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PROSITE entry PS50188


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PURL: https://purl.expasy.org/prosite/signature/PS50188

Direct ScanProsite submission
General information about the entry

Entry name [info] B302_SPRY
Accession [info] PS50188
Entry type [info] MATRIX
Date [info] 01-APR-2006 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50188
Associated ProRule [info] PRU00548

Name and characterization of the entry

Description [info] B30.2/SPRY domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=196;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=191;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1948702; R2=0.0160971; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13169.6132812; R2=4.9483871; TEXT='Heuristic 0.5%';
/CUT_OFF: LEVEL=0; SCORE=392; H_SCORE=15109; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=268; H_SCORE=14496; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-6; D=-100; I=-100; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;
...
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 375 in 347 different sequences
Number of true positive hits 375 in 347 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 2
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 99.47 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] B30.2/SPRY
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
347 sequences

A33_PLEWA   (Q02084), ASH2L_HUMAN (Q9UBL3), ASH2L_MOUSE (Q91X20), 
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UniProtKB/Swiss-Prot
False negative sequences
2 sequences

BRE2_YEAST  (P43132), CCLA_ASPOR  (Q2U741)

		
PDB
[Detailed view]
393 PDB

2AFJ; 2FBE; 2FNJ; 2IHS; 2IWG; 2JK9; 2LM3; 2V24; 2VOK; 2WL1; 2YYO; 3EK9;
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