PROSITE entry PS51120
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General information about the entry
| Entry name [info] | LDLRB |
| Accession [info] | PS51120 |
| Entry type [info] | MATRIX |
| Date [info] |
01-MAY-2005 CREATED;
01-OCT-2013 DATA UPDATE; 03-MAY-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51120 |
| Associated ProRule [info] | PRU00461 |
Name and characterization of the entry
| Description [info] | LDL-receptor class B (LDLRB) repeat profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=43; /DISJOINT: DEFINITION=PROTECT; N1=1; N2=43; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=1.7791114; R2=0.0232049; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=381; N_SCORE=10.6; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=109; N_SCORE=4.3; MODE=1; TEXT='R?'; /DEFAULT: M0=-8; D=-100; I=-100; B1=-100; E1=-100; MI=-105; MD=-105; IM=-105; DM=-105; ... A B C D E F G H I K L M N P Q R S T V W Y Z /I: B1=0; BI=-105; BD=-105; /M: SY='D'; M= -9, 7,-28, 9, 3,-29, 8, -5,-31, 5,-27,-17, 9,-13, 4, 6, 0,-10,-26,-26,-18, 3; /M: SY='R'; M=-13, -7,-24,-10, -3, -9,-21, -2,-13, 8, -9, -3, -2,-19, 1, 16, -8, -5,-12,-16, 2, -3; /M: SY='I'; M= -8,-29,-22,-33,-25, 5,-32,-24, 31,-27, 29, 20,-25,-24,-20,-23,-22, -8, 22,-21, -2,-24; /M: SY='Y'; M=-19,-23,-21,-26,-23, 38,-30, 5, -1,-17, 2, -1,-21,-30,-19,-14,-20,-11, -7, 23, 58,-23; /M: SY='W'; M=-19,-36,-42,-38,-28, 21,-23,-24,-13,-20,-12,-13,-34,-30,-21,-18,-34,-24,-22,110, 32,-21; /M: SY='T'; M= 8,-11,-10,-17,-14,-11,-16,-21, 1,-15, -5, -4, -8,-16,-13,-16, 9, 17, 8,-29,-13,-14; /M: SY='D'; M=-17, 38,-27, 52, 17,-34,-11, 1,-34, -1,-27,-25, 17,-11, 1, -9, 1, -7,-26,-38,-18, 9; /M: SY='A'; M= 1,-12,-24,-16,-11,-10,-12,-13, -9,-10,-11, -7, -9,-16, -6,-10, -3, -4, -8, 1, -3, -9; /M: SY='N'; M= -5, -3,-24, -4, -4,-17, -1, -7,-19, -1,-17,-10, 1,-16, -4, -1, 0, -4,-15,-22,-11, -5; /I: I=-17; MD=-17; /M: SY='T'; M= -6, -4,-21, -6, -1,-11,-17, -7,-11, -3, -5, -4, -3,-17, 0, 0, -2, 2,-10,-23, -7, -1; D=-17; /I: I=-17; MD=-17; /M: SY='D'; M= -9, 8,-26, 10, 7,-25, -7, 2,-25, 4,-20,-12, 7,-10, 5, 4, 0, -8,-22,-28,-13, 5; D=-17; /I: I=-17; MI=0; MD=-17; IM=0; DM=-17; /M: SY='R'; M= -5, -8,-18,-11, -7,-14,-14,-10,-12, 3,-11, -4, -5,-18, -4, 7, -2, 0, -6,-22, -8, -7; /M: SY='I'; M= -8,-28,-27,-36,-27, 1,-34,-26, 39,-28, 20, 18,-21,-22,-20,-27,-19, -9, 25,-19, 0,-27; /M: SY='E'; M= -8, -1,-23, 1, 13,-14,-14, -3,-20, -1,-15,-12, -1,-13, 3, -1, 0, -5,-18,-20, -7, 7; /M: SY='R'; M= -6,-12,-14,-14, -9,-12,-19, -9,-10, 2,-12, -5, -7,-20, -5, 14, -2, -2, -2,-24, -8, -9; /M: SY='A'; M= 13,-11, -4,-18,-14,-13,-13,-17, -2,-14, -7, -3, -8,-17,-12,-17, 3, 1, 4,-28,-15,-13; /M: SY='N'; M= -9, 9,-23, 8, 2,-18,-11, 0,-23, 4,-20,-13, 10,-16, 0, 4, 0, -4,-20,-24, -9, 0; /M: SY='L'; M=-10,-21,-24,-23,-15, 3,-26,-12, 8,-12, 13, 12,-19,-18,-11,-11,-18, -8, 2,-11, 6,-14; /M: SY='D'; M=-13, 30,-26, 36, 10,-28, -8, 2,-30, -1,-25,-21, 19,-12, 0, -6, 2, -5,-25,-33,-16, 5; /M: SY='G'; M= -1, -5,-27, -5,-13,-28, 49,-17,-35,-15,-28,-19, 2,-17,-15,-16, 3,-13,-26,-23,-27,-14; /I: I=-18; MI=0; MD=-18; IM=0; DM=-18; /M: SY='S'; M= -1, -1,-17, -3, 0,-16, -9, -6,-14, -4,-13, -9, 1,-12, 0, -3, 8, 8, -9,-26,-12, 0; D=-18; /I: I=-18; DM=-18; /M: SY='N'; M= -8, 8,-24, 7, 3,-20, -4, 5,-23, -2,-21,-14, 11,-13, 1, -2, 3, -3,-21,-27,-11, 1; /M: SY='R'; M=-11, -6,-20, -8, -2,-16,-18, -3,-19, 6,-15, -9, 0,-15, 1, 22, -5, -6,-14,-22, -9, -3; /M: SY='R'; M= -7, -6,-24, -6, 4,-19,-19, -7,-14, 7,-13, -6, -4,-12, 4, 10, -3, -2, -9,-25,-11, 2; /M: SY='V'; M= -4,-13,-18,-17,-13, -9,-24,-18, 7,-11, -2, 2,-12,-16,-11,-11, -2, 9, 12,-26, -8,-13; /M: SY='L'; M= -7,-25,-20,-28,-22, 2,-29,-21, 23,-22, 24, 14,-22,-26,-19,-18,-18, -7, 20,-23, -4,-22; /M: SY='I'; M= -4,-25,-19,-29,-23, 4,-28,-21, 20,-22, 16, 10,-22,-24,-20,-19,-15, -6, 19,-18, -1,-23; /M: SY='N'; M= -3, 3,-20, 0, 1,-18,-12, -4,-17, 0,-17,-10, 5,-15, 3, 0, 5, 1,-14,-26,-10, 2; /M: SY='N'; M= -5, 4,-22, 3, 3,-21, -6, -3,-20, -2,-20,-13, 8,-12, 2, -3, 7, 1,-16,-29,-14, 2; /I: I=-21; MD=-22; /M: SY='N'; M= -6, 4,-21, 4, -1,-20, 1, -2,-21, -3,-18,-11, 6,-11, -1, -4, 3, -3,-18,-24,-12, -2; D=-21; /I: I=-21; MI=0; MD=-22; IM=0; DM=-22; /M: SY='L'; M= -7,-17,-21,-19,-14, -2,-23,-16, 10,-18, 14, 7,-14,-20,-14,-15,-13, -5, 8,-24, -6,-15; /M: M= -5, -3,-24, -2, -1,-18, -7, -4,-16, -5,-14, -8, -2,-11, -2, -5, -2, -5,-13,-24,-10, -3; /M: SY='H'; M= -9, -8,-25,-11, -6,-11,-15, 3,-12, -6,-10, -4, -3,-17, 0, -2, -6, -5,-13,-11, -1, -4; /M: SY='P'; M= -5,-18,-30,-13, -6,-21,-20,-20, -8,-12,-17,-11,-17, 47,-12,-18, -7, -5,-12,-29,-22,-12; /M: SY='H'; M=-10, -1,-23, -3, 1, -6,-17, 6,-16, -3,-13, -7, 2,-17, -2, 2, -4, -6,-14,-21, 0, -2; /M: SY='G'; M= 7, -3,-21, -4, -9,-25, 21,-14,-25,-13,-22,-16, 0, -9,-10,-16, 5, -7,-18,-26,-23,-10; /M: SY='L'; M=-10,-28,-23,-33,-24, 9,-32,-22, 28,-26, 29, 20,-24,-25,-19,-21,-23, -9, 18,-18, 2,-23; /M: SY='A'; M= 21, -9,-12,-15,-11,-16, -8,-19, -7,-10,-10, -8, -9,-14,-11,-15, 7, 6, 3,-24,-16,-11; /M: SY='V'; M= -6,-27,-18,-30,-25, 7,-30,-23, 24,-23, 17, 12,-24,-27,-23,-21,-16, -4, 26,-20, 1,-25; /M: SY='D'; M=-16, 21,-25, 30, 4,-16,-16, 5,-25, -6,-19,-17, 7,-16, -6,-10, -4, -8,-19,-26, -3, -1; /M: SY='W'; M=-11,-16,-34,-14, -6,-10,-17, -1,-14,-12,-14,-10,-14, -1, -7,-13,-15,-14,-19, 14, 4, -8; /M: M= -7,-10,-22,-11, -8, -7,-20,-11, -3,-10, -3, -2, -9,-14, -9,-11, -8, -5, -3,-20, -3, -9; /M: SY='S'; M= -3, -1,-22, -3, 0,-16, -5, -2,-19, -3,-17,-11, 2,-15, -1, -3, 4, -1,-16,-21, -8, -1; /I: E1=0; IE=-105; DE=-105;» more |
Numerical results [info]
| Total number of hits | 765 in 67 different sequences |
| Number of true positive hits | 765 in 67 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 5 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 99.35 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | N_Hulo |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 37 |
| Feature key [info] | REPEAT |
| Feature description [info] | LDL-receptor class B |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
67 sequences
CUE_DROAN (B3M8G0 ), CUE_DROER (B3NBB6 ), CUE_DROGR (B4IXJ2 ), CUE_DROME (Q95RU0 ), CUE_DROMO (B4L8V5 ), CUE_DROPE (B4H1F5 ), CUE_DROPS (Q29FE9 ), CUE_DROSE (B4HVU2 ), CUE_DROSI (B4QMF4 ), CUE_DROVI (B4LCX4 ), CUE_DROWI (B4MLE8 ), CUE_DROYA (B4PD96 ), EGF_CANLF (Q9BEA0 ), EGF_FELCA (Q95ND4 ), EGF_HUMAN (P01133 ), EGF_MOUSE (P01132 ), EGF_PIG (Q00968 ), EGF_RAT (P07522 ), LDLR1_XENLA (Q99087 ), LDLR2_XENLA (Q99088 ), LDLR_BOVIN (P01131 ), LDLR_CRIGR (P35950 ), LDLR_HUMAN (P01130 ), LDLR_MOUSE (P35951 ), LDLR_PIG (Q28832 ), LDLR_RABIT (P20063 ), LDLR_RAT (P35952 ), LRP1B_HUMAN (Q9NZR2 ), LRP1B_MOUSE (Q9JI18 ), LRP1_CHICK (P98157 ), LRP1_HUMAN (Q07954 ), LRP1_MOUSE (Q91ZX7 ), LRP1_RAT (G3V928 ), LRP2_HUMAN (P98164 ), LRP2_MOUSE (A2ARV4 ), LRP2_PIG (C0HL13 ), LRP2_RAT (P98158 ), LRP4_HUMAN (O75096 ), LRP4_MOUSE (Q8VI56 ), LRP4_RAT (Q9QYP1 ), LRP5L_HUMAN (A4QPB2 ), LRP5_HUMAN (O75197 ), LRP5_MOUSE (Q91VN0 ), LRP6_HUMAN (O75581 ), LRP6_MOUSE (O88572 ), LRP8_CHICK (Q98931 ), LRP8_HUMAN (Q14114 ), LRP8_MOUSE (Q924X6 ), LRP_CAEEL (Q04833 ), NDG_DROME (A1Z877 ), NID1_HUMAN (P14543 ), NID1_MOUSE (P10493 ), NID2_HUMAN (Q14112 ), NID2_MOUSE (O88322 ), NID2_RAT (B5DFC9 ), SORL_CHICK (Q98930 ), SORL_HUMAN (Q92673 ), SORL_MOUSE (O88307 ), SORL_RABIT (Q95209 ), SORL_RAT (P0DSP1 ), VGR_SOLIN (Q6X0I2 ), VLDLR_CHICK (P98165 ), VLDLR_HUMAN (P98155 ), VLDLR_MOUSE (P98156 ), VLDLR_RABIT (P35953 ), VLDLR_RAT (P98166 ), YL_DROME (P98163 )» more
|
| UniProtKB/Swiss-Prot False negative sequences |
5 sequences
7LESS_DROME (P13368 ), 7LESS_DROVI (P20806 ), CUE_AEDAE (Q16YE7 ), CUE_ANOGA (Q7QIQ6 ), CUE_CULQU (B0WH58 )» more |
| PDB [Detailed view] |
24 PDB
1IJQ; 1N7D; 1NPE; 3M0C; 3P5B; 3P5C; 3S2K; 3S8V; 3S8Z; 3S94; 3SOB; 3SOQ; 3SOV; 3V64; 3V65; 4A0P; 4DG6; 5B4X; 5FWW; 5GJE; 6H15; 6H16; 6L6R; 7NAM » more |