We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS51190

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PURL: https://purl.expasy.org/prosite/signature/PS51190

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General information about the entry

Entry name [info]	FATC
Accession [info]	PS51190
Entry type [info]	MATRIX
Date [info]	01-MAR-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51189
Associated ProRule [info]	PRU00535

Name and characterization of the entry

Description [info]

FATC domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4131293; R2=0.0067563; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3606.0351562; R2=0.1685185; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1123; H_SCORE=3795; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=605; H_SCORE=3708; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-42; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -18, -95,  13,  37, -27,   0, -15, -27,  10,   6, -57,  24, -28,  19,  10, -10,  21, -24,-104, -52;
/M: SY='P';  M=   0, -68,   3,  -9, -32,   9, -89, -99,   4, -32,  -7,  36,  69, -36, -15,   1,   9,  -4,-106, -58;
/M: SY='L';  M= -96, -92, -43, -47, -32, -72, -22, -23, -48,  74,  38, -96, -43,  15, -38, -13,  -9,  -2,-103, -36;
/M: SY='S';  M= -76, -98,  23, -90, -99,  -9, -90, -57, -69, -61,-106,  33,  25,  -1, -19,  81,   1,   8,-111, -99;
/M: SY='V';  M=   5,   6, -94,  13, -94, -47, -97,  25, -25, -60, -96, -28,  10, -98, -39, -50,   1,  77,-110, -93;
/M: SY='E';  M= -27, -31,  14,  63,-106, -48,  25, -32,   2, -97, -44,  45,  32,   4, -13,   7,  13,-103,-106, -46;
/M: SY='Q';  M=  12, -98,  25,  25,-104,  38, -47, -39, -29, -46,-100, -15, -93,  59, -19,  20,   6, -22,-101, -46;
/M: SY='Q';  M= -68, -16, -41, -39,   0, -66,  35, -19, -15, -50, -99, -92, -93, 113, -48, -16,  22, -80, -99,   3;
/M: SY='V';  M=  -1,   2, -97,-103, -89, -53,-101,  36,-100, -34, -93, -96,-107,-104, -96, -92, -17,  93,-111, -90;
/M: SY='D';  M= -29, -94,  53,  37,-102, -47,  -9,   2, -40,  -8,-100,  51, -96,  36,   5,  30, -94, -58,-108, -98;
/I:         I=-10; MD=-22;
/M: SY='D';  M= -33,  23,  43,  40, -25,-102,   2, -52,  25, -23,  18, -93, -95,   3,  35,  -5,  -6, -29,-102,   0; D=-10;
/I:         I=-10; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='L';  M= -27,  15, -93, -93, -32,-103, -93, -25,-100,  90, -85, -98,-106, -99, -98, -97, -93, -29,-102, -30;
/M: SY='I';  M= -94, -95,-105,-103, -88, -99, -96, 102,-101,   8, -14, -49,-106,-101,-101, -93, -38,  20,-108, -90;
/M: SY='Q';  M=  14, -97,  19,  23, -67, -51,  20, -28,  23, -77, -62,   1, -93,  69,  12,  40, -80, -43,-106, -98;
/M: SY='Q';  M=  -5,   4,   6,  66,-107,-100,  20, -74, -21, -33, -17, -60, -91,  85, -12,   5, -51, -59,-102, -97;
/M: SY='A';  M=  99,-100, -84, -89,-100, -92, -95, -97, -90,-100, -94, -90, -96, -85, -91,  33, -88, -89,-119,-113;
/M: SY='T';  M= -38,  -6, -92, -95, -99,-100, -95,   2,  -7, -59,  24, -26, -96,  -7, -56,  11,  94,  25,-115, -95;
/M: SY='D';  M= -25, -44,  76, -87,-103, -92, -92,-103, -30, -81,-106,  71, -98, -93, -11,  69, -89,-102,-117,-103;
/M: SY='P';  M= -39, -99, -24,  -2,-100, -97,  22,  12,  -8,   0,-101, -17,  85, -94, -94,  12,   0,  26,-109, -95;
/M: SY='E';  M= -75, -93,  47,  70,-107, -99,   1,-107,  13, -59, -49,  22, -55,  14,  48,  -5, -30, -59,-104, -97;
/M: SY='N';  M= -94, -92, -83, -91, -95, -93,  -4, -27, -34,  -9, -96, 120,-106, -37, -16, -47, -89, -45,-124, -35;
/M: SY='L';  M=-101, -89, -93, -93, -79,-103, -92, -13,-100,  93, -84, -98,-106, -99, -99, -98, -92, -35,-102,  -6;
/M: SY='C';  M=  63,  98, -90, -88,-101,   7, -27, -99, -57, -98,-101, -91, -98, -93, -93,  55, -27, -71,-107,-111;
/M: SY='Q';  M=   0, -17, -74,   0,-100,-101, -31, -56,  15, -18,   0, -47, -44,  85,  50,  -4, -18,   5,-102, -93;
/M: SY='M';  M=  -7,  43, -98, -92, -98, -57,  30,  -2, -88,   3, 122, -43,-106, -95, -92, -14,  21, -37,-108, -94;
/M: SY='Y';  M=-106,-107,  50, -59,  61, -60, -92,-100, -31, -53,-103,-102, -13, -98, -87, -95,-102, -58,  72, 106;
/I:         I=-9; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='P';  M=   1,  24, -63,  17,  -5, -44, -31,  49, -54, -19, -21, -42,  55,  14, -56, -19, -39,  22,-105, -95;
/M: SY='G';  M= -18,-104, -91, -66,-103,  91, -97, -98, -95, -10,-102, -43, -94, -99, -97, -16,  24,-103,  56,-100;
/M: SY='W';  M=-117, -92,-109, -93,  13, -86,-107,-107, -67, -98,-109,-127,-103, -97, -88, -73,-120, -76, 177,  19;
/M: SY='M';  M=   3,  80, -67, -17,-100, -21,  57, -67, -50, -19,  92, -92,-100,  18, -62,  17,   1, -75,-102,   6;
/M: SY='P';  M=  48,-104, -89, -85,-109, -79, -84,-105, -61,-105,-111,-100, 112, -38, -92,  16, -92,-104,-109,-105;
/M: SY='W';  M= -69, -97,-108, -98,  74, -94, -24,-100, -99, -30, -60, -63,-105, -57, -88, -99, -33,-100, 151,  59;
/M: SY='W';  M= -69, -28,-101, -96,  39, -98, -49,  11, -98,  47,  43, -60,-107, -58, -93, -98, -54,   9, 118,  22;
/I:         E1=0; IE=-105; DE=-105;

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Post-processing [info]

PROMOTED_BY

PS51189

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	73 in 72 different sequences
Number of true positive hits	73 in 72 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	FATC
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

72 sequences

ATM_ARATH   (Q9M3G7), ATM_ASPFU   (Q4WVM7), ATM_ASPOR   (Q2U639),

ATM_CAEEL   (Q9N3Q4), ATM_CANAL   (Q5ABX0), ATM_CANGA   (Q6FRZ9), 
ATM_CRYNB   (P0CP61), ATM_CRYNJ   (P0CP60), ATM_DEBHA   (Q6BV76), 
ATM_DROME   (Q5EAK6), ATM_EMENI   (Q5BHE2), ATM_EREGS   (Q751J3), 
ATM_GIBZE   (Q4IB89), ATM_HUMAN   (Q13315), ATM_KLULA   (Q6CP76), 
ATM_MOUSE   (Q62388), ATM_NEUCR   (Q7RZT9), ATM_PIG (Q6PQD5), 
ATM_SCHPO   (O74630), ATM_YARLI   (Q6CAD2), ATM_YEAST   (P38110), 
ATR1_DICDI  (Q54ER4), ATR_ARATH   (Q9FKS4), ATR_CAEEL   (Q22258), 
ATR_CANAL   (Q59LR2), ATR_CANGA   (Q6FX42), ATR_DROME   (Q9VXG8), 
ATR_ENCCU   (Q8SSE7), ATR_EREGS   (Q75DB8), ATR_HUMAN   (Q13535), 
ATR_KLULA   (Q6CT34), ATR_MOUSE   (Q9JKK8), ATR_ORYSI   (A2YH41), 
ATR_ORYSJ   (Q5Z987), ATR_XENLA   (Q9DE14), ATR_YEAST   (P38111), 
MTOR_HUMAN  (P42345), MTOR_MOUSE  (Q9JLN9), MTOR_RAT(P42346), 
PRKDC_CANLF (Q8WN22), PRKDC_CHICK (Q8QGX4), PRKDC_DICDI (Q54UC0), 
PRKDC_HUMAN (P78527), PRKDC_MOUSE (P97313), PRKDC_XENLA (Q9DEI1), 
RAD3_SCHPO  (Q02099), SMG1_CAEBR  (Q61CW2), SMG1_CAEEL  (O01510), 
SMG1_DANRE  (C5J7W8), SMG1_DICDI  (Q553E9), SMG1_DROME  (Q70PP2), 
SMG1_HUMAN  (Q96Q15), SMG1_MOUSE  (Q8BKX6), TOR1_SCHPO  (O14356), 
TOR1_YEAST  (P35169), TOR2_SCHPO  (Q9Y7K2), TOR2_YEAST  (P32600), 
TOR_ARATH   (Q9FR53), TOR_CAEEL   (Q95Q95), TOR_DICDI   (Q86C65), 
TOR_DROME   (Q9VK45), TOR_ORYSJ   (Q0DJS1), TRA1_DICDI  (Q54T85), 
TRA1_DROME  (Q8I8U7), TRA1_SCHPO  (Q9HFE8), TRA1_YEAST  (P38811), 
TRA2_SCHPO  (Q10064), TRR1_CAEBR  (A8WTE8), TRR1_CAEEL  (G5EEV2), 
TRRAP_DANRE (A0A0R4ITC5), TRRAP_HUMAN (Q9Y4A5), TRRAP_MOUSE (Q80YV3)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

129 PDB

pdb_00001w1n; pdb_00002kio; pdb_00002kit; pdb_00003jbz; pdb_00004jsn; pdb_00004jsp; pdb_00004jsv; pdb_00004jsx; pdb_00004jt5; pdb_00004jt6; pdb_00005flc; pdb_00005h64; pdb_00005luq; pdb_00005np0; pdb_00005np1; pdb_00005ojs; pdb_00005w1r; pdb_00005wbu; pdb_00005wby; pdb_00005x6o; pdb_00005y3r; pdb_00005y81; pdb_00005yz0; pdb_00005zcs; pdb_00006bcu; pdb_00006bcx; pdb_00006emk; pdb_00006hka; pdb_00006ig9; pdb_00006jxa; pdb_00006jxc; pdb_00006k9k; pdb_00006k9l; pdb_00006l53; pdb_00006l54; pdb_00006s8f; pdb_00006sb0; pdb_00006sb2; pdb_00006syt; pdb_00006t9i; pdb_00006t9j; pdb_00006z2w; pdb_00006z2x; pdb_00006z3a; pdb_00006z3r; pdb_00006zfp; pdb_00006zh2; pdb_00006zh4; pdb_00006zh6; pdb_00006zh8; pdb_00006zha; pdb_00006zhe; pdb_00006zwm; pdb_00006zwo; pdb_00007k0y; pdb_00007k10; pdb_00007k11; pdb_00007k19; pdb_00007k1b; pdb_00007k1j; pdb_00007k1k; pdb_00007k1n; pdb_00007ktr; pdb_00007lt3; pdb_00007nfc; pdb_00007nfe; pdb_00007ni4; pdb_00007ni5; pdb_00007ni6; pdb_00007otm; pdb_00007otp; pdb_00007otv; pdb_00007otw; pdb_00007oty; pdb_00007owg; pdb_00007pe7; pdb_00007pe8; pdb_00007pe9; pdb_00007pea; pdb_00007peb; pdb_00007pec; pdb_00007pqh; pdb_00007pw4; pdb_00007pw5; pdb_00007pw6; pdb_00007pw7; pdb_00007pw8; pdb_00007pw9; pdb_00007sgl; pdb_00007sic; pdb_00007sid; pdb_00007su3; pdb_00007sud; pdb_00007tyr; pdb_00007tzo; pdb_00007uxc; pdb_00007uxh; pdb_00007vvy; pdb_00007vvz; pdb_00007wzr; pdb_00007wzw; pdb_00007yfn; pdb_00007yfp; pdb_00007z87; pdb_00007z88; pdb_00008bh3; pdb_00008bhv; pdb_00008bhy; pdb_00008bot; pdb_00008era; pdb_00008esc; pdb_00008ez9; pdb_00008eza; pdb_00008ezb; pdb_00008h7g; pdb_00008oxm; pdb_00008oxo; pdb_00008oxp; pdb_00008oxq; pdb_00008qri; pdb_00008rch; pdb_00008rck; pdb_00008rcn; pdb_00008rd4; pdb_00008xvg; pdb_00008xvv; pdb_00009c47; pdb_00009f44; pdb_00009f45
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