PROSITE entry PS51183

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
Direct ScanProsite submission

General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51183
Entry name [info]	JMJN
Accession [info]	PS51183
Entry type [info]	MATRIX
Date [info]	01-FEB-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51183
Associated ProRule [info]	PRU00537

Name and characterization of the entry

Description [info]

JmjN domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=42;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=38;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0609195; R2=0.0138589; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=2398.1782227; R2=1.2883356; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=465; H_SCORE=2997; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=321; H_SCORE=2812; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-9; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='I';  M= -2,-21, -8,-30,-25, -6,-30,-25, 26,-24,  7,  8,-13,-22,-20,-25,-12, -7, 20,-26, -9,-25;
/M: SY='P';  M= -9,-21,-34,-14, -4,-22,-22,-19,-10,-13,-14,-10,-21, 56, -9,-18,-12, -9,-17,-28,-23,-10;
/M: SY='V';  M= -1,-17,-15,-20,-14, -7,-24,-20,  9,-10,  1,  5,-16,-20,-14, -8, -3,  7, 20,-27,-10,-15;
/M: SY='F';  M=-14,-30,-20,-37,-29, 46,-32,-23, 15,-28, 16,  7,-23,-28,-33,-22,-19, -8, 14, -5, 15,-29;
/M: SY='R';  M=-12, -4,-26, -7,  1, -9,-22, -3,-10,  5, -9, -6,  0,-18,  0,  8, -8, -3,-12,-16,  5, -2;
/M: SY='P';  M= -9,-20,-34,-14, -4,-21,-22,-20,-12,-14,-14,-12,-20, 61,-12,-19,-11, -5,-21,-28,-23,-12;
/M: SY='T';  M=  3, -1,-15, -7, -4,-17,-15, -7,-17,  0,-18,-11,  2,-11, -3, -4, 15, 25, -7,-29,-10, -4;
/M: SY='M';  M= -8,-13,-30,-14, -2,-12,-14,-10,-10,  1,-10,  4,-13,-11, -2, -5,-14,-13,-12,  1, -1, -2;
/M: SY='E';  M= -5,  1,-27,  3, 24,-27,-17, -3,-23, 17,-20, -8, -1, -8, 18, 11, -1, -7,-21,-25,-14, 20;
/M: SY='E';  M=-11, 13,-30, 23, 54,-31,-19,  1,-30,  9,-21,-19,  2, -1, 21,  0,  0,-10,-30,-30,-19, 38;
/M: SY='F';  M=-18,-29,-20,-38,-28, 67,-29,-18,  4,-28, 15,  7,-21,-29,-35,-19,-21,-10,  2,  5, 25,-27;
/M: SY='K';  M= -1, -1,-23,  0,  4,-24,-16, -6,-19,  5,-20,-11, -2, -2,  2,  1,  3,  2,-12,-28,-14,  2;
/M: SY='D';  M=-17, 42,-27, 49, 13,-33, -8,  3,-34,  3,-29,-26, 29,-14,  1,  0,  2, -7,-29,-38,-19,  6;
/M: SY='P';  M=-11,-21,-31,-19,-11,  1,-15,-18,-13,-16,-15, -8,-17, 37,-18,-19,-11, -8,-18,-18,-12,-16;
/M: SY='L';  M= -9,-21,-25,-23,-11, -2,-27,-13, 14,-18, 17, 15,-19,-15, -7,-16,-16, -8,  4,-19,  0,-11;
/M: SY='D';  M= -4,  1,-24,  3,  2,-21, -3, -8,-19, -1,-17,-12,  0,-14,  0, -6,  2, -5,-16,-24,-10,  0;
/M: SY='Y';  M=-20,-25,-25,-29,-25, 53,-30,  2,  0,-19,  5,  0,-20,-30,-24,-15,-20,-10, -5, 21, 57,-25;
/M: SY='I';  M=-12,-28,-19,-37,-28,  9,-37,-24, 34,-28, 16, 14,-21,-24,-21,-27,-20,-10, 20,-15,  8,-28;
/M: SY='E';  M= -4,  6,-25, 12, 30,-27,-14, -5,-27, 11,-23,-18,  3, -6, 11,  5,  6, -3,-22,-30,-18, 20;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='R';  M= -5, -9,-24, -9,  1,-17,-19, -5,-14,  9, -9, -4, -5,-16,  1, 10, -5, -5,-10,-24, -9, -1;
/M: SY='I';  M= -9,-26,-24,-30,-22,  5,-34,-19, 29,-22, 16, 12,-22,-24,-18,-21,-18, -8, 22,-14, 10,-23;
/M: SY='E';  M= -8, 10,-24,  9, 15,-24,-14, -3,-25, 10,-22,-16, 11,-12,  6, 15,  4,  1,-21,-29,-16,  9;
/M: SY='Q';  M= -9,  1,-29,  5,  7,-26,-17, -1,-23, 10,-23,-12, -1, -1, 15,  9, -2, -7,-23,-22, -8, 10;
/M: SY='M';  M=-10,-14,-24,-19,-12, -2,-20,-10,  2, -9,  6,  7,-10,-21, -5, -6,-12, -5, -3,-17,  1,-10;
/M: SY='G';  M= 20,-11,-21,-15,-17,-25, 37,-21,-25,-16,-20,-15, -5,-17,-17,-20,  3,-11,-14,-21,-25,-17;
/M: SY='E';  M= -5, -7,-24, -7,  7,-18,-14, -4,-13,  2,-10, -3, -6,-14,  1,  1, -4, -7,-10,-25,-12,  3;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='K';  M= -9, -4,-27, -3,  7,-25,-19,-11,-23, 31,-24,-10, -3, -8,  5, 22, -5, -7,-14,-24,-12,  5;
/M: SY='Y';  M= -4,-11,-22,-14,-14, 13,-18,  6, -7,-11, -9, -7, -7,-23, -9,-11, -1, -2, -9,  3, 37,-14;
/M: SY='G';  M=  0,-10,-30,-10,-20,-30, 70,-20,-40,-20,-30,-20,  0,-20,-20,-20,  0,-20,-30,-20,-30,-20;
/M: SY='I';  M=  5,-23, -7,-31,-23, -6,-25,-22, 20,-21, 10, 14,-19,-21,-16,-23,-12, -7, 16,-24, -8,-21;
/M: SY='C';  M=  1,-24, 33,-30,-27, -9,-27,-28,  5,-24,  1, -1,-23,-30,-26,-24,-10, -5, 18,-34,-17,-27;
/M: SY='K';  M=-12, -3,-23, -4,  6,-27,-20, -9,-30, 42,-27,-10, -1,-14,  8, 36,-10,-10,-20,-21,-11,  6;
/M: SY='V';  M= -5,-30,-18,-34,-29,  1,-34,-29, 36,-25, 18, 15,-26,-26,-25,-24,-16, -5, 39,-25, -5,-29;
/M: SY='I';  M= -7,-26,-22,-31,-24, -4,-33,-26, 30,-15,  9, 11,-21,-23,-19,-14,-15, -6, 30,-24, -5,-24;
/M: SY='P';  M= -7,-20,-36,-14, -4,-26,-21,-19,-13, -9,-23,-15,-18, 65, -9,-14,-10, -9,-22,-28,-25,-11;
/M: SY='P';  M=-10,-21,-39,-13, -3,-27,-22,-21,-13,-12,-25,-16,-20, 80,-11,-21,-11,-10,-24,-29,-27,-12;
/M: SY='P';  M=  0, -2,-25,  2,  6,-25,-13,-13,-18, -3,-23,-17, -3, 21, -4,-11,  3, -3,-16,-31,-22, -1;
/M: SY='D';  M= -3, 11,-23, 14,  9,-20,  4, -8,-27, -7,-23,-20,  9,-12, -4,-11,  7, -5,-21,-29,-18,  3;
/M: SY='W';  M=-12,-34,-37,-37,-28, 20,-21,-27,-11,-21,-11,-13,-32,-28,-24,-20,-29,-21,-15, 92, 22,-22;
/M: SY='K';  M=-10,  0,-16,  0,  1,-22,-18, -9,-21, 13,-15, -9,  0,-16,  3, 12, -4, -3,-15,-27,-12,  1;
/M: SY='P';  M=-10,-10,-21, -7,  2,-27,-19,-15,-21,  0,-26,-15, -9, 43, -5,-10, -8, -9,-25,-30,-24, -5;
/M: SY='P';  M=-12,-14,-33, -9,  5,-17,-22,-12,-19,  0,-18,-12,-13, 33, -1, -1,-10,-10,-23,-23,-16,  0;
/I:         E1=0; IE=-105; DE=-105;

» more

Post-processing [info]

PROMOTED_BY

PS51184

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	57 in 57 different sequences
Number of true positive hits	57 in 57 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	JmjN
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

57 sequences

ECM5_YEAST  (Q03214), ELF6_ARATH  (Q6BDA0), GIS1_YEAST  (Q03833),

JARD2_CHICK (Q5F363), JARD2_DANRE (Q1LVC2), JARD2_DROME (Q9VT00), 
JARD2_HUMAN (Q92833), JARD2_MOUSE (Q62315), JHD2_YEAST  (P47156), 
JM703_ORYSJ (Q53WJ1), JM705_ORYSJ (Q5N712), JM706_ORYSJ (Q336N8), 
JMJ13_ARATH (F4KIX0), JMJ14_ARATH (Q8GUI6), JMJ15_ARATH (O64752), 
JMJ16_ARATH (C0SUT9), JMJ18_ARATH (F4I6G4), JMJ19_ARATH (Q8L7T6), 
JMJ2_SCHPO  (Q9US53), JMJ3_SCHPO  (O94691), KD5BB_DANRE (Q6IQX0), 
KDM4A_DROME (Q9V333), KDM4A_HUMAN (O75164), KDM4A_MOUSE (Q8BW72), 
KDM4A_PONAB (Q5RD88), KDM4B_DROME (Q9V6L0), KDM4B_HUMAN (O94953), 
KDM4B_MOUSE (Q91VY5), KDM4C_HUMAN (Q9H3R0), KDM4C_MOUSE (Q8VCD7), 
KDM4D_HUMAN (Q6B0I6), KDM4D_MOUSE (Q3U2K5), KDM4D_RAT   (A1A5Q5), 
KDM4E_HUMAN (B2RXH2), KDM4F_HUMAN (A0A1W2PPD8), KDM4_CAEEL  (Q9U297), 
KDM5A_HUMAN (P29375), KDM5A_MOUSE (Q3UXZ9), KDM5B_CHICK (Q5F3R2), 
KDM5B_HUMAN (Q9UGL1), KDM5B_MOUSE (Q80Y84), KDM5C_CANLF (Q38JA7), 
KDM5C_HUMAN (P41229), KDM5C_MOUSE (P41230), KDM5C_PIG   (A1YVX4), 
KDM5D_CANLF (Q30DN6), KDM5D_HUMAN (Q9BY66), KDM5D_MOUSE (Q62240), 
KDM5D_PANTR (Q5XUN4), KDM5_CAEBR  (Q61T02), KDM5_CAEEL  (Q23541), 
KDM5_DROME  (Q9VMJ7), LID2_SCHPO  (Q9HDV4), MSC1_SCHPO  (Q9UT79), 
REF6_ARATH  (Q9STM3), RPH1_YEAST  (P39956), SE14_ORYSJ  (Q10RP4)

» more

Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

473 PDB

2GP3; 2GP5; 2OQ6; 2OQ7; 2OS2; 2OT7; 2OX0; 2P5B; 2PXJ; 2Q8C; 2Q8D; 2Q8E; 2VD7; 2W2I; 2WWJ; 2XML; 2YBK; 2YBP; 2YBS; 3DXT; 3DXU; 3NJY; 3OPT; 3OPW; 3PDQ; 3RVH; 3U4S; 4AI9; 4BIS; 4D6Q; 4D6R; 4D6S; 4GD4; 4HON; 4HOO; 4IGO; 4IGP; 4IGQ; 4LXL; 4URA; 4V2V; 4V2W; 4XDO; 4XDP; 5A1F; 5A3N; 5A3P; 5A3T; 5A3W; 5A7N; 5A7O; 5A7P; 5A7Q; 5A7S; 5A7W; 5A80; 5ANQ; 5CEH; 5E6H; 5F2S; 5F2W; 5F32; 5F37; 5F39; 5F3C; 5F3E; 5F3G; 5F3I; 5F5A; 5F5C; 5F5I; 5FJH; 5FJK; 5FP4; 5FP7; 5FP8; 5FP9; 5FPA; 5FPB; 5FPL; 5FPU; 5FPV; 5FUN; 5FUP; 5FV3; 5FWE; 5FWJ; 5FY4; 5FY5; 5FY8; 5FY9; 5FYB; 5FYC; 5FYH; 5FYI; 5FYS; 5FYT; 5FYU; 5FYV; 5FYY; 5FYZ; 5FZ0; 5FZ1; 5FZ3; 5FZ4; 5FZ6; 5FZ7; 5FZ8; 5FZ9; 5FZA; 5FZB; 5FZC; 5FZD; 5FZE; 5FZF; 5FZG; 5FZH; 5FZI; 5FZK; 5FZL; 5FZM; 5ISL; 5IVB; 5IVC; 5IVE; 5IVF; 5IVJ; 5IVV; 5IVY; 5IW0; 5IWF; 5K4L; 5KR7; 5LW9; 5LWB; 5LY1; 5LY2; 5PH0; 5PH1; 5PH2; 5PH3; 5PH4; 5PH5; 5PH6; 5PH7; 5PH8; 5PH9; 5PHA; 5PHB; 5PHC; 5PHD; 5PHE; 5PHF; 5PHG; 5PHH; 5PHI; 5PHJ; 5PHK; 5PHL; 5PHM; 5PHN; 5PHO; 5PHP; 5PHQ; 5PHR; 5PHS; 5PHT; 5PHU; 5PHV; 5PHW; 5PHX; 5PHY; 5PHZ; 5PI0; 5PI1; 5PI2; 5PI3; 5PI4; 5PI5; 5PI6; 5PI7; 5PI8; 5PI9; 5PIA; 5PIB; 5PIC; 5PID; 5PIE; 5PIF; 5PIG; 5PIH; 5PII; 5PIJ; 5PIK; 5PIL; 5PIM; 5PIN; 5PIO; 5PIP; 5PIQ; 5PIR; 5PIS; 5PIT; 5PIU; 5PIV; 5PIW; 5PIX; 5PIY; 5PIZ; 5PJ0; 5PJ1; 5PJ2; 5PJ3; 5PJ4; 5PJ5; 5PJ6; 5PJ7; 5PJ8; 5PJ9; 5PJA; 5PJB; 5PJC; 5PJD; 5PJE; 5PJF; 5PJG; 5PJH; 5PJI; 5PJJ; 5PJK; 5PJL; 5PJM; 5PJN; 5PJO; 5PJP; 5PJQ; 5PJR; 5PJS; 5PJT; 5PJU; 5PJV; 5PJW; 5PJX; 5PJY; 5PJZ; 5PK0; 5PK1; 5PK2; 5PK3; 5PK4; 5PK5; 5PK6; 5PK7; 5PK8; 5PK9; 5PKA; 5PKB; 5PKC; 5PKD; 5PKE; 5PKF; 5PKG; 5PKH; 5PKI; 5PKJ; 5PKK; 5PKL; 5PKM; 5PKN; 5PKO; 5PKP; 5PKQ; 5PKR; 5PKS; 5PKT; 5PKU; 5PKV; 5PKW; 5PKX; 5PKY; 5PKZ; 5PL0; 5PL1; 5PL2; 5PL3; 5PL4; 5PL5; 5PL6; 5PL7; 5PL8; 5PL9; 5PLA; 5PLB; 5PLC; 5PLD; 5PLE; 5PLF; 5PLG; 5PLH; 5PLI; 5PLJ; 5PLK; 5PLL; 5PLM; 5PLN; 5PLO; 5PLP; 5PLQ; 5PLR; 5PLS; 5PLT; 5PLU; 5PLV; 5PLW; 5PLX; 5PLY; 5PLZ; 5PM0; 5PM1; 5PM2; 5PM3; 5PM4; 5PM5; 5PM6; 5PM7; 5PM8; 5PM9; 5PMA; 5PMB; 5PMC; 5PMD; 5PME; 5PMF; 5PMG; 5PMH; 5PMI; 5PMJ; 5PMK; 5PML; 5PMM; 5PMN; 5PMO; 5PMP; 5PMQ; 5PMR; 5PMS; 5PMT; 5PMU; 5PMV; 5PMW; 5PMX; 5PMY; 5PMZ; 5PN0; 5PN1; 5PN2; 5PN3; 5PN4; 5PN5; 5PN6; 5PN7; 5PN8; 5PN9; 5PNA; 5PNB; 5PNC; 5PND; 5PNE; 5PNF; 5PNG; 5PNH; 5PNI; 5PNJ; 5PNK; 5PNL; 5PNM; 5PNN; 5PNO; 5PNP; 5PNQ; 5PNR; 5PNS; 5PNU; 5PNV; 5PNW; 5TVR; 5TVS; 5V9P; 5V9T; 5VGI; 5VMP; 5YKN; 5YKO; 6BGU; 6BGV; 6BGW; 6BGX; 6BGY; 6BGZ; 6BH0; 6BH1; 6BH2; 6BH3; 6BH4; 6BH5; 6CG1; 6CG2; 6DQ4; 6DQ5; 6DQ6; 6DQ7; 6DQ8; 6DQ9; 6DQA; 6DQB; 6DQC; 6DQD; 6DQE; 6DQF; 6EIN; 6EIU; 6EIY; 6EJ0; 6EJ1; 6EK6; 6ETE; 6ETG; 6ETS; 6ETT; 6ETU; 6ETV; 6ETW; 6F5Q; 6F5R; 6F5S; 6F5T; 6G5W; 6G5X; 6H0W; 6H0X; 6H0Y; 6H0Z; 6H10; 6H11; 6H4O; 6H4P; 6H4Q; 6H4R; 6H4S; 6H4T; 6H4U; 6H4V; 6H4W; 6H4X; 6H4Y; 6H4Z; 6H50; 6H51; 6H52; 6H8P; 6HGT; 6IP0; 6IP4; 6RBI; 7DYG; 7DYQ; 7EQV; 7JM5; 7KSO; 8WD3; 8WUG; 9GLE; 9GP1
» more