PROSITE entry PS50868

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PURL: https://purl.expasy.org/prosite/signature/PS50868

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General information about the entry

Entry name [info]	POST_SET
Accession [info]	PS50868
Entry type [info]	MATRIX
Date [info]	01-NOV-2002 CREATED; 07-APR-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC50280
Associated ProRule [info]	PRU00155

Name and characterization of the entry

Description [info]

Post-SET domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=17;
/DISJOINT: DEFINITION=PROTECT; N1=2; N2=16;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1220000; R2=0.0163836; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=164.0236969; R2=0.1421801; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=359; H_SCORE=215; N_SCORE=8.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=268; H_SCORE=202; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-11; D=-20; I=-20; B0=-60; B1=-60; E0=-60; E1=-60; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B0=0; B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -7,  0,-25, -2,  6,-24,-16, -8,-17,  5,-17,-10,  1,-13,  2, -4, -2, -6,-11,-30,-18,  4;
/M: SY='K';  M= -4, -5,-26, -7,  5,-25,-14, -8,-25, 14,-20,-12, -5,-10,  6,  9, -3,-10,-19,-27,-16,  4;
/M: SY='M';  M=-10,-18,-20,-20, -9, -9,-28,-13, -2, -3,  0,  2,-16,-18,  0, -8,-11, -9, -1,-22, -7, -6;
/M: SY='P';  M= -9, -5,-26,  0,  1,-27,-19,-14,-22, -2,-22,-15, -8, 15, -2,-10, -4, -4,-16,-32,-22, -1;
/M: SY='C';  M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='Y';  M=-13,-16,-19,-19, -9, -3,-25,  6,-13, -6, -7, -5, -8,-23, -2, -4, -9,-12,-14,-14,  9, -8;
/M: SY='C';  M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='G';  M= -2, -7,-30, -8,-10,-30, 47,-17,-38,-10,-37,-27,  3,-19,-15,-15,  0,-18,-29,-22,-28,-14;
/M: SY='A';  M= 18, -9,-10, -9, -1,-19, -5,-13,-16, -4,-15,-11, -6,-11, -3, -7, 18,  6,-10,-28,-18, -2;
/M: SY='P';  M=  1,-10,-21, -7,  2,-26,-17,-15,-16,  0,-18,-12,-10,  4, -3, -8,  0, -1, -8,-32,-21,  0;
/M: SY='N';  M= -7,  5,-18, -4, -1,-22, -8, -2,-23,  2,-22,-14, 17,-18, -1, -1,  4, -4,-20,-30,-16, -1;
/M: SY='C';  M=-40,-40,110,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40,-40;
/M: SY='R';  M= -7,-11,-24,-18, -3,-25,-20, -7,-20, 12,-14, -5, -3,-18,  5, 27, -4, -4,-19,-28,-18, -2;
/M: SY='G';  M= -3, -6,-29,-10,-11,-29, 31,-10,-35, -2,-33,-23,  3,-18,-10, -6,  0,-16,-27,-24,-24,-11;
/M: SY='Y';  M=-12,-23,-19,-25,-16,  8,-24, -9, -9,-10, -8, -4,-18,-26,-12,-11,-11, -7, -9,  3, 11,-16;
/M: SY='L';  M= -7,-34,-11,-34,-26, -1,-35,-27, 18,-17, 27, 18,-27,-27,-18,-19,-16, -9, 11,-21,-10,-25;
/M: SY='G';  M= -9, -6,-27,-10,-12,-16, 12, -9,-26,-12,-25,-18,  5,-16,-11,-12, -2,-13,-23,-21,-13,-12;
/I:         E0=0; E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_01 which contains 574'627 sequence entries.

Total number of hits	127 in 127 different sequences
Number of true positive hits	127 in 127 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	10
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	92.70 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	window20_shuffled
Author [info]	N_Hulo
Feature key [info]	DOMAIN
Feature description [info]	Post-SET
Version [info]	6

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

127 sequences

ASH1L_HUMAN (Q9NR48), ASH1L_MOUSE (Q99MY8), ASH1_DROME  (Q9VW15),

ASHH1_ARATH (Q84WW6), ASHH2_ARATH (Q2LAE1), ASHH3_ARATH (Q945S8), 
ASHH4_ARATH (Q9M1X9), ASHR3_ARATH (Q949T8), ATX1_ARATH  (Q9C5X4), 
ATX2_ARATH  (P0CB22), ATX3_ARATH  (Q9M364), ATX4_ARATH  (Q9SUE7), 
ATX5_ARATH  (Q8GZ42), CLR4_CRYN9  (J9VWH9), CLR4_SCHPO  (O60016), 
DIM5_NEUCR  (Q8X225), FLVH_ASPFN  (B8NHE3), KMT1_FUSMA  (A0A1L7TZE5), 
KMT2A_HUMAN (Q03164), KMT2A_MOUSE (P55200), KMT2B_HUMAN (Q9UMN6), 
KMT2B_MOUSE (O08550), KMT2C_HUMAN (Q8NEZ4), KMT2C_MOUSE (Q8BRH4), 
KMT2D_HUMAN (O14686), KMT2D_MOUSE (Q6PDK2), MES4_CAEEL  (Q9NH52), 
MET2_CAEEL  (P34544), NSD1_HUMAN  (Q96L73), NSD1_MOUSE  (O88491), 
NSD2_HUMAN  (O96028), NSD2_MOUSE  (Q8BVE8), NSD3_HUMAN  (Q9BZ95), 
NSD3_MOUSE  (Q6P2L6), NSD_DROME   (Q8MT36), SE1BA_DANRE (Q1LY77), 
SET1A_HUMAN (O15047), SET1A_MOUSE (E9PYH6), SET1B_CHICK (Q5F3P8), 
SET1B_HUMAN (Q9UPS6), SET1B_MOUSE (Q8CFT2), SET1B_XENLA (Q66J90), 
SET1B_XENTR (Q08D57), SET1_ASPFU  (Q4WNH8), SET1_ASPOR  (Q2UMH3), 
SET1_CAEEL  (Q18221), SET1_CANAL  (Q5ABG1), SET1_CANGA  (Q6FKB1), 
SET1_CHAGB  (Q2GWF3), SET1_COCIM  (Q1DR06), SET1_CRYD1  (P0CO26), 
SET1_CRYD3  (P0CO27), SET1_DEBHA  (Q6BKL7), SET1_DICDI  (Q54HS3), 
SET1_DROME  (Q5LJZ2), SET1_EMENI  (Q5B0Y5), SET1_EREGS  (Q75D88), 
SET1_GIBZE  (Q4I5R3), SET1_KLULA  (Q6CIT4), SET1_MYCMD  (Q4PB36), 
SET1_NEUCR  (Q8X0S9), SET1_PLAF7  (C6KTD2), SET1_SCHPO  (Q9Y7R4), 
SET1_YARLI  (Q6CEK8), SET1_YEAST  (P38827), SET23_CAEBR (A8XI75), 
SET23_CAEEL (Q95Y12), SET2_ASPFU  (Q4WTT2), SET2_ASPOR  (Q2UTN6), 
SET2_CANAL  (Q59XV0), SET2_CANGA  (Q6FX50), SET2_CHAGB  (Q2H988), 
SET2_COCIM  (Q1DU03), SET2_CRYD1  (P0CO28), SET2_CRYD3  (P0CO29), 
SET2_DEBHA  (Q6BM04), SET2_DROME  (Q9VYD1), SET2_EMENI  (Q5ASA5), 
SET2_EREGS  (Q757Y8), SET2_GIBZE  (Q4IB50), SET2_KLULA  (Q6CXP5), 
SET2_MYCMD  (Q4PBL3), SET2_NEUCR  (Q7RZU4), SET2_SCHPO  (O14026), 
SET2_YARLI  (Q6C5G5), SET2_YEAST  (P46995), SETB1_DROME (Q32KD2), 
SETB1_DROPS (Q28Z18), SETB1_HUMAN (Q15047), SETB1_MOUSE (O88974), 
SETB1_XENLA (Q6INA9), SETB2_XENLA (Q6YI93), SETD2_HUMAN (Q9BYW2), 
SETD2_MOUSE (E9Q5F9), SETMR_BOVIN (Q0VD24), SETMR_HUMAN (Q53H47), 
SETMR_MOUSE (Q80UJ9), SETMR_RAT   (Q5I0M0), STB1B_DANRE (Q08BR4), 
SUV39_DROME (P45975), SUV39_DROPS (Q294B9), SUV91_BOVIN (Q2NL30), 
SUV91_HUMAN (O43463), SUV91_MOUSE (O54864), SUV91_PONAB (Q5RB81), 
SUV91_XENLA (Q6NRE8), SUV92_BOVIN (Q32PH7), SUV92_CHICK (Q5F3W5), 
SUV92_HUMAN (Q9H5I1), SUV92_MACFA (Q4R3E0), SUV92_MOUSE (Q9EQQ0), 
SUV92_XENTR (Q28CQ7), SUVH1_ARATH (Q9FF80), SUVH1_TOBAC (Q93YF5), 
SUVH3_ARATH (Q9C5P4), SUVH4_ARATH (Q8GZB6), SUVH5_ARATH (O82175), 
SUVH6_ARATH (Q8VZ17), SUVH7_ARATH (Q9C5P1), SUVH8_ARATH (Q9C5P0), 
SUVR3_ARATH (Q9SRV2), SUVR5_ARATH (O64827), SV91A_DANRE (Q6DGD3), 
TRR_DROME   (Q8IRW8), TRX1_ORYSJ  (Q6K431), TRX_DROME   (P20659), 
TRX_DROVI   (Q24742)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

10 sequences

ATXR3_ARATH (O23372), EHMT2_HUMAN (Q96KQ7), EHMT2_MOUSE (Q9Z148),

SET25_CAEEL (G5EEU2), STB1A_DANRE (Q1L8U8), SUVH3_CHLRE (Q5QD03), 
SUVHA_ARATH (Q3EC60), SUVR1_ARATH (Q946J2), SUVR2_ARATH (Q9FNC7), 
SUVR4_ARATH (Q8W595)

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PDB
[Detailed view]

134 PDB

pdb_00001ml9; pdb_00001mvh; pdb_00001mvx; pdb_00001peg; pdb_00002o8j; pdb_00002r3a; pdb_00002w5y; pdb_00002w5z; pdb_00003bo5; pdb_00003k5k; pdb_00003ooi; pdb_00003ope; pdb_00003rjw; pdb_00004fmu; pdb_00004h12; pdb_00004nvq; pdb_00004qen; pdb_00004qeo; pdb_00004qep; pdb_00004ynm; pdb_00004ynp; pdb_00004ypa; pdb_00004ype; pdb_00004ypu; pdb_00004z4p; pdb_00005f59; pdb_00005f5e; pdb_00005f6k; pdb_00005f6l; pdb_00005jhn; pdb_00005jin; pdb_00005jiy; pdb_00005jj0; pdb_00005jjy; pdb_00005jlb; pdb_00005jle; pdb_00005lss; pdb_00005lsu; pdb_00005lsx; pdb_00005lsy; pdb_00005lsz; pdb_00005lt6; pdb_00005lt7; pdb_00005lt8; pdb_00005t0k; pdb_00005t0m; pdb_00005ttf; pdb_00005tuy; pdb_00005upd; pdb_00005v21; pdb_00005v22; pdb_00005v9i; pdb_00005vsc; pdb_00005vse; pdb_00006a5k; pdb_00006a5m; pdb_00006a5n; pdb_00006ago; pdb_00006box; pdb_00006bp4; pdb_00006cen; pdb_00006chg; pdb_00006ine; pdb_00006j9j; pdb_00006kiu; pdb_00006kiv; pdb_00006kiw; pdb_00006kix; pdb_00006kiz; pdb_00006kqp; pdb_00006kqq; pdb_00006p0r; pdb_00006pwv; pdb_00006pww; pdb_00006u9k; pdb_00006u9m; pdb_00006u9n; pdb_00006u9r; pdb_00006ugm; pdb_00006uh5; pdb_00006vdb; pdb_00006ven; pdb_00006w5i; pdb_00006w5m; pdb_00006w5n; pdb_00006wzw; pdb_00006x0p; pdb_00007bre; pdb_00007btv; pdb_00007buc; pdb_00007cro; pdb_00007crp; pdb_00007crq; pdb_00007crr; pdb_00007dcf; pdb_00007e8d; pdb_00007ea5; pdb_00007ea8; pdb_00007lzb; pdb_00007lzd; pdb_00007lzf; pdb_00007mbm; pdb_00007mbn; pdb_00007t7l; pdb_00007ty2; pdb_00007ty3; pdb_00007u5v; pdb_00007w67; pdb_00007w6a; pdb_00007w6i; pdb_00007w6j; pdb_00007w6l; pdb_00007x73; pdb_00007xua; pdb_00007xub; pdb_00007xuc; pdb_00007xud; pdb_00008fbg; pdb_00008fbh; pdb_00008q5p; pdb_00008rzu; pdb_00008vv8; pdb_00008z7c; pdb_00008z7d; pdb_00008z7e; pdb_00009cvd; pdb_00009egz; pdb_00009eh0; pdb_00009eh1; pdb_00009eh2; pdb_00009isz; pdb_00009it4; pdb_00009klb; pdb_00009klc
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