PROSITE entry PS50912
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General information about the entry
| PURL [info] | https://purl.expasy.org/prosite/signature/PS50912 |
| Entry name [info] | EAR |
| Accession [info] | PS50912 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JUN-2003 CREATED;
28-FEB-2018 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC50912 |
| Associated ProRule [info] | PRU00075 |
Name and characterization of the entry
| Description [info] | EAR repeat profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=43; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=43; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=0.7769146; R2=0.0084072; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=979; N_SCORE=9.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=562; N_SCORE=5.5; MODE=1; TEXT='R?'; /DEFAULT: M0=-15; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='R'; M=-27,-51, 0, -6,-46, 6,-15,-23, 25, -9, -4, 19,-47, 22, 31, 17, -8, 6,-55,-15; /M: SY='F'; M=-51,-49,-64,-59,102,-61,-45,-23,-56, 24,-24,-56,-35,-61,-53,-52,-44,-22, 5, 18; /M: SY='V'; M= -1,-49,-29, -3,-17,-50,-42, 8,-11,-33,-31,-38,-48, 29, 27, -3, 26, 44,-52, 14; /M: SY='P'; M= -4,-53, -6, -6,-40,-46,-40,-26, 15, 22,-32, 19, 55,-23, -5, 2,-25, -8, 27, -5; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='F'; M=-43,-52,-46, 0, 56,-56, 55, 0,-42, 6,-26,-21,-30, -3,-21,-26,-19, 20,-36, 50; /M: SY='Q'; M=-30,-60, 6, 19,-65,-21, 1,-54, -8,-50,-38,-27,-43,108,-21,-27,-11,-54,-53,-40; /M: SY='S'; M=-12,-13, 35, 28,-23,-40,-35,-50, -9,-51,-46, 16,-10, 1, 8, 44, 35,-35,-61,-44; /M: SY='I'; M=-43,-50,-63,-58, 27,-65,-53, 58,-56, 53, 8,-57,-58,-52,-55,-52,-38, 20,-47,-28; /M: SY='P'; M= 8,-54, 5, -8,-34, -9, 38,-30,-17,-22,-41, -7, 68,-34, 8, 16, -1,-45,-56,-14; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='W'; M= -8,-20, -3,-32,-10,-22,-19, 20,-34, 0, 7, -7,-52,-45,-50, 4, 27, 29, 52,-38; D=-36; /I: I=-36; DM=-90; /M: SY='Q'; M=-13,-23,-35, 23, 2,-23, 22,-44,-20,-18,-37,-15, 9, 38, 27, 28, -2,-23,-47, 27; /M: SY='G'; M= 21,-51, 23, -4,-19, 47,-39,-56, -6,-54,-47, 6,-26, 6, 17, 25,-24,-49,-55,-46; /I: I=-45; MD=-115; /M: SY='P'; M= 35, 11, 2,-41,-49,-44,-51, 3,-45,-28,-38,-42, 55,-44,-51, 12, 6, 23,-62,-50; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='R'; M=-28,-23,-41,-14, 5,-35, -2,-15, 6, 16, 7, 19,-50, -7, 28, 0, 19, 13,-50, 13; /M: SY='D'; M= 15,-49, 55,-18,-54, -4, 5,-45,-22,-49,-44,-25,-44, 26,-13, 44, 4, 3,-63,-44; /M: SY='W'; M= 4, 63,-62,-55, 35,-55,-59, 26,-52, -5,-13,-54,-57,-53,-54,-44,-24, 43, 92,-26; /M: SY='E'; M=-10, 37, -2, 59,-53,-49, 16,-49, 36,-28,-41,-32,-42, 20, 13,-23, -2,-14,-58,-44; /M: SY='P'; M= 19,-52,-44,-39, 19,-16, 60,-29,-42,-15,-35,-38, 62,-27,-45, 12, -2,-11,-49, 16; /M: SY='F'; M=-47,-49,-64,-58, 93,-61,-17, 8,-55, 18, 15,-55,-61,-59,-53,-51,-41, 17,-28, 4; /M: SY='T'; M=-18,-48, -9, 2,-32,-42,-22,-40,-19,-14,-38, 15, 5, 29, 11, 40, 42, -6, 19,-41; /M: SY='I'; M= 0,-48,-50,-48,-21,-13,-47, 46,-36, 6, 14,-26,-11,-43,-15, 6, 20, 27,-51, 11; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='D'; M= 8,-53, 51, 16,-58, 42,-37,-56, -1,-44,-37, 27, 10, 0,-26,-13,-18,-44,-60,-50; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='G'; M= -9,-52, 26,-16,-34, 46,-37,-51, -8,-26,-45, 32, 0, -9, 14, 17,-10,-29,-57,-28; /I: I=-25; MI=0; MD=-63; IM=0; DM=-63; /M: SY='D'; M=-19,-55, 50, 15,-51,-18,-27,-17, 11,-40,-43, -6,-46, 33, 27, 17,-13,-13,-57, 1; D=-25; /I: I=-25; MI=0; MD=-63; IM=0; DM=-63; /M: SY='P'; M=-13,-52, -5, -1,-20,-47, 20, -5,-25, 10,-31, -2, 36, 34,-13, 7, 6, 12, 27,-29; /M: SY='Y'; M=-50, 0,-51,-50, 71,-57, 55,-34,-44, -7,-28,-46,-60,-44, -6,-46,-44,-38,-19, 89; /M: SY='L'; M= -4,-47,-61,-54, 30,-35,-50, 14,-54, 60, -1,-56,-59,-50,-53,-48,-38, 30,-47,-28; /M: SY='I'; M= 27, 32,-58,-53, 15,-37,-54, 48,-51, 21, -4,-51,-54,-50,-53,-29,-34, 36,-52,-34; /M: SY='V'; M= 24,-46,-57,-50,-10,-54,-50, 34,-24, 39, 5,-52,-54,-47,-49,-42,-25, 42,-50, 0; /M: SY='A'; M= 58, 3,-43,-40,-50, 14,-46,-25,-41,-31,-39,-34,-17,-37,-46, 40, 19, -5,-57,-47; /M: SY='S'; M=-19, -6, 11,-21,-53, -4, 29,-51,-20,-32,-42, 40,-46, 42, 26, 47, 0,-36,-61,-42; /I: I=-17; MI=0; MD=-44; IM=0; DM=-44; /M: SY='F'; M=-31,-57, 17,-41, 40,-32,-20,-33, 18, 9,-38, -8,-30,-23, -1,-10, 4,-43,-47, 21; D=-17; /I: I=-17; DM=-44; /M: SY='Q'; M= 12,-53,-27, -6, 24,-46,-41, -2, 19,-32,-15, -3, -5, 32,-19, 12, 0,-17, 20, 8; D=-17; /I: I=-17; DM=-44; /M: SY='G'; M= 2,-53,-10, 6,-57, 52,-43,-32,-39,-41,-46, 16, -6, 22,-45, 15, 2,-13,-59,-51; D=-17; /I: I=-17; DM=-44; /M: SY='N'; M= -1,-53, 25,-36, 17, 17, -6,-36, -9,-14,-11, 31, -8, 7, 2, 11,-18,-35,-55,-23; D=-17; /I: I=-17; DM=-44; /M: SY='S'; M=-30, 57,-41,-42,-49,-41,-46,-11,-41,-21,-42,-10, 10,-39,-47, 62, 48,-20,-65,-48; D=-17; /I: I=-17; DM=-44; /M: SY='Q'; M= -5,-50,-17, 10,-30,-48, 31, -6, 12, -6, 8,-34,-46, 46, 0, 10, 10, 21,-55,-14; /M: SY='I'; M=-40,-50,-62,-58, -1,-65,-57, 67,-55, 34,-14,-56,-56,-53,-56,-50,-35, 48,-51,-10; /M: SY='Y'; M=-49,-31,-55,-54, 60,-58,-27,-27,-48, 19, 20,-53,-61,-46,-46,-48,-44,-33, 29, 98; /M: SY='R'; M=-30, 27,-35, 9,-51,-49, 18,-20, 44,-35,-18, -3,-47, 44, 45, -2,-17, 2,-56,-41; /M: SY='W'; M=-50,-68,-65,-38, 15,-53, 33,-42,-43, -4,-39,-59,-57,-44, 4,-54,-55,-32,151, 25; /M: SY='N'; M=-37,-51, 52, 5,-52,-17, 21,-10,-30,-35,-42, 52,-28, 25, -4, 7, 14, -7,-66,-43; /M: SY='G'; M= -6,-52, 4, 0,-49, 39, 21,-12, -2,-47, -8,-17, 10, -6, 13, 26,-17,-14,-54, -4; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 137 in 20 different sequences |
| Number of true positive hits | 137 in 20 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 7 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | REPEAT |
| Feature description [info] | EAR |
| Version [info] | 5 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
20 sequences
AGRV1_DANRE (Q6JAN0), AGRV1_HUMAN (Q8WXG9), AGRV1_MOUSE (Q8VHN7), LGI1_BOVIN (Q5E9T6), LGI1_HUMAN (O95970), LGI1_MOUSE (Q9JIA1), LGI1_PANTR (Q1EGL2), LGI1_PONAB (Q5R945), LGI1_RAT(Q8K4Y5), LGI2_HUMAN (Q8N0V4), LGI2_MOUSE (Q8K4Z0), LGI2_PANTR (Q1EGL1), LGI3_HUMAN (Q8N145), LGI3_MACFA (Q4R4H3), LGI3_MOUSE (Q8K406), LGI3_PANTR (Q1EGL0), LGI4_HUMAN (Q8N135), LGI4_MOUSE (Q8K1S1), TSEAR_HUMAN (Q8WU66), TSEAR_MOUSE (J3S6Y1)» more
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| PDB [Detailed view] |
6 PDB
5Y2Z; 5Y31; 8HPY; 8HQ1; 8HQ2; 8Y6B |