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| Entry: PS50063 |
General information about the entry
| Entry name [info] | BH4_2 |
| Accession [info] | PS50063 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE; 22-FEB-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00829 |
| Associated ProRule [info] | PRU00025 |
Name and characterization of the entry
| Description [info] | Apoptosis regulator, Bcl-2 family BH4 motif profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=20; /DISJOINT: DEFINITION=PROTECT; N1=3; N2=18; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3853000; R2=0.0180308; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=877.5354614; R2=0.6903226; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=493; H_SCORE=1218; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=382; H_SCORE=1141; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-50; E1=0; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='N'; M= -5, 6,-21, -6,-11,-13,-14, -9, 5,-13,-12, -6, 20,-18, -7,-13, 6, 1, -4,-33,-13,-11; /M: SY='R'; M=-16, -5,-30, -3, 15,-25,-20, 2,-28, 23,-20,-10, 0,-15, 20, 47, -6,-10,-24,-22,-12, 14; /M: SY='E'; M= -9, 12,-30, 21, 22,-32, 14, -7,-36, -3,-26,-22, 5, -9, 1, -9, 0,-14,-30,-29,-24, 12; /M: SY='F'; M=-14,-30,-23,-36,-26, 32,-33,-23, 20,-30, 28, 13,-24,-27,-27,-23,-24,-10, 12, -9, 11,-26; /M: SY='V'; M= 0,-30,-10,-30,-30, 0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10, 0, 50,-30,-10,-30; /M: SY='V'; M= -5,-19,-17,-18, -7, -6,-26,-18, 13,-13, 9, 11,-22,-22,-13,-14,-11, -5, 21,-27,-10,-10; /M: SY='D'; M=-15, 26,-30, 36, 15,-35,-15, -5,-35, 24,-30,-20, 10,-10, 5, 9, -5,-10,-25,-30,-15, 10; /M: SY='Y'; M=-20,-24,-26,-28,-24, 49,-30, 4, 0,-18, 4, 0,-20,-30,-22,-14,-20,-10, -6, 22, 61,-24; /M: SY='F'; M=-11,-30,-20,-36,-28, 30,-33,-25, 23,-28, 19, 11,-24,-27,-29,-23,-19, -8, 21,-12, 8,-28; /M: SY='T'; M= -1, 0,-15, -4, -4,-16,-12, 14,-19,-10,-20,-11, 6,-13, -1, -7, 20, 21,-12,-34, -6, -4; /M: SY='Y'; M=-18,-12,-30,-12, -9, 7,-26, 28,-13, 4,-11, -2,-10,-23, -2, 1,-16,-12,-16, 7, 48, -9; /M: SY='R'; M=-14, -4,-30, -4, 6,-26,-20, -6,-30, 43,-26,-10, 0,-14, 10, 44,-10,-10,-20,-20,-10, 6; /M: SY='L'; M=-10,-30,-24,-34,-24, 6,-34,-24, 31,-30, 39, 20,-26,-26,-20,-24,-26,-10, 17,-20, 0,-24; /M: SY='S'; M= 11, -4,-14, -5, -2,-20, -4,-10,-20, -3,-25,-16, 5,-12, 0, 3, 26, 11,-10,-33,-18, -2; /M: SY='Q'; M=-10, 0,-30, 0, 20,-40,-20, 10,-20, 10,-20, 0, 0,-10, 60, 10, 0,-10,-30,-20,-10, 40; /M: SY='N'; M=-13, 21,-24, 9, 2,-22, -8, 4,-24, 15,-27,-16, 35,-18, 4, 22, 2, -4,-26,-32,-16, 2; /M: SY='G'; M= 0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20, 0,-20,-20,-20, 0,-20,-30,-20,-30,-20; /M: SY='Y'; M=-15,-22,-25,-25,-20, 18,-28, 6, 9,-14, 16, 19,-22,-28,-10,-12,-22,-10, -1, 7, 43,-18; /M: SY='D'; M=-10, 23,-26, 34, 33,-32,-12, -2,-32, 2,-26,-24, 9, -6, 9, -6, 8, -4,-26,-36,-20, 21; /M: SY='W'; M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 19 in 19 different sequences |
| Number of true positive hits | 19 in 19 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 7 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 73.08 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | MOTIF |
| Feature description [info] | BH4 |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
19 sequences
B2CL1_CHICK (Q07816 ), B2CL1_HUMAN (Q07817 ), B2CL1_MOUSE (Q64373 ), B2CL1_PIG (O77737 ), B2CL1_RAT (P53563 ), B2CL2_BOVIN (Q1RMX3 ), B2CL2_CANLF (Q45T69 ), B2CL2_HUMAN (Q92843 ), B2CL2_MOUSE (P70345 ), BCL2_BOVIN (O02718 ), BCL2_CANLF (Q6R755 ), BCL2_CHICK (Q00709 ), BCL2_CRIGR (Q9JJV8 ), BCL2_HUMAN (P10415 ), BCL2_MOUSE (P10417 ), BCL2_RAT (P49950 ), BOKB_DANRE (Q7T381 ), CED9_CAEBR (P41957 ), CED9_CAEEL (P41958 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
7 sequences
B2L13_HUMAN (Q9BXK5 ), B2L13_MOUSE (P59017 ), BOKA_DANRE (Q6DC66 ), BOK_CHICK (Q9I8I2 ), BOK_HUMAN (Q9UMX3 ), BOK_MOUSE (O35425 ), BOK_RAT (Q792S6 )» more |
| PDB [Detailed view] |
141 PDB
1AF3; 1BXL; 1G5J; 1G5M; 1GJH; 1LXL; 1MAZ; 1MK3; 1O0L; 1OHU; 1PQ0; 1PQ1; 1R2D; 1R2E; 1R2G; 1R2H; 1R2I; 1TY4; 1YSG; 1YSI; 1YSN; 1YSW; 1ZY3; 2A5Y; 2B48; 2BZW; 2LP8; 2LPC; 2M03; 2M04; 2ME8; 2ME9; 2MEJ; 2O1Y; 2O21; 2O22; 2O2F; 2O2M; 2O2N; 2P1L; 2PON; 2W3L; 2XA0; 2Y6W; 2YJ1; 2YQ6; 2YQ7; 2YXJ; 3CVA; 3FDL; 3FDM; 3IHC; 3IHD; 3IHE; 3IHF; 3IIG; 3IIH; 3ILB; 3ILC; 3INQ; 3IO8; 3PL7; 3QKD; 3R85; 3SP7; 3SPF; 3WIZ; 3ZK6; 3ZLN; 3ZLO; 3ZLR; 4A1U; 4A1W; 4AQ3; 4BPK; 4C52; 4C5D; 4CIM; 4CIN; 4EHR; 4HNJ; 4IEH; 4K5A; 4K5B; 4LVT; 4LXD; 4MAN; 4PPI; 4QNQ; 4QVE; 4QVF; 4QVX; 4TUH; 4YJ4; 4YK9; 4Z9V; 5AGW; 5AGX; 5B1Z; 5C3G; 5FCG; 5FMJ; 5FMK; 5JSN; 5VAU; 5VAX; 5VAY; 5VX3; 5WDD; 6BF2; 6CKV; 6DCN; 6DCO; 6GL8; 6HJL; 6IJQ; 6IWB; 6LHD; 6O0K; 6O0L; 6O0M; 6O0O; 6O0P; 6RNU; 6ST2; 6UVC; 6UVD; 6UVE; 6UVF; 6UVG; 6UVH; 6VWC; 6YLI; 6ZHC; 7CA4; 7JGV; 7JGW; 7LH7; 7LHB; 7WJH; 7XGG » more |
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