PROSITE logo

PROSITE entry PS50229


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS50229

Direct ScanProsite submission
General information about the entry

Entry name [info] WH1
Accession [info] PS50229
Entry type [info] MATRIX
Date [info] 01-MAR-2005 CREATED;
13-FEB-2019 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC50229
Associated ProRule [info] PRU00410

Name and characterization of the entry

Description [info] WH1 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=114;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=109;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4736438; R2=0.0174257; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=7780.8222656; R2=5.0197740; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=387; H_SCORE=9723; N_SCORE=9.2; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=232; H_SCORE=8945; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105;
...
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.


Total number of hits 45 in 45 different sequences
Number of true positive hits 45 in 45 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 12
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 78.95 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] PS_Langendijk_Genevaux
Feature key [info] DOMAIN
Feature description [info] WH1
Version [info] 6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
45 sequences

ENAH_HUMAN  (Q8N8S7), ENAH_MOUSE  (Q03173), ENA_DROME   (Q8T4F7), 
» more

UniProtKB/Swiss-Prot
False negative sequences
12 sequences

P4R3A_HUMAN (Q6IN85), P4R3A_MOUSE (Q6P2K6), P4R3A_XENLA (Q7ZX60), 
» more

PDB
[Detailed view]
46 PDB

1DDV; 1DDW; 1EGX; 1EVH; 1I2H; 1I7A; 1MKE; 1QC6; 1TJ6; 1XOD; 2IFS; 2IYB;
» more