PROSITE entry PS51110

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

Entry name [info]	SAP_A
Accession [info]	PS51110
Entry type [info]	MATRIX
Date [info]	01-APR-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51110
Associated ProRule [info]	PRU00414

Name and characterization of the entry

Description [info]

Saposin A-type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=41;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2327433; R2=0.0107069; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=586; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=371; N_SCORE=6.2; MODE=1; TEXT='RR';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='W';  M=-15,-30,-45,-25,-15,-10,-20,-25,-20,-15,-25,-20,-30, 30,-15,-20,-25,-20,-30, 59,  0,-15;
/M: SY='T';  M=  0,-15,-10,-20,-20, -5,-25,-25, 10,-15,  0,  0,-15,-20,-20,-15,  5, 25, 25,-30,-10,-20;
/M: SY='T';  M= -5, -9,-17,-14, -7,-10,-23,-14, -3,-12,  6,  1, -9,-16,  1, -9,  1, 20, -3,-25, -7, -3;
/M: SY='S';  M= -2,  3,-23,  7, -3,-21,  5,-12,-27,-11,-28,-22,  3,-15, -6,-13, 14,  0,-20, -8,-14, -4;
/M: SY='S';  M=  0, -8,-21, -6,  0,-21,-11,-10,-14,-10,-17,-11, -3,  8,  4,-10, 14,  5,-14,-32,-18,  1;
/M: SY='K';  M=-10,-15,-25,-15, -5,-10,-25,-15, -5, 10, 10,  5,-15,-20, -5,  5,-20,-10, -5,-20, -5, -5;
/M: SY='A';  M= 20,  4,-16,  2,  5,-22, -9,-14,-18, -6,-15,-15, -2, -9, -4,-14,  9,  7, -9,-27,-18,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A';  M= 35, -7,-10,-14, -8,-19, -3,-18,-12,-10,-14,-12, -4,-10, -8,-17, 18, 11, -2,-26,-19, -8;
/M: SY='Q';  M= -9, -3,-30, -3,  7,-34, -2, -1,-27, 13,-24, -7,  0,-13, 29, 16, -3,-12,-27,-20,-14, 17;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='P';  M= -3,-13,-30, -7,  0,-27,-13,-17,-20,-10,-30,-20,-10, 55, -7,-17,  7,  0,-23,-33,-27, -7;
/M: SY='E';  M= 11,  3,-23,  6, 36,-27,-13, -7,-23,  3,-17,-17, -3, -3, 10, -7,  3, -7,-20,-27,-20, 23;
/M: SY='F';  M=-10,-30,-15,-35,-30, 40,-30,-25, 15,-25, 10,  5,-25,-30,-35,-20,-15, -5, 25,-10, 10,-30;
/M: SY='W';  M=-18,-38,-44,-38,-28, 10,-22,-28,-12,-22, -6,-12,-38,-30,-20,-20,-38,-26,-22,115, 24,-20;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M=-12, -2,-30, -2, 16,-36,-20,  8,-22, 14,-20, -2,  0,-12, 50, 22, -2,-10,-28,-20,-10, 32;
/M: SY='S';  M=  1, 16,-16, 17,  4,-24, -2, -5,-24, -7,-30,-22, 19,-11,  0, -9, 28, 11,-17,-40,-20,  2;
/M: SY='L';  M= -7,-30,-17,-30,-23,  7,-30,-23, 23,-27, 36, 17,-30,-30,-23,-20,-23, -7, 24,-23, -3,-23;
/M: SY='E';  M=-12,  3,-30,  8, 33,-28,-20, -3,-30, 27,-23,-15,  0, -7, 15, 21, -5,-10,-25,-25,-15, 23;
/M: SY='Q';  M= -5,  0,-20, -5,  5,-25,-20, -5,-15,  0,-15, -5,  0,-10, 25,  0, 10, 20,-15,-25,-10, 15;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='L';  M= -2,-21,-15,-21,-16, -1,-21,-19, 10,-22, 18,  6,-18,-24,-16,-17, -5,  1, 12,-28, -8,-16;
/M: SY='Q';  M=-13, 17,-30, 24, 20,-40,-17,  7,-27,  7,-23,-10,  7,-10, 39,  3,  0,-10,-30,-27,-13, 30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M=-10,-10,-30,-10,-10,-25, 25,-10,-35,  5,-25,-15,  0,-20, -5, 25, -5,-15,-25,-20,-20,-10;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='L';  M= -5,-30,-15,-30,-25,  5,-30,-25, 25,-25, 30, 15,-30,-30,-25,-20,-20, -5, 30,-25, -5,-25;
/M: SY='G';  M= -5, -5,-30, -5, -5,-30, 25,-15,-35, 15,-30,-15,  0,-15, -5,  5, -5,-15,-25,-20,-20, -5;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='L';  M=-10,-19,-24,-19, -6, -8,-26, -9,  6,-16, 25, 13,-19,-23,  9, -9,-19,-10, -4,-20, -4,  2;
/M: SY='Q';  M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='E';  M= -9,  7,-24,  5, 24,-19,-17, -1,-15,  1,-12, -2,  5, -9,  9, -3,  0,  0,-18,-30,-14, 16;
/M: SY='V';  M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='G';  M=  2,  1,-21, -2,-10,-25, 35,-12,-30,-14,-30,-20, 12,-16,-10,-14, 16, -3,-23,-30,-25,-10;
/M: SY='H';  M=-15,  0,-30,  0,  5,-25,-20, 45,-30, 20,-25, -5,  5,-15, 10, 15,-10,-15,-25,-25,  5,  5;
/M: SY='P';  M= -5,-25,-25,-20,-15,-15,-25,-25,  5,-15,-10, -5,-25, 30,-20,-20,-10, -5, 10,-30,-20,-20;
/M: SY='G';  M=  8, -7,-20,-12,-15,-21, 28,-20,-25,-15,-20,-15, -2,-15,-15,-17,  9,  7,-15,-23,-21,-15;
/M: SY='A';  M= 35,-16,-10,-23,-16,-14, -9,-23,  2,-13, -4, -4,-16,-16,-16,-20,  4,  0, 15,-23,-17,-16;
/I:         E1=0; IE=-105; DE=-105;

» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	21 in 14 different sequences
Number of true positive hits	20 in 13 different sequences
Number of 'unknown' hits	1
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	Saposin A-type
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

13 sequences

PSPB_BOVIN  (P15781), PSPB_CANLF  (P17129), PSPB_HUMAN  (P07988),

PSPB_MOUSE  (P50405), PSPB_RABIT  (P15285), PSPB_RAT(P22355), 
SAPL1_HUMAN (Q6NUJ1), SAPL1_MOUSE (Q8C1C1), SAP_BOVIN   (P26779), 
SAP_CHICK   (O13035), SAP_HUMAN   (P07602), SAP_MOUSE   (Q61207), 
SAP_RAT (P10960)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
'Unknown' sequences

1 sequence

GILT_CARAU  (E7E2N8)