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PROSITE entry PS50063


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PURL: https://purl.expasy.org/prosite/signature/PS50063

Direct ScanProsite submission
General information about the entry

Entry name [info] BH4_2
Accession [info] PS50063
Entry type [info] MATRIX
Date [info] 01-NOV-1997 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00829
Associated ProRule [info] PRU00025

Name and characterization of the entry

Description [info] Apoptosis regulator, Bcl-2 family BH4 motif profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=20;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=18;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.3853000; R2=0.0180308; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=877.5354614; R2=0.6903226; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=493; H_SCORE=1218; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=382; H_SCORE=1141; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: D=-20; I=-20; B1=-50; E1=0; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='N';  M= -5,  6,-21, -6,-11,-13,-14, -9,  5,-13,-12, -6, 20,-18, -7,-13,  6,  1, -4,-33,-13,-11;
/M: SY='R';  M=-16, -5,-30, -3, 15,-25,-20,  2,-28, 23,-20,-10,  0,-15, 20, 47, -6,-10,-24,-22,-12, 14;
/M: SY='E';  M= -9, 12,-30, 21, 22,-32, 14, -7,-36, -3,-26,-22,  5, -9,  1, -9,  0,-14,-30,-29,-24, 12;
/M: SY='F';  M=-14,-30,-23,-36,-26, 32,-33,-23, 20,-30, 28, 13,-24,-27,-27,-23,-24,-10, 12, -9, 11,-26;
/M: SY='V';  M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='V';  M= -5,-19,-17,-18, -7, -6,-26,-18, 13,-13,  9, 11,-22,-22,-13,-14,-11, -5, 21,-27,-10,-10;
/M: SY='D';  M=-15, 26,-30, 36, 15,-35,-15, -5,-35, 24,-30,-20, 10,-10,  5,  9, -5,-10,-25,-30,-15, 10;
/M: SY='Y';  M=-20,-24,-26,-28,-24, 49,-30,  4,  0,-18,  4,  0,-20,-30,-22,-14,-20,-10, -6, 22, 61,-24;
/M: SY='F';  M=-11,-30,-20,-36,-28, 30,-33,-25, 23,-28, 19, 11,-24,-27,-29,-23,-19, -8, 21,-12,  8,-28;
/M: SY='T';  M= -1,  0,-15, -4, -4,-16,-12, 14,-19,-10,-20,-11,  6,-13, -1, -7, 20, 21,-12,-34, -6, -4;
/M: SY='Y';  M=-18,-12,-30,-12, -9,  7,-26, 28,-13,  4,-11, -2,-10,-23, -2,  1,-16,-12,-16,  7, 48, -9;
/M: SY='R';  M=-14, -4,-30, -4,  6,-26,-20, -6,-30, 43,-26,-10,  0,-14, 10, 44,-10,-10,-20,-20,-10,  6;
/M: SY='L';  M=-10,-30,-24,-34,-24,  6,-34,-24, 31,-30, 39, 20,-26,-26,-20,-24,-26,-10, 17,-20,  0,-24;
/M: SY='S';  M= 11, -4,-14, -5, -2,-20, -4,-10,-20, -3,-25,-16,  5,-12,  0,  3, 26, 11,-10,-33,-18, -2;
/M: SY='Q';  M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='N';  M=-13, 21,-24,  9,  2,-22, -8,  4,-24, 15,-27,-16, 35,-18,  4, 22,  2, -4,-26,-32,-16,  2;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='Y';  M=-15,-22,-25,-25,-20, 18,-28,  6,  9,-14, 16, 19,-22,-28,-10,-12,-22,-10, -1,  7, 43,-18;
/M: SY='D';  M=-10, 23,-26, 34, 33,-32,-12, -2,-32,  2,-26,-24,  9, -6,  9, -6,  8, -4,-26,-36,-20, 21;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/I:         E1=0; IE=-105; DE=-105;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 19 in 19 different sequences
Number of true positive hits 19 in 19 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 7
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 73.08 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] K_Hofmann
Feature key [info] MOTIF
Feature description [info] BH4
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
19 sequences

B2CL1_CHICK (Q07816), B2CL1_HUMAN (Q07817), B2CL1_MOUSE (Q64373), 
B2CL1_PIG   (O77737), B2CL1_RAT   (P53563), B2CL2_BOVIN (Q1RMX3), 
B2CL2_CANLF (Q45T69), B2CL2_HUMAN (Q92843), B2CL2_MOUSE (P70345), 
BCL2_BOVIN  (O02718), BCL2_CANLF  (Q6R755), BCL2_CHICK  (Q00709), 
BCL2_CRIGR  (Q9JJV8), BCL2_HUMAN  (P10415), BCL2_MOUSE  (P10417), 
BCL2_RAT(P49950), BOKB_DANRE  (Q7T381), CED9_CAEBR  (P41957), 
CED9_CAEEL  (P41958)
» more

UniProtKB/Swiss-Prot
False negative sequences
7 sequences

B2L13_HUMAN (Q9BXK5), B2L13_MOUSE (P59017), BOKA_DANRE  (Q6DC66), 
BOK_CHICK   (Q9I8I2), BOK_HUMAN   (Q9UMX3), BOK_MOUSE   (O35425), 
BOK_RAT (Q792S6)
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PDB
[Detailed view]
169 PDB

pdb_00001af3; pdb_00001bxl; pdb_00001g5j; pdb_00001g5m; pdb_00001gjh; pdb_00001lxl; pdb_00001maz; pdb_00001mk3; pdb_00001o0l; pdb_00001ohu; pdb_00001pq0; pdb_00001pq1; pdb_00001r2d; pdb_00001r2e; pdb_00001r2g; pdb_00001r2h; pdb_00001r2i; pdb_00001ty4; pdb_00001ysg; pdb_00001ysi; pdb_00001ysn; pdb_00001ysw; pdb_00001zy3; pdb_00002a5y; pdb_00002b48; pdb_00002bzw; pdb_00002lp8; pdb_00002lpc; pdb_00002m03; pdb_00002m04; pdb_00002me8; pdb_00002me9; pdb_00002mej; pdb_00002o1y; pdb_00002o21; pdb_00002o22; pdb_00002o2f; pdb_00002o2m; pdb_00002o2n; pdb_00002p1l; pdb_00002pon; pdb_00002w3l; pdb_00002xa0; pdb_00002y6w; pdb_00002yj1; pdb_00002yq6; pdb_00002yq7; pdb_00002yxj; pdb_00003cva; pdb_00003fdl; pdb_00003fdm; pdb_00003ihc; pdb_00003ihd; pdb_00003ihe; pdb_00003ihf; pdb_00003iig; pdb_00003iih; pdb_00003ilb; pdb_00003ilc; pdb_00003inq; pdb_00003io8; pdb_00003pl7; pdb_00003qkd; pdb_00003r85; pdb_00003sp7; pdb_00003spf; pdb_00003wiz; pdb_00003zk6; pdb_00003zln; pdb_00003zlo; pdb_00003zlr; pdb_00004a1u; pdb_00004a1w; pdb_00004aq3; pdb_00004bpk; pdb_00004c52; pdb_00004c5d; pdb_00004cim; pdb_00004cin; pdb_00004ehr; pdb_00004hnj; pdb_00004ieh; pdb_00004k5a; pdb_00004k5b; pdb_00004lvt; pdb_00004lxd; pdb_00004man; pdb_00004ppi; pdb_00004qnq; pdb_00004qve; pdb_00004qvf; pdb_00004qvx; pdb_00004tuh; pdb_00004yj4; pdb_00004yk9; pdb_00004z9v; pdb_00005agw; pdb_00005agx; pdb_00005b1z; pdb_00005c3g; pdb_00005fcg; pdb_00005fmj; pdb_00005fmk; pdb_00005jsn; pdb_00005vau; pdb_00005vax; pdb_00005vay; pdb_00005vx3; pdb_00005wdd; pdb_00006bf2; pdb_00006ckv; pdb_00006dcn; pdb_00006dco; pdb_00006gl8; pdb_00006hjl; pdb_00006ijq; pdb_00006iwb; pdb_00006lhd; pdb_00006o0k; pdb_00006o0l; pdb_00006o0m; pdb_00006o0o; pdb_00006o0p; pdb_00006rnu; pdb_00006st2; pdb_00006uvc; pdb_00006uvd; pdb_00006uve; pdb_00006uvf; pdb_00006uvg; pdb_00006uvh; pdb_00006vwc; pdb_00006yli; pdb_00006zhc; pdb_00007ca4; pdb_00007jgv; pdb_00007jgw; pdb_00007lh7; pdb_00007lhb; pdb_00007wjh; pdb_00007xgf; pdb_00007xgg; pdb_00007y8d; pdb_00007y90; pdb_00007y99; pdb_00007ya5; pdb_00007yaa; pdb_00008fy0; pdb_00008fy1; pdb_00008fy2; pdb_00008hll; pdb_00008hlm; pdb_00008hln; pdb_00008hog; pdb_00008hoh; pdb_00008hoi; pdb_00008htr; pdb_00008hts; pdb_00008iqk; pdb_00008iql; pdb_00008u27; pdb_00008vwx; pdb_00008vwz; pdb_00008vxm; pdb_00008vxn; pdb_00008wls; pdb_00008xp5; pdb_00008zeb; pdb_00009aqz
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