PROSITE entry PS50812

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PURL: https://purl.expasy.org/prosite/signature/PS50812

Direct ScanProsite submission

General information about the entry

Entry name [info]	PWWP
Accession [info]	PS50812
Entry type [info]	MATRIX
Date [info]	01-DEC-2001 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50812
Associated ProRule [info]	PRU00162

Name and characterization of the entry

Description [info]

PWWP domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=62;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=57;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.9419000; R2=0.0123090; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3817.5488281; R2=4.8558640; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=615; H_SCORE=6804; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=452; H_SCORE=6012; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='F';  M=-10,-28,-25,-31,-23, 16,-30,-25, 15,-23,  3,  3,-22,  0,-26,-22,-15, -8, 13,-16, -1,-25;
/M: SY='G';  M= -7, -5,-30, -5, -4,-31, 24, 16,-32, -9,-25,-10,  2,-17,  9, -7, -2,-17,-30,-22,-13,  2;
/M: SY='D';  M=-15, 24,-32, 39, 25,-35,-15, -5,-33,  0,-28,-25,  6, 15,  3,-10, -2,-10,-30,-35,-22, 13;
/M: SY='L';  M=-10,-30,-23,-33,-23,  7,-33,-23, 28,-30, 42, 20,-27,-27,-20,-23,-27,-10, 16,-20,  0,-23;
/M: SY='V';  M= -3,-30,-16,-33,-30,  0,-33,-30, 36,-23, 13, 13,-27,-27,-27,-23,-13, -3, 44,-27, -7,-30;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='A';  M= 14,-13,-15,-16,-16,-17,  9,-20, -9,-15,-14, -9, -8,-18,-16,-18,  9,  0,  4,-28,-20,-16;
/M: SY='K';  M=-10,  0,-30,  0, 10,-30,-20,-10,-30, 50,-30,-10,  0,-10, 10, 30,-10,-10,-20,-20,-10, 10;
/M: SY='L';  M= -8,-30,-18,-30,-22,  8,-30,-22, 22,-28, 40, 18,-30,-30,-22,-20,-25, -8, 20,-22, -2,-22;
/M: SY='R';  M= -5, -5,-25, -5, -3,-25, 10,-10,-30, 11,-28,-15,  2,-15, -1, 16,  5, -6,-20,-25,-18, -3;
/M: SY='G';  M= -3,  4,-27, -2,-14,-27, 50,-12,-34,-14,-30,-20, 17,-20,-14,-14,  3,-14,-30,-26,-27,-14;
/M: SY='Y';  M=-20,-25,-25,-30,-25, 54,-30,  1,  0,-20,  5,  0,-20,-30,-24,-15,-20,-10, -5, 20, 56,-25;
/M: SY='P';  M= -8,-12,-30, -8,  0,-25,-15,-12,-23,  1,-27,-17, -7, 34, -2,  8,  2, -3,-22,-30,-22, -5;
/M: SY='W';  M=-20,-38,-43,-40,-30, 26,-22,-28,-15,-22,-13,-15,-35,-30,-25,-20,-35,-25,-23,118, 30,-22;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='P';  M=-10,-20,-40,-10,  0,-30,-20,-20,-20,-10,-30,-20,-20, 90,-10,-20,-10,-10,-30,-30,-30,-10;
/M: SY='A';  M= 23,-12, 17,-20,-17,-22, 10,-22,-22,-17,-17,-15,-10,-20,-17,-22,  3, -7,-10,-27,-25,-17;
/M: SY='R';  M=-12, -4,-28, -4, 14,-20,-20, -2,-18, 19,-13,  4, -5,-12, 10, 22,-10,-10,-16,-23,-10, 11;
/M: SY='V';  M=  9,-25,-15,-30,-25, -5,-26,-28, 26,-20,  8,  8,-23,-23,-23,-22, -8, -2, 34,-25,-10,-25;
/M: SY='C';  M= -3,-20, 24,-23,-20, -8,-23,-23, -1,-23,  1, -3,-17,-28,-20,-20, -2,  0,  9,-36,-16,-20;
/M: SY='H';  M=  4, -5,-20, -7, -2,-20,-10, 21,-23, -1,-20,-10,  3,-15,  3,  9,  7, -3,-16,-28, -6, -2;
/M: SY='D';  M=-17,  8,-38, 20,  2,-25,-15,-13,-29, -8,-28,-25, -6, 13, -8,-15,-13,-15,-30,  9,-11, -3;
/I:         I=-4; MD=-18;
/M: SY='W';  M=-10,-15,-30,-12, -5,-13,-15,-15,-18,  7,-21,-13,-15, 12, -5, -1,-15,-13,-20, 24, -3, -5; D=-4;
/I:         I=-4; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='M';  M= -5,-21,-13,-23,-18,  2,-21,-13, 18,-15, 20, 22,-21,-21,-13,-13,-15, -5, 19,-18, -3,-16; D=-4;
/I:         I=-4; DM=-18;
/M: SY='P';  M= -5,-13,-19,-13, -7, -8,-18,-15, -3,-13,  1, -3,-13, 16,-10,-13, -5,  7, -6,-21,-11,-10; D=-4;
/I:         I=-4; DM=-18;
/M: SY='P';  M= -8, -8,-26, -5, -5,-21,  7, 14,-23,-10,-21,-11, -3, 16, -5,-11, -5,-13,-23,-21,-11, -8; D=-4;
/I:         I=-4; DM=-18;
/M: SY='N';  M= -5,  9,-15,  3,  0,-15, -5,  0,-18,  5,-21,-13, 19,-13,  2, 15, 10,  2,-16,-26,-13,  0; D=-4;
/I:         I=-4; DM=-18;
/M: SY='Y';  M= -5,-13,-18,-16,-13,  2,-19, -6,  9,-13, -2,  1, -8,-15, -8,-13, -1,  0,  4, -8, 15,-13; D=-4;
/I:         I=-4; DM=-18;
/M: SY='R';  M= -8, -2,-18, -5,  3,-19,-15, -2,-15,  8,-13, -5,  0,-10, 17, 18,  2,  7,-13,-18, -8,  9; D=-4;
/I:         I=-4; DM=-18;
/M: SY='K';  M=  7, -2,-18, -5,  3,-21,-10,-10,-18, 24,-18, -8, -2, -8,  3, 11, -3, -5,-10,-15,-10,  3; D=-4;
/I:         I=-4; DM=-18;
/M: SY='M';  M=  5,-15,-20,-21,-11, -9,-18,-12,  1, -1,  8, 17,-15,-18, -5, -6,-13, -8,  1,-20, -7, -8;
/M: SY='K';  M=-12, 14,-30, 21, 25,-32,-18, -5,-32, 29,-28,-17,  5, -8, 10, 13, -5,-10,-25,-27,-15, 17;
/M: SY='G';  M= -6, -7,-30, -7,-14,-27, 45, 14,-37,-17,-27,-14,  3,-20,-12,-14, -3,-20,-30,-23,-16,-14;
/M: SY='Q';  M= -8,  3,-25,  3, 24,-30,-20,  0,-20,  5,-18, -8,  0, -7, 32,  2,  5,  5,-23,-25,-13, 28;
/I:         I=-4; MD=-22;
/M: SY='I';  M= -5, -8,-16,-11, -6, -7,-16,-11,  7,  4, -2,  3, -6, -8, -3, -1, -8, -5,  4,-10, -2, -6; D=-4;
/I:         I=-4; MD=-22;
/M: SY='G';  M= -2, -3,-16, -3, -3,-16, 15, -8,-19,  6,-16, -8,  0, -8, -3,  2, -2, -8,-13,-10,-11, -3; D=-4;
/I:         I=-4; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='E';  M= -5,  3,-16,  6, 22,-18,-10,  2,-13,  5,-10, -6,  0, -2, 20,  2,  0, -5,-16,-13, -8, 21; D=-4;
/I:         I=-4; DM=-22;
/M: SY='F';  M=-15,-23,-23,-25,-20, 25,-28, -8,  0, -8,  0,  0,-17,-28,-18,  5,-15, -8,  4, -2, 23,-20;
/M: SY='W';  M=-17, -4,-38,  3, -3,-20,-18, 11,-27,-10,-25,-17, -8, 11, -5,-13,-15,-17,-30, 12, -1, -5;
/M: SY='V';  M= 11,-25,-10,-28,-25, -5,-23,-28, 21,-18,  5,  5,-25,-25,-25,-20, -5,  0, 39,-28,-12,-25;
/M: SY='M';  M=-15,-16,-25,-21, -9,  8,-23, -3, -7, -2, -2, 12,-11,-20,  6, 10,-13,-10, -9,-12,  4, -1;
/M: SY='F';  M=-20,-32,-27,-40,-30, 63,-28,-22, -5,-28,  3, -5,-25,-30,-35,-20,-25,-15, -7, 44, 30,-28;
/M: SY='F';  M=-20,-30,-20,-40,-30, 80,-30,-20,  0,-30, 10,  0,-20,-30,-40,-20,-20,-10,  0, 10, 30,-30;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='D';  M= -9, 24,-24, 34, 14,-34, -9, -1,-30, -1,-28,-20, 13,-10, 14, -5, 11, -2,-24,-35,-18, 14;
/M: SY='H';  M=  5, -5,-25, -7, -5,-25,  7, 10,-28,  4,-23,-10,  0,-15, -2, -1, -3,-12,-20,-22,-10, -5;
/I:         I=-6; MI=0; MD=-32; IM=0; DM=-32;
/M: SY='D';  M=-15, 28,-30, 41, 27,-35,-15, -2,-35, 15,-28,-23, 10, -8,  7,  2, -2,-10,-28,-33,-18, 17;
/M: SY='R';  M=-20,-18,-28,-20,-13, 19,-25,  1,-14,  4, -7, -5,-11,-25, -8, 25,-15,-10,-12,  1, 25,-13;
/M: SY='A';  M= 20,-10,-16,-15,-10, -6, -8, -6,-10,-10,-12,-10, -8,-16, -8,-15,  9,  2, -5,-11,  8,-10;
/M: SY='W';  M=-15,-38,-40,-38,-30,  8,-22,-30, -8,-20,-13,-13,-38,-30,-22,-20,-33,-23,-10,106, 20,-22;
/M: SY='V';  M= -2,-22,-15,-27,-24, -3,-30,-27, 24,-20,  7,  7,-19,-22,-22,-20, -4, 12, 31,-28, -8,-24;
/I:         I=-6; MD=-32;
/M: SY='H';  M=-10,-10, 12,-10, -7,-17,-18, 16,-20,-12,-17,-10, -7,  5, -7,-12, -8,-10,-18,-28, -9,-10; D=-6;
/I:         I=-6; MI=-32; IM=-32; DM=-32;
/M: SY='I';  M=-10,-22,-23,-26,-16,  8,-29,-16, 13,-16,  4,  7,-17,-22, -5,-14,-12, -8, 11,-15,  2,-10;
/M: SY='E';  M=  7, 11,-22,  9, 26,-25,-10, -3,-22,  2,-19,-17, 11, -7,  7, -6,  5, -5,-22,-29,-20, 17;
/M: SY='R';  M=-13,  6,-28,  2,  5,-25,-15, -3,-28, 33,-27,-12, 14,-15,  8, 34, -5, -8,-22,-25,-12,  5;
/M: SY='C';  M= -2,-20, 17,-23,-20, -7,-23,-23,  2,-22,  3, -2,-18,-27,-20,-20, -3,  0, 12,-35,-15,-20;
/M: SY='F';  M=-15,-25,-22,-31,-23, 32,-28, -6, 10,-20, 20, 20,-22,-28,-18,-15,-22,-10,  3,  0, 27,-20;
/M: SY='P';  M= -8,-25,-28,-19,-12,-14,-25,-22,  1,-17, -2, -4,-25, 33,-17,-20,-15, -8, -1,-28,-18,-17;
/M: SY='Y';  M=  2,-20,-20,-25,-18,  6,-20, -4,  7,-15, 14, 16,-20,-23,-10,-15,-15, -8,  2, -6, 18,-15;
/M: SY='F';  M= -3,-13,-15,-18,-13, 10,-13,-10, -4,-15, -6,  7, -6,-18,-10,-12,  9,  4, -2,-22, -2,-10;
/M: SY='E';  M= -5,  5,-25, 10, 34,-28,-15, -5,-28, 14,-25,-18,  2, -5, 13,  4,  8, -3,-23,-30,-18, 23;
/M: SY='G';  M= -7,-10,-28,-10, -4, -3, 25,-15,-28,-16,-18,-15, -5,-18,-16,-15, -5,-15,-23,-15,-13, -9;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	99 in 93 different sequences
Number of true positive hits	99 in 93 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	8
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	92.52 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	PWWP
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

93 sequences

ATM_ARATH   (Q9M3G7), ATX1_ARATH  (Q9C5X4), ATX2_ARATH  (P0CB22),

ATX3_ARATH  (Q9M364), ATX4_ARATH  (Q9SUE7), ATX5_ARATH  (Q8GZ42), 
BRD1_HUMAN  (O95696), BRD1_MOUSE  (G5E8P1), BRDH_DROME  (Q7JVP4), 
BRPF1_HUMAN (P55201), BRPF1_MOUSE (B2RRD7), BRPF3_HUMAN (Q9ULD4), 
BRPF3_MOUSE (B2KF05), DNM3A_CHICK (Q4W5Z4), DNM3A_HUMAN (Q9Y6K1), 
DNM3A_MOUSE (O88508), DNM3A_RAT   (Q1LZ53), DNM3B_HUMAN (Q9UBC3), 
DNM3B_MOUSE (O88509), GLYR1_AEDAE (Q175F8), GLYR1_ANOGA (Q7Q161), 
GLYR1_BOVIN (A4FUF0), GLYR1_CHICK (Q5ZLS7), GLYR1_DANRE (Q5RKN4), 
GLYR1_DROME (Q8T079), GLYR1_DROPS (Q29NG1), GLYR1_HUMAN (Q49A26), 
GLYR1_MOUSE (Q922P9), GLYR1_PONAB (Q5R7T2), GLYR1_RAT   (Q5RKH0), 
GLYR1_XENTR (Q562D5), HDGF_BOVIN  (Q9XSK7), HDGF_HUMAN  (P51858), 
HDGF_MOUSE  (P51859), HDGF_RAT(Q8VHK7), HDGL1_HUMAN (Q5TGJ6), 
HDGR2_DANRE (Q5XXA7), HDGR2_HUMAN (Q7Z4V5), HDGR2_MOUSE (Q3UMU9), 
HDGR2_RAT   (Q925G1), HDGR2_XENLA (Q32N87), HDGR2_XENTR (Q6P4K1), 
HDGR3_HUMAN (Q9Y3E1), HDGR3_MOUSE (Q9JMG7), HDGR3_RAT   (Q923W4), 
HUA2_ARATH  (Q9XER9), HUAL1_ARATH (Q9LEY4), HUAL2_ARATH (F4IN78), 
HUAL3_ARATH (F4IZM8), MBD56_DROME (A8JR92), MBD5_HUMAN  (Q9P267), 
MSH6_CHICK  (E1BYJ2), MSH6_HUMAN  (P52701), MSH6_MOUSE  (P54276), 
NSD1_HUMAN  (Q96L73), NSD1_MOUSE  (O88491), NSD2_HUMAN  (O96028), 
NSD2_MOUSE  (Q8BVE8), NSD3_HUMAN  (Q9BZ95), NSD3_MOUSE  (Q6P2L6), 
NSD_DROME   (Q8MT36), PDP1_ARATH  (F4K4D6), PDP1_SCHPO  (O59676), 
PDP2_ARATH  (Q9SF36), PDP2_SCHPO  (O94312), PDP3_ARATH  (Q9FNE4), 
PDP3_SCHPO  (Q09842), PDP3_YEAST  (Q06188), PDP4_ARATH  (Q9MA56), 
PDP5_ARATH  (Q9LYZ0), PDP6_ARATH  (Q9LK91), PSIP1_BOVIN (Q8MJG1), 
PSIP1_CHICK (Q5XXA9), PSIP1_FELCA (Q66T72), PSIP1_HUMAN (O75475), 
PSIP1_MOUSE (Q99JF8), PSIP1_RAT   (Q812D1), PWP2A_HUMAN (Q96N64), 
PWP2A_MOUSE (Q69Z61), PWP2A_XENLA (A0A1L8GR68), PWP2A_XENTR (F7AQ22), 
PWP2B_HUMAN (Q6NUJ5), PWP2B_MOUSE (E9Q9M8), TRX1_ORYSJ  (Q6K431), 
Y1745_ARATH (P59278), ZCPW1_HUMAN (Q9H0M4), ZCPW1_MOUSE (Q6IR42), 
ZCPW2_HUMAN (Q504Y3), ZCPW2_MOUSE (Q08EN7), ZMY11_HUMAN (Q15326), 
ZMY11_MOUSE (Q8R5C8), ZMYD8_DROME (Q7KRS9), ZMYD8_HUMAN (Q9ULU4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

8 sequences

MBD5_MOUSE  (B1AYB6), PWP3A_BOVIN (Q08DK9), PWP3A_HUMAN (Q2TAK8),

PWP3A_MOUSE (Q6DID5), PWP3A_RAT   (B1H224), PWP3B_HUMAN (Q5H9M0), 
PWP3B_MOUSE (Q4VA55), PWWP4_HUMAN (A0A494C071)

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PDB
[Detailed view]

170 PDB

pdb_00001h3z; pdb_00001khc; pdb_00001n27; pdb_00001ri0; pdb_00002b8a; pdb_00002daq; pdb_00002gfu; pdb_00002l89; pdb_00002m16; pdb_00002nlu; pdb_00002x35; pdb_00002x4w; pdb_00002x4x; pdb_00002x4y; pdb_00003eae; pdb_00003flg; pdb_00003l42; pdb_00003llr; pdb_00003lyi; pdb_00003mo8; pdb_00003pfs; pdb_00003pmi; pdb_00003qby; pdb_00003qj6; pdb_00003qkj; pdb_00003zeh; pdb_00004cos; pdb_00004fu6; pdb_00004ld6; pdb_00004n4g; pdb_00004n4h; pdb_00004n4i; pdb_00004ns5; pdb_00004rxj; pdb_00004z02; pdb_00005b73; pdb_00005c6s; pdb_00005ciu; pdb_00005nr3; pdb_00005nrr; pdb_00005nrs; pdb_00005nrv; pdb_00005nv0; pdb_00005nv2; pdb_00005nv7; pdb_00005nvo; pdb_00005vc8; pdb_00005xsk; pdb_00005xsl; pdb_00005y1z; pdb_00006g24; pdb_00006g25; pdb_00006g27; pdb_00006g29; pdb_00006g2b; pdb_00006g2c; pdb_00006g2e; pdb_00006g2f; pdb_00006g2o; pdb_00006g3p; pdb_00006g3t; pdb_00006iip; pdb_00006iiq; pdb_00006iir; pdb_00006iis; pdb_00006iit; pdb_00006oqm; pdb_00006pa7; pdb_00006r3e; pdb_00006s01; pdb_00006ue6; pdb_00006xcg; pdb_00007cro; pdb_00007crp; pdb_00007crq; pdb_00007crr; pdb_00007hg0; pdb_00007hg1; pdb_00007hg2; pdb_00007hg3; pdb_00007hg4; pdb_00007hg5; pdb_00007hg6; pdb_00007hg7; pdb_00007hg8; pdb_00007hg9; pdb_00007hga; pdb_00007hgb; pdb_00007hgc; pdb_00007hgd; pdb_00007hge; pdb_00007hgf; pdb_00007hgg; pdb_00007hgh; pdb_00007hgi; pdb_00007hgj; pdb_00007hgk; pdb_00007hgl; pdb_00007hgm; pdb_00007hgn; pdb_00007hgo; pdb_00007hgp; pdb_00007hgq; pdb_00007hgr; pdb_00007hgs; pdb_00007hgt; pdb_00007hgu; pdb_00007hgv; pdb_00007hgw; pdb_00007hgx; pdb_00007hgy; pdb_00007hgz; pdb_00007hh0; pdb_00007hh1; pdb_00007hh2; pdb_00007hh3; pdb_00007hh4; pdb_00007hh5; pdb_00007hh6; pdb_00007hh7; pdb_00007hh8; pdb_00007hh9; pdb_00007hha; pdb_00007hhb; pdb_00007hhc; pdb_00007hhd; pdb_00007hhe; pdb_00007hhf; pdb_00007hhg; pdb_00007hhh; pdb_00007hhi; pdb_00007hhj; pdb_00007hhk; pdb_00007hhl; pdb_00007hhm; pdb_00007hhn; pdb_00007hho; pdb_00007hhp; pdb_00007hhq; pdb_00007hhr; pdb_00007lh9; pdb_00007lmt; pdb_00007mdn; pdb_00007ouf; pdb_00007oug; pdb_00007ouh; pdb_00007pel; pdb_00007vln; pdb_00008ag6; pdb_00008cbn; pdb_00008cbq; pdb_00008eih; pdb_00008eii; pdb_00008eij; pdb_00008eik; pdb_00008pc5; pdb_00008pc6; pdb_00008peo; pdb_00008pep; pdb_00008qzm; pdb_00009exw; pdb_00009exx; pdb_00009exy; pdb_00009g91; pdb_00009g94; pdb_00009g96; pdb_00009grs; pdb_00009grt; pdb_00009gru; pdb_00009grv
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