Entry: PS50868

General information about the entry

Entry name [info] POST_SET
Accession [info] PS50868
Entry type [info] MATRIX
Date [info] 01-NOV-2002 CREATED; 10-MAY-2017 DATA UPDATE; 25-APR-2018 INFO UPDATE.
PROSITE Doc. [info] PDOC50280
Associated ProRule [info] PRU00155

Name and characterization of the entry

Description [info] Post-SET domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=17;
/DISJOINT: DEFINITION=PROTECT; N1=2; N2=16;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1220000; R2=0.0163836; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=161.0268402; R2=0.1543624; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=359; H_SCORE=216; N_SCORE=8.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=268; H_SCORE=202; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-20; I=-20; B0=-60; B1=-60; E0=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...
 
                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B0=0; B1=0; BI=-105; BD=-105;
/M: SY='E'; M= -7,  0,-25, -2,  6,-24,-16, -8,-17,  5,-17,-10,  1,-13,  2, -4, -2, -6,-11,-30,-18,  4;
/M: SY='K'; M= -4, -5,-26, -7,  5,-25,-14, -8,-25, 14,-20,-12, -5,-10,  6,  9, -3,-10,-19,-27,-16,  4;
/M: SY='M'; M=-10,-18,-20,-20, -9, -9,-28,-13, -2, -3,  0,  2,-16,-18,  0, -8,-11, -9, -1,-22, -7, -6;
/M: SY='P'; M= -9, -5,-26,  0,  1,-27,-19,-14,-22, -2,-22,-15, -8, 15, -2,-10, -4, -4,-16,-32,-22, -1;
/M: SY='C'; M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='Y'; M=-13,-16,-19,-19, -9, -3,-25,  6,-13, -6, -7, -5, -8,-23, -2, -4, -9,-12,-14,-14,  9, -8;
/M: SY='C'; M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='G'; M= -2, -7,-30, -8,-10,-30, 47,-17,-38,-10,-37,-27,  3,-19,-15,-15,  0,-18,-29,-22,-28,-14;
/M: SY='A'; M= 18, -9,-10, -9, -1,-19, -5,-13,-16, -4,-15,-11, -6,-11, -3, -7, 18,  6,-10,-28,-18, -2;
/M: SY='P'; M=  1,-10,-21, -7,  2,-26,-17,-15,-16,  0,-18,-12,-10,  4, -3, -8,  0, -1, -8,-32,-21,  0;
/M: SY='N'; M= -7,  5,-18, -4, -1,-22, -8, -2,-23,  2,-22,-14, 17,-18, -1, -1,  4, -4,-20,-30,-16, -1;
/M: SY='C'; M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='R'; M= -7,-11,-24,-18, -3,-25,-20, -7,-20, 12,-14, -5, -3,-18,  5, 27, -4, -4,-19,-28,-18, -2;
/M: SY='G'; M= -3, -6,-29,-10,-11,-29, 31,-10,-35, -2,-33,-23,  3,-18,-10, -6,  0,-16,-27,-24,-24,-11;
/M: SY='Y'; M=-12,-23,-19,-25,-16,  8,-24, -9, -9,-10, -8, -4,-18,-26,-12,-11,-11, -7, -9,  3, 11,-16;
/M: SY='L'; M= -7,-34,-11,-34,-26, -1,-35,-27, 18,-17, 27, 18,-27,-27,-18,-19,-16, -9, 11,-21,-10,-25;
/M: SY='G'; M= -9, -6,-27,-10,-12,-16, 12, -9,-26,-12,-25,-18,  5,-16,-11,-12, -2,-13,-23,-21,-13,-12;
/I:         E0=0; E1=0; IE=-105; DE=-105;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2018_04 which contains 557'275 sequence entries.


Total number of hits 123 in 123 different sequences
Number of true positive hits 123 in 123 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 9
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 93.18 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] window20_shuffled
Author [info] N_Hulo
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] Post-SET
Version [info] 5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 123 sequences 

ASH1L_HUMAN (Q9NR48    ), ASH1L_MOUSE (Q99MY8    ), ASH1_DROME  (Q9VW15    ), 

ASHH1_ARATH (Q84WW6    ), ASHH2_ARATH (Q2LAE1    ), ASHH3_ARATH (Q945S8    ), 
ASHH4_ARATH (Q9M1X9    ), ASHR3_ARATH (Q949T8    ), ATX1_ARATH  (Q9C5X4    ), 
ATX2_ARATH  (P0CB22    ), ATX3_ARATH  (Q9M364    ), ATX4_ARATH  (Q9SUE7    ), 
ATX5_ARATH  (Q8GZ42    ), C1716_DROME (Q9VYD1    ), CLR4_SCHPO  (O60016    ), 
DIM5_NEUCR  (Q8X225    ), KMT2A_HUMAN (Q03164    ), KMT2A_MOUSE (P55200    ), 
KMT2B_HUMAN (Q9UMN6    ), KMT2B_MOUSE (O08550    ), KMT2C_HUMAN (Q8NEZ4    ), 
KMT2C_MOUSE (Q8BRH4    ), KMT2D_HUMAN (O14686    ), KMT2D_MOUSE (Q6PDK2    ), 
MES4_CAEEL  (Q9NH52    ), MES4_DROME  (Q8MT36    ), MET2_CAEEL  (P34544    ), 
NSD1_HUMAN  (Q96L73    ), NSD1_MOUSE  (O88491    ), NSD2_HUMAN  (O96028    ), 
NSD2_MOUSE  (Q8BVE8    ), NSD3_HUMAN  (Q9BZ95    ), NSD3_MOUSE  (Q6P2L6    ), 
SE1BA_DANRE (Q1LY77    ), SET1A_HUMAN (O15047    ), SET1B_CHICK (Q5F3P8    ), 
SET1B_HUMAN (Q9UPS6    ), SET1B_MOUSE (Q8CFT2    ), SET1B_XENLA (Q66J90    ), 
SET1B_XENTR (Q08D57    ), SET1_ASHGO  (Q75D88    ), SET1_ASPFU  (Q4WNH8    ), 
SET1_ASPOR  (Q2UMH3    ), SET1_CANAL  (Q5ABG1    ), SET1_CANGA  (Q6FKB1    ), 
SET1_CHAGB  (Q2GWF3    ), SET1_COCIM  (Q1DR06    ), SET1_CRYNB  (P0CO27    ), 
SET1_CRYNJ  (P0CO26    ), SET1_DEBHA  (Q6BKL7    ), SET1_DICDI  (Q54HS3    ), 
SET1_DROME  (Q5LJZ2    ), SET1_EMENI  (Q5B0Y5    ), SET1_GIBZE  (Q4I5R3    ), 
SET1_KLULA  (Q6CIT4    ), SET1_NEUCR  (Q8X0S9    ), SET1_PLAF7  (C6KTD2    ), 
SET1_SCHPO  (Q9Y7R4    ), SET1_USTMA  (Q4PB36    ), SET1_YARLI  (Q6CEK8    ), 
SET1_YEAST  (P38827    ), SET23_CAEBR (A8XI75    ), SET23_CAEEL (Q95Y12    ), 
SET2_ASHGO  (Q757Y8    ), SET2_ASPFU  (Q4WTT2    ), SET2_ASPOR  (Q2UTN6    ), 
SET2_CAEEL  (Q18221    ), SET2_CANAL  (Q59XV0    ), SET2_CANGA  (Q6FX50    ), 
SET2_CHAGB  (Q2H988    ), SET2_COCIM  (Q1DU03    ), SET2_CRYNB  (P0CO29    ), 
SET2_CRYNJ  (P0CO28    ), SET2_DEBHA  (Q6BM04    ), SET2_EMENI  (Q5ASA5    ), 
SET2_GIBZE  (Q4IB50    ), SET2_KLULA  (Q6CXP5    ), SET2_NEUCR  (Q7RZU4    ), 
SET2_SCHPO  (O14026    ), SET2_USTMA  (Q4PBL3    ), SET2_YARLI  (Q6C5G5    ), 
SET2_YEAST  (P46995    ), SETB1_DROME (Q32KD2    ), SETB1_DROPS (Q28Z18    ), 
SETB1_HUMAN (Q15047    ), SETB1_MOUSE (O88974    ), SETB1_XENLA (Q6INA9    ), 
SETB2_XENLA (Q6YI93    ), SETD2_HUMAN (Q9BYW2    ), SETD2_MOUSE (E9Q5F9    ), 
SETMR_BOVIN (Q0VD24    ), SETMR_HUMAN (Q53H47    ), SETMR_MOUSE (Q80UJ9    ), 
SETMR_RAT   (Q5I0M0    ), STB1B_DANRE (Q08BR4    ), SUV39_DROME (P45975    ), 
SUV39_DROPS (Q294B9    ), SUV91_BOVIN (Q2NL30    ), SUV91_HUMAN (O43463    ), 
SUV91_MOUSE (O54864    ), SUV91_PONAB (Q5RB81    ), SUV91_XENLA (Q6NRE8    ), 
SUV92_BOVIN (Q32PH7    ), SUV92_CHICK (Q5F3W5    ), SUV92_HUMAN (Q9H5I1    ), 
SUV92_MACFA (Q4R3E0    ), SUV92_MOUSE (Q9EQQ0    ), SUV92_XENTR (Q28CQ7    ), 
SUVH1_ARATH (Q9FF80    ), SUVH1_TOBAC (Q93YF5    ), SUVH3_ARATH (Q9C5P4    ), 
SUVH4_ARATH (Q8GZB6    ), SUVH5_ARATH (O82175    ), SUVH6_ARATH (Q8VZ17    ), 
SUVH7_ARATH (Q9C5P1    ), SUVH8_ARATH (Q9C5P0    ), SUVR3_ARATH (Q9SRV2    ), 
SUVR5_ARATH (O64827    ), SV91A_DANRE (Q6DGD3    ), TRR_DROME   (Q8IRW8    ), 
TRX1_ORYSJ  (Q6K431    ), TRX_DROME   (P20659    ), TRX_DROVI   (Q24742    )
» more

UniProtKB/Swiss-Prot
False negative sequences		 9 sequences 

EHMT2_HUMAN (Q96KQ7    ), EHMT2_MOUSE (Q9Z148    ), SET25_CAEEL (G5EEU2    ), 

STB1A_DANRE (Q1L8U8    ), SUVH3_CHLRE (Q5QD03    ), SUVHA_ARATH (Q3EC60    ), 
SUVR1_ARATH (Q946J2    ), SUVR2_ARATH (Q9FNC7    ), SUVR4_ARATH (Q8W595    )
» more

PDB
[Detailed view]		 36 PDB

1PEG; 2R3A; 2W5Y; 2W5Z; 3BO5; 3OOI; 3OPE; 4FMU; 4H12; 4QEN; 4QEO; 4QEP; 4YNM; 4YNP; 4YPA; 4YPE; 4YPU; 4Z4P; 5F59; 5F5E; 5F6K; 5F6L; 5JJY; 5JLB; 5JLE; 5LSS; 5LSU; 5LSX; 5LSY; 5LSZ; 5LT6; 5LT7; 5LT8; 5UPD; 5V21; 5V22
» more

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