PROSITE entry PS51110

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General information about the entry

Entry name [info]	SAP_A
Accession [info]	PS51110
Entry type [info]	MATRIX
Date [info]	01-APR-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51110
Associated ProRule [info]	PRU00414

Name and characterization of the entry

Description [info]

Saposin A-type domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=41;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=37;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2327433; R2=0.0107069; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=586; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=371; N_SCORE=6.2; MODE=1; TEXT='RR';
/DEFAULT: M0=-9; D=-20; I=-20; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='W';  M=-15,-30,-45,-25,-15,-10,-20,-25,-20,-15,-25,-20,-30, 30,-15,-20,-25,-20,-30, 59,  0,-15;
/M: SY='T';  M=  0,-15,-10,-20,-20, -5,-25,-25, 10,-15,  0,  0,-15,-20,-20,-15,  5, 25, 25,-30,-10,-20;
/M: SY='T';  M= -5, -9,-17,-14, -7,-10,-23,-14, -3,-12,  6,  1, -9,-16,  1, -9,  1, 20, -3,-25, -7, -3;
/M: SY='S';  M= -2,  3,-23,  7, -3,-21,  5,-12,-27,-11,-28,-22,  3,-15, -6,-13, 14,  0,-20, -8,-14, -4;
/M: SY='S';  M=  0, -8,-21, -6,  0,-21,-11,-10,-14,-10,-17,-11, -3,  8,  4,-10, 14,  5,-14,-32,-18,  1;
/M: SY='K';  M=-10,-15,-25,-15, -5,-10,-25,-15, -5, 10, 10,  5,-15,-20, -5,  5,-20,-10, -5,-20, -5, -5;
/M: SY='A';  M= 20,  4,-16,  2,  5,-22, -9,-14,-18, -6,-15,-15, -2, -9, -4,-14,  9,  7, -9,-27,-18,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='A';  M= 35, -7,-10,-14, -8,-19, -3,-18,-12,-10,-14,-12, -4,-10, -8,-17, 18, 11, -2,-26,-19, -8;
/M: SY='Q';  M= -9, -3,-30, -3,  7,-34, -2, -1,-27, 13,-24, -7,  0,-13, 29, 16, -3,-12,-27,-20,-14, 17;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='P';  M= -3,-13,-30, -7,  0,-27,-13,-17,-20,-10,-30,-20,-10, 55, -7,-17,  7,  0,-23,-33,-27, -7;
/M: SY='E';  M= 11,  3,-23,  6, 36,-27,-13, -7,-23,  3,-17,-17, -3, -3, 10, -7,  3, -7,-20,-27,-20, 23;
/M: SY='F';  M=-10,-30,-15,-35,-30, 40,-30,-25, 15,-25, 10,  5,-25,-30,-35,-20,-15, -5, 25,-10, 10,-30;
/M: SY='W';  M=-18,-38,-44,-38,-28, 10,-22,-28,-12,-22, -6,-12,-38,-30,-20,-20,-38,-26,-22,115, 24,-20;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='Q';  M=-12, -2,-30, -2, 16,-36,-20,  8,-22, 14,-20, -2,  0,-12, 50, 22, -2,-10,-28,-20,-10, 32;
/M: SY='S';  M=  1, 16,-16, 17,  4,-24, -2, -5,-24, -7,-30,-22, 19,-11,  0, -9, 28, 11,-17,-40,-20,  2;
/M: SY='L';  M= -7,-30,-17,-30,-23,  7,-30,-23, 23,-27, 36, 17,-30,-30,-23,-20,-23, -7, 24,-23, -3,-23;
/M: SY='E';  M=-12,  3,-30,  8, 33,-28,-20, -3,-30, 27,-23,-15,  0, -7, 15, 21, -5,-10,-25,-25,-15, 23;
/M: SY='Q';  M= -5,  0,-20, -5,  5,-25,-20, -5,-15,  0,-15, -5,  0,-10, 25,  0, 10, 20,-15,-25,-10, 15;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='L';  M= -2,-21,-15,-21,-16, -1,-21,-19, 10,-22, 18,  6,-18,-24,-16,-17, -5,  1, 12,-28, -8,-16;
/M: SY='Q';  M=-13, 17,-30, 24, 20,-40,-17,  7,-27,  7,-23,-10,  7,-10, 39,  3,  0,-10,-30,-27,-13, 30;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='G';  M=-10,-10,-30,-10,-10,-25, 25,-10,-35,  5,-25,-15,  0,-20, -5, 25, -5,-15,-25,-20,-20,-10;
/M: SY='A';  M= 50,-10,-10,-20,-10,-20,  0,-20,-10,-10,-10,-10,-10,-10,-10,-20, 10,  0,  0,-20,-20,-10;
/M: SY='L';  M= -5,-30,-15,-30,-25,  5,-30,-25, 25,-25, 30, 15,-30,-30,-25,-20,-20, -5, 30,-25, -5,-25;
/M: SY='G';  M= -5, -5,-30, -5, -5,-30, 25,-15,-35, 15,-30,-15,  0,-15, -5,  5, -5,-15,-25,-20,-20, -5;
/M: SY='H';  M=-20,  0,-30,  0,  0,-20,-20,100,-30,-10,-20,  0, 10,-20, 10,  0,-10,-20,-30,-30, 20,  0;
/M: SY='C';  M=-10,-20,120,-30,-30,-20,-30,-30,-30,-30,-20,-20,-20,-40,-30,-30,-10,-10,-10,-50,-30,-30;
/M: SY='L';  M=-10,-19,-24,-19, -6, -8,-26, -9,  6,-16, 25, 13,-19,-23,  9, -9,-19,-10, -4,-20, -4,  2;
/M: SY='Q';  M=-10,  0,-30,  0, 20,-40,-20, 10,-20, 10,-20,  0,  0,-10, 60, 10,  0,-10,-30,-20,-10, 40;
/M: SY='E';  M= -9,  7,-24,  5, 24,-19,-17, -1,-15,  1,-12, -2,  5, -9,  9, -3,  0,  0,-18,-30,-14, 16;
/M: SY='V';  M=  0,-30,-10,-30,-30,  0,-30,-30, 30,-20, 10, 10,-30,-30,-30,-20,-10,  0, 50,-30,-10,-30;
/M: SY='W';  M=-20,-40,-50,-40,-30, 10,-20,-30,-20,-20,-20,-20,-40,-30,-20,-20,-40,-30,-30,150, 30,-20;
/M: SY='G';  M=  2,  1,-21, -2,-10,-25, 35,-12,-30,-14,-30,-20, 12,-16,-10,-14, 16, -3,-23,-30,-25,-10;
/M: SY='H';  M=-15,  0,-30,  0,  5,-25,-20, 45,-30, 20,-25, -5,  5,-15, 10, 15,-10,-15,-25,-25,  5,  5;
/M: SY='P';  M= -5,-25,-25,-20,-15,-15,-25,-25,  5,-15,-10, -5,-25, 30,-20,-20,-10, -5, 10,-30,-20,-20;
/M: SY='G';  M=  8, -7,-20,-12,-15,-21, 28,-20,-25,-15,-20,-15, -2,-15,-15,-17,  9,  7,-15,-23,-21,-15;
/M: SY='A';  M= 35,-16,-10,-23,-16,-14, -9,-23,  2,-13, -4, -4,-16,-16,-16,-20,  4,  0, 15,-23,-17,-16;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	21 in 14 different sequences
Number of true positive hits	20 in 13 different sequences
Number of 'unknown' hits	1
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	DOMAIN
Feature description [info]	Saposin A-type
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

13 sequences

PSPB_BOVIN  (P15781), PSPB_CANLF  (P17129), PSPB_HUMAN  (P07988),

PSPB_MOUSE  (P50405), PSPB_RABIT  (P15285), PSPB_RAT(P22355), 
SAPL1_HUMAN (Q6NUJ1), SAPL1_MOUSE (Q8C1C1), SAP_BOVIN   (P26779), 
SAP_CHICK   (O13035), SAP_HUMAN   (P07602), SAP_MOUSE   (Q61207), 
SAP_RAT (P10960)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
'Unknown' sequences

1 sequence

GILT_CARAU  (E7E2N8)