PROSITE entry PS50108

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General information about the entry

Entry name [info]	CRIB
Accession [info]	PS50108
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50108
Associated ProRule [info]	PRU00057

Name and characterization of the entry

Description [info]

CRIB domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=14;
/DISJOINT: DEFINITION=PROTECT; N1=2; N2=13;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.2255000; R2=0.0176662; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=419.6926270; R2=0.3792415; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=421; H_SCORE=579; N_SCORE=7.2; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=381; H_SCORE=564; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I';  M= -7,-30,-25,-37,-30,  0,-37,-30, 45,-27, 17, 17,-23,-23,-23,-27,-17, -7, 35,-23, -3,-30;
/M: SY='G';  M=  6, -4,-18, -4, -8,-24, 27,-14,-28,-14,-30,-20,  6,-14, -8,-14, 25,  5,-18,-32,-24, -8;
/M: SY='S';  M=  4, -4,-19, -8, -4,-14, -9, -6,-13, -9,-13, -9,  1, -9, -4,-10,  6,  5,-11,-26,-11, -5;
/M: SY='P';  M= -9,-19,-39,-10,  0,-30,-19,-20,-20,-10,-30,-20,-19, 87,-10,-20, -8, -9,-29,-30,-30,-10;
/M: SY='T';  M= -4,-11,-15,-17,-13,  8,-19,-15, -5,-15, -4, -3, -6,-17,-12,-12,  7, 18, -1,-21, -1,-11;
/I:         I=-6; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='N';  M=-12, 39,-23, 31,  4,-26,  2,  4,-27, -2,-30,-23, 43,-17, -2, -4,  7, -4,-30,-38,-21,  1;
/M: SY='F';  M=-13,-29,-19,-35,-27, 50,-29,-21,  6,-26,  9,  2,-22,-24,-34,-20,-17, -8, 10, -2, 18,-28;
/M: SY='K';  M= -9, -1,-26, -1, 12,-25,-20, -7,-20, 22,-20, -8, -1,-12, 11, 18, -4, -5,-14,-24,-12, 11;
/M: SY='H';  M=-20, -1,-30, -1,  0,-19,-20, 91,-29, -7,-20, -1,  9,-20, 10,  5,-10,-19,-29,-28, 19,  0;
/M: SY='T';  M= -7, -6,-21, -9, -5,-13,-23, -9, -2, -6, -4, -2, -5,-17, -4, -4, -3,  4,  1,-27, -8, -6;
/M: SY='V';  M=  3,-20,-14,-25,-21, -2,-17,-19, 11,-18,  1,  5,-16,-21,-18,-19, -3,  0, 17,-23, -6,-20;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='V';  M= -2,-27,-15,-31,-28, -1,-30,-28, 31,-21, 11, 13,-25,-26,-25,-21,-11,  0, 40,-27, -7,-27;
/M: SY='G';  M= -1, -2,-27, -3,-15,-29, 54,-15,-36,-16,-30,-20,  8,-19,-16,-17,  4,-14,-28,-24,-28,-15;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_04 which contains 571'864 sequence entries.

Total number of hits	127 in 127 different sequences
Number of true positive hits	127 in 127 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	4
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	96.95 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	CRIB
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

127 sequences

ACKL_DROME  (Q9I7F7), ARK1_CAEEL  (G5EBZ8), BORG1_BOVIN (Q08DN6),

BORG1_HUMAN (O14613), BORG1_MOUSE (Q8JZX9), BORG1_RAT   (Q5PQP4), 
BORG2_HUMAN (Q9UKI2), BORG2_MOUSE (Q9CQC5), BORG3_HUMAN (Q6NZY7), 
BORG3_MOUSE (Q9Z0X0), BORG4_HUMAN (Q9H3Q1), BORG4_MOUSE (Q9JM96), 
BORG5_BOVIN (Q17QW1), BORG5_HUMAN (Q00587), BORG5_MOUSE (Q91W92), 
BORG5_RAT   (A1A5P0), C42ES_DROME (Q9VNE7), C42S1_BOVIN (Q5BIS3), 
C42S1_CHICK (Q5ZKB1), C42S1_DANRE (Q6TEL3), C42S1_HUMAN (Q9NRR8), 
C42S1_MOUSE (Q8BHL7), C42S1_PONAB (Q5RDD6), C42S1_RAT   (Q5BJM7), 
C42S1_XENTR (Q5BKH3), C42S2_BOVIN (A6QLJ4), C42S2_DANRE (A9JR56), 
C42S2_HUMAN (Q9NRR3), C42S2_MOUSE (Q8BGH7), C42S2_PONAB (Q5R4F8), 
C42S2_RAT   (A1L1K4), C4S1A_XENLA (Q66KZ1), C4S1B_XENLA (Q6GPV4), 
C4S2A_XENLA (Q5FVD7), C4S2A_XENTR (Q28EW5), C4S2B_XENLA (Q6AX78), 
C4S2B_XENTR (Q28GG3), C4S2C_XENLA (Q4V853), CLA4_CANAL  (Q5APR8), 
CLA4_CANAX  (O14427), CLA4_EREGS  (Q9HFW2), CLA4_YEAST  (P48562), 
GEK_DROME   (Q9W1B0), GIC1_YEAST  (P38785), GIC2_YEAST  (Q06648), 
MAX2_CAEEL  (G5EGQ3), MRCKA_HUMAN (Q5VT25), MRCKA_MOUSE (Q3UU96), 
MRCKA_RAT   (O54874), MRCKB_HUMAN (Q9Y5S2), MRCKB_MOUSE (Q7TT50), 
MRCKB_RAT   (Q7TT49), MRCKG_HUMAN (Q6DT37), MRCKG_MOUSE (Q80UW5), 
MRCK_CAEEL  (O01583), PAK1_BOVIN  (Q08E52), PAK1_HUMAN  (Q13153), 
PAK1_MOUSE  (O88643), PAK1_RAT(P35465), PAK2_HUMAN  (Q13177), 
PAK2_MOUSE  (Q8CIN4), PAK2_RABIT  (Q29502), PAK2_RAT(Q64303), 
PAK3_HUMAN  (O75914), PAK3_MOUSE  (Q61036), PAK3_PANTR  (Q7YQL4), 
PAK3_PONPY  (Q7YQL3), PAK3_RAT(Q62829), PAK3_XENLA  (Q8AXB4), 
PAK4_HUMAN  (O96013), PAK4_MOUSE  (Q8BTW9), PAK5_HUMAN  (Q9P286), 
PAK5_MOUSE  (Q8C015), PAK5_RAT(D4A280), PAK6_HUMAN  (Q9NQU5), 
PAK6_MOUSE  (Q3ULB5), PAK6_PONAB  (Q5R8Z4), PAKA_DICDI  (Q55D99), 
PAKB_DICDI  (Q869N2), PAKC_DICDI  (Q55GV3), PAKD_DICDI  (Q55DD4), 
PAKG_DICDI  (Q54RV3), PAKM_DROME  (Q9VXE5), PAK_DROME   (Q9VI13), 
PK1_CAEEL   (Q17850), PK2_CAEEL   (G5EFU0), RGAP1_ARATH (Q9FMR1), 
RGAP2_ARATH (F4JI46), RGAP4_ARATH (Q9CAX8), RGAP5_ARATH (Q6NKT5), 
RIC10_ARATH (Q9M0Y9), RIC11_ARATH (Q0WL69), RIC1_ARATH  (F4IVV0), 
RIC2_ARATH  (Q8GYU0), RIC3_ARATH  (F4I5N6), RIC4_ARATH  (Q9FFD5), 
RIC5_ARATH  (F4J424), RIC6_ARATH  (Q1PF35), RIC7_ARATH  (Q1G3K8), 
RIC8_ARATH  (Q9ZWB8), RIC9_ARATH  (Q1G3Y0), SHK2_SCHPO  (Q10056), 
SKM1_YEAST  (Q12469), STE20_ASPFU (Q4WHP3), STE20_ASPOR (Q2ULU3), 
STE20_CANAL (P0CY24), STE20_CANAW (C4YRB7), STE20_CANAX (P0CY23), 
STE20_CANGA (Q6FN53), STE20_DEBHA (Q6BNF3), STE20_EMENI (Q5BBL3), 
STE20_EREGS (Q75DK7), STE20_KLULA (Q6CVA2), STE20_NEUCR (Q7RZD3), 
STE20_PYRO7 (Q7Z8E9), STE20_SCHPO (P50527), STE20_TALMA (Q2VWQ3), 
STE20_USTMA (Q4P5N0), STE20_YARLI (Q6C3D7), STE20_YEAST (Q03497), 
WASL_BOVIN  (Q95107), WASL_HUMAN  (O00401), WASL_MOUSE  (Q91YD9), 
WASL_RAT(O08816), WASP_HUMAN  (P42768), WASP_MOUSE  (P70315), 
YN03_CAEEL  (Q03607)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

4 sequences

ACK1_HUMAN  (Q07912), ACK1_MOUSE  (O54967), PAKF_DICDI  (Q869T7),

RGAP3_ARATH (Q8GYY5)

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PDB
[Detailed view]

11 PDB

1CEE; 1E0A; 1EES; 1F3M; 2ODB; 2OV2; 2QME; 4FIE; 5UPK; 5UPL; 6UHC