PROSITE entry PS51147

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51147
Entry name [info]	PFTA
Accession [info]	PS51147
Entry type [info]	MATRIX
Date [info]	01-OCT-2005 CREATED; 01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00703
Associated ProRule [info]	PRU00488

Name and characterization of the entry

Description [info]

Protein prenyltransferases alpha subunit repeat profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=35;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=35;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3351829; R2=0.0088513; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=900; N_SCORE=10.3; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=211; N_SCORE=4.2; MODE=1; TEXT='R?';
/DEFAULT: M0=-33; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='Y';  M= -16, -91,  44, -31, -26, -34, -73, -12, -38,  18,  24,  30, -23, -19,  -9,  -6, -31,  -2, -84,  59;
/M: SY='W';  M= -49, -92,  19, -41,   9, -89, -83,  11, -80,  39, -68, -23,   9, -79,   5,  36, -75, -18,  90,   3;
/M: SY='E';  M=  20, -92,  45,  50, -43, -49, -74, -45,  24, -19, -81,  20, -10,  15,  -9,  -8, -43, -84, -94,   4;
/M: SY='R';  M= -42, -95,  32,  46, -93, -42,  -5, -42,  32, -58, -83,  -2, -83,  18,  59,  13,  -9, -88, -96, -22;
/M: SY='E';  M=  22, -95, -20, 105, -97, -89, -74, -39, -63, -89, -86, -75, -76, -56, -72, -72, -76, -22, -98, -90;
/M: SY='L';  M= -84, -87,-102, -95,  30,-103, -87,  -4, -95,  83,  29, -99,-100, -90, -92, -93, -80,   2, -86, -66;
/M: SY='N';  M=  15, -91,   3,  46, -31, -22,  18, -48,   4, -57, -82,  49,  -4,  43, -17,  12, -26, -43, -98, -83;
/M: SY='Y';  M= -87, -92, -98, -93,  73, -99, -77,  -1,  -8,  41, -61, -94,-100, -88, -85, -89, -82, -21,  59,  81;
/M: SY='T';  M=  -7,  60, -87, -86, -76, -91, -91,  17, -84,  17, -66, -78, -88, -86, -89, -15,  78,  38,-101, -81;
/M: SY='E';  M=  -6, -91,  30,  35, -86, -31, -18,  -4,  28, -16,  18,  18, -84,  15, -17,  23,  -7, -27, -96, -18;
/M: SY='E';  M= -11, -94,  43,  58, -35, -86,  -2, -39,  37, -18, -10,  15, -83,  26,   7, -16, -75, -42, -97, -82;
/M: SY='M';  M=  29,  37, -93, -86,  -5, -46, -87,  44,  18,  34,  52, -86, -92, -21, -82, -80, -41,   4, -91, -75;
/M: SY='I';  M=  -8, -90,-101, -96,   8,-101, -93,  81, -94,  55,   4, -94, -95, -90, -95, -88, -35, -47, -88, -70;
/M: SY='E';  M= -78, -93,  17,  56,  10, -17, -74, -25,  19,   4, -13,  21, -84,  36,  14,  -8, -35, -42, -93, -78;
/M: SY='D';  M=  -4, -89,  40,  15, -33, -86, -78, -21,  26,  26,  -9,  23, -86,  -3, -34,  -3,  24, -10, -97, -80;
/M: SY='N';  M= -27,  -7,  83, -30,  -7, -78, -69, -39, -72, -53, -86,  84, -89, -25, -79, -20, -70, -22,-103,   1;
/M: SY='P';  M=  30,  -9, -82, -15,   6, -82, -85,   5, -79, -50, -78,  -1,  95,   1, -87,   0, -39, -26, -93, -85;
/M: SY='K';  M=   3, -93,   9,  25, -42, -23,  -9, -94,  68, -92, -83,  -2, -83,   7,  31,  17, -74, -89, -90,  16;
/M: SY='N';  M= -80,  -5,  11, -74,  16, -73,  39, -38, -70, -92, -83, 114, -91, -71, -77, -12, -67, -45,-106, -79;
/M: SY='Y';  M= -43, -96, -76,  14,  23, -89,  -4, -34, -76, -76, -72,  48, -29,  30, -77, -77, -79, -82, -60, 112;
/M: SY='H';  M= -41, -87, -74, -72, -89, -39,  82, -90, -73, -89, -81, -64, -82,  45, -75,  78,  49, -85,  44, -74;
/M: SY='A';  M=  59,  18, -91, -86, -25, -27, -92,  37, -86, -29, -68, -84,  -5, -85, -90,  -7,  -9,  48, -96, -82;
/M: SY='W';  M= -93,-118,-120, -98, -57, -91,-117, -91, -89, -88, -91,-113, -97, -89, -93,-100,-105,-105, 181,  -4;
/M: SY='H';  M= -45, -90,  -7, -72,  -4, -78,  94, -42, -69, -88, -79,  81, -88,  24,  -2,  26,   7, -89,-102, -16;
/M: SY='Y';  M= -87,  -5, -81, -80,  10, -92,  99, -35, -78, -75, -69, -22, -95,  34, -75, -80, -83, -84, -63, 110;
/M: SY='R';  M= -84, -98, -84, -73, -85, -96, -10, -34, -48,  16, -73, -77, -94, -62, 111, -80, -34, -83, -93, -78;
/M: SY='R';  M= -23,  18, -83, -72,  27, -90,  -9, -83,  20, -30,  -8, -76, -91,  47,  81, -20, -29, -23, -85,  15;
/M: SY='W';  M= -49, -13, -38, -18,  46,  21, -90,  -7, -15, -25, -77,  -6, -92,   1, -85, -41, -31,  -6, 128,   2;
/M: SY='V';  M= -25,  17,-100, -95,   3,-100, -93,  50, -93,  49, -55, -94, -96, -91, -94, -86, -12,  56, -91, -16;
/M: SY='L';  M=  -8, -10, -99, -92, -29, -99, -10,  42, -92,  65,   1, -94, -97, -20, -91, -87, -78,  27,  17,  -1;
/M: SY='E';  M= -26, -93,  -9,  44,   8, -13, -76, -22,  39, -53, -80, -27,  -2,  43,  20,   9,  10, -41, -92, -80;
/M: SY='N';  M= -22, -90,   2,  10, -33, -83,  44, -83,   5,   2, -10,  60, -87,  25,  30,   3,  14, -43,   7, -77;
/M: SY='F';  M=  -2, -88,   4, -42,  41, -46, -12,  14, -37,  40,  32,  -7, -92, -20, -10, -11,  13, -66, -85,   9;
/M: SY='P';  M= -26, -93,   9,   9, -30,  29,  31, -34,  33, -86,  31, -10,  42, -26, -34,  15, -14, -42, -92,   3;
/M: SY='D';  M= -27, -91,  25,  18, -87,  -4,  11, -78,  10,   2, -77,  14,  17,   1,   2,  19,   3,  15,  12, -82;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	144 in 27 different sequences
Number of true positive hits	144 in 27 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.31 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	6
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	PS_Langendijk_Genevaux
Feature key [info]	REPEAT
Feature description [info]	PFTA
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

27 sequences

FNTA_ARATH  (Q9LX33), FNTA_BOVIN  (P29702), FNTA_CANAX  (Q9Y765),

FNTA_DICDI  (Q54RT9), FNTA_HUMAN  (P49354), FNTA_MOUSE  (Q61239), 
FNTA_PEA(O24304), FNTA_RAT(Q04631), FNTA_SCHPO  (O60052), 
FNTA_SOLLC  (P93227), FNTA_YEAST  (P29703), PGTA1_ARATH (Q8VYB7), 
PGTA2_ARATH (Q9FJ32), PGTA_BOVIN  (Q5EA80), PGTA_CANAX  (O93829), 
PGTA_DICDI  (Q55DQ4), PGTA_HUMAN  (Q92696), PGTA_MOUSE  (Q9JHK4), 
PGTA_PIG(A5A779), PGTA_PONAB  (Q5NVK5), PGTA_RAT(Q08602), 
PGTA_SCHPO  (O94412), PGTA_YEAST  (Q00618), PTAR1_DANRE (A3KPW7), 
PTAR1_HUMAN (Q7Z6K3), PTR1A_XENLA (Q0IHB3), PTR1B_XENLA (A1L3L1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

RAM1_PETHY  (A0A0M4FMK2)

PDB
[Detailed view]

98 PDB

1D8D; 1D8E; 1DCE; 1FPP; 1FT1; 1FT2; 1JCQ; 1JCR; 1JCS; 1KZO; 1KZP; 1LD7; 1LD8; 1LTX; 1MZC; 1N4P; 1N4Q; 1N4R; 1N4S; 1N94; 1N95; 1N9A; 1NI1; 1NL4; 1O1R; 1O1S; 1O1T; 1O5M; 1QBQ; 1S63; 1S64; 1SA4; 1SA5; 1TN6; 1TN7; 1TN8; 1TNB; 1TNO; 1TNU; 1TNY; 1TNZ; 1X81; 2BED; 2F0Y; 2H6F; 2H6G; 2H6H; 2H6I; 2IEJ; 2R2L; 2ZIR; 2ZIS; 3C72; 3DPY; 3DRA; 3DSS; 3DST; 3DSU; 3DSV; 3DSW; 3DSX; 3E30; 3E32; 3E33; 3E34; 3E37; 3EU5; 3EUV; 3HXB; 3HXC; 3HXD; 3HXE; 3HXF; 3KSL; 3KSQ; 3PZ1; 3PZ2; 3PZ3; 3PZ4; 4EHM; 4GTM; 4GTO; 4GTP; 4GTQ; 4GTR; 4GTS; 4GTT; 4GTV; 4YDO; 6J6X; 6J74; 6J7F; 6J7X; 6O60; 7RN5; 7RNI; 8E9E; 8RDX
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