PROSITE logo

PROSITE entry PS50171


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission
General information about the entry

Entry name [info] ZF_MATRIN
Accession [info] PS50171
Entry type [info] MATRIX
Date [info] 01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50171
Associated ProRule [info] PRU00130

Name and characterization of the entry

Description [info] Zinc finger matrin-type profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.5940000; R2=0.0123623; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1566.0997314; R2=1.6650832; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=559; H_SCORE=2497; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=397; H_SCORE=2227; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;
...
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y';  M=-18,-22,-27,-26,-21, 37,-30, -1,  2,-12,  2,  1,-18,-27,-18,-11,-19,-10, -4, 13, 46,-21;
/M: SY='Y';  M=-18,-12,-27,-15,-10, 25,-25,  5, -8, -8, -5, -5, -7,-25,-11, -2,-14, -9,-13,  7, 38,-12;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='E';  M=-13, 11,-32, 22, 25,-33,-17, -7,-30, 12,-27,-20,  1, 15,  6,  0, -4,-10,-28,-30,-20, 15;
/M: SY='Y';  M=-14,-27,-27,-31,-24, 20,-33,-10, 21,-23, 19, 11,-22,-27,-18,-20,-22,-10,  9,  0, 30,-24;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='S';  M= -2,  3,-20,  6,  0,-22, -1, -1,-23, -5,-21,-15,  5,-14, -2, -7, 13,  1,-16,-33,-15, -2;
/M: SY='T';  M= -7, -2, -2,-10,-11,-10,-18,-12,-10,-11, -3, -7,  4,-21,-10, -5,  1, 10, -8,-32,-13,-11;
/M: SY='W';  M=-18,-26,-30,-30,-22, 34,-27,-10, -5,-14,  1, -3,-23,-28,-21,-12,-24,-14,-10, 38, 37,-20;
/M: SY='Y';  M=-12,-21,-22,-24,-20, 14,-29,  0,  9,-20, 13,  7,-18,-26,-16,-16,-16, -3,  5, -8, 23,-20;
/M: SY='T';  M=  0, -1,-17, -8, -8, -7,-15, -6,-12, -3,-14,-10,  2,-15, -6, -6,  9, 17, -8,-17,  6, -8;
/M: SY='N';  M=-12, 16,-25, 11, -1,-22, -1, 22,-27, -3,-25,-14, 24,-18,  0,  3,  2, -5,-26,-32,-10, -2;
/M: SY='D';  M= -8, 17,-27, 23, 21,-30,  6, -4,-32, -2,-27,-22, 12,-10,  3, -8,  5, -8,-28,-32,-22, 12;
/M: SY='R';  M= -5, -4,-24, -3,  6,-24, -6,-10,-26,  7,-25,-16,  0, -1,  2, 11,  7,  2,-19,-28,-18,  2;
/I:         I=-6; MD=-32;
/M: SY='P';  M=  1,-10,-21, -9, -2,-17,-12,-12,-13,  1,-13, -9, -8, 15, -3,  0, -2, -4,-12,-20,-14, -4; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='S';  M=  6,-12,-13,-16,-13, -7,-14,-12,  0,-12, -8,  1, -9,-18,-10,-13, 10, 10,  8,-25, -4,-12;
/M: SY='F';  M=  2,-24,-14,-30,-24, 21,-24,-23, 10,-22,  9,  3,-21,-25,-27,-19, -9, -1, 18,-15,  2,-24;
/I:         I=-5; MD=-27;
/M: SY='E';  M=-10,  1,-23,  4, 22,-22,-15,  0,-22, 17,-17,-10,  0, -7, 16, 21, -4, -8,-20,-19,-11, 18; D=-5;
/I:         I=-5; MD=-27;
/M: SY='R';  M= -8,  3,-16,  0,  2,-14, -9, -1,-16, 18,-15, -7,  7, -9,  4, 22, -3, -4,-13,-14, -7,  2; D=-5;
/I:         I=-5; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='T';  M=  3,  1,-10, -6, -7, -2, -9,-10,-10, -9,-12,-10,  6,-11, -8, -9, 13, 16, -6,-21, -8, -7; D=-5;
/I:         I=-5; DM=-27;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='C';  M=-11,-14, 25,-21,-14,  7,-26,-19,-12,-21,  0, -7,-12,-27,-21,-19,-10, -3, -7,-27, -8,-16;
/M: SY='S';  M=  2, -4,-19, -8, -5,-20, -7,-10,-13,  2,-18, -9,  1,-17,  0,  3,  6, -1, -6,-28,-16, -3;
/M: SY='G';  M=  0, -3,-25, -1,  2,-28, 34,-13,-33,-11,-28,-20,  2,-13, -7,-13, 10, -8,-25,-27,-25, -2;
/M: SY='K';  M=-11, -9,-28, -9,  3,-17,-21,-12,-20, 18,-14, -8, -8,-15,  2, 16,-11, -5,-16, -3, -5,  2;
/M: SY='R';  M=-13, -1,-29, -5,  0,-22,-18, -6,-19, 18,-22,-10,  7, -4,  3, 26, -7, -8,-18,-25,-13, -2;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='K';  M= -5, -9,-27,-11, -2,-16,-22, -8,-11, 17,-11, -2, -8,-15,  5,  7,-11, -9,-10,-14,  2,  0;
/M: SY='Q';  M=-13,  3,-28,  5, 15,-23,-20, 13,-23,  9,-19, -9,  1,-12, 19,  9, -3, -5,-23,-20,  0, 16;
/M: SY='N';  M=-10, 19,-24,  7, -4,-21,  0, 10,-18,  0,-25,-13, 34,-19, -2, -1,  2, -6,-24,-33,-14, -4;
/M: SY='L';  M= -5,-19,-16,-21,-13, -2,-26,-18, 11,-17, 17, 12,-20,-22,-14,-15,-10,  5, 14,-26, -7,-13;
/M: SY='R';  M=  7, -5,-22, -6,  7,-23,-12, -9,-23, 16,-20,-12, -2,-12,  4, 19,  2, -4,-14,-23,-15,  4;
/M: SY='K';  M=-14,  0,  3,  1, -1,-25,-21,-10,-28, 16,-22,-10, -2,-19, -1, 16, -9,-10,-17,-30,-15, -2;
/I:         E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 84 in 83 different sequences
Number of true positive hits 84 in 83 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 50
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 62.69 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] window20
Author [info] K_Hofmann, N_Hulo
Feature key [info] ZN_FING
Feature description [info] Matrin-type
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
83 sequences

ATO_ARATH   (Q9FG01), CIZ1_HUMAN  (Q9ULV3), MATR3_HUMAN (P43243), 
MATR3_MOUSE (Q8K310), MATR3_RAT   (P43244), NOI_DROME   (O46106), 
PRP9_YEAST  (P19736), RBM20_HUMAN (Q5T481), RBM20_MOUSE (Q3UQS8), 
RBM20_PIG   (P0DW16), RBM20_RAT   (E9PT37), RU1C1_PUCGT (E3LAN7), 
RU1C1_SORBI (C5XZK6), RU1C2_PUCGT (E3KIY6), RU1C2_SORBI (C5XYW4), 
RU1C_AEDAE  (Q16IW3), RU1C_AJECG  (C0NN85), RU1C_ANODA  (E3X5D6), 
RU1C_ANOGA  (Q7PXU6), RU1C_ARATH  (Q56XE4), RU1C_ASPFU  (Q4WQM6), 
RU1C_BATDJ  (F4NYQ2), RU1C_BOVIN  (Q32PA0), RU1C_BRAFL  (C3Z1P5), 
RU1C_CAEBR  (A8XW44), RU1C_CAEEL  (P90815), RU1C_CANAL  (Q59P44), 
RU1C_CANAW  (C4YIU5), RU1C_CANLF  (E2RGI3), RU1C_CHICK  (E1C6F0), 
RU1C_CIOIN  (Q1RLC9), RU1C_COPC7  (A8NYM5), RU1C_CRYNJ  (Q5KC16), 
RU1C_DANRE  (Q8JGS0), RU1C_DICDI  (Q54YA5), RU1C_DROME  (Q9VE17), 
RU1C_DROPS  (Q298E0), RU1C_EMENI  (Q5BBX9), RU1C_FUSV7  (C7YRT4), 
RU1C_HETP5  (D3B3B7), RU1C_HUMAN  (P09234), RU1C_IXOSC  (B7Q2M2), 
RU1C_MACMU  (F6TFD9), RU1C_MONDO  (F7ARS3), RU1C_MOUSE  (Q62241), 
RU1C_NEMVE  (A7SEP9), RU1C_NEUCR  (Q1K7T5), RU1C_PEDHC  (E0VI98), 
RU1C_PHYIT  (D0NHA2), RU1C_PLABA  (Q4YBG7), RU1C_PLACU  (Q4XRM7), 
RU1C_PLAF7  (Q8IAW3), RU1C_PLAKH  (B3LC82), RU1C_PLAVS  (A5JZQ2), 
RU1C_PLAYO  (Q7RNM5), RU1C_RAT(D3ZCL3), RU1C_SCHPO  (Q9P794), 
RU1C_SCLS1  (A7EYK3), RU1C_THEAN  (Q4UJ14), RU1C_THEPA  (Q4N6K2), 
RU1C_TUBMM  (D5GDH4), RU1C_USTMA  (Q4P2Q5), RU1C_VITVI  (F6HQ26), 
RU1C_XENLA  (Q03369), RU1C_XENTR  (B0JYS7), RU1C_YEAST  (Q05900), 
SAP61_SCHPO (O59706), SAP62_SCHPO (Q9P7L8), SF3A2_BOVIN (A5PJN8), 
SF3A2_HUMAN (Q15428), SF3A2_MOUSE (Q62203), SF3A2_RAT   (Q6AXT8), 
SF3A3_HUMAN (Q12874), SF3A3_MOUSE (Q9D554), WBP4_CHICK  (Q5F457), 
WBP4_HUMAN  (O75554), WBP4_MOUSE  (Q61048), WBP4_RAT(Q5HZF2), 
YNS7_SCHPO  (O60138), ZMAT4_MOUSE (Q8BZ94), ZN638_HUMAN (Q14966), 
ZN638_MOUSE (Q61464), ZOP1_ARATH  (Q7XA66)
» more

UniProtKB/Swiss-Prot
False negative sequences
50 sequences

MOD5_HUMAN  (Q9H3H1), MOD5_MOUSE  (Q80UN9), MOD5_SCHPO  (Q9UT75), 
MOD5_YEAST  (P07884), PRP11_YEAST (Q07350), SCNM1_BOVIN (Q3ZBR0), 
SCNM1_DANRE (Q2YDS5), SCNM1_HUMAN (Q9BWG6), SCNM1_MOUSE (Q8K136), 
SCNM1_XENLA (Q3KQ71), SF3A2_DICDI (Q54B65), SNU23_CAEEL (P34670), 
SNU23_SCHPO (Q09776), STPAP_AILME (D2HS90), STPAP_BOVIN (Q1JPD6), 
STPAP_DANRE (Q4KMD7), STPAP_HUMAN (Q9H6E5), STPAP_MOUSE (Q8R3F9), 
STPAP_RAT   (Q3MHT4), STPAP_XENTR (A9JTS5), UBA1C_ARATH (O64571), 
Y9776_DROME (Q9V468), Z385A_HUMAN (Q96PM9), Z385A_MOUSE (Q8VD12), 
Z385B_DANRE (Q6PBT9), Z385B_HUMAN (Q569K4), Z385B_MOUSE (Q8BXJ8), 
Z385C_HUMAN (Q66K41), Z385C_MOUSE (A2A5E6), Z385D_HUMAN (Q9H6B1), 
Z385D_RAT   (Q6AXX3), ZMAT1_HUMAN (Q5H9K5), ZMAT1_MOUSE (Q3V0C1), 
ZMAT1_XENTR (Q28EG9), ZMAT2_HUMAN (Q96NC0), ZMAT2_MOUSE (Q9CPW7), 
ZMAT3_BOVIN (Q0IIC4), ZMAT3_HUMAN (Q9HA38), ZMAT3_MOUSE (O54836), 
ZMAT3_RAT   (O08781), ZMAT4_BOVIN (Q0VD35), ZMAT4_HUMAN (Q9H898), 
ZN318_HUMAN (Q5VUA4), ZN318_MOUSE (Q99PP2), ZN346_DANRE (A2RV29), 
ZN346_HUMAN (Q9UL40), ZN346_MOUSE (Q9R0B7), ZN346_PONAB (Q5R4W8), 
ZN346_XENLA (Q8AVN9), ZN346_XENTR (B0JZ85)
» more

PDB
[Detailed view]
53 PDB

1ZU1; 2MKD; 2MKN; 2VRD; 3CW1; 3EPH; 3EPJ; 3EPK; 3EPL; 4DGW; 4PJO; 5GM6; 5NRL; 5O9Z; 5Z56; 5Z57; 5Z58; 5ZWM; 5ZWN; 5ZWO; 6AH0; 6AHD; 6FF4; 6FF7; 6G90; 6N7P; 6N7R; 6N7X; 6QX9; 6Y50; 6Y53; 6Y5Q; 7AAV; 7ABF; 7ABG; 7ABH; 7ABI; 7DVQ; 7EVO; 7ONB; 7OQB; 7OQC; 7OQE; 7Q3L; 7Q4O; 7Q4P; 7QTT; 7VPX; 8CH6; 8HK1; 8IDF; 8Q7N; 8QO9
» more