-15,-29,-19,  6,-17,-12,-15,  9,-10,-25,-25,-26,-13;
/M: SY='R';  M=-18,-10,-29,-10,  1,-20,-20, -1,-28, 28,-19,-10,  0,-19, 10, 64, -9, -9,-19,-20,-10,  1;
/M: SY='T';  M=  6, -1, -8, -7, -6,-15,-11,-16,-14,-10,-18,-14,  3,-10, -6,-11, 27, 35, -4,-34,-15, -6;
/M: SY='G';  M=  8,-11,-23,-12,-16,-26, 42,-20,-30,-16,-25,-17, -4,-12,-17,-19,  3,-12,-20,-22,-26,-17;
/M: SY='T';  M=  0,-11, -3,-18,-16, -7,-22,-20,  0,-15, -3, -3,-10,-18,-14,-15,  6, 22,  8,-28, -8,-16;
/M: SY='F';  M=-12,-29,-20,-34,-26, 35,-30,-19, 15,-26, 20, 11,-24,-28,-28,-20,-20, -8, 13, -7, 15,-26;
/M: SY='I';  M= -2,-24,  0,-31,-26, -5,-30,-27, 22,-24,  8,  7,-20,-24,-21,-24,-11, -3, 22,-27, -9,-26;
/M: SY='A';  M= 16,-18, -8,-24,-19,-10,-12,-22,  4,-18,  3,  1,-16,-20,-17,-20, -3, -1, 11,-24,-14,-18;
/M: SY='I';  M=  8,-21,-12,-27,-19, -5,-22,-21, 13,-19, 11,  8,-18,-21,-16,-19, -9, -4, 12,-23, -9,-19;
/M: SY='Y';  M=-12,  1,-25,  5,  0, -4,-18,  3,-17, -8,-11,-10, -5,-19, -6,-10, -8, -9,-16, -4, 14, -4;
/M: SY='L';  M= -6,-20,-17,-25,-19,  1,-27,-17, 15,-21, 17, 11,-17,-23,-16,-17,-14, -4, 10,-20,  0,-19;
/M: SY='M';  M= -6,-23,-15,-29,-22, -1,-22,-16, 19,-20, 18, 27,-20,-23,-14,-18,-17, -7, 14,-23, -5,-19;
/I:         I=-5; MI=0; IM=0; DM=-15; MD=-15;
/M: SY='E';  M= -6,  4,-25,  4, 14,-21,-12, -4,-20,  2,-18,-13,  3, -8,  4, -2,  1, -2,-19,-25,-11,  8;
/M: SY='E';  M= -8, -3,-20, -3,  1,-15,-10, -4,-18, -2,-11, -7, -3,-15, -1, -2, -6, -8,-16,-23, -8, -1;
/M:         M= -6, -3,-18, -5, -5,-19, -3,-10,-15, -6,-16, -9,  0,-14, -5, -6, -1, -4,-10,-27,-15, -6;
/M: SY='I';  M= -8,-26,-16,-29,-22,  6,-29,-21, 19,-20, 16, 14,-23,-25,-20,-17,-17, -7, 19,-17, -1,-21;
/M: SY='D';  M= -9, 20,-24, 25,  8,-27, -8, -4,-27,  2,-26,-20, 13,-10,  1, -2,  8,  1,-21,-33,-15,  4;
/M: SY='I';  M= -3,-24,-22,-26,-19, -1,-27,-21, 16,-20,  9,  6,-21,-11,-18,-20,-12, -5, 15,-19, -2,-20;
/M:         M= -9, -4,-23, -6, -1,  0,-16, -6,-15, -5,-10, -9, -3,-13, -7, -4, -7, -8,-15,-17, -1, -4;
/M: SY='D';  M= -9, 14,-27, 20, 16,-29, -8,  1,-28,  3,-23,-16,  8, -9, 10, -1,  1, -8,-25,-29,-16, 13;
/M: SY='A';  M= 17,-16, -9,-23,-17, -7,-16,-20,  3,-16,  1,  0,-14,-17,-15,-19,  0,  4,  9,-23,-11,-16;
/M: SY='V';  M= -7,-27,-19,-31,-26,  8,-31,-21, 24,-21, 15, 12,-24,-27,-22,-18,-16, -5, 26,-15,  6,-26;
/M: SY='K';  M= -9,  2,-21,  5,  8,-23,-16, -3,-22,  9,-16,-11, -1,-14,  6,  8, -3, -7,-18,-26,-11,  6;
/M: SY='Y';  M= -7,-11,-22,-14, -5, -1,-20, -6, -7, -6, -3,  0, -8,-18, -4, -4, -7, -4, -7,-15,  3, -5;
/M: SY='L';  M= -8,-28,-19,-31,-23,  7,-29,-20, 24,-24, 29, 23,-26,-27,-18,-19,-21, -8, 20,-21, -1,-21;
/M: SY='R';  M=-17, -7,-29, -7,  4,-22,-20,  0,-28, 29,-21, -9,  0,-17, 12, 53, -9,-10,-20,-20, -9,  4;
/M: SY='Q';  M= -5,  1,-23,  1,  5,-21,-16, -1,-17,  4,-15, -7,  1,-14,  8,  3,  1, -1,-14,-26,-10,  6;
/M: SY='Q';  M= -7, -5,-22, -6,  3,-21,-19,  2,-18,  8,-15, -4, -3,-16, 17, 11, -4, -8,-17,-20, -5,  9;
/M: SY='R';  M=-19, -8,-30, -8,  1,-21,-20, -1,-30, 31,-21,-10,  1,-19, 10, 65,-10,-10,-20,-20,-10,  1;
/M: SY='P';  M= -7,-12,-27,-11, -6,-20,-12, -9,-15, -8,-17, -8, -7, 26, -7, -8, -6, -7,-18,-28,-19, -9;
/M: SY='G';  M= -3, -4,-25, -8,-13,-18, 27, -6,-23,-14,-19, -9,  5,-20,-10,-13,  0,-11,-21,-22,-15,-12;
/M: SY='M';  M=  0,-19,-19,-25,-17, -4,-16,-11, 11,-14, 14, 27,-17,-20, -8,-13,-11, -6,  7,-22, -6,-13;
/M: SY='V';  M= -2,-28,-16,-31,-28,  2,-28,-28, 28,-22, 10, 11,-24,-26,-26,-22,-11, -3, 36,-25, -7,-28;
/M: SY='Q';  M= -9, -2,-25, -5,  9,-28,-19,  1,-11,  1,-12, -1,  0,-14, 32,  2, -2, -7,-18,-24,-11, 20;
/M: SY='T';  M=  0,  0,-14, -5, -4,-17,-13,-12,-14, -7,-15, -9,  1,-11,  0, -7, 17, 29, -7,-30,-12, -2;
/M: SY='E';  M=-10,  0,-26,  4, 11,-16,-19, -9,-20,  1,-16,-13, -4,  6,  0, -5, -5, -6,-20,-24,-11,  5;
/M: SY='E';  M= -3, 10,-23, 13, 23,-27,-13, -1,-23,  1,-19,-14,  4, -9, 11, -5,  3, -5,-21,-30,-16, 17;
/M: SY='Q';  M=-11, -2,-29, -2, 16,-34,-21, 11,-18,  8,-15,  1, -2,-12, 47,  8, -4,-11,-26,-21, -8, 31;
/M: SY='Y';  M=-17,-14,-29,-13,-12, 14,-27, 11, -6, -5, -2, -2,-15,-23, -5, -5,-16, -9,-12, 11, 48,-12;
/M: SY='Y';  M= -9,-15,-25,-17, -6, -2,-25, -7,  0, -6, -1,  0,-13,-20, -4, -3,-11, -6, -1,-12,  6, -7;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 443 in 402 different sequences
Number of true positive hits 442 in 401 different sequences
Number of 'unknown' hits 0
Number of false positive hits 1
Number of false negative sequences 46
Number of 'partial' sequences 27
Precision (true positives / (true positives + false positives)) 99.77 %
Recall (true positives / (true positives + false negatives)) 90.57 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 401 sequences 

123R_IIV6   (O55737), AUXI_BOVIN  (Q27974), AUXI_HUMAN  (O75061), 

AUXI_MOUSE  (Q80TZ3), CC14A_DANRE (A0A0R4IVA4), CC14A_HUMAN (Q9UNH5), 
CC14A_MOUSE (Q6GQT0), CC14B_HUMAN (O60729), CC14B_MOUSE (Q6PFY9), 
CC14C_HUMAN (A4D256), CC14C_SYMSY (A6N3Q4), CDC14_CAEEL (P81299), 
CDC14_CANAL (Q59NH8), CDC14_EMENI (Q5B323), CDC14_YEAST (Q00684), 
CDKN3_HUMAN (Q16667), CDKN3_MOUSE (Q810P3), CDKN3_PIG   (Q9MYN5), 
CDKN3_RAT   (B2RZ50), CPP1_CANAL  (Q5APU2), CSW_DROME   (P29349), 
CSW_DROVI   (Q24708), DEP1_CAEEL  (G5EGJ9), DPHS1_ARATH (Q75QN6), 
DS13A_HUMAN (Q6B8I1), DS13A_MOUSE (Q6B8I0), DS13B_HUMAN (Q9UII6), 
DS13B_MOUSE (Q9QYJ7), DS22A_DANRE (Q1LWL2), DS22B_DANRE (Q566R7), 
DSP2_ARATH  (Q84MD6), DSP4_ARATH  (Q940L5), DSPG4_ARATH (Q9FEB5), 
DSPG4_CASSA (G4LTX4), DUS10_BOVIN (Q0IID7), DUS10_HUMAN (Q9Y6W6), 
DUS10_MOUSE (Q9ESS0), DUS11_BOVIN (Q5E999), DUS11_CAEEL (Q22707), 
DUS11_HUMAN (O75319), DUS11_MOUSE (Q6NXK5), DUS11_RAT   (Q4KM79), 
DUS12_HUMAN (Q9UNI6), DUS12_MOUSE (Q9D0T2), DUS12_RAT   (Q9JIM4), 
DUS14_BOVIN (Q17QM8), DUS14_HUMAN (O95147), DUS14_MOUSE (Q9JLY7), 
DUS15_HUMAN (Q9H1R2), DUS15_MOUSE (Q8R4V2), DUS15_RAT   (B4F7B7), 
DUS16_HUMAN (Q9BY84), DUS18_BOVIN (Q5BIP9), DUS18_HUMAN (Q8NEJ0), 
DUS18_MOUSE (Q8VE01), DUS18_PONAB (Q5R8X2), DUS18_RAT   (Q6AXW7), 
DUS19_HUMAN (Q8WTR2), DUS19_MOUSE (Q8K4T5), DUS1A_XENLA (Q91790), 
DUS1B_ARATH (Q9M8K7), DUS1B_XENLA (Q90W58), DUS1_ARATH  (Q9ZR37), 
DUS1_HUMAN  (P28562), DUS1_MOUSE  (P28563), DUS1_RAT(Q64623), 
DUS21_HUMAN (Q9H596), DUS21_MOUSE (Q9D9D8), DUS22_HUMAN (Q9NRW4), 
DUS22_MOUSE (Q99N11), DUS22_XENLA (Q6GQJ8), DUS22_XENTR (Q5XHB2), 
DUS23_HUMAN (Q9BVJ7), DUS23_MOUSE (Q6NT99), DUS26_BOVIN (Q17QJ3), 
DUS26_HUMAN (Q9BV47), DUS26_MOUSE (Q9D700), DUS26_PONAB (Q5R6H6), 
DUS26_RAT   (Q5FVI9), DUS28_HUMAN (Q4G0W2), DUS28_MOUSE (Q8BTR5), 
DUS29_ANOCA (P0C598), DUS29_BOVIN (P0C591), DUS29_CALMI (P0C5A2), 
DUS29_CHICK (P0C597), DUS29_DANRE (Q29RA3), DUS29_GASAC (P0C5A0), 
DUS29_HORSE (P0C592), DUS29_HUMAN (Q68J44), DUS29_MONDO (P0C593), 
DUS29_MOUSE (Q8BK84), DUS29_ORYLA (P0C5A1), DUS29_PANTR (P0C594), 
DUS29_PIG   (P0C596), DUS29_RAT   (P0C595), DUS29_TAKRU (P0C599), 
DUS29_TETNG (Q4RQD3), DUS29_XENLA (Q4KL92), DUS29_XENTR (A4IHU7), 
DUS3_HUMAN  (P51452), DUS3_MOUSE  (Q9D7X3), DUS3_PONAB  (Q5RD73), 
DUS4_CHICK  (Q9PW71), DUS4_HUMAN  (Q13115), DUS4_MOUSE  (Q8BFV3), 
DUS4_RAT(Q62767), DUS5_HUMAN  (Q16690), DUS5_RAT(O54838), 
DUS6_BOVIN  (Q2KJ36), DUS6_HUMAN  (Q16828), DUS6_MOUSE  (Q9DBB1), 
DUS6_RAT(Q64346), DUS7_HUMAN  (Q16829), DUS7_MOUSE  (Q91Z46), 
DUS7_RAT(Q63340), DUS8_HUMAN  (Q13202), DUS8_MOUSE  (O09112), 
DUS9_HUMAN  (Q99956), DUSK3_DROME (Q9VVW5), DUSK4_DROME (Q9VWF4), 
DUSL_CAEEL  (V6CIV8), DUSP1_DICDI (Q55E39), DUSP2_DICDI (Q54R42), 
DUSP2_HUMAN (Q05923), DUSP2_MOUSE (Q05922), DUSP3_DICDI (Q55BI8), 
DUSP4_DICDI (Q54T76), DUSPR_DICDI (Q556Y8), DUSP_FOWPN  (Q9J592), 
DUSP_MONPV  (A0A7H0DN78), DUSP_MYXVL  (Q85297), DUSP_RACVI  (P80994), 
DUSP_VACCC  (P20495), DUSP_VACCW  (P07239), DUSP_VAR67  (P0DOQ5), 
DUSP_VARV   (P0DOQ6), EAK6_CAEEL  (G5EGU2), EGG4_CAEEL  (O01767), 
EGG5_CAEEL  (O61789), EPM2A_CANLF (Q1M199), EPM2A_HUMAN (O95278), 
EPM2A_MOUSE (Q9WUA5), EPM2A_RAT   (Q91XQ2), FLP1_SCHPO  (Q9P7H1), 
HOPD2_PSESM (Q79LY0), IBR5_ARATH  (Q84JU4), IDA1_CAEEL  (G5EGJ5), 
IPHP_NOSCO  (Q05918), LAR_CAEEL   (Q9BMN8), LAR_DROME   (P16621), 
LSF2_ARATH  (Q9SRK5), MCE1_CAEEL  (Q17607), MCE1_DANRE  (Q6NY98), 
MCE1_HUMAN  (O60942), MCE1_MOUSE  (O55236), MKP1_ARATH  (Q9C5S1), 
MPL1_DICDI  (Q55CS7), MPL2_DICDI  (Q55CS8), MPL3_DICDI  (Q54Y32), 
MSG5_YEAST  (P38590), MTM1_BOVIN  (A6QLT4), MTM1_HUMAN  (Q13496), 
MTM1_MOUSE  (Q9Z2C5), MTM1_PONAB  (Q5R9S3), MTM1_XENLA  (Q52KU6), 
MTM1_XENTR  (Q5EB32), MTMR1_HUMAN (Q13613), MTMR1_MOUSE (Q9Z2C4), 
MTMR2_BOVIN (A6QLT2), MTMR2_CHICK (Q5ZIV1), MTMR2_DANRE (A0JMK5), 
MTMR2_HUMAN (Q13614), MTMR2_MOUSE (Q9Z2D1), MTMR2_PONAB (Q5REB9), 
MTMR4_HUMAN (Q9NYA4), MTMR4_MOUSE (Q91XS1), MTMR7_HUMAN (Q9Y216), 
MTMR7_MOUSE (Q9Z2C9), MTMR7_PONAB (Q5R6F6), PLIP_DICDI  (Q86IG3), 
PMP1_SCHPO  (O13453), PPS1_YEAST  (P38148), PRL1_DROME  (O61722), 
PRL1_LEIMA  (Q4QEZ7), PRL1_TRYCC  (Q4CUJ8), PTEN1_ARATH (Q9FLZ5), 
PTEN_CAEEL  (G5EE01), PTEN_CANLF  (P60483), PTEN_DICDI  (Q8T9S7), 
PTEN_HUMAN  (P60484), PTEN_MOUSE  (O08586), PTEN_RAT(O54857), 
PTEN_SCHPO  (O94526), PTEN_XENLA  (Q9PUT6), PTN11_CHICK (Q90687), 
PTN11_HUMAN (Q06124), PTN11_MOUSE (P35235), PTN11_RAT   (P41499), 
PTN12_HUMAN (Q05209), PTN12_MOUSE (P35831), PTN13_HUMAN (Q12923), 
PTN13_MOUSE (Q64512), PTN14_HUMAN (Q15678), PTN14_MOUSE (Q62130), 
PTN18_HUMAN (Q99952), PTN18_MOUSE (Q61152), PTN1_CHICK  (O13016), 
PTN1_HUMAN  (P18031), PTN1_MOUSE  (P35821), PTN1_RAT(P20417), 
PTN20_HUMAN (Q4JDL3), PTN20_MOUSE (O55082), PTN20_RAT   (A1L1L3), 
PTN21_HUMAN (Q16825), PTN21_MOUSE (Q62136), PTN21_RAT   (Q62728), 
PTN22_HUMAN (Q9Y2R2), PTN22_MOUSE (P29352), PTN23_HUMAN (Q9H3S7), 
PTN23_MOUSE (Q6PB44), PTN23_RAT   (O88902), PTN2A_ARATH (Q9LT75), 
PTN2B_ARATH (Q8H106), PTN2_HUMAN  (P17706), PTN2_MOUSE  (Q06180), 
PTN2_RAT(P35233), PTN3_HUMAN  (P26045), PTN3_MOUSE  (A2ALK8), 
PTN4_HUMAN  (P29074), PTN4_MOUSE  (Q9WU22), PTN5_HUMAN  (P54829), 
PTN5_MOUSE  (P54830), PTN5_RAT(P35234), PTN6_HUMAN  (P29350), 
PTN6_MOUSE  (P29351), PTN6_RAT(P81718), PTN7_HUMAN  (P35236), 
PTN7_MOUSE  (Q8BUM3), PTN7_RAT(P49445), PTN9_HUMAN  (P43378), 
PTN9_MOUSE  (O35239), PTN9_RAT(Q641Z2), PTP10_DROME (P35992), 
PTP1_AEDAE  (A0A6I8TCE0), PTP1_ARATH  (O82656), PTP1_CAEEL  (P28191), 
PTP1_CULQU  (B0X4T2), PTP1_DICDI  (P34137), PTP1_NPVOP  (O10274), 
PTP1_YEAST  (P25044), PTP2_CAEEL  (G5EC24), PTP2_DICDI  (P34138), 
PTP2_NPVOP  (O10273), PTP2_YEAST  (P29461), PTP3_CHLMO  (Q39491), 
PTP3_DICDI  (P54637), PTP3_YEAST  (P40048), PTP4_CAEEL  (P28192), 
PTP5_CAEEL  (P34442), PTP61_DROME (Q9W0G1), PTP69_DROME (P16620), 
PTP99_DROME (P35832), PTPB_MYCTU  (I6WXK4), PTPC1_BOVIN (A7E379), 
PTPC1_DANRE (A1L1R5), PTPC1_HUMAN (A2A3K4), PTPC1_MOUSE (Q6NZK8), 
PTPH1_MDBVW (Q5I147), PTPH2_MDBVW (Q5I146), PTPH3_MDBVW (Q5I145), 
PTPH4_MDBVW (Q5I143), PTPH_AMEPV  (Q9EMX1), PTPH_MIMIV  (Q5UR74), 
PTPJ1_MDBVW (Q5I141), PTPJ2_MDBVW (Q5I139), PTPJ4_MDBVW (Q5I137), 
PTPM1_DROME (Q86BN8), PTPM1_HUMAN (Q8WUK0), PTPM1_MOUSE (Q66GT5), 
PTPM1_RAT   (P0C089), PTPN1_MDBVW (Q5I128), PTPR2_HUMAN (Q92932), 
PTPR2_MACNE (O02695), PTPR2_MOUSE (P80560), PTPR2_RAT   (Q63475), 
PTPRA_HUMAN (P18433), PTPRA_MOUSE (P18052), PTPRA_RAT   (Q03348), 
PTPRB_HUMAN (P23467), PTPRB_MOUSE (B2RU80), PTPRC_CYPCA (Q9IBD8), 
PTPRC_HUMAN (P08575), PTPRC_MOUSE (P06800), PTPRC_RAT   (P04157), 
PTPRD_HUMAN (P23468), PTPRD_MOUSE (Q64487), PTPRE_HUMAN (P23469), 
PTPRE_MOUSE (P49446), PTPRE_RAT   (B2GV87), PTPRF_BOVIN (A7MBJ4), 
PTPRF_DANRE (A4IFW2), PTPRF_HUMAN (P10586), PTPRF_MOUSE (A2A8L5), 
PTPRF_RAT   (Q64604), PTPRG_CHICK (Q98936), PTPRG_HUMAN (P23470), 
PTPRG_MOUSE (Q05909), PTPRH_HUMAN (Q9HD43), PTPRH_MOUSE (E9Q0N2), 
PTPRJ_CHICK (Q9W6V5), PTPRJ_HUMAN (Q12913), PTPRJ_MOUSE (Q64455), 
PTPRK_HUMAN (Q15262), PTPRK_MOUSE (P35822), PTPRM_HUMAN (P28827), 
PTPRM_MOUSE (P28828), PTPRN_BOVIN (P56722), PTPRN_HUMAN (Q16849), 
PTPRN_MOUSE (Q60673), PTPRN_RAT   (Q63259), PTPRO_HUMAN (Q16827), 
PTPRO_MOUSE (E9Q612), PTPRQ_HUMAN (Q9UMZ3), PTPRQ_MOUSE (P0C5E4), 
PTPRQ_RAT   (O88488), PTPRR_HUMAN (Q15256), PTPRR_MOUSE (Q62132), 
PTPRR_RAT   (O08617), PTPRS_CHICK (F1NWE3), PTPRS_HUMAN (Q13332), 
PTPRS_MOUSE (B0V2N1), PTPRS_RAT   (Q64605), PTPRT_HUMAN (O14522), 
PTPRT_MOUSE (Q99M80), PTPRU_CHICK (Q6YI48), PTPRU_DANRE (B3DK56), 
PTPRU_HUMAN (Q92729), PTPRU_MOUSE (B1AUH1), PTPRV_MOUSE (P70289), 
PTPRV_RAT   (Q64612), PTPRZ_HUMAN (P23471), PTPRZ_MOUSE (B9EKR1), 
PTPRZ_RAT   (Q62656), PTPR_CAEEL  (H2KZM6), PTPX_CANAW  (P43078), 
PTP_NPVAC   (P24656), PVH1_SCHPO  (O13632), PVH1_YEAST  (Q02256), 
PYP1_SCHPO  (P27574), PYP2_SCHPO  (P32586), PYP3_SCHPO  (P32587), 
SDP1_YEAST  (P40479), SPTP_SALPA  (Q5PEA9), SPTP_SALTI  (P74851), 
SPTP_SALTY  (P74873), SSH1_HUMAN  (Q8WYL5), SSH1_MOUSE  (Q76I79), 
SSH2_HUMAN  (Q76I76), SSH2_MOUSE  (Q5SW75), SSH3_HUMAN  (Q8TE77), 
SSH3_MOUSE  (Q8K330), SSH3_RAT(Q5XIS1), SSH_DROME   (Q6NN85), 
SSH_XENLA   (Q6IVY4), STYL2_DANRE (F1QWM2), STYL2_HUMAN (Q5VZP5), 
STYL2_MOUSE (Q148W8), STYXA_XENLA (Q4V7N3), STYXB_XENLA (Q5U593), 
STYX_HUMAN  (Q8WUJ0), STYX_MOUSE  (Q60969), STYX_PONAB  (Q5RDP3), 
TP4A1_HUMAN (Q93096), TP4A1_MACFA (Q9TSM6), TP4A1_MOUSE (Q63739), 
TP4A1_PONAB (Q5R7J8), TP4A1_RAT   (Q78EG7), TP4A2_HUMAN (Q12974), 
TP4A2_MOUSE (O70274), TP4A2_RAT   (Q6P9X4), TP4A3_BOVIN (A2VDT1), 
TP4A3_HUMAN (O75365), TP4A3_MOUSE (Q9D658), TP4AA_DICDI (Q54DU9), 
TP4AB_DICDI (Q86IL4), TPBA_PSEAB  (A0A0H2ZFK2), TPBA_PSEAE  (Q9HXC7), 
TPMT1_ARATH (Q9ZQP1), TPMT2_ARATH (Q6NKR2), VF197_IIV3  (Q196Z3), 
VF197_IIV6  (Q91FX3), VHP1_CAEEL  (Q10038), Y669_CUPNH  (P40289), 
YAV4_XANCP  (P0A0W0), YAV4_XANEU  (P0A0W1), YK13_CAEEL  (P34337), 
YNBD_ECOLI  (P76093), YO42_CAEEL  (P34680), YOPH_YEREN  (P15273), 
YOPH_YERPS  (P08538), YVH1_PLAF7  (O77334)
» more

UniProtKB/Swiss-Prot
False negative sequences		 46 sequences 

D1060_DICDI (Q1ZXG8), DSP1_ARATH  (Q9ZVN4), DSP2_ORYSJ  (Q0DX67), 

DSP3_ARATH  (Q681Z2), DSP5_ARATH  (Q9FFD7), EAK5_CAEEL  (G5EGA9), 
EGG3_CAEEL  (Q20402), LSF1_ARATH  (F4J117), MTM1_RAT(Q6AXQ4), 
MTMR3_HUMAN (Q13615), MTMR3_MOUSE (Q8K296), MTMR3_RAT   (Q5PQT2), 
MTMR4_XENLA (Q7ZXF1), MTMR6_HUMAN (Q9Y217), MTMR6_MOUSE (Q8VE11), 
MTMRC_DANRE (A2BGG1), MTMRC_HUMAN (Q9C0I1), MTMRC_MOUSE (Q80TA6), 
MTMRC_PONAB (Q5R989), MTMRC_RAT   (Q5FVM6), MTMR_DICDI  (Q54GQ1), 
MYTM1_ARATH (F4J3T8), MYTM2_ARATH (F4JWB3), OCA1_CANAL  (Q59XY9), 
OCA1_CANGA  (Q6FSZ8), OCA1_DEBHA  (Q6BLZ8), OCA1_EREGS  (Q75B37), 
OCA1_KLULA  (Q6CTE4), OCA1_PICGU  (A5DE24), OCA1_PICST  (A3LW52), 
OCA1_USTMA  (Q4P7L6), OCA1_YARLI  (Q6C4X9), OCA1_YEAS7  (A6ZRY1), 
OCA1_YEAST  (P50946), OCA6_YEAST  (Q12454), PTPD1_MDBVW (Q5I154), 
PTPH5_MDBVW (Q5I142), PTPJ3_MDBVW (Q5I138), PTPN2_MDBVW (Q5I127), 
PTPN3_MDBVW (Q5I124), SIW14_SCHPO (Q9UUF3), SIW14_YEAST (P53965), 
STYL1_HUMAN (Q9Y6J8), Y7071_DICDI (Q550K8), YKCA_CAEEL  (P42083), 
YMR1_YEAST  (P47147)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 27 sequences 

PTP10_STYPL (P28202), PTP11_STYPL (P28203), PTP12_STYPL (P28204), 

PTP13_STYPL (P28205), PTP14_STYPL (P28206), PTP15_STYPL (P28207), 
PTP16_STYPL (P28208), PTP17_STYPL (P28209), PTP18_STYPL (P28210), 
PTP19_STYPL (P28211), PTP1_STYPL  (P28193), PTP20_STYPL (P28212), 
PTP21_STYPL (P28213), PTP22_STYPL (P28214), PTP23_STYPL (P28215), 
PTP24_STYPL (P28216), PTP25_STYPL (P28217), PTP26_STYPL (P28218), 
PTP27_STYPL (P28219), PTP2_STYPL  (P28194), PTP3_STYPL  (P28195), 
PTP4_STYPL  (P28196), PTP5_STYPL  (P28197), PTP6_STYPL  (P28198), 
PTP7_STYPL  (P28199), PTP8_STYPL  (P28200), PTP9_STYPL  (P28201)
» more

UniProtKB/Swiss-Prot
False positive sequences		 1 sequence 

Y3520_METJA (Q60280)


				
	

	

		PDB
[Detailed view]		
		
			856 PDB
			


			1A5Y; 1AAX; 1BZC; 1BZH; 1BZJ; 1C83; 1C84; 1C85; 1C86; 1C87; 1C88; 1D5R; 
			
				1ECV; 1EEN; 1EEO; 1FPR; 1FPZ; 1FQ1; 1G1F; 1G1G; 1G1H; 1G4U; 1G4W; 1G7F; 
				1G7G; 1GFY; 1GWZ; 1I57; 1I9S; 1I9T; 1J4X; 1JF7; 1JLN; 1KAK; 1KAV; 1L8G; 
				1L8K; 1LAR; 1LQF; 1LW3; 1LYV; 1M3G; 1M7R; 1MKP; 1NL9; 1NNY; 1NO6; 1NWE; 
				1NWL; 1NZ7; 1OEM; 1OEO; 1OES; 1OET; 1OEU; 1OEV; 1OHC; 1OHD; 1OHE; 1ONY; 
				1ONZ; 1P15; 1PA1; 1PA9; 1PH0; 1PTT; 1PTU; 1PTV; 1PTY; 1PXH; 1PYN; 1Q1M; 
				1Q6J; 1Q6M; 1Q6N; 1Q6P; 1Q6S; 1Q6T; 1QXK; 1R6H; 1RPM; 1RXD; 1SUG; 1T48; 
				1T49; 1T4J; 1V3A; 1VHR; 1WAX; 1WCH; 1WRM; 1X24; 1XBO; 1XM2; 1XRI; 1XXP; 
				1XXV; 1YFO; 1YGR; 1YGU; 1YN9; 1YPT; 1YTN; 1YTS; 1YTW; 1YWF; 1YZ4; 1ZC0; 
				1ZCK; 1ZCL; 1ZSQ; 1ZVR; 1ZZW; 2A3K; 2A8B; 2AHS; 2AZR; 2B07; 2B3O; 2B49; 
				2B4S; 2BGD; 2BGE; 2BIJ; 2BV5; 2BZL; 2C46; 2C7S; 2CFV; 2CJZ; 2CM2; 2CM3; 
				2CM7; 2CM8; 2CMA; 2CMB; 2CMC; 2CNE; 2CNF; 2CNG; 2CNH; 2CNI; 2E0T; 2ESB; 
				2F6F; 2F6T; 2F6V; 2F6W; 2F6Y; 2F6Z; 2F70; 2F71; 2FH7; 2FJM; 2FJN; 2G59; 
				2G6Z; 2GJT; 2GP0; 2GWO; 2H02; 2H03; 2H04; 2H4G; 2H4K; 2H4V; 2HB1; 2HC1; 
				2HC2; 2HCM; 2HNP; 2HNQ; 2HVL; 2HXP; 2HY3; 2I1Y; 2I3R; 2I3U; 2I42; 2I4E; 
				2I4G; 2I4H; 2I5X; 2I75; 2IMG; 2J16; 2J17; 2JJD; 2M3V; 2MBC; 2NLK; 2NT2; 
				2NT7; 2NTA; 2NV5; 2NZ6; 2OC3; 2OOQ; 2OUD; 2OZ5; 2P4D; 2P6X; 2PA5; 2PBN; 
				2PQ5; 2Q05; 2Q47; 2QBP; 2QBQ; 2QBR; 2QBS; 2QCJ; 2QCT; 2QDC; 2QDM; 2QDP; 
				2QEP; 2R0B; 2RF6; 2SHP; 2VEU; 2VEV; 2VEW; 2VEX; 2VEY; 2WGP; 2Y96; 2YF0; 
				2ZMM; 2ZN7; 3A5J; 3A5K; 3B7O; 3BLT; 3BLU; 3BM8; 3BRH; 3CM3; 3CWE; 3D42; 
				3D44; 3D9C; 3EAX; 3EB1; 3EU0; 3EZZ; 3F81; 3F99; 3F9A; 3F9B; 3H2X; 3I7Z; 
				3I80; 3LJ8; 3MOW; 3N0A; 3NME; 3O4S; 3O4T; 3O4U; 3O5X; 3OLR; 3OMH; 3PS5; 
				3QCB; 3QCC; 3QCD; 3QCE; 3QCF; 3QCG; 3QCH; 3QCI; 3QCJ; 3QCK; 3QCL; 3QCM; 
				3QCN; 3QKP; 3QKQ; 3RGO; 3RGQ; 3RZ2; 3S3E; 3S3F; 3S3H; 3S3K; 3S4E; 3S4O; 
				3SME; 3SR9; 3U96; 3ZM0; 3ZM1; 3ZM2; 3ZM3; 3ZMP; 3ZMQ; 3ZV2; 4B04; 4BJO; 
				4BPC; 4D3P; 4D3Q; 4D3R; 4DGP; 4DGX; 4ERC; 4GE2; 4GE5; 4GE6; 4GFU; 4GFV; 
				4GRY; 4GRZ; 4GS0; 4GWF; 4H1O; 4H34; 4HJP; 4HJQ; 4HRF; 4I8N; 4ICZ; 4IKC; 
				4J51; 4JMJ; 4JMK; 4JNB; 4KI9; 4KYQ; 4KYR; 4MBB; 4NND; 4NWF; 4NWG; 4NYH; 
				4OHD; 4OHE; 4OHH; 4OHI; 4OHL; 4PVG; 4PYH; 4QAH; 4QAP; 4QBE; 4QBW; 4QUM; 
				4QUN; 4R0S; 4R0T; 4R30; 4RDD; 4RH5; 4RH9; 4RHG; 4RI4; 4RI5; 4RKK; 4S0G; 
				4WOH; 4Y14; 4Y2E; 4YAA; 4YR8; 4Z6B; 4ZI4; 4ZN5; 4ZRT; 5AWX; 5BK8; 5BUG; 
				5BX1; 5BZX; 5BZZ; 5C16; 5EHP; 5EHR; 5GNH; 5GTJ; 5H08; 5HDE; 5I6V; 5IBM; 
				5IBS; 5J8R; 5K22; 5K23; 5K24; 5K25; 5K9V; 5K9W; 5KA0; 5KA1; 5KA2; 5KA3; 
				5KA4; 5KA7; 5KA8; 5KA9; 5KAA; 5KAB; 5KAC; 5KAD; 5LXQ; 5MMZ; 5OVR; 5OVX; 
				5OW1; 5QDE; 5QDF; 5QDG; 5QDH; 5QDI; 5QDJ; 5QDK; 5QDL; 5QDM; 5QDN; 5QDO; 
				5QDP; 5QDQ; 5QDR; 5QDS; 5QDT; 5QDU; 5QDV; 5QDW; 5QDX; 5QDY; 5QDZ; 5QE0; 
				5QE1; 5QE2; 5QE3; 5QE4; 5QE5; 5QE6; 5QE7; 5QE8; 5QE9; 5QEA; 5QEB; 5QEC; 
				5QED; 5QEE; 5QEF; 5QEG; 5QEH; 5QEI; 5QEJ; 5QEK; 5QEL; 5QEM; 5QEN; 5QEO; 
				5QEP; 5QEQ; 5QER; 5QES; 5QET; 5QEU; 5QEV; 5QEW; 5QEX; 5QEY; 5QEZ; 5QF0; 
				5QF1; 5QF2; 5QF3; 5QF4; 5QF5; 5QF6; 5QF7; 5QF8; 5QF9; 5QFA; 5QFB; 5QFC; 
				5QFD; 5QFE; 5QFF; 5QFG; 5QFH; 5QFI; 5QFJ; 5QFK; 5QFL; 5QFM; 5QFN; 5QFO; 
				5QFP; 5QFQ; 5QFR; 5QFS; 5QFT; 5QFU; 5QFV; 5QFW; 5QFX; 5QFY; 5QFZ; 5QG0; 
				5QG1; 5QG2; 5QG3; 5QG4; 5QG5; 5QG6; 5QG7; 5QG8; 5QG9; 5QGA; 5QGB; 5QGC; 
				5QGD; 5QGE; 5QGF; 5T19; 5TSR; 5XJV; 5XW4; 5XW5; 5XZR; 5Y15; 5Y16; 6APX; 
				6ATD; 6B8E; 6B8T; 6B8X; 6B8Z; 6B90; 6B95; 6BAI; 6BMR; 6BMU; 6BMV; 6BMW; 
				6BMX; 6BMY; 6BN5; 6BYF; 6CMP; 6CMQ; 6CMR; 6CMS; 6CRF; 6CRG; 6CWU; 6CWV; 
				6D3F; 6D4D; 6D4F; 6D65; 6D66; 6D67; 6G84; 6G85; 6G86; 6H8R; 6H8S; 6IWD; 
				6J6U; 6KIP; 6KR4; 6KRW; 6KRX; 6KZQ; 6L03; 6L1S; 6LMY; 6LOT; 6LOU; 6LVQ; 
				6MC1; 6MD7; 6MD9; 6MDA; 6MDB; 6MDC; 6MDD; 6N8M; 6N8N; 6N8O; 6NTP; 6OL4; 
				6OLQ; 6OLV; 6OMY; 6PFW; 6PG0; 6PGT; 6PHA; 6PHS; 6PM8; 6RZZ; 6S05; 6SUB; 
				6SUC; 6T36; 6UZT; 6W30; 6WU8; 6WUR; 6WUS; 6XE8; 6XEA; 6XED; 6XEE; 6XEF; 
				6XEG; 6XFT; 6ZZ4; 7C8S; 7EMN; 7F5N; 7F5O; 7FQM; 7FQN; 7FQO; 7FQP; 7FQQ; 
				7FQR; 7FQS; 7FQT; 7FQU; 7FQV; 7FQW; 7FQX; 7FQY; 7FQZ; 7FRE; 7FRF; 7FRG; 
				7FRH; 7FRI; 7FRJ; 7FRK; 7FRL; 7FRM; 7FRN; 7FRO; 7FRP; 7FRQ; 7FRR; 7FRS; 
				7FRT; 7FRU; 7GS7; 7GS8; 7GS9; 7GSA; 7GSB; 7GSC; 7GSD; 7GSE; 7GSF; 7GSG; 
				7GSH; 7GSI; 7GSJ; 7GSK; 7GSL; 7GSM; 7GSN; 7GSO; 7GSQ; 7GSR; 7GST; 7GSU; 
				7GSV; 7GSW; 7GSX; 7GSY; 7GSZ; 7GT0; 7GT1; 7GT2; 7GT3; 7GT4; 7GT5; 7GT6; 
				7GT7; 7GT8; 7GT9; 7GTA; 7GTB; 7GTC; 7GTD; 7GTE; 7GTF; 7GTG; 7GTH; 7GTI; 
				7GTJ; 7GTK; 7GTL; 7GTM; 7GTN; 7GTO; 7GTP; 7GTQ; 7GTR; 7GTS; 7GTT; 7GTU; 
				7GTV; 7GTW; 7GTX; 7GTY; 7GTZ; 7GU0; 7GU1; 7GU2; 7GU3; 7GU4; 7GU5; 7GU6; 
				7GU7; 7GU8; 7GU9; 7GUA; 7GUB; 7GUC; 7JTX; 7JUK; 7JUL; 7JVM; 7JVN; 7JVX; 
				7KEN; 7KEY; 7KLX; 7L0C; 7L0H; 7LFO; 7MKZ; 7MM1; 7MN7; 7MN9; 7MNA; 7MNB; 
				7MNC; 7MND; 7MNE; 7MNF; 7MOK; 7MOL; 7MOM; 7MOU; 7MOV; 7MOW; 7R75; 7R7D; 
				7R7I; 7R7L; 7RCT; 7RIN; 7S4F; 7TVJ; 7U4O; 7U4R; 7UAD; 7UMU; 7UMV; 7UN0; 
				7UN4; 7VXG; 7XC0; 7XHQ; 7Y4B; 7Y4C; 7Y4D; 7Y4E; 8B5Y; 8CBH; 8CT8; 8DU7; 
				8EXI; 8EXJ; 8EXK; 8EXM; 8EXN; 8EYA; 8EYB; 8EYC; 8F88; 8G65; 8G67; 8G68; 
				8G69; 8G6A; 8GVV; 8GWH; 8GWW; 8GXE; 8GZ4; 8I7O; 8I7R; 8IYJ; 8JBN; 8JBY; 
				8P4A; 8P4B; 8P4C; 8P4D; 8P4E; 8RZW; 8RZY; 8S01; 8S04; 8S06; 8S07; 8S0H; 
				8S0I; 8S0J; 8S0K; 8S0O; 8S0P; 8S0Q; 8S0S; 8SKL; 8SLS; 8SLT; 8SLU; 8T6D; 
				8T6G; 8T7Q; 8T8Q; 8TK2; 8TK3; 8TK4; 8TK5; 8TK6; 8TO0; 8U0H; 8U1E; 8U7W; 
				8U7X; 8W8E; 8W8F; 8WFY; 8WX7; 8XOY; 8XQD; 8YHI; 9BLG; 9C54; 9C55; 9C56; 
				9CYO; 9CYP; 9CYQ; 9CYR
			
			

			» more