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| Entry: PS50304 |
General information about the entry
| Entry name [info] | TUDOR |
| Accession [info] | PS50304 |
| Entry type [info] | MATRIX |
| Date [info] |
01-DEC-2001 CREATED;
10-MAY-2017 DATA UPDATE; 22-FEB-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50304 |
| Associated ProRule [info] | PRU00211 |
Name and characterization of the entry
| Description [info] | Tudor domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=61; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=56; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.0072000; R2=0.0201488; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2856.1633301; R2=2.1802721; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=273; H_SCORE=3451; N_SCORE=8.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=174; H_SCORE=3236; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: D=-20; I=-20; B1=*; E1=*; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='Q'; M= -1, 0,-18, -3, 1,-24,-12, -9,-19, 0,-19,-12, 2, -2, 5, -3, 5, 5,-17,-28,-16, 3; /M: SY='W'; M=-10,-26,-25,-28,-20, 8,-22,-23, -8,-19, -6, -9,-24,-11,-18,-18,-18,-10,-10, 33, 6,-18; /M: SY='K'; M= -4, -2,-19, -3, 6,-24,-18, -8,-20, 16,-21,-11, -1, -9, 5, 9, -2, -6,-15,-24,-12, 5; /M: SY='V'; M= 2,-17,-17,-20,-17, -9,-20,-20, 11,-12, 1, 2,-13,-22,-16,-10, -6, -3, 18,-27,-12,-17; /M: SY='G'; M= 0, -3,-28, -3,-13,-29, 48,-17,-36,-11,-28,-19, 3,-18,-15,-14, 1,-14,-27,-22,-26,-14; /M: SY='D'; M= 4, 6,-22, 9, 1,-24, -5,-12,-19, -6,-14,-12, -1, -9, -5,-12, 1, -3,-12,-28,-17, -2; /M: M= -7,-12,-25,-14,-11,-11,-11,-17, -4, -5, -3, -1, -9,-12,-11, -8,-10, -7, -5,-22,-10,-12; /M: SY='C'; M= -9,-21, 95,-30,-30,-16,-30,-29,-19,-28,-14,-12,-21,-38,-29,-28,-10, -9, 0,-46,-26,-29; /I: I=-6; MD=-29; /M: SY='V'; M= 0,-10, -8,-14,-12, -7,-15,-10, 4, -7, -1, 6, -7,-17, -7, -9, -4, -3, 7,-20, -7,-10; D=-6; /I: I=-6; MI=-29; MD=-29; IM=-29; DM=-29; /M: SY='A'; M= 22,-13,-11,-18,-14,-12, -3,-19, 0,-12, -5, -4,-11,-14,-14,-17, 4, 1, 9,-20,-15,-14; D=-6; /I: I=-6; DM=-29; /M: SY='V'; M= -3,-15,-22,-16, -9, -9,-23,-14, 3, -7, 0, 2,-15,-15, -7, -4,-10, -6, 6,-22, -7,-10; /M: SY='F'; M= -9,-23,-15,-26,-18, 15,-23,-15, -9,-15, -6, -7,-19,-16,-17,-13,-15,-11,-10, 13, 12,-17; /M: SY='P'; M= -3, -8,-24, -6, 2,-16,-11, -9,-20, -1,-23,-15, -4, 7, 0, -2, 7, 1,-18,-24,-10, -1; /M: SY='E'; M= -6, 6,-19, 10, 21,-25,-16, -7,-21, 5,-20,-15, 2,-11, 6, 0, 2, -5,-15,-31,-18, 13; /M: SY='D'; M=-17, 42,-29, 55, 18,-37, -7, 1,-36, 0,-29,-26, 22,-11, 3, -8, 1, -9,-30,-38,-20, 10; /M: SY='G'; M= -1, -1,-25, -4, -8,-26, 34,-13,-30,-11,-24,-17, 7,-17, -9,-12, 3, -9,-25,-25,-24, -8; /M: SY='E'; M= -1, -3, 1, -5, 8,-19,-17, -3,-19, -8,-14,-12, -3,-16, 1,-10, 1, -5,-15,-30,-12, 4; /M: SY='W'; M=-13,-31,-29,-34,-27, 16,-25,-19, 1,-21, -1, -2,-28,-28,-20,-19,-26,-17, -6, 54, 25,-22; /M: SY='Y'; M=-18,-17,-29,-18,-15, 19,-27, 18, -5, -8, -3, -1,-16,-26, -6, -8,-17, -9,-12, 19, 56,-14; /M: SY='R'; M=-16, -6,-31, -3, 3,-23,-19, -6,-27, 15,-22,-14, -3, 6, 4, 36, -7, -5,-22,-25,-15, -1; /M: SY='A'; M= 38,-11, 5,-21,-13,-18, -5,-19,-12,-12,-11,-11,-11,-15,-12,-20, 7, -1, -2,-22,-17,-13; /M: SY='T'; M= -7, -7,-22, -8, 0,-17,-19, -6,-15, 1,-15, -7, -5,-10, 4, 3, 3, 7,-10,-20, -9, 1; /M: SY='I'; M= -4,-28,-22,-35,-28, -1,-34,-29, 38,-26, 16, 15,-22,-22,-22,-26,-15, -4, 32,-23, -4,-28; /M: SY='T'; M= -3, -7,-17, -9, 2,-17,-20, -8, -9, -3, -9, -5, -6,-14, 1, -3, 2, 4, -5,-27,-11, 1; /M: SY='E'; M= 0, 4,-24, 4, 5,-23, -9, -8,-22, 4,-22,-15, 5,-13, 3, 3, 5, -3,-17,-21,-15, 4; /I: I=-4; MD=-21; /M: SY='V'; M= -7,-15,-15,-17,-13, -6,-24,-16, 10,-13, 2, 6,-14,-15,-11,-15,-10, -6, 11,-23, -5,-13; D=-4; /I: I=-4; MD=-21; /M: SY='D'; M=-10, 6,-19, 11, 2, -9,-13, -5,-12, -7, -7, -9, 0, -4, -5, -9, -4, -3,-12,-19, -4, -2; D=-4; /I: I=-4; MI=0; MD=-21; IM=0; DM=-21; /M: SY='E'; M= -7, 3,-14, 4, 9,-12,-13, 4,-18, 3,-13, -9, 2,-10, 4, 1, -2, -6,-15,-19, -6, 6; D=-4; /I: I=-4; DM=-21; /M: SY='E'; M=-10, 5,-26, 10, 16,-24,-12, -5,-24, 9,-21,-13, 2, 2, 5, 7, -2, -6,-21,-26,-16, 9; D=-4; /I: I=-4; DM=-21; /M: SY='B'; M= 1, 9,-22, 8, 5,-25,-11, -6,-22, 5,-21,-13, 7, -8, 3, 2, 4, 0,-17,-29,-16, 3; /M: SY='E'; M= -6, 9,-27, 11, 12,-25, -4, 0,-25, -1,-20,-15, 8, -8, 4, -3, 0, -8,-24,-27,-14, 8; /M: M= -7, -7,-21, -8, 0,-18, -3,-10,-19, 0,-12, -6, -5,-16, 0, 0, -3, -2,-15,-22,-10, -1; /M: SY='V'; M= -6,-22, 8,-27,-23, 7,-26,-16, 1,-15, -1, 0,-20,-28,-21,-14,-12, -7, 9,-16, 7,-22; /M: SY='H'; M= -9, -8,-25, -7, 3,-10,-17, 4,-14, -3,-13, -7, -6,-12, -4, -1, -5, -8, -9,-22, -3, -2; /M: SY='V'; M= -2,-29,-14,-31,-29, -1,-27,-29, 30,-22, 11, 11,-27,-28,-28,-21,-12, -3, 42,-28, -9,-29; /M: SY='F'; M= -9,-19,-20,-23,-14, 11,-26,-14, 1,-10, 4, 1,-15,-23,-15, -1,-11, -3, 6,-17, 1,-14; /M: SY='Y'; M=-17,-23,-18,-27,-22, 35,-29, 1, 0,-18, 6, 1,-20,-30,-20,-12,-19,-10, -3, 8, 41,-22; /M: SY='I'; M= -4,-21,-21,-25,-20, -4,-31,-25, 27,-21, 10, 9,-18,-21,-19,-22,-10, 0, 26,-25, -7,-22; /M: SY='D'; M=-15, 34,-29, 49, 14,-34, -5, -2,-36, -1,-27,-25, 13,-12, -1, -7, -1,-10,-27,-33,-16, 6; /M: SY='Y'; M=-19,-22,-28,-24,-22, 33,-30, 8, 2,-14, 1, 0,-20,-29,-15,-13,-19, -8, -7, 26, 62,-22; /M: SY='G'; M= 1, -9,-28, -9,-18,-29, 64,-19,-38,-19,-30,-20, 1,-19,-18,-19, 3,-17,-28,-22,-29,-18; /M: SY='N'; M= -7, 21,-22, 9, -5,-20, 12, 1,-24, -3,-28,-18, 36,-19, -5, -4, 7, -2,-26,-32,-17, -5; /M: SY='T'; M= -6, -8,-14,-10, -1,-13,-21, -9, -9, -2,-10, -6, -6,-17, 0, 1, -1, 4, -5,-23, -5, -2; /M: SY='E'; M= 2, 0,-21, 1, 16,-21,-16,-10,-14, -3,-14,-12, -2, -8, 5, -8, 7, 2,-12,-29,-16, 10; /M: SY='V'; M= -6, -8,-15, -8, 1,-15,-23,-14, -3, -5, -5, -4, -9,-18, -4, -6, -4, 2, 4,-29,-12, -2; /M: SY='V'; M= -5,-21,-12,-24,-19, -6,-28,-22, 15,-13, 8, 9,-20,-24,-14,-13,-10, 0, 22,-26, -8,-17; /M: SY='P'; M= -3, 1,-25, 3, 4,-26,-13, -6,-21, 0,-25,-16, 2, 14, 2, -6, 7, 1,-19,-32,-19, 2; /M: M= -7, -8,-23, -8, -5,-11,-18, -8, -8, -3, -3, 0, -7,-14, -3, -1, -7, -4, -7,-18, -5, -5; /M: SY='E'; M= -6, 1,-18, 3, 9,-20,-18, -5,-18, -1,-15,-11, -1,-10, 3, -5, 1, -2,-14,-29,-13, 6; /M: SY='D'; M=-13, 11,-25, 13, 1,-19,-15, -4,-19, 2,-15,-12, 8,-17, 0, 3, -4, -5,-17,-22, -9, 0; /M: SY='L'; M= -8,-22,-22,-23,-14, -1,-28,-16, 17,-22, 29, 17,-22,-24,-10,-17,-21, -9, 8,-21, -3,-13; /I: I=-6; MD=-32; /M: SY='L'; M=-10,-20,-26,-21,-15, -5,-15,-10, -5, -7, 4, 3,-16,-23,-10, 2,-17,-12, -4, -5, -2,-13; D=-6; /I: I=-6; MI=-32; IM=-32; DM=-32; /M: SY='P'; M= -6, -9,-29, -6, 8,-24,-18, -6,-18, -2,-16,-10, -9, 14, 8, -5, -3, -5,-21,-21,-14, 7; /M: SY='L'; M= -8,-17,-26,-18, -5,-10,-26,-15, 9,-16, 10, 7,-15, -5, -5,-16,-15, -9, 0,-24, -9, -7; /M: SY='E'; M= -4, -4,-27, 1, 15,-22,-18,-11,-17, -3,-14,-13, -7, 11, 1, -5, -2, -4,-17,-28,-18, 6; /M: SY='P'; M= -7,-13,-20,-13, 0,-12,-22,-12,-11, -6,-10, -5,-11, 3, 0, -2, -7, -6,-13,-23,-12, -2; /M: SY='E'; M= -1, 4,-25, 7, 8,-25, -4, -9,-25, 3,-21,-17, 1,-10, -1, 1, 0, -6,-19,-21,-17, 3; /M: SY='F'; M= -8,-16,-22,-19, -9, 7,-23,-10, 1,-14, 6, 5,-13,-17,-11,-10,-11, -7, -1,-19, -1,-10; /M: SY='A'; M= 2,-12,-22,-14, -5, -7,-20, -9, -1,-11, 1, 0,-12,-13, -8,-14, -6, -4, -1,-19, -2, -7; /M: SY='E'; M= -7, 3,-24, 4, 6,-19,-18,-10,-12, -4,-10,-10, 0, -6, -3, -6, -2, -1,-12,-30,-15, 1; /M: SY='S'; M= -3, -7,-22, -6, 0,-15,-15, -8,-12, -7,-12, -7, -4, -1, -1, -7, 3, -1,-11,-28,-13, -1; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 166 in 102 different sequences |
| Number of true positive hits | 162 in 98 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 4 in 4 different sequences |
| Number of false negative sequences | 65 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 97.59 % |
| Recall (true positives / (true positives + false negatives)) | 71.37 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | V_Jongeneel |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 9 |
| Feature key [info] | DOMAIN |
| Feature description [info] | Tudor |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
98 sequences
AKAP1_CAEEL (Q09285 ), AKAP1_HUMAN (Q92667 ), AKAP1_MOUSE (O08715 ), AKAP1_RAT (O88884 ), ALG13_HUMAN (Q9NP73 ), ALG13_MOUSE (Q9D8C3 ), OTU_DROME (P10383 ), RNF17_HUMAN (Q9BXT8 ), RNF17_MACFA (Q4R3G4 ), RNF17_MOUSE (Q99MV7 ), SMN1_DANRE (Q9W6S8 ), SMN_BOVIN (O18870 ), SMN_CANLF (O02771 ), SMN_FELCA (Q8HYB8 ), SMN_HUMAN (Q16637 ), SMN_MACFA (Q4R4F8 ), SMN_MOUSE (P97801 ), SMN_PONAB (Q5RE18 ), SMN_RAT (O35876 ), SND1_BOVIN (Q863B3 ), SND1_DANRE (Q7ZT42 ), SND1_DROME (Q9W0S7 ), SND1_HUMAN (Q7KZF4 ), SND1_MOUSE (Q78PY7 ), SND1_PONAB (Q5REU4 ), SND1_RAT (Q66X93 ), SND1_SCHPO (Q9Y7U7 ), SPF30_BOVIN (Q3T045 ), SPF30_DANRE (Q7ZV80 ), SPF30_HUMAN (O75940 ), SPF30_MOUSE (Q8BGT7 ), SPF30_PONAB (Q5R591 ), SPF30_RAT (Q4QQU6 ), SPF30_XENTR (Q6DEY1 ), SPNE_CULQU (B0XDC4 ), SPNE_DROAN (B3M383 ), SPNE_DROER (B3P3W1 ), SPNE_DROME (Q9VF26 ), SPNE_DROMO (B4K5R2 ), SPNE_DROPE (B4GEU5 ), SPNE_DROPS (Q296Q5 ), SPNE_DROSE (B4HLH4 ), SPNE_DROVI (B4LX81 ), SPNE_DROWI (B4NBB0 ), SPNE_DROYA (B4PRJ9 ), STK31_HUMAN (Q9BXU1 ), STK31_MOUSE (Q99MW1 ), TDR12_BOMMO (Q1XG89 ), TDR15_HUMAN (B5MCY1 ), TDRD1_DANRE (Q58EK5 ), TDRD1_HUMAN (Q9BXT4 ), TDRD1_MOUSE (Q99MV1 ), TDRD1_ORYLA (A9CPT4 ), TDRD3_BOVIN (Q2HJG4 ), TDRD3_CHICK (Q5ZMS6 ), TDRD3_DANRE (Q6NYG6 ), TDRD3_HUMAN (Q9H7E2 ), TDRD3_MOUSE (Q91W18 ), TDRD3_RAT (Q66HC1 ), TDRD3_XENLA (Q6NRP6 ), TDRD3_XENTR (Q6P1U3 ), TDRD5_AILME (D2H3M0 ), TDRD5_BOVIN (E1BPH3 ), TDRD5_CANLF (E2QTD3 ), TDRD5_DANRE (Q1L981 ), TDRD5_HUMAN (Q8NAT2 ), TDRD5_MOUSE (Q5VCS6 ), TDRD5_RAT (B4F7C4 ), TDRD5_XENLA (A1L1H3 ), TDRD5_XENTR (A0JM98 ), TDRD6_DANRE (F1R237 ), TDRD6_HUMAN (O60522 ), TDRD6_MOUSE (P61407 ), TDRD6_XENLA (Q90WE3 ), TDRD7_AILME (D2H0H6 ), TDRD7_BOVIN (A6QLE1 ), TDRD7_CANLF (E2RDV1 ), TDRD7_CHICK (E1C3S7 ), TDRD7_HUMAN (Q8NHU6 ), TDRD7_MOUSE (Q8K1H1 ), TDRD7_PONAB (Q5RAH6 ), TDRD7_RAT (Q9R1R4 ), TDRD7_XENLA (Q6NU04 ), TDRD7_XENTR (Q5M7P8 ), TDRD9_DANRE (B8A4F4 ), TDRD9_HUMAN (Q8NDG6 ), TDRD9_MOUSE (Q14BI7 ), TDRD9_RAT (Q3MHU3 ), TDRKH_BOMMO (H9JD76 ), TDRKH_DROME (Q9VQ91 ), TDRKH_HUMAN (Q9Y2W6 ), TDRKH_MOUSE (Q80VL1 ), TRD7A_DANRE (A6NAF9 ), TRD7B_DANRE (E7FDW8 ), TSN1_ARATH (Q8VZG7 ), TSN2_ARATH (Q9FLT0 ), TUD_DROME (P25823 ), VRET_DROME (Q9VCU7 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
65 sequences
BOYB_DROME (Q9VNP5 ), COIL_ARATH (Q8RWK8 ), COIL_HUMAN (P38432 ), COIL_MOUSE (Q5SU73 ), COIL_XENLA (Q09003 ), FMR1_DROME (Q9NFU0 ), FMR1_HUMAN (Q06787 ), FMR1_MOUSE (P35922 ), FMR1_PONAB (Q5R9B4 ), FMR1_RAT (Q80WE1 ), FMR1_XENTR (Q6GLC9 ), FXR1_BOVIN (Q2TBT7 ), FXR1_CRIGR (O70523 ), FXR1_HUMAN (P51114 ), FXR1_MOUSE (Q61584 ), FXR1_RAT (Q5XI81 ), FXR1_XENTR (Q5BJ56 ), FXR2_HUMAN (P51116 ), FXR2_MOUSE (Q9WVR4 ), HPO40_CAEEL (Q23647 ), KDM4A_HUMAN (O75164 ), KDM4A_MOUSE (Q8BW72 ), KDM4A_PONAB (Q5RD88 ), KDM4B_HUMAN (O94953 ), KDM4B_MOUSE (Q91VY5 ), KDM4C_HUMAN (Q9H3R0 ), KDM4C_MOUSE (Q8VCD7 ), LBR_CHICK (P23913 ), LBR_HUMAN (Q14739 ), LBR_MOUSE (Q3U9G9 ), LBR_PONAB (Q5R7H4 ), LBR_RAT (O08984 ), MTF2_HUMAN (Q9Y483 ), MTF2_MOUSE (Q02395 ), MTF2_PONAB (Q5R7T9 ), P20L1_BOVIN (A2VE56 ), P20L1_CHICK (Q5F3G6 ), P20L1_HUMAN (A8MW92 ), P20L1_MOUSE (Q8CCJ9 ), P20L1_RAT (Q4V9H5 ), PCL_DROME (Q24459 ), PHF19_HUMAN (Q5T6S3 ), PHF19_MOUSE (Q9CXG9 ), PHF1_HUMAN (O43189 ), PHF1_MOUSE (Q9Z1B8 ), PHF20_HUMAN (Q9BVI0 ), PHF20_MOUSE (Q8BLG0 ), SETB1_DROME (Q32KD2 ), SETB1_DROPS (Q28Z18 ), SETB1_HUMAN (Q15047 ), SETB1_MOUSE (O88974 ), SETB1_XENLA (Q6INA9 ), SIMR1_CAEEL (O01477 ), SMN_DROME (Q9VV74 ), SOYB_DROME (Q9VL52 ), SPF30_SCHPO (O94519 ), SPNE_AEDAE (Q16JS8 ), SPNE_ANOGA (Q7QCW2 ), SPNE_DROGR (B4JT42 ), STB1A_DANRE (Q1L8U8 ), STB1B_DANRE (Q08BR4 ), TDR10_HUMAN (Q5VZ19 ), TDR12_HUMAN (Q587J7 ), TDR12_MOUSE (Q9CWU0 ), TG250_CAEEL (P34344 )» more |
| UniProtKB/Swiss-Prot False positive sequences |
4 sequences
NHR61_CAEEL (O62389 ), U90A1_ARATH (Q9ZVX4 ), U90A2_ARATH (Q9SY84 ), ZGPAT_NEMVE (A7SBN6 )» more |
| PDB [Detailed view] |
47 PDB
1G5V; 1MHN; 2D9T; 2DIQ; 2E6N; 2EQK; 2HQE; 2HQX; 2LTO; 2O4X; 2WAC; 3BDL; 3FDR; 3NTH; 3NTI; 3NTK; 3OMC; 3OMG; 3PMT; 3PNW; 3S6W; 4A4E; 4A4F; 4A4G; 4A4H; 4B9W; 4B9X; 4Q5W; 4Q5Y; 4QQ6; 4V98; 5J39; 5M9N; 5M9O; 5VQG; 5VQH; 5VY1; 5YGB; 5YGC; 5YGD; 5YGF; 5YJ8; 6B57; 6PI7; 6V9T; 7W2P; 7W30 » more |
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