PROSITE entry PS50073
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General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS50073 |
| Entry name [info] | COPPER_FIST_2 |
| Accession [info] | PS50073 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-1997 CREATED;
07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00863 |
| Associated ProRule [info] | PRU00055 |
Name and characterization of the entry
| Description [info] | Copper-fist DNA-binding domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=40; /DISJOINT: DEFINITION=PROTECT; N1=5; N2=36; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.2387000; R2=0.0126923; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3371.3508301; R2=0.4912281; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=651; H_SCORE=3691; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=494; H_SCORE=3614; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-40; E1=-40; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='M'; M=-10,-20,-20,-30,-20, 0,-20, 0, 20,-10, 20, 60,-20,-20, 0,-10,-20,-10, 10,-20, 0,-10; /M: SY='V'; M= -3,-28,-19,-28,-25, -5,-30,-28, 24,-20, 4, 6,-27, -7,-25,-22,-12, -3, 32,-28,-12,-26; /M: SY='V'; M= -4,-30,-18,-33,-29, 1,-33,-29, 36,-24, 18, 14,-27,-27,-26,-23,-15, -4, 39,-26, -6,-29; /M: SY='I'; M=-12,-30,-28,-40,-30, 13,-38,-28, 42,-30, 18, 17,-20,-22,-23,-28,-20,-10, 25,-15, 5,-30; /M: SY='N'; M=-10, 36,-21, 20, 8,-21, -3, 9,-21, 1,-29,-20, 52,-17, 3, 0, 9, -1,-30,-39,-20, 5; /M: SY='G'; M= -1, -3,-29, -6,-17,-29, 61,-16,-37,-17,-30,-20, 8,-20,-17,-17, 1,-17,-30,-23,-29,-17; /M: SY='I'; M= -6,-13,-20,-19,-16,-10,-26,-16, 18,-14, 1, 6, -8,-22, -7,-14, -7, -4, 18,-27, -9,-13; /M: SY='K'; M=-10, 0,-30, 0, 10,-30,-20,-10,-30, 50,-30,-10, 0,-10, 10, 30,-10,-10,-20,-20,-10, 10; /M: SY='Y'; M=-17,-20,-27,-23,-20, 21,-27, 14, 6,-10, 6, 19,-20,-27, -7,-10,-20,-10, -4, 14, 55,-17; /M: SY='A'; M= 50,-10,-10,-20,-10,-20, 0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10, 0, 0,-20,-20,-10; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='E'; M= -1, 7,-26, 11, 17,-26, 1, -7,-24, -3,-17,-10, -1,-10, 2,-10, -1,-10,-20,-27,-19, 9; /M: SY='R'; M= -4, -6,-23, -5, 0,-22,-13,-10,-23, 7,-25,-15, 0, 6, 1, 13, 10, 7,-16,-30,-17, -2; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='I'; M=-10,-30,-30,-40,-30, 0,-40,-30, 50,-30, 20, 20,-20,-20,-20,-30,-20,-10, 30,-20, 0,-30; /M: SY='R'; M=-18, -8,-30, -8, 2,-22,-20, -2,-30, 34,-22,-10, 0,-18, 10, 63,-10,-10,-20,-20,-10, 2; /M: SY='G'; M= 2, -8,-26, -8,-16,-28, 57,-18,-36,-18,-30,-20, 2,-18,-16,-18, 7,-13,-26,-24,-28,-16; /M: SY='H'; M=-20, 0,-30, 0, 0,-20,-20,100,-30,-10,-20, 0, 10,-20, 10, 0,-10,-20,-30,-30, 20, 0; /M: SY='R'; M=-18, -8,-30, -8, 2,-22,-20, -2,-30, 34,-22,-10, 0,-18, 10, 63,-10,-10,-20,-20,-10, 2; /M: SY='A'; M= 19,-10,-10,-13,-10,-15, -7,-18, -5,-12,-15,-10, -5,-15,-10,-15, 19, 9, 7,-32,-18,-10; /M: SY='S'; M= 19, -3,-10, -9, -6,-17, -6,-16,-14,-10,-18,-14, 1,-10, -6,-13, 26, 23, -4,-31,-17, -6; /M: SY='T'; M= -3, 0,-19, -4, 4,-24,-17, -8,-18, 7,-19, -8, 1,-10, 15, 3, 11, 18,-14,-27,-11, 9; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='N'; M= -9, 12,-22, 5, 10,-21,-14, -3,-22, 11,-22,-15, 17,-13, 4, 13, 5, 7,-20,-30,-15, 6; /M: SY='H'; M=-20, 0,-30, 0, 0,-20,-20,100,-30,-10,-20, 0, 10,-20, 10, 0,-10,-20,-30,-30, 20, 0; /M: SY='T'; M= -5, 9,-17, -1, -7, -8,-12, -2,-13, -7,-18,-13, 17,-17, -5, -7, 13, 19,-13,-24, 1, -7; /I: I=-6; MI=-6; IM=-6; DM=-15; MD=-15; /M: SY='D'; M=-17, 28,-30, 40, 24,-35,-15, 17,-34, 2,-25,-19, 12,-10, 13, -4, -2,-12,-30,-34,-12, 18; /M: SY='R'; M=-15, -8,-30, -8, 3,-26,-10, 0,-29, 20,-21, -9, 0,-18, 19, 46, -7,-11,-23,-20,-12, 7; /M: SY='P'; M= -8,-18,-30,-13, -1,-20,-22,-16, -6, -9,-14, -2,-19, 39, -8,-16,-10, -8, -9,-28,-20, -7; /M: SY='L'; M=-10,-28,-20,-30,-20, 8,-28,-16, 20,-26, 45, 27,-28,-28,-16,-18,-28,-10, 10,-20, 0,-18; /M: SY='I'; M=-10,-20,-24,-26,-16, 1,-29,-18, 15, -7, 3, 12,-16,-20, -8, -9,-14, -8, 12,-18, -1,-13; /M: SY='P'; M=-11,-17,-31,-18, -8,-17,-24,-13, -2, 1, -9, 7,-14, 16, -4, 0,-14,-10, -8,-23,-12, -9; /M: SY='I'; M= -7,-30,-21,-35,-28, 2,-35,-28, 38,-27, 22, 17,-25,-25,-23,-25,-18, -7, 33,-23, -3,-28; /M: SY='R'; M=-16, -6,-30, -6, 4,-24,-20, -4,-30, 38,-24,-10, 0,-16, 10, 53,-10,-10,-20,-20,-10, 4; /M: SY='P'; M= -9,-12,-32, -8, 0,-26,-20,-16,-21, 5,-26,-16,-11, 44, -4, 0, -5, 0,-22,-27,-21, -5; /M: SY='R'; M=-13, -7,-32, -5, 5,-27,-20, -8,-28, 32,-27,-12, -4, 5, 6, 35,-10,-10,-22,-22,-14, 3; /M: SY='G'; M= 0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20, 0,-20,-20,-20, 0,-20,-30,-20,-30,-20; /M: SY='R'; M=-20,-10,-30,-10, 0,-20,-20, 0,-30, 30,-20,-10, 0,-20, 10, 70,-10,-10,-20,-20,-10, 0; /M: SY='P'; M=-10,-20,-40,-10, 0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10; /M: SY='S'; M= 5,-14,-20,-15, -9,-14,-14,-18, -2,-16, -6, -6, -9, 4, -9,-18, 6, 2, -3,-29,-16,-11; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 10 in 10 different sequences |
| Number of true positive hits | 10 in 10 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann |
| Feature key [info] | DNA_BIND |
| Feature description [info] | Copper-fist |
| Version [info] | 6 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
10 sequences
AMT1_CANGA (P41772), CRF1_YARLI (P45815), CUF1_CRYNH (J9VT33), CUF1_SCHPO (Q09728), CUF2_SCHPO (O94588), CUP2_YEAST (P15315), GRISA_PODAS (Q92258), HAA1_YEAST (Q12753), MAC1_CANAL (Q5AFK0), MAC1_YEAST (P35192)» more
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| PDB [Detailed view] |
1 PDB
1CO4 |