PROSITE entry PS51183

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General information about the entry

Entry name [info]	JMJN
Accession [info]	PS51183
Entry type [info]	MATRIX
Date [info]	01-FEB-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51183
Associated ProRule [info]	PRU00537

Name and characterization of the entry

Description [info]

JmjN domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=42;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=38;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0609195; R2=0.0138589; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2398.1782227; R2=1.2883356; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=465; H_SCORE=2997; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=321; H_SCORE=2812; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I';  M= -2,-21, -8,-30,-25, -6,-30,-25, 26,-24,  7,  8,-13,-22,-20,-25,-12, -7, 20,-26, -9,-25;
/M: SY='P';  M= -9,-21,-34,-14, -4,-22,-22,-19,-10,-13,-14,-10,-21, 56, -9,-18,-12, -9,-17,-28,-23,-10;
/M: SY='V';  M= -1,-17,-15,-20,-14, -7,-24,-20,  9,-10,  1,  5,-16,-20,-14, -8, -3,  7, 20,-27,-10,-15;
/M: SY='F';  M=-14,-30,-20,-37,-29, 46,-32,-23, 15,-28, 16,  7,-23,-28,-33,-22,-19, -8, 14, -5, 15,-29;
/M: SY='R';  M=-12, -4,-26, -7,  1, -9,-22, -3,-10,  5, -9, -6,  0,-18,  0,  8, -8, -3,-12,-16,  5, -2;
/M: SY='P';  M= -9,-20,-34,-14, -4,-21,-22,-20,-12,-14,-14,-12,-20, 61,-12,-19,-11, -5,-21,-28,-23,-12;
/M: SY='T';  M=  3, -1,-15, -7, -4,-17,-15, -7,-17,  0,-18,-11,  2,-11, -3, -4, 15, 25, -7,-29,-10, -4;
/M: SY='M';  M= -8,-13,-30,-14, -2,-12,-14,-10,-10,  1,-10,  4,-13,-11, -2, -5,-14,-13,-12,  1, -1, -2;
/M: SY='E';  M= -5,  1,-27,  3, 24,-27,-17, -3,-23, 17,-20, -8, -1, -8, 18, 11, -1, -7,-21,-25,-14, 20;
/M: SY='E';  M=-11, 13,-30, 23, 54,-31,-19,  1,-30,  9,-21,-19,  2, -1, 21,  0,  0,-10,-30,-30,-19, 38;
/M: SY='F';  M=-18,-29,-20,-38,-28, 67,-29,-18,  4,-28, 15,  7,-21,-29,-35,-19,-21,-10,  2,  5, 25,-27;
/M: SY='K';  M= -1, -1,-23,  0,  4,-24,-16, -6,-19,  5,-20,-11, -2, -2,  2,  1,  3,  2,-12,-28,-14,  2;
/M: SY='D';  M=-17, 42,-27, 49, 13,-33, -8,  3,-34,  3,-29,-26, 29,-14,  1,  0,  2, -7,-29,-38,-19,  6;
/M: SY='P';  M=-11,-21,-31,-19,-11,  1,-15,-18,-13,-16,-15, -8,-17, 37,-18,-19,-11, -8,-18,-18,-12,-16;
/M: SY='L';  M= -9,-21,-25,-23,-11, -2,-27,-13, 14,-18, 17, 15,-19,-15, -7,-16,-16, -8,  4,-19,  0,-11;
/M: SY='D';  M= -4,  1,-24,  3,  2,-21, -3, -8,-19, -1,-17,-12,  0,-14,  0, -6,  2, -5,-16,-24,-10,  0;
/M: SY='Y';  M=-20,-25,-25,-29,-25, 53,-30,  2,  0,-19,  5,  0,-20,-30,-24,-15,-20,-10, -5, 21, 57,-25;
/M: SY='I';  M=-12,-28,-19,-37,-28,  9,-37,-24, 34,-28, 16, 14,-21,-24,-21,-27,-20,-10, 20,-15,  8,-28;
/M: SY='E';  M= -4,  6,-25, 12, 30,-27,-14, -5,-27, 11,-23,-18,  3, -6, 11,  5,  6, -3,-22,-30,-18, 20;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='R';  M= -5, -9,-24, -9,  1,-17,-19, -5,-14,  9, -9, -4, -5,-16,  1, 10, -5, -5,-10,-24, -9, -1;
/M: SY='I';  M= -9,-26,-24,-30,-22,  5,-34,-19, 29,-22, 16, 12,-22,-24,-18,-21,-18, -8, 22,-14, 10,-23;
/M: SY='E';  M= -8, 10,-24,  9, 15,-24,-14, -3,-25, 10,-22,-16, 11,-12,  6, 15,  4,  1,-21,-29,-16,  9;
/M: SY='Q';  M= -9,  1,-29,  5,  7,-26,-17, -1,-23, 10,-23,-12, -1, -1, 15,  9, -2, -7,-23,-22, -8, 10;
/M: SY='M';  M=-10,-14,-24,-19,-12, -2,-20,-10,  2, -9,  6,  7,-10,-21, -5, -6,-12, -5, -3,-17,  1,-10;
/M: SY='G';  M= 20,-11,-21,-15,-17,-25, 37,-21,-25,-16,-20,-15, -5,-17,-17,-20,  3,-11,-14,-21,-25,-17;
/M: SY='E';  M= -5, -7,-24, -7,  7,-18,-14, -4,-13,  2,-10, -3, -6,-14,  1,  1, -4, -7,-10,-25,-12,  3;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='K';  M= -9, -4,-27, -3,  7,-25,-19,-11,-23, 31,-24,-10, -3, -8,  5, 22, -5, -7,-14,-24,-12,  5;
/M: SY='Y';  M= -4,-11,-22,-14,-14, 13,-18,  6, -7,-11, -9, -7, -7,-23, -9,-11, -1, -2, -9,  3, 37,-14;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='I';  M=  5,-23, -7,-31,-23, -6,-25,-22, 20,-21, 10, 14,-19,-21,-16,-23,-12, -7, 16,-24, -8,-21;
/M: SY='C';  M=  1,-24, 33,-30,-27, -9,-27,-28,  5,-24,  1, -1,-23,-30,-26,-24,-10, -5, 18,-34,-17,-27;
/M: SY='K';  M=-12, -3,-23, -4,  6,-27,-20, -9,-30, 42,-27,-10, -1,-14,  8, 36,-10,-10,-20,-21,-11,  6;
/M: SY='V';  M= -5,-30,-18,-34,-29,  1,-34,-29, 36,-25, 18, 15,-26,-26,-25,-24,-16, -5, 39,-25, -5,-29;
/M: SY='I';  M= -7,-26,-22,-31,-24, -4,-33,-26, 30,-15,  9, 11,-21,-23,-19,-14,-15, -6, 30,-24, -5,-24;
/M: SY='P';  M= -7,-20,-36,-14, -4,-26,-21,-19,-13, -9,-23,-15,-18, 65, -9,-14,-10, -9,-22,-28,-25,-11;
/M: SY='P';  M=-10,-21,-39,-13, -3,-27,-22,-21,-13,-12,-25,-16,-20, 80,-11,-21,-11,-10,-24,-29,-27,-12;
/M: SY='P';  M=  0, -2,-25,  2,  6,-25,-13,-13,-18, -3,-23,-17, -3, 21, -4,-11,  3, -3,-16,-31,-22, -1;
/M: SY='D';  M= -3, 11,-23, 14,  9,-20,  4, -8,-27, -7,-23,-20,  9,-12, -4,-11,  7, -5,-21,-29,-18,  3;
/M: SY='W';  M=-12,-34,-37,-37,-28, 20,-21,-27,-11,-21,-11,-13,-32,-28,-24,-20,-29,-21,-15, 92, 22,-22;
/M: SY='K';  M=-10,  0,-16,  0,  1,-22,-18, -9,-21, 13,-15, -9,  0,-16,  3, 12, -4, -3,-15,-27,-12,  1;
/M: SY='P';  M=-10,-10,-21, -7,  2,-27,-19,-15,-21,  0,-26,-15, -9, 43, -5,-10, -8, -9,-25,-30,-24, -5;
/M: SY='P';  M=-12,-14,-33, -9,  5,-17,-22,-12,-19,  0,-18,-12,-13, 33, -1, -1,-10,-10,-23,-23,-16,  0;
/I:         E1=0; IE=-105; DE=-105;

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Post-processing [info]

PROMOTED_BY

PS51184

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	56 in 56 different sequences
Number of true positive hits	56 in 56 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	JmjN
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

56 sequences

ECM5_YEAST  (Q03214), ELF6_ARATH  (Q6BDA0), GIS1_YEAST  (Q03833),

JARD2_CHICK (Q5F363), JARD2_DANRE (Q1LVC2), JARD2_HUMAN (Q92833), 
JARD2_MOUSE (Q62315), JHD2_YEAST  (P47156), JM703_ORYSJ (Q53WJ1), 
JM705_ORYSJ (Q5N712), JM706_ORYSJ (Q336N8), JMJ13_ARATH (F4KIX0), 
JMJ14_ARATH (Q8GUI6), JMJ15_ARATH (O64752), JMJ16_ARATH (C0SUT9), 
JMJ18_ARATH (F4I6G4), JMJ19_ARATH (Q8L7T6), JMJ2_SCHPO  (Q9US53), 
JMJ3_SCHPO  (O94691), KD5BB_DANRE (Q6IQX0), KDM4A_DROME (Q9V333), 
KDM4A_HUMAN (O75164), KDM4A_MOUSE (Q8BW72), KDM4A_PONAB (Q5RD88), 
KDM4B_DROME (Q9V6L0), KDM4B_HUMAN (O94953), KDM4B_MOUSE (Q91VY5), 
KDM4C_HUMAN (Q9H3R0), KDM4C_MOUSE (Q8VCD7), KDM4D_HUMAN (Q6B0I6), 
KDM4D_MOUSE (Q3U2K5), KDM4D_RAT   (A1A5Q5), KDM4E_HUMAN (B2RXH2), 
KDM4F_HUMAN (A0A1W2PPD8), KDM4_CAEEL  (Q9U297), KDM5A_HUMAN (P29375), 
KDM5A_MOUSE (Q3UXZ9), KDM5B_CHICK (Q5F3R2), KDM5B_HUMAN (Q9UGL1), 
KDM5B_MOUSE (Q80Y84), KDM5C_CANLF (Q38JA7), KDM5C_HUMAN (P41229), 
KDM5C_MOUSE (P41230), KDM5C_PIG   (A1YVX4), KDM5D_CANLF (Q30DN6), 
KDM5D_HUMAN (Q9BY66), KDM5D_MOUSE (Q62240), KDM5D_PANTR (Q5XUN4), 
KDM5_CAEBR  (Q61T02), KDM5_CAEEL  (Q23541), KDM5_DROME  (Q9VMJ7), 
LID2_SCHPO  (Q9HDV4), MSC1_SCHPO  (Q9UT79), REF6_ARATH  (Q9STM3), 
RPH1_YEAST  (P39956), SE14_ORYSJ  (Q10RP4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

471 PDB

2GP3; 2GP5; 2OQ6; 2OQ7; 2OS2; 2OT7; 2OX0; 2P5B; 2PXJ; 2Q8C; 2Q8D; 2Q8E; 2VD7; 2W2I; 2WWJ; 2XML; 2YBK; 2YBP; 2YBS; 3DXT; 3DXU; 3NJY; 3OPT; 3OPW; 3PDQ; 3RVH; 3U4S; 4AI9; 4BIS; 4D6Q; 4D6R; 4D6S; 4GD4; 4HON; 4HOO; 4IGO; 4IGP; 4IGQ; 4LXL; 4URA; 4V2V; 4V2W; 4XDO; 4XDP; 5A1F; 5A3N; 5A3P; 5A3T; 5A3W; 5A7N; 5A7O; 5A7P; 5A7Q; 5A7S; 5A7W; 5A80; 5ANQ; 5CEH; 5E6H; 5F2S; 5F2W; 5F32; 5F37; 5F39; 5F3C; 5F3E; 5F3G; 5F3I; 5F5A; 5F5C; 5F5I; 5FJH; 5FJK; 5FP4; 5FP7; 5FP8; 5FP9; 5FPA; 5FPB; 5FPL; 5FPU; 5FPV; 5FUN; 5FUP; 5FV3; 5FWE; 5FWJ; 5FY4; 5FY5; 5FY8; 5FY9; 5FYB; 5FYC; 5FYH; 5FYI; 5FYS; 5FYT; 5FYU; 5FYV; 5FYY; 5FYZ; 5FZ0; 5FZ1; 5FZ3; 5FZ4; 5FZ6; 5FZ7; 5FZ8; 5FZ9; 5FZA; 5FZB; 5FZC; 5FZD; 5FZE; 5FZF; 5FZG; 5FZH; 5FZI; 5FZK; 5FZL; 5FZM; 5ISL; 5IVB; 5IVC; 5IVE; 5IVF; 5IVJ; 5IVV; 5IVY; 5IW0; 5IWF; 5K4L; 5KR7; 5LW9; 5LWB; 5LY1; 5LY2; 5PH0; 5PH1; 5PH2; 5PH3; 5PH4; 5PH5; 5PH6; 5PH7; 5PH8; 5PH9; 5PHA; 5PHB; 5PHC; 5PHD; 5PHE; 5PHF; 5PHG; 5PHH; 5PHI; 5PHJ; 5PHK; 5PHL; 5PHM; 5PHN; 5PHO; 5PHP; 5PHQ; 5PHR; 5PHS; 5PHT; 5PHU; 5PHV; 5PHW; 5PHX; 5PHY; 5PHZ; 5PI0; 5PI1; 5PI2; 5PI3; 5PI4; 5PI5; 5PI6; 5PI7; 5PI8; 5PI9; 5PIA; 5PIB; 5PIC; 5PID; 5PIE; 5PIF; 5PIG; 5PIH; 5PII; 5PIJ; 5PIK; 5PIL; 5PIM; 5PIN; 5PIO; 5PIP; 5PIQ; 5PIR; 5PIS; 5PIT; 5PIU; 5PIV; 5PIW; 5PIX; 5PIY; 5PIZ; 5PJ0; 5PJ1; 5PJ2; 5PJ3; 5PJ4; 5PJ5; 5PJ6; 5PJ7; 5PJ8; 5PJ9; 5PJA; 5PJB; 5PJC; 5PJD; 5PJE; 5PJF; 5PJG; 5PJH; 5PJI; 5PJJ; 5PJK; 5PJL; 5PJM; 5PJN; 5PJO; 5PJP; 5PJQ; 5PJR; 5PJS; 5PJT; 5PJU; 5PJV; 5PJW; 5PJX; 5PJY; 5PJZ; 5PK0; 5PK1; 5PK2; 5PK3; 5PK4; 5PK5; 5PK6; 5PK7; 5PK8; 5PK9; 5PKA; 5PKB; 5PKC; 5PKD; 5PKE; 5PKF; 5PKG; 5PKH; 5PKI; 5PKJ; 5PKK; 5PKL; 5PKM; 5PKN; 5PKO; 5PKP; 5PKQ; 5PKR; 5PKS; 5PKT; 5PKU; 5PKV; 5PKW; 5PKX; 5PKY; 5PKZ; 5PL0; 5PL1; 5PL2; 5PL3; 5PL4; 5PL5; 5PL6; 5PL7; 5PL8; 5PL9; 5PLA; 5PLB; 5PLC; 5PLD; 5PLE; 5PLF; 5PLG; 5PLH; 5PLI; 5PLJ; 5PLK; 5PLL; 5PLM; 5PLN; 5PLO; 5PLP; 5PLQ; 5PLR; 5PLS; 5PLT; 5PLU; 5PLV; 5PLW; 5PLX; 5PLY; 5PLZ; 5PM0; 5PM1; 5PM2; 5PM3; 5PM4; 5PM5; 5PM6; 5PM7; 5PM8; 5PM9; 5PMA; 5PMB; 5PMC; 5PMD; 5PME; 5PMF; 5PMG; 5PMH; 5PMI; 5PMJ; 5PMK; 5PML; 5PMM; 5PMN; 5PMO; 5PMP; 5PMQ; 5PMR; 5PMS; 5PMT; 5PMU; 5PMV; 5PMW; 5PMX; 5PMY; 5PMZ; 5PN0; 5PN1; 5PN2; 5PN3; 5PN4; 5PN5; 5PN6; 5PN7; 5PN8; 5PN9; 5PNA; 5PNB; 5PNC; 5PND; 5PNE; 5PNF; 5PNG; 5PNH; 5PNI; 5PNJ; 5PNK; 5PNL; 5PNM; 5PNN; 5PNO; 5PNP; 5PNQ; 5PNR; 5PNS; 5PNU; 5PNV; 5PNW; 5TVR; 5TVS; 5V9P; 5V9T; 5VGI; 5VMP; 5YKN; 5YKO; 6BGU; 6BGV; 6BGW; 6BGX; 6BGY; 6BGZ; 6BH0; 6BH1; 6BH2; 6BH3; 6BH4; 6BH5; 6CG1; 6CG2; 6DQ4; 6DQ5; 6DQ6; 6DQ7; 6DQ8; 6DQ9; 6DQA; 6DQB; 6DQC; 6DQD; 6DQE; 6DQF; 6EIN; 6EIU; 6EIY; 6EJ0; 6EJ1; 6EK6; 6ETE; 6ETG; 6ETS; 6ETT; 6ETU; 6ETV; 6ETW; 6F5Q; 6F5R; 6F5S; 6F5T; 6G5W; 6G5X; 6H0W; 6H0X; 6H0Y; 6H0Z; 6H10; 6H11; 6H4O; 6H4P; 6H4Q; 6H4R; 6H4S; 6H4T; 6H4U; 6H4V; 6H4W; 6H4X; 6H4Y; 6H4Z; 6H50; 6H51; 6H52; 6H8P; 6HGT; 6IP0; 6IP4; 6RBI; 7DYG; 7DYQ; 7EQV; 7JM5; 7KSO; 8WD3; 8WUG
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