PROSITE entry PS50174

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS50174
Entry name [info]	G_PATCH
Accession [info]	PS50174
Entry type [info]	MATRIX
Date [info]	01-JAN-2002 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50174
Associated ProRule [info]	PRU00092

Name and characterization of the entry

Description [info]

G-patch domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=47;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=43;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.0889000; R2=0.0170978; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1365.4576416; R2=4.1952276; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=434; H_SCORE=3186; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=317; H_SCORE=2695; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='T';  M= -4, -4,-23, -4, -2,-19,-12,-11,-13, -5,-15,-10, -5, -2, -4, -9,  2,  5,-10,-26,-12, -4;
/M: SY='E';  M= -6,  8,-23,  9, 10,-25, -2, -4,-24,  2,-23,-13,  9,-12,  5,  1,  8, -2,-20,-31,-18,  7;
/M: SY='N';  M= -5, 11,-24,  6, -3,-24,  7, -7,-25, -4,-28,-19, 19, -3, -5, -5,  8,  0,-24,-32,-22, -5;
/M: SY='I';  M= -8,-23,-23,-27,-20,  1,-30,-23, 16,-15,  6,  6,-19,-11,-18,-14,-13, -3, 15,-21, -4,-21;
/M: SY='G';  M=  8,-10,-24,-11,-15,-25, 43,-19,-28,-17,-23,-16, -3,-18,-17,-19,  4,-12,-17,-23,-26,-16;
/M: SY='H';  M= -9, -8,-23,-11, -6, -5,-14, 10,-13, -7,-10, -2, -3,-19, -1, -4, -5, -5,-12,-17,  5, -4;
/M: SY='K';  M= -5, -2,-20, -3,  6,-28,-17, -7,-26, 25,-24,-10, -1,-13, 13, 23, -4, -8,-19,-23,-13,  8;
/M: SY='M';  M= -9,-24,-20,-29,-20,  5,-26,-13, 19,-20, 28, 31,-23,-24,-11,-16,-21, -9, 11,-20,  0,-15;
/M: SY='L';  M=-10,-25,-20,-29,-18,  4,-26,-11, 18,-20, 35, 35,-25,-25, -8,-15,-25,-10,  8,-20,  0,-13;
/M: SY='Q';  M= -3, -7,-19, -7,  7,-20,-19, -8,-12, -2, -6, -2, -8,-11,  9, -1, -5, -5,-11,-25,-13,  7;
/M: SY='K';  M= -1,  2,-24,  0,  4,-27, -9, -9,-26, 23,-26,-13,  4,-12,  5, 15,  2, -3,-18,-25,-14,  4;
/M: SY='M';  M=-10,-17,-16,-24,-16,  0,-18, -2,  6,-10,  8, 31,-15,-21,  0, -8,-13, -6,  0,-16,  4, -9;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='W';  M=-20,-34,-43,-35,-27, 18,-23,-18,-13,-19,-11,-13,-34,-30,-19,-18,-34,-24,-22,109, 40,-20;
/M: SY='K';  M= -9, -5,-26, -5,  5,-20,-19, -8,-21, 23,-19, -9, -2,-13,  5, 23, -3, -1,-14,-22, -8,  3;
/I:         I=-6; MD=-32;
/M: SY='E';  M= -7, -4,-30,  4, 25,-27,-15, -9,-22,  2,-21,-16, -8, 24,  6, -7, -4, -9,-23,-27,-21, 14; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='G';  M=  0, -7,-29, -7,-16,-29, 61,-18,-38,-18,-30,-20,  3,-19,-17,-18,  2,-17,-29,-22,-29,-16;
/M: SY='Q';  M=-10,  0,-27,  0, 12,-27,-14,  1,-21, 11,-18, -2, -1,-11, 20,  8, -3, -6,-20,-24,-11, 16;
/M: SY='G';  M=  0,-10,-29,-10,-20,-29, 66,-20,-39,-20,-29,-20,  0,-20,-20,-20,  1,-17,-29,-20,-29,-20;
/M: SY='L';  M=-10,-30,-21,-31,-21,  9,-31,-21, 24,-30, 46, 20,-29,-29,-20,-21,-29,-10, 13,-20,  0,-21;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='K';  M= -6, -9,-24, -9, -1,-17,-19, -6,-15, 14,-12, -5, -6,-13,  2, 11, -6, -5,-11,-21, -5, -1;
/M: SY='N';  M= -4,  6,-23,  3,  4,-24, -7,  4,-23,  5,-23,-13, 12,-11,  6,  5,  5, -4,-21,-29,-14,  4;
/M: SY='E';  M= -5,  2,-23,  3, 15,-24, -2,  3,-27, -1,-21,-15,  5, -8,  3, -1,  1, -9,-24,-29,-17,  8;
/M: SY='Q';  M=-10,  5,-27,  7, 13,-31,-17,  1,-19,  8,-20, -6,  3, -7, 26,  4, -1, -7,-21,-26,-13, 19;
/I:         I=-6; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='G';  M=  1, -6,-29, -7,-13,-29, 53,-17,-37,-13,-29,-19,  2,-18,-15,-15,  0,-17,-28,-21,-27,-14;
/M: SY='I';  M=-10,-15,-26,-20,-15, -9,-28,-14, 18,-17,  8, 10,-10,-19, -6,-13,-12, -8,  7,-24, -4,-13;
/M: SY='K';  M=  2,-10,-21,-13, -7,-17,-18,-15, -6,  3,-11, -5, -7, -9, -5,  1, -2, -1, -1,-25,-13, -7;
/M: SY='B';  M= -8, 10,-23,  9,  8,-20,-15,  2,-18, -2,-16,-11,  9,-13,  5, -4,  3,  1,-17,-30,-11,  6;
/M: SY='P';  M= -2,-15,-31,-10, -2,-26,-16,-18,-16, -6,-25,-16,-12, 49, -7,-13, -1, -4,-20,-29,-24, -8;
/M: SY='I';  M= -9,-25,-23,-28,-20,  0,-31,-18, 24,-21, 16, 11,-19,-23,-17,-16,-16, -7, 19,-23, -2,-21;
/M: SY='E';  M= -4, -3,-26, -2,  8,-24,-12, -4,-18,  5,-16, -7, -2, -5,  6,  2, -3, -8,-17,-25,-14,  6;
/M: SY='A';  M= 11,-16,-11,-20,-17,-10, -9,-20, -2,-12, -3, -3,-15,-20,-16,-15, -1,  1,  8,-22,-10,-17;
/M: SY='E';  M= -8, -3,-28, -2, 14,-22,-11, -6,-18,  8,-18,-10, -3,-11,  4,  2, -4, -8,-16,-24,-11,  8;
/M: SY='V';  M= -2,-11,-21,-12,-10,-15,-14,-18,  1, -8, -6, -2, -9,-18, -9,-12, -2, -3,  5,-27,-12,-11;
/M: SY='R';  M= -8, -2,-17, -7, -3,-17,-17, -9,-14,  3,-16, -9,  4,-18,  2,  6,  0,  0,-12,-20,-11, -1;
/I:         I=-4; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='D';  M= -6,  2,-23,  3,  3,-22,-13, -6,-18,  1,-15, -8,  0,-10,  2,  0,  1,  1,-13,-28,-13,  2;
/M: SY='K';  M= -3,  8,-24,  9,  4,-24, -5, -7,-27, 10,-24,-16,  8,-13,  1,  7,  1, -6,-20,-26,-15,  2;
/M: SY='R';  M=-13, -2,-28, -5, -3,-21, -5, -3,-25, 13,-22,-11,  7,-19,  6, 26, -6,-10,-21,-16,-10,  0;
/M: SY='K';  M=  0, -9,-23, -9,  1,-15, -8,-13,-18,  3,-14,-10, -7, -9, -4,  3, -3, -4,-12,-22,-13, -2;
/M: SY='G';  M=  1, -4,-27, -3,-11,-29, 50,-17,-36,-16,-29,-20,  2,-17,-14,-17,  6,-13,-26,-24,-27,-13;
/M: SY='L';  M= -9,-25,-20,-28,-20, 12,-29,-21, 14,-20, 22, 10,-22,-26,-20,-13,-18, -5, 13,-18,  1,-20;
/M: SY='G';  M= -4, -5,-30, -3,-10,-28, 42,-16,-32,-12,-25,-17,  0,-18,-13,-12, -2,-17,-25,-22,-25,-12;
/M: SY='A';  M=  8,-13,-14,-19,-11, -5,-17, -7, -5,-11, -6, -4,-11,-19, -8,-14, -6, -7, -3, -9,  3,-10;
/M: SY='S';  M=  0, -2,-22, -2, -1,-13, -6,-10,-18, -3,-17,-13,  0,-12, -5, -5,  2, -4,-12,-23,-11, -3;
/M:         M= -2,-10,-23,-11, -5,-15, -1,-14,-16,  0, -9, -4, -7,-17, -7, -3, -5, -8,-11,-22,-13, -6;
/M: SY='P';  M= -8, -2,-27,  2,  8,-23,-17,-10,-18,  4,-19,-11, -4,  9,  1, -1,  0, -2,-17,-29,-17,  3;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	201 in 201 different sequences
Number of true positive hits	201 in 201 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	2
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.01 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	K_Hofmann, CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	G-patch
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

201 sequences

AGGF1_HUMAN (Q8N302), AGGF1_MOUSE (Q7TN31), C3H18_ORYSJ (Q6K687),

C3H22_ARATH (Q9SK49), CHERP_HUMAN (Q8IWX8), CHERP_MOUSE (Q8CGZ0), 
CMTR1_AILME (D2HRF1), CMTR1_BOVIN (A2VE39), CMTR1_DANRE (Q803R5), 
CMTR1_DROME (Q9W4N2), CMTR1_HUMAN (Q8N1G2), CMTR1_MOUSE (Q9DBC3), 
CMTR1_PONAB (Q5R981), CMTR1_RAT   (Q5U2Z5), CMTR1_XENLA (Q6GQ76), 
DR111_ARATH (P42698), GAG_IPMA(P11365), GPAN1_CAEEL (Q09655), 
GPAN1_DROME (Q9V7A7), GPAN1_HUMAN (O95872), GPAN1_MOUSE (Q61858), 
GPDP1_ARATH (Q940M0), GPKOW_CAEEL (Q21924), GPKOW_DANRE (Q90X38), 
GPKOW_HUMAN (Q92917), GPKOW_MOUSE (Q56A08), GPKOW_XENLA (Q6NU07), 
GPT11_BOVIN (Q2KI19), GPT11_DANRE (Q6DGZ0), GPT11_HUMAN (Q8N954), 
GPT11_MOUSE (Q3UFS4), GPT11_XENTR (Q6DF57), GPTC1_BOVIN (Q24K12), 
GPTC1_CAEEL (Q21827), GPTC1_DROME (Q9VUA0), GPTC1_HUMAN (Q9BRR8), 
GPTC1_MOUSE (Q9DBM1), GPTC2_HUMAN (Q9NW75), GPTC2_MOUSE (Q7TQC7), 
GPTC3_HUMAN (Q96I76), GPTC3_MOUSE (Q8BIY1), GPTC4_BOVIN (Q2KJE1), 
GPTC4_HUMAN (Q5T3I0), GPTC4_MOUSE (Q3TFK5), GPTC4_RAT   (Q566R3), 
GPTC4_XENLA (Q4V842), GPTC4_XENTR (Q6P859), GPTC8_HUMAN (Q9UKJ3), 
GPTC8_MOUSE (A2A6A1), MOS2_ARATH  (Q9C801), MTR1A_CAEBR (A8XYX2), 
MTR1B_CAEBR (A8XYX3), MTR1_CAEEL  (Q9NAA5), MTR1_DICDI  (Q54WR1), 
NKRF_HUMAN  (O15226), NKRF_MOUSE  (Q8BY02), PINX1_HUMAN (Q96BK5), 
PINX1_MOUSE (Q9CZX5), PINX1_RAT   (A4L691), POK9_HUMAN  (P63128), 
POL_JSRV(P31623), POL_MPMV(P07572), POL_SMRVH   (P03364), 
POL_SRV1(P04025), POL_SRV2(P51517), PRO_JSRV(P31625), 
PRO_MPMV(P07570), PRO_SMRVH   (P21407), PRO_SRV1(P04024), 
PRO_SRV2(P51518), PXR1_AJECN  (A6R371), PXR1_ASPCL  (A1CD56), 
PXR1_ASPFU  (Q4WG40), PXR1_ASPNC  (A2R156), PXR1_ASPOR  (Q2UDW7), 
PXR1_ASPTN  (Q0CU52), PXR1_BOTFB  (A6RIE1), PXR1_CANAL  (Q5A660), 
PXR1_CANGA  (Q6FTR8), PXR1_CHAGB  (Q2HFA6), PXR1_COCIM  (Q1DQE9), 
PXR1_DEBHA  (Q6BUE3), PXR1_EREGS  (Q751P0), PXR1_KLULA  (Q6CTA7), 
PXR1_LODEL  (A5E4P1), PXR1_NEOFI  (A1DC33), PXR1_NEUCR  (Q7SHT5), 
PXR1_PHANO  (Q0UWF6), PXR1_PICGU  (A5DRH5), PXR1_PYRO7  (A4R0T9), 
PXR1_SCHPO  (Q9URX9), PXR1_SCLS1  (A7EFS3), PXR1_VANPO  (A7TG30), 
PXR1_YARLI  (Q6C1L3), PXR1_YEAS7  (A6ZUT6), PXR1_YEAST  (P53335), 
RBM10_HUMAN (P98175), RBM10_MOUSE (Q99KG3), RBM10_RAT   (P70501), 
RBM5A_XENLA (A0JMV4), RBM5B_XENLA (Q6DDU9), RBM5_BOVIN  (Q1RMU5), 
RBM5_HUMAN  (P52756), RBM5_MOUSE  (Q91YE7), RBM5_RAT(B2GV05), 
RBM5_XENTR  (A4IGK4), RBM6_HUMAN  (P78332), SON_DROME   (Q9VHB0), 
SON_HUMAN   (P18583), SON_MOUSE   (Q9QX47), SP382_YEAST (Q06411), 
SPF45_HUMAN (Q96I25), SPF45_MOUSE (Q8JZX4), SPP2_ASPFU  (Q4WP02), 
SPP2_EMENI  (Q5B4R9), SPP2_MYCMD  (Q4P9X4), SQS1_CANAL  (Q59UG4), 
SQS1_CANGA  (Q6FP19), SQS1_DEBHA  (Q6BYP9), SQS1_EREGS  (Q75E62), 
SQS1_KLULA  (Q6CQ59), SQS1_LODEL  (A5DSB5), SQS1_PICGU  (A5DEF8), 
SQS1_PODAS  (Q875B6), SQS1_VANPO  (A7TQN2), SQS1_YARLI  (Q6C233), 
SQS1_YEAS7  (A6ZRL6), SQS1_YEAST  (P53866), STIP1_ARATH (Q9SHG6), 
STIP2_ARATH (Q9SLC6), SUA_ARATH   (F4JCU0), SUGP1_ARATH (Q94C11), 
SUGP1_HUMAN (Q8IWZ8), SUGP1_MOUSE (Q8CH02), SUGP1_RAT   (Q68FU8), 
SUGP2_HUMAN (Q8IX01), SUGP2_MOUSE (Q8CH09), TFP11_BOVIN (Q29RR5), 
TFP11_CAEEL (Q17784), TFP11_CANLF (A1XD97), TFP11_CHICK (Q5ZII9), 
TFP11_DANRE (Q6DI35), TFP11_DICDI (A1XDC0), TFP11_DROME (Q9Y103), 
TFP11_HUMAN (Q9UBB9), TFP11_MACFA (A1XD95), TFP11_MACMU (A1XD94), 
TFP11_MONDO (A4UMC6), TFP11_MOUSE (Q9ERA6), TFP11_PANTR (A1XD93), 
TFP11_PIG   (Q06AK6), TFP11_PONAB (Q5R5K8), TFP11_RABIT (A4UMC5), 
TFP11_RAT   (Q5U2Y6), TFP11_XENLA (Q66J74), TFP11_XENTR (Q0IIX9), 
TGHH_ORYSI  (B8B2G4), TGHH_ORYSJ  (Q67VW6), VP113_HUMAN (P63121), 
VPK04_HUMAN (P63124), VPK10_HUMAN (P10265), VPK18_HUMAN (P63123), 
VPK19_HUMAN (P63120), VPK21_HUMAN (P63119), VPK24_HUMAN (P63129), 
VPK25_HUMAN (P63125), VPK6_HUMAN  (Q9Y6I0), VPK7_HUMAN  (P63131), 
VPK8_HUMAN  (P63122), VPK9_HUMAN  (P63127), Y5282_DICDI (Q54XG0), 
YAB4_SCHPO  (Q09806), YDMD_SCHPO  (P87143), YG0G_SCHPO  (O94728), 
YKR3_SCHPO  (Q9UTK6), YL271_YEAST (Q06152), YND2_SCHPO  (O74363), 
YQ7D_SCHPO  (O94585), ZGPAT_AEDAE (Q17CQ8), ZGPAT_ANOGA (Q7PYU6), 
ZGPAT_BOVIN (Q17QX2), ZGPAT_DANRE (Q7SXW2), ZGPAT_DROAN (B3MPC0), 
ZGPAT_DROER (B3N8L3), ZGPAT_DROGR (B4JCG4), ZGPAT_DROME (Q9VL59), 
ZGPAT_DROMO (B4KH32), ZGPAT_DROPE (B4G7U3), ZGPAT_DROPS (Q29NF3), 
ZGPAT_DROSE (B4HWD7), ZGPAT_DROSI (B4Q8A7), ZGPAT_DROVI (B4M9F7), 
ZGPAT_DROYA (B4NYQ2), ZGPAT_HUMAN (Q8N5A5), ZGPAT_MOUSE (Q8VDM1), 
ZGPAT_NEMVE (A7SBN6), ZGPAT_RAT   (Q5PPF5), ZGPAT_SALSA (C0HAV3), 
ZGPAT_SHEEP (C5IJB0), ZGPAT_XENLA (Q5U4Z3), ZGPAT_XENTR (Q28H71)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

2 sequences

SPP2_YEAST  (Q02521), TGH_ARATH   (Q8GXN9)

PDB
[Detailed view]

18 PDB

5Y88; 6SH6; 6SH7; 7DVQ; 7QTT; 8CH6; 8EJM; 8GXL; 8GXM; 8P4E; 8P4F; 8RDY;
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