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| Entry: PS50184 |
General information about the entry
| Entry name [info] | VWFC_2 |
| Accession [info] | PS50184 |
| Entry type [info] | MATRIX |
| Date [info] |
01-NOV-2002 CREATED;
10-MAY-2017 DATA UPDATE; 22-FEB-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00928 |
| Associated ProRule [info] | PRU00220 |
Name and characterization of the entry
| Description [info] | VWFC domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=56; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=-1.8590000; R2=0.0091000; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=4813.4291992; R2=2.8005822; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1139; H_SCORE=8003; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=919; H_SCORE=7387; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=-30; E1=-30; MM=1; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='P'; M= 1, -8,-26, -8, -4,-23, 3,-16,-19, -7,-20,-14, -5, 5, -8, -9, 1, -4,-16,-26,-20, -8; /M: SY='A'; M= 7,-13,-18,-16,-12,-15,-12,-18, -4,-11, -8, -5,-11, -6,-10,-11, 1, 2, 3,-27,-16,-12; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='V'; M= -7,-23,-12,-25,-19, 1,-27,-16, 11,-19, 6, 6,-21,-25,-18,-17,-12, -4, 16,-13, 1,-19; /M: SY='H'; M=-11, -9,-29, -9, -7,-15, 7, 21,-24,-12,-16, -5, -2,-20, 4, -8, -7,-16,-24,-17, 0, -3; /M: SY='N'; M=-10, 12,-28, 12, 7,-25, -4, -5,-24, -3,-24,-18, 14, 7, -2, -6, 1, -6,-26,-33,-21, 1; /I: MI=-10; MD=-20; IM=-10; II=-8; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='G'; M= -1, 0,-26, -4,-14,-27, 51,-14,-34,-16,-30,-20, 11,-19,-14,-16, 6,-12,-28,-26,-27,-14; /M: SY='E'; M= -2,-10,-20,-10, 2,-16,-21,-12, -6, -1, -6, -2,-10,-16, 2, 1, -2, 2, 1,-26,-12, 2; /M: M= -7,-14,-25,-14, -1,-14,-23,-14, 0, -6, -7, -1,-12, -1, -1, -7, -5, -4, -2,-25,-12, -3; /M: SY='Y'; M=-17,-18,-27,-20,-17, 16,-28, 12, -2, -6, -3, 0,-15,-26,-10, -2,-16,-10, -4, 6, 42,-17; /M: SY='Q'; M= -2, -3,-26, -3, 10,-27,-11, -2,-22, 9,-20, -9, -1, -7, 16, 8, 0, -7,-21,-24,-14, 12; /M: SY='N'; M= -7, 5,-24, 4, -1, -9,-14,-10,-15, -9,-19,-15, 6, 5,-10,-12, -1, -4,-15,-28,-14, -6; /M: SY='G'; M= -5, -5,-28, -7,-12,-25, 35,-13,-32, -6,-24,-16, 5,-20,-11, -1, -2,-14,-25,-23,-23,-12; /M: SY='E'; M=-12, 19,-28, 29, 33,-32,-16, 9,-32, 6,-24,-19, 8, -7, 13, -2, 2, -9,-28,-33,-15, 22; /M: SY='T'; M= -1,-11,-18,-14, -8, -9,-20, -7, -2,-13, -8, -2, -9, -8,-10,-13, 3, 7, 3,-28, -8,-10; /M: SY='W'; M=-16,-36,-36,-38,-30, 24,-24,-28, -6,-22, -8,-10,-34,-30,-26,-20,-30,-20, -9, 85, 23,-24; /M: SY='Q'; M= -8, -6,-24, -7, 4,-18,-18, -7,-11, 5,-12, -2, -7,-14, 9, 0, -3, 0, -8,-20, -4, 6; /M: SY='P'; M= -2,-17,-23,-17, -9, -9,-20,-19, -3,-14,-11, -6,-15, 17,-13,-17, -2, 0, -2,-26,-14,-13; /M: SY='D'; M= -8, 28,-25, 34, 13,-31, 1, -3,-31, -3,-28,-24, 20,-12, 0, -9, 8, -4,-26,-36,-21, 6; /I: MI=-5; MD=-20; IM=-5; II=-7; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='P'; M= -1, -6,-13, -4, -1,-13, -7, -9, -9, -1,-14, -8, -4, 14, -3, -5, 5, 1, -7,-18,-12, -3; D=-5; /I: DM=-20; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='Q'; M=-10, 5,-25, 4, 8,-28,-19, 4,-23, 13,-21, -8, 3,-11, 20, 11, 1, 3,-20,-25, -9, 13; /M: M=-11, -2,-25, -3, -2,-13,-24, -6, -1, -5, -7, -4, -4,-16, -6, -9, -6, -2, -1,-23, -1, -5; /I: MI=-10; MD=-20; IM=-10; II=-8; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='T'; M= -2,-11,-12,-16,-16, -8,-23,-16, 2,-11, -4, -3,-10,-18,-15, -9, 6, 26, 15,-29, -9,-16; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='T'; M=-10, 2,-23, 2, 0,-17,-20, -9, -9, -5, -2, -2, -1,-16, 2, -5, -4, 3, -9,-27,-10, 1; /M: SY='D'; M= -6, 22,-23, 26, 12,-28, -6, -5,-26, 0,-25,-20, 15,-12, 0, -7, 7, -2,-20,-35,-19, 6; /I: MI=-5; MD=-20; IM=-5; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='G'; M= 3, -8,-24,-11,-16,-19, 40,-18,-29,-18,-22,-16, 1,-19,-17,-18, 5, -9,-21,-22,-22,-16; /M: SY='K'; M= 2, -3,-21, -8, -2,-14,-12,-10,-16, 5,-17,-10, 2,-16, -2, 2, 1, -3,-12,-17,-10, -2; /M: SY='T'; M= -3,-13,-18,-18,-16,-11,-17,-22, 2, -7, -5, -2,-10,-18,-14, -8, 0, 13, 11,-26,-11,-16; /M: SY='I'; M= -6,-26,-22,-28,-23, -3,-18,-23, 19,-24, 18, 11,-22,-25,-18,-21,-17, -9, 17,-22, -7,-22; /I: MI=-5; MD=-20; IM=-5; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='R'; M= -8, 3,-24, 4, 1,-22,-18, 1,-18, 4,-15, -7, 1,-14, 4, 6, -1, 0,-13,-27, -9, 1; /M: SY='P'; M=-11, -2,-32, 3, 7,-29,-19, -2,-23, 4,-23,-13, -5, 26, 6, -3, -6, -7,-25,-28,-16, 5; /M: SY='V'; M= -8,-17,-23,-20,-12,-11,-27,-18, 7, 2, 0, 5,-14,-20, -6, 1,-12, -5, 10,-23, -7,-11; /I: I=-8; MI=-25; MD=-20; IM=-25; /M: SY='P'; M= -6, -9,-23, -9, 1,-16,-19,-13, -6, -5,-10, -6, -7, 8, -1, -6, -1, 3, -8,-23,-12, -2; D=-6; /I: DM=-20; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /I: MD=-20; /M: SY='P'; M= -5, 2,-28, 7, 12,-27,-12, -8,-22, -4,-26,-19, 2, 29, 1,-10, 3, -4,-25,-31,-22, 4; D=-4; /I: MD=-20; /M: SY='E'; M= -8, -1,-21, 1, 3,-17,-16, -7,-10, -2, -7, -3, -4, -2, 3, -3, -3, -2,-11,-22,-10, 2; D=-4; /I: MD=-20; /M: SY='E'; M= -1, -1,-17, 1, 6,-16, -4, -7,-14, -1,-13, -9, -3, 6, 0, -5, 0, -3,-12,-17,-13, 3; D=-4; /I: MI=-5; MD=-20; IM=-5; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='P'; M= -4,-11,-25,-13,-10,-14,-15,-16, -3,-13, -4, -1,-10, 7,-11,-15, -6, 0, -6,-27,-15,-12; /M: SY='D'; M= -4, 6,-23, 8, -2,-22,-10, -8,-18,-10,-18,-15, 2, 1, -7,-13, 6, 5,-14,-32,-16, -5; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='P'; M= 0,-10,-27, -7, 4,-24,-16,-15,-18, 1,-21,-14, -9, 24, -3, -5, 0, -2,-16,-28,-20, -2; /M: SY='N'; M= -6, 5,-21, 2, 0,-10,-10, -8,-14,-10,-15,-13, 11, -9, -7,-10, 5, 1,-14,-31,-14, -4; /M: SY='P'; M= 3, -5,-30, 1, -1,-29, 5,-16,-26,-10,-26,-19, -7, 28,-10,-18, -2,-10,-24,-27,-26, -7; /M: SY='E'; M= -9, -7,-25, -6, 7, -7, -8, -8,-21, -1,-15,-12, -4,-15, -3, 6, -1, -3,-16,-19, -6, 1; /M: SY='F'; M=-11,-15,-22,-19, -9, 2,-26,-16, 0, -5, 1, 0,-12,-19,-11, 2, -9, 1, 2,-19, -3,-11; /M: SY='P'; M=-10,-22,-27,-19,-11, -6,-26,-14, 2,-11, 0, -1,-20, 5,-13, -8,-15, -8, 1,-18, -1,-15; /M: SY='E'; M=-10, -9,-25, -6, 4, -9,-24,-13, -5, -4, -4, -2,-12, -8, -4, -8,-10, -8, -3,-23, -9, 0; /I: MI=0; MD=-20; IM=0; II=-5; DM=-20; I=0,0,-50,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='P'; M= -1, -3,-15, -4, -4,-12,-11, -3, -5, -6, -8, -5, -1, 3, -4, -8, -3, -4, -5,-19,-10, -5; D=-4; /I: DM=-21; /M: SY='P'; M= 4, 0,-16, 0, 1,-16, -3, -9,-13, -5,-15,-11, 0, 12, -4, -9, 3, -1,-13,-19,-15, -3; D=-4; /I: DM=-21; /M: SY='G'; M= -5, 4,-30, 9, -9,-32, 77,-15,-39,-12,-30,-22, 4,-17,-14,-15, -1,-17,-29,-24,-27,-12; /M: SY='E'; M= -8, 6,-26, 10, 57,-29,-19, -2,-25, 10,-20,-15, 1, -4, 21, 3, 4, -1,-24,-28,-16, 29; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='P'; M= -6, -5,-32, -1, 9,-29, -3,-12,-26, -1,-27,-19, -3, 31, -3, -9, -4,-10,-28,-28,-25, 1; /I: MI=-8; MD=-20; IM=-8; II=-5; DM=-20; I=0,0,-15,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0; /M: SY='V'; M= -7,-15,-21,-15, -9, -9,-23, -8, 0, -1, -8, -2,-11,-21, -8, 4, -4, -3, 8,-23, -2,-11; /M: SY='C'; M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30; /M: SY='E'; M= -7, -4,-28, 2, 7,-20,-18,-12,-17, -3,-13,-12, -9, 1, -1, -9, -6, -8,-16,-14,-13, 3; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 269 in 120 different sequences |
| Number of true positive hits | 269 in 120 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 23 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 92.12 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | K_Hofmann, N_Hulo |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 23 |
| Feature key [info] | DOMAIN |
| Feature description [info] | VWFC |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
120 sequences
BMPER_HUMAN (Q8N8U9 ), BMPER_MOUSE (Q8CJ69 ), CCN1_CHICK (P19336 ), CCN1_HUMAN (O00622 ), CCN1_MOUSE (P18406 ), CCN1_PANTR (A5A6L1 ), CCN1_RAT (Q9ES72 ), CCN2_BOVIN (O18739 ), CCN2_HUMAN (P29279 ), CCN2_MOUSE (P29268 ), CCN2_PIG (O19113 ), CCN2_RAT (Q9R1E9 ), CCN3_CHICK (P28686 ), CCN3_COTJA (P42642 ), CCN3_HUMAN (P48745 ), CCN3_MOUSE (Q64299 ), CCN3_RAT (Q9QZQ5 ), CCN3_XENLA (P51609 ), CCN4_HUMAN (O95388 ), CCN4_MOUSE (O54775 ), CCN4_RAT (Q99PP0 ), CCN5_HUMAN (O76076 ), CCN5_MOUSE (Q9Z0G4 ), CCN5_RAT (Q9JHC6 ), CHRD_DANRE (O57472 ), CHRD_HUMAN (Q9H2X0 ), CHRD_MOUSE (Q9Z0E2 ), CHRD_RAT (Q63148 ), CHRD_XENLA (Q91713 ), CO1A1_BOVIN (P02453 ), CO1A1_CANLF (Q9XSJ7 ), CO1A1_CHICK (P02457 ), CO1A1_CYNPY (Q9YIB4 ), CO1A1_HUMAN (P02452 ), CO1A1_MOUSE (P11087 ), CO1A1_RAT (P02454 ), CO2A1_BOVIN (P02459 ), CO2A1_HUMAN (P02458 ), CO2A1_MOUSE (P28481 ), CO2A1_XENLA (Q91717 ), CO2A1_XENTR (Q6P4Z2 ), CO3A1_CHICK (P12105 ), CO3A1_HUMAN (P02461 ), CO3A1_MOUSE (P08121 ), CO3A1_RAT (P13941 ), CO5A2_HUMAN (P05997 ), CO5A2_MOUSE (Q3U962 ), CRDL1_CHICK (Q90ZD5 ), CRDL1_HUMAN (Q9BU40 ), CRDL1_MOUSE (Q920C1 ), CRDL1_RAT (Q76LD0 ), CRDL2_HUMAN (Q6WN34 ), CRDL2_MOUSE (Q8VEA6 ), CRIM1_CHICK (Q8AWW5 ), CRIM1_DANRE (Q7T3Q2 ), CRIM1_HUMAN (Q9NZV1 ), CRIM1_MOUSE (Q9JLL0 ), ECM2_BOVIN (Q3MHH9 ), ECM2_HUMAN (O94769 ), ECM2_MOUSE (Q5FW85 ), FRAS1_HUMAN (Q86XX4 ), FRAS1_MOUSE (Q80T14 ), JAG2_HUMAN (Q9Y219 ), KCP_HUMAN (Q6ZWJ8 ), KCP_MOUSE (Q3U492 ), KCP_XENLA (Q9IBG7 ), MUC19_BOVIN (P98091 ), MUC19_HUMAN (Q7Z5P9 ), MUC19_MOUSE (Q6PZE0 ), MUC2L_RAT (P98089 ), MUC2_HUMAN (Q02817 ), MUC2_MOUSE (Q80Z19 ), MUC5A_HUMAN (P98088 ), MUC5B_CHICK (Q98UI9 ), MUC5B_HUMAN (Q9HC84 ), MUCAP_PIG (P12021 ), MUCB1_XENLA (P38565 ), NELL1_HUMAN (Q92832 ), NELL1_MOUSE (Q2VWQ2 ), NELL1_RAT (Q62919 ), NELL2_BOVIN (A6QR11 ), NELL2_DANRE (A1A5Y0 ), NELL2_HUMAN (Q99435 ), NELL2_MOUSE (Q61220 ), NELL2_PONAB (Q5R3Z7 ), NELL2_RAT (Q62918 ), NELL2_XENLA (Q7ZXL5 ), NELL2_XENTR (A2VCU8 ), NEL_CHICK (Q90827 ), PXDNL_HUMAN (A1KZ92 ), PXDN_DROME (Q9VZZ4 ), PXDN_HUMAN (Q92626 ), PXDN_MOUSE (Q3UQ28 ), PXDN_XENTR (A4IGL7 ), SAS_DROME (Q04164 ), SOG_DROME (Q24025 ), SSPO_BOVIN (P98167 ), SSPO_CHICK (Q2PC93 ), SSPO_HUMAN (A2VEC9 ), SSPO_MOUSE (Q8CG65 ), SSPO_RAT (Q700K0 ), TSP1_BOVIN (Q28178 ), TSP1_HUMAN (P07996 ), TSP1_MOUSE (P35441 ), TSP1_XENLA (P35448 ), TSP2_BOVIN (Q95116 ), TSP2_CHICK (P35440 ), TSP2_HUMAN (P35442 ), TSP2_MOUSE (Q03350 ), VWC2L_DANRE (B0UZC8 ), VWC2L_HUMAN (B2RUY7 ), VWC2L_MOUSE (Q505H4 ), VWC2_HUMAN (Q2TAL6 ), VWC2_MOUSE (Q8C8N3 ), VWCE_HUMAN (Q96DN2 ), VWCE_MOUSE (Q3U515 ), VWF_CANLF (Q28295 ), VWF_HUMAN (P04275 ), VWF_MOUSE (Q8CIZ8 ), VWF_PIG (Q28833 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
23 sequences
AMNLS_CANLF (Q6UKI2 ), AMNLS_HUMAN (Q9BXJ7 ), AMNLS_MOUSE (Q99JB7 ), AMNLS_PIG (F1SAM7 ), FSTL1_BOVIN (Q58D84 ), FSTL1_HUMAN (Q12841 ), FSTL1_MACFA (Q9GKY0 ), FSTL1_MOUSE (Q62356 ), FSTL1_PONAB (Q5R9Y1 ), FSTL1_RAT (Q62632 ), HMCT_BOMMO (P98092 ), IDD_HUMAN (P98153 ), IDD_MOUSE (P98154 ), JAG1B_DANRE (Q90Y54 ), MUC2_RAT (Q62635 ), TECTA_CHICK (Q9YH85 ), TECTA_HUMAN (O75443 ), TECTA_MOUSE (O08523 ), VWC2L_MACFA (Q95K75 ), ZAN_HUMAN (Q9Y493 ), ZAN_MOUSE (O88799 ), ZAN_PIG (Q28983 ), ZAN_RABIT (P57999 )» more |
| PDB [Detailed view] |
14 PDB
1U5M; 5NB8; 5NIR; 6N29; 6TM2; 7A5O; 7KWO; 7PMV; 7PNF; 7POV; 7PP6; 7ZWH; 8D3C; 8D3D » more |
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