PROSITE entry PS50108

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

Entry name [info]	CRIB
Accession [info]	PS50108
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50108
Associated ProRule [info]	PRU00057

Name and characterization of the entry

Description [info]

CRIB domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=14;
/DISJOINT: DEFINITION=PROTECT; N1=2; N2=13;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-0.2255000; R2=0.0176662; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=419.6926270; R2=0.3792415; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=421; H_SCORE=579; N_SCORE=7.2; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=381; H_SCORE=564; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I';  M= -7,-30,-25,-37,-30,  0,-37,-30, 45,-27, 17, 17,-23,-23,-23,-27,-17, -7, 35,-23, -3,-30;
/M: SY='G';  M=  6, -4,-18, -4, -8,-24, 27,-14,-28,-14,-30,-20,  6,-14, -8,-14, 25,  5,-18,-32,-24, -8;
/M: SY='S';  M=  4, -4,-19, -8, -4,-14, -9, -6,-13, -9,-13, -9,  1, -9, -4,-10,  6,  5,-11,-26,-11, -5;
/M: SY='P';  M= -9,-19,-39,-10,  0,-30,-19,-20,-20,-10,-30,-20,-19, 87,-10,-20, -8, -9,-29,-30,-30,-10;
/M: SY='T';  M= -4,-11,-15,-17,-13,  8,-19,-15, -5,-15, -4, -3, -6,-17,-12,-12,  7, 18, -1,-21, -1,-11;
/I:         I=-6; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='N';  M=-12, 39,-23, 31,  4,-26,  2,  4,-27, -2,-30,-23, 43,-17, -2, -4,  7, -4,-30,-38,-21,  1;
/M: SY='F';  M=-13,-29,-19,-35,-27, 50,-29,-21,  6,-26,  9,  2,-22,-24,-34,-20,-17, -8, 10, -2, 18,-28;
/M: SY='K';  M= -9, -1,-26, -1, 12,-25,-20, -7,-20, 22,-20, -8, -1,-12, 11, 18, -4, -5,-14,-24,-12, 11;
/M: SY='H';  M=-20, -1,-30, -1,  0,-19,-20, 91,-29, -7,-20, -1,  9,-20, 10,  5,-10,-19,-29,-28, 19,  0;
/M: SY='T';  M= -7, -6,-21, -9, -5,-13,-23, -9, -2, -6, -4, -2, -5,-17, -4, -4, -3,  4,  1,-27, -8, -6;
/M: SY='V';  M=  3,-20,-14,-25,-21, -2,-17,-19, 11,-18,  1,  5,-16,-21,-18,-19, -3,  0, 17,-23, -6,-20;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='V';  M= -2,-27,-15,-31,-28, -1,-30,-28, 31,-21, 11, 13,-25,-26,-25,-21,-11,  0, 40,-27, -7,-27;
/M: SY='G';  M= -1, -2,-27, -3,-15,-29, 54,-15,-36,-16,-30,-20,  8,-19,-16,-17,  4,-14,-28,-24,-28,-15;
/I:         E1=0; IE=-105; DE=-105;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	127 in 127 different sequences
Number of true positive hits	127 in 127 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	4
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	96.95 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	CRIB
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

127 sequences

ACKL_DROME  (Q9I7F7), ARK1_CAEEL  (G5EBZ8), BORG1_BOVIN (Q08DN6),

BORG1_HUMAN (O14613), BORG1_MOUSE (Q8JZX9), BORG1_RAT   (Q5PQP4), 
BORG2_HUMAN (Q9UKI2), BORG2_MOUSE (Q9CQC5), BORG3_HUMAN (Q6NZY7), 
BORG3_MOUSE (Q9Z0X0), BORG4_HUMAN (Q9H3Q1), BORG4_MOUSE (Q9JM96), 
BORG5_BOVIN (Q17QW1), BORG5_HUMAN (Q00587), BORG5_MOUSE (Q91W92), 
BORG5_RAT   (A1A5P0), C42ES_DROME (Q9VNE7), C42S1_BOVIN (Q5BIS3), 
C42S1_CHICK (Q5ZKB1), C42S1_DANRE (Q6TEL3), C42S1_HUMAN (Q9NRR8), 
C42S1_MOUSE (Q8BHL7), C42S1_PONAB (Q5RDD6), C42S1_RAT   (Q5BJM7), 
C42S1_XENTR (Q5BKH3), C42S2_BOVIN (A6QLJ4), C42S2_DANRE (A9JR56), 
C42S2_HUMAN (Q9NRR3), C42S2_MOUSE (Q8BGH7), C42S2_PONAB (Q5R4F8), 
C42S2_RAT   (A1L1K4), C4S1A_XENLA (Q66KZ1), C4S1B_XENLA (Q6GPV4), 
C4S2A_XENLA (Q5FVD7), C4S2A_XENTR (Q28EW5), C4S2B_XENLA (Q6AX78), 
C4S2B_XENTR (Q28GG3), C4S2C_XENLA (Q4V853), CLA4_CANAL  (Q5APR8), 
CLA4_CANAX  (O14427), CLA4_EREGS  (Q9HFW2), CLA4_YEAST  (P48562), 
GEK_DROME   (Q9W1B0), GIC1_YEAST  (P38785), GIC2_YEAST  (Q06648), 
MAX2_CAEEL  (G5EGQ3), MRCKA_HUMAN (Q5VT25), MRCKA_MOUSE (Q3UU96), 
MRCKA_RAT   (O54874), MRCKB_HUMAN (Q9Y5S2), MRCKB_MOUSE (Q7TT50), 
MRCKB_RAT   (Q7TT49), MRCKG_HUMAN (Q6DT37), MRCKG_MOUSE (Q80UW5), 
MRCK_CAEEL  (O01583), PAK1_BOVIN  (Q08E52), PAK1_HUMAN  (Q13153), 
PAK1_MOUSE  (O88643), PAK1_RAT(P35465), PAK2_HUMAN  (Q13177), 
PAK2_MOUSE  (Q8CIN4), PAK2_RABIT  (Q29502), PAK2_RAT(Q64303), 
PAK3_HUMAN  (O75914), PAK3_MOUSE  (Q61036), PAK3_PANTR  (Q7YQL4), 
PAK3_PONPY  (Q7YQL3), PAK3_RAT(Q62829), PAK3_XENLA  (Q8AXB4), 
PAK4_HUMAN  (O96013), PAK4_MOUSE  (Q8BTW9), PAK5_HUMAN  (Q9P286), 
PAK5_MOUSE  (Q8C015), PAK5_RAT(D4A280), PAK6_HUMAN  (Q9NQU5), 
PAK6_MOUSE  (Q3ULB5), PAK6_PONAB  (Q5R8Z4), PAKA_DICDI  (Q55D99), 
PAKB_DICDI  (Q869N2), PAKC_DICDI  (Q55GV3), PAKD_DICDI  (Q55DD4), 
PAKG_DICDI  (Q54RV3), PAKM_DROME  (Q9VXE5), PAK_DROME   (Q9VI13), 
PK1_CAEEL   (Q17850), PK2_CAEEL   (G5EFU0), RGAP1_ARATH (Q9FMR1), 
RGAP2_ARATH (F4JI46), RGAP4_ARATH (Q9CAX8), RGAP5_ARATH (Q6NKT5), 
RIC10_ARATH (Q9M0Y9), RIC11_ARATH (Q0WL69), RIC1_ARATH  (F4IVV0), 
RIC2_ARATH  (Q8GYU0), RIC3_ARATH  (F4I5N6), RIC4_ARATH  (Q9FFD5), 
RIC5_ARATH  (F4J424), RIC6_ARATH  (Q1PF35), RIC7_ARATH  (Q1G3K8), 
RIC8_ARATH  (Q9ZWB8), RIC9_ARATH  (Q1G3Y0), SHK2_SCHPO  (Q10056), 
SKM1_YEAST  (Q12469), STE20_ASPFU (Q4WHP3), STE20_ASPOR (Q2ULU3), 
STE20_CANAL (P0CY24), STE20_CANAW (C4YRB7), STE20_CANAX (P0CY23), 
STE20_CANGA (Q6FN53), STE20_DEBHA (Q6BNF3), STE20_EMENI (Q5BBL3), 
STE20_EREGS (Q75DK7), STE20_KLULA (Q6CVA2), STE20_NEUCR (Q7RZD3), 
STE20_PYRO7 (Q7Z8E9), STE20_SCHPO (P50527), STE20_TALMA (Q2VWQ3), 
STE20_USTMA (Q4P5N0), STE20_YARLI (Q6C3D7), STE20_YEAST (Q03497), 
WASL_BOVIN  (Q95107), WASL_HUMAN  (O00401), WASL_MOUSE  (Q91YD9), 
WASL_RAT(O08816), WASP_HUMAN  (P42768), WASP_MOUSE  (P70315), 
YN03_CAEEL  (Q03607)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

4 sequences

ACK1_HUMAN  (Q07912), ACK1_MOUSE  (O54967), PAKF_DICDI  (Q869T7),

RGAP3_ARATH (Q8GYY5)

» more

PDB
[Detailed view]

11 PDB

1CEE; 1E0A; 1EES; 1F3M; 2ODB; 2OV2; 2QME; 4FIE; 5UPK; 5UPL; 6UHC