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PROSITE entry PS51022


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General information about the entry

Entry name [info] L27
Accession [info] PS51022
Entry type [info] MATRIX
Date [info] 01-SEP-2004 CREATED;
01-OCT-2013 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51022
Associated ProRule [info] PRU00365

Name and characterization of the entry

Description [info] L27 domain profile.
Matrix / Profile [info] 
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=58;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=58;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7863903; R2=0.0291390; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=197; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=83; N_SCORE=5.2; MODE=1; TEXT='RR';
/DEFAULT: B1=*; E1=*; MM=*; II=*;

...
 
                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=-85; E0=*; BD=-50;
/M: SY='P';  M= -1,  0, -7, -1,-10, -8,-20,-37,  1, 12,-28,-12, 17,-15, -1,  9, -2,-33,  5, -7; M0=-6;
/I:         MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=  1,-38, 13, 12,-13,-10,  3, -6, -6, -1,-29, -7,-34,  7, -8, 13, -2,-15,-40, -2; M0=-5;
/I:         MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=  7,-38, -3,  6,-41,-17,-20, -6, -6, -9,  4,  4, 21, -3,  6,  2,  3,-18,-40,-33; M0=-6;
/I:         MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M= 12,-36, 19,  3,-38,  7,-21, -6, -7,  2,-27, -3,-35,-16,-22,-12,-23, 10,-38,-32; M0=-8;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=  3,  2,-48,-42,-24,-41,  8, 11, -3, 13, 10,-37,-42, -8,  2,-12, -1, 17,-29,-26; M0=-12;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M=-14,  3, -2, 10,-42,-23, 23,-39, -1,-12, -8, -5, -7, 19,-21, 14,-17,-12,-40, 13; M0=-9;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='R';  M=-24,-38,  5, 10,-42,-10, -3,-15,  8,-16,-29, 15,-34, 16, 20,  1,-10,-35,-40,-33; M0=-10;
/I:         MM=0; MI=-102; MD=-112; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 20, -1,-50,-44,-25,-42,-31,  6,-40,  9,-17,  9,-43,-36,-38, -3, -3, 16,-30,-26; M0=-16;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M= -2,-25,-48,-42, -7,-21,-30,  9, -7, 23,  4,-16,-26,  8,-16,-19,-26,  4,-29, -7; M0=-11;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='E';  M=  5,-39, 14, 21,-42, -7,  2,-39, -7,-39, -4, -5, -2, 14, -6,  2, -5,-35,-40,-34; M0=-11;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=  2,  2,-48,-42,-24,-42, -1,  0,-38, 20,-17,  4,-42,  1,-37, 10,-11,  9,-29,-26; M0=-14;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=  6,  3,-51,-45,-25,-43,-32,  4,-41, 26,  7,-40,-44,-10,-39,-34,-16,  4,-31,-27; M0=-20;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='E';  M=-15,-39, 14, 23,-42,-16,-20,-39, 14,-17,-30,-10,  3,  6, -1, -9, -2,-35,-40, -7; M0=-11;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=  4,-39, 21, 19,-42,-14,  7,-14,  3,-14,-30,-20,-35,  5,  3, -5,-23,-14,-40,-34; M0=-10;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M= -9, 11,-50,-12,-24,-42,-31, 22,-39, 15,-17,-38,-28,  7,-37,-16,-13, 13,-29,  9; M0=-14;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M= -5,  1,-24,  0,-38,-34,  8,  3,  1,  7, -5, -6,  4, 24, -6, -4, -5, -7,-39, -7; M0=-6;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=  0, -1, -7, 10,-42, -2, 11,-39, -2,-21, -1, -3, -4, 14,  6, 14,  4,-18,-40,-34; M0=-7;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M= -9,-39,  0, -1,-42,-15,-20,-39,  8, 10, -6,-10,  8,  1,  3, 10,  8,-12,-40, -9; M0=-6;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-13, 13,-15,-42,  3,  4, 11,  2,-38, 18, -5,-37, -3, -1,-37,  4,  3, -4,-29,-26; M0=-9;
/I:         MM=-1; MI=-102; MD=-42; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=-12,-38, 17,  9,-41, -3,  0,-39,  0,-38,-29,  4,-34, 14,-13, 13, -3,  3,-40, -2; M0=-10;
/I:         MM=-1; MI=-101; MD=-41; IM=-9; II=-11; DM=-18; DD=-5;
/M: SY='Q';  M=  6, 12,  8, 12,-19, -9,-10,-14,-15,-12,-28,  4,  6, 14, -7,  0, -8,  1,-39,-32; M0=-4;
/I:         MM=0; MI=-101; MD=-60; IM=-9; II=-11; DM=-25; DD=-3;
/M: SY='H';  M= -4,-37,-21, -7,-15,-14, 21,-37,  4,-12,  0,  7,  7,-14,  5, 20, -6,-16,-39,-22; M0=-7;
/I:         MM=-4; MI=-100; MD=-20; IM=-9; II=-11; DM=-26; DD=-3;
/M: SY='C';  M=-13, 19,  4,  4, -7,  7,  8,-17,-11,-23,-25, -3,-16, 15, 11,  9,-19, -1,-36,-15; M0=-5;
/I:         MM=-7; MI=-97; MD=-14; IM=-9; II=-11; DM=-38; DD=-1;
/M: SY='D';  M= -6,  7, 21,  0,-28,-25,  9,-10, -8,-10,-17,  2,  7, -7,-13, 10,-14, -1,-28,  6; M0=-5;
/I:         MM=-14; MI=-7; MD=-100; IM=-16; II=-6; DM=-4; DD=-19;
/M: SY='Q';  M=-11,-37,  8,  8,-40,-32, 10,-38,  1,-37,-28, 15,  6, 17, 12,  4, -5, -8,-39,-32; M0=-10;
/I:         MM=0; MI=-100; MD=-111; IM=-9; II=-11; DM=-8; DD=-12;
/M: SY='E';  M= -4,-38, 10, 15,-41,-33,  9, -5,  8,-10,-29,  3, 10,  7,-16,  4,  3,-34,-40,-16; M0=-7;
/I:         MM=0; MI=-101; MD=-112; IM=-9; II=-11; DM=-2; DD=-27;
/M: SY='D';  M= -3,-39, 24, 16,-42, -5,  9,-40, 12,-21,-30,  1,-35,-16, -9,  0, -5,-35,-41,-34; M0=-12;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M= 12, 11,-49,-19, -8,-11,-31, 15,-19, 16,  0,-38,-14,-35, -8, -4,-12,  3,-29,-26; M0=-9;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=  5,  5,  5,  8,-42, -5,  0,  3,  5,-13,-30, -8,-35, 13,  8,  7,  1,-35,-41,-34; M0=-7;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='E';  M=  0,-27,-40, 24, 22,-40,-28,-22,-32,  4,  5,-33,-41,-30,  6,-10, -2,-10,-31,-27; M0=-13;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-19,-48,-78,-73,  3,-75,-64, -9,-71, 30,-21,-72,-68,-61,-67,-69,-52,  9,-51,-52; M0=-42;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='W';  M=  1,  2,-38,-15,  3,-17, 11,  7,  6,  5, -8,-32,-40, 14, 12, -5,-13, -8, 14,  6; M0=-6;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M= -1, -5, 13, -6,-42,  5, 10,-40, 10,-39,-30,  7,-35, 18, 12,  0, -4,-21,-41,-34; M0=-10;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='I';  M=-42,-38,-34,-62,-38,-62,-54, 23,-59, 19, 21,-58,-60,-56,-58,-54, -4, 16,-49,-46; M0=-32;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M=-56,-51,-79,-73, 25,-76,  0,-27,-71, 28, 10,-72,-68,-59,-66,-69,-55, -3,-48,-46; M0=-44;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-10,-39, -8,  2,-42,  0,  3,-40, 11,-39,-30,  5,-35, 31,  3,  5, -1,-35,-41,-34; M0=-13;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='S';  M= -5,-39, 15, 13,-42,-34,-21,-40,  0,-39,-30,  2,-35,  2,-22, 22,  6,-35,-41, -4; M0=-14;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=-24,-39,  2, -3,-42,-14,  2,-40,  9,-39,-30,  3, 31, -5,  4, -3,-14,-11,-41, -8; M0=-12;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M=-25,-35, -1,  3, 10,-35, 37, -5, -3,  4,-26, -3,-36,-18,-10,  6,-24, -6,  9,-32; M0=-10;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='F';  M=-51, 20,-75,-69, 31,-71,-59, -5,-67, 18, 21,-68,-65,-57,-63,-63,-50,  6,-48,-49; M0=-40;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-12,-39,-12, -3,-42,-15, 25,-40,  6,-39, -5,  9,-35, 28, 15, -4, -8,-16,-41,-34; M0=-13;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 22,-39,-23, -9,-42, -8, -1,-39, -8,-39, -6,  7,-35,  8,-21, 18, -3,-35,-41, -8; M0=-14;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M= -6,  4,-68,-62,-10,-62,-53, 15,-60, 28,-24,-59,-60,-55,-58,-54,-42,  1,-48,-46; M0=-34;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='L';  M= -4,-33,-59,-53,  3,-51,-40,-12,-49, 26,  7,-48,-51,-44,  7,-42,-35, 14,-37,-34; M0=-24;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=-24,-39,  9, 15, -2,-34,  7,-40, 16, -6,  3,  5,-35, 14, -1,  4, -8,-35,-41,-34; M0=-10;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 19,-25,-51,-44,-25,-43, -8, 18,-40,  7,-18,-39,-43,-37,-38,-14,  0, 17,-30,-27; M0=-18;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='H';  M=-67,-57,-71,-74,  5,-70, 46,-56,-69,-18,-51,-57,-69, 19,-64,-27,-66,-58,-26, 26; M0=-46;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='D';  M=-38,-55, 34, 18,-57,-41,-20,-55,-31,-54,-46,  2,-45,  5,-38,-16, -4,-51,-56,-15; M0=-27;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='K';  M=  0,  5,-28,  0,  2,-36, 10, -9, 16,-18, -8,-24,-37,-10, 11, 10,  8,  1,-35, -1; M0=-7;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=-30,-28,-23,-48,-28,-46,-35, 23,-44, 10, -2,-43,-46,-40,-20,-37,-30, 25,-34, 13; M0=-22;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='A';  M= 23,-39,-22, 10,-42,-10,  5,-39,  0,-39,-30,  0,-35,  8, -5, -6,-10, -5,-40, 11; M0=-11;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M= -2, 12, -2, 15,-42,-34, 10,-39,  1,-10,-30, -7,-35, 20, -1,  8,  0, -2,-40, -3; M0=-8;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='T';  M=-17,-37,-16,  2, -3,-34, 11,-15, 18,  4,-28,-21,-35,  3, -9, -2, 18, -9,-39,  9; M0=-8;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='V';  M=-24,  9,  4,  6,-39,-16,-21, -1, 10, -2,  9,  9,-10, -8,-22,  2,  5, 11,-39, -6; M0=-5;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Y';  M=-12,  3, 14, -1, 11,-13,  0,-15, -3,  2,  8,  0,-35, -7,  7, -8, -5,-15,-39, 21; M0=-5;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='Q';  M=-14, -4, 16, 14,-42, -9,-20, -1,  2,-39, -9, -7, -7, 21,  0,  0,-11,-17,-40,  2; M0=-8;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M=  5,-39,  6,  1,-42,-27,-20,-14,  1, -4,-30,  7, 21,  3, -8,  5,  3, -9,-40,-34; M0=-6;
/I:         MM=0; MI=-102; MD=-113; IM=-9; II=-11; DM=-7; DD=-14;
/M: SY='P';  M= -4,-39, -9,  8,-42, -1, 11,-13, -6, -2,-30,  3, 16, -4,  2,  6, -4,  5,-40,-34; M0=-5;
/I:         B0=*; E1=-10;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 85 in 58 different sequences
Number of true positive hits 85 in 58 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] L27
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 58 sequences 

CSKP_DROME  (Q24210), CSKP_HUMAN  (O14936), CSKP_MOUSE  (O70589), 

CSKP_RAT(Q62915), DLG1_CAEEL  (G5ECY0), DLG1_CANLF  (A0A8C0TYJ0), 
DLG1_DANRE  (Q5PYH6), DLG1_DROME  (P31007), DLG1_HUMAN  (Q12959), 
DLG1_MOUSE  (Q811D0), DLG1_RAT(Q62696), DLG1_XENTR  (Q28C55), 
DLG4_DANRE  (Q6R005), INADL_CANLF (E2QYC9), INADL_HUMAN (Q8NI35), 
INADL_MOUSE (Q63ZW7), INADL_RAT   (F1MAD2), LIN2_CAEEL  (P54936), 
LIN7A_BOVIN (Q32LM6), LIN7A_HUMAN (O14910), LIN7A_MOUSE (Q8JZS0), 
LIN7A_RAT   (Q9Z250), LIN7B_BOVIN (Q2KIB6), LIN7B_HUMAN (Q9HAP6), 
LIN7B_MOUSE (O88951), LIN7B_RAT   (Q9Z252), LIN7C_BOVIN (Q0P5F3), 
LIN7C_CHICK (Q5F425), LIN7C_HUMAN (Q9NUP9), LIN7C_MOUSE (O88952), 
LIN7C_PONAB (Q5RAA5), LIN7C_RAT   (Q792I0), MPDZ_HUMAN  (O75970), 
MPDZ_MOUSE  (Q8VBX6), MPDZ_RAT(O55164), MPP2_HUMAN  (Q14168), 
MPP2_MOUSE  (Q9WV34), MPP2_RAT(D3ZAA9), MPP3_HUMAN  (Q13368), 
MPP3_MOUSE  (O88910), MPP3_RAT(O88954), MPP4_HUMAN  (Q96JB8), 
MPP4_MOUSE  (Q6P7F1), MPP7_BOVIN  (A6QQZ7), MPP7_DANRE  (Q6P0D7), 
MPP7_HUMAN  (Q5T2T1), MPP7_MOUSE  (Q8BVD5), MPP7_RAT(Q5U2Y3), 
MPP7_XENTR  (A8KBF6), PAL1A_DANRE (Q8JHF4), PALS1_CANLF (E2QY99), 
PALS1_HUMAN (Q8N3R9), PALS1_MOUSE (Q9JLB2), PALS1_PONAB (Q5RDQ2), 
PALS1_RAT   (B4F7E7), PALS2_HUMAN (Q9NZW5), PALS2_MOUSE (Q9JLB0), 
PATJ_DROME  (Q9NB04)
» more

PDB
[Detailed view]		 10 PDB

1RSO; 1VF6; 1Y74; 1Y76; 1ZL8; 3LRA; 3UIT; 4RP3; 4RP4; 4RP5