PROSITE entry PS51190

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PURL: https://purl.expasy.org/prosite/signature/PS51190

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General information about the entry

Entry name [info]	FATC
Accession [info]	PS51190
Entry type [info]	MATRIX
Date [info]	01-MAR-2006 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51189
Associated ProRule [info]	PRU00535

Name and characterization of the entry

Description [info]

FATC domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=33;
/DISJOINT: DEFINITION=PROTECT; N1=4; N2=30;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4131293; R2=0.0067563; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=3606.0351562; R2=0.1685185; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1123; H_SCORE=3795; N_SCORE=10.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=605; H_SCORE=3708; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-42; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-105; BD=-105;
/M: SY='E';  M= -18, -95,  13,  37, -27,   0, -15, -27,  10,   6, -57,  24, -28,  19,  10, -10,  21, -24,-104, -52;
/M: SY='P';  M=   0, -68,   3,  -9, -32,   9, -89, -99,   4, -32,  -7,  36,  69, -36, -15,   1,   9,  -4,-106, -58;
/M: SY='L';  M= -96, -92, -43, -47, -32, -72, -22, -23, -48,  74,  38, -96, -43,  15, -38, -13,  -9,  -2,-103, -36;
/M: SY='S';  M= -76, -98,  23, -90, -99,  -9, -90, -57, -69, -61,-106,  33,  25,  -1, -19,  81,   1,   8,-111, -99;
/M: SY='V';  M=   5,   6, -94,  13, -94, -47, -97,  25, -25, -60, -96, -28,  10, -98, -39, -50,   1,  77,-110, -93;
/M: SY='E';  M= -27, -31,  14,  63,-106, -48,  25, -32,   2, -97, -44,  45,  32,   4, -13,   7,  13,-103,-106, -46;
/M: SY='Q';  M=  12, -98,  25,  25,-104,  38, -47, -39, -29, -46,-100, -15, -93,  59, -19,  20,   6, -22,-101, -46;
/M: SY='Q';  M= -68, -16, -41, -39,   0, -66,  35, -19, -15, -50, -99, -92, -93, 113, -48, -16,  22, -80, -99,   3;
/M: SY='V';  M=  -1,   2, -97,-103, -89, -53,-101,  36,-100, -34, -93, -96,-107,-104, -96, -92, -17,  93,-111, -90;
/M: SY='D';  M= -29, -94,  53,  37,-102, -47,  -9,   2, -40,  -8,-100,  51, -96,  36,   5,  30, -94, -58,-108, -98;
/I:         I=-10; MD=-22;
/M: SY='D';  M= -33,  23,  43,  40, -25,-102,   2, -52,  25, -23,  18, -93, -95,   3,  35,  -5,  -6, -29,-102,   0; D=-10;
/I:         I=-10; MI=0; MD=-22; IM=0; DM=-22;
/M: SY='L';  M= -27,  15, -93, -93, -32,-103, -93, -25,-100,  90, -85, -98,-106, -99, -98, -97, -93, -29,-102, -30;
/M: SY='I';  M= -94, -95,-105,-103, -88, -99, -96, 102,-101,   8, -14, -49,-106,-101,-101, -93, -38,  20,-108, -90;
/M: SY='Q';  M=  14, -97,  19,  23, -67, -51,  20, -28,  23, -77, -62,   1, -93,  69,  12,  40, -80, -43,-106, -98;
/M: SY='Q';  M=  -5,   4,   6,  66,-107,-100,  20, -74, -21, -33, -17, -60, -91,  85, -12,   5, -51, -59,-102, -97;
/M: SY='A';  M=  99,-100, -84, -89,-100, -92, -95, -97, -90,-100, -94, -90, -96, -85, -91,  33, -88, -89,-119,-113;
/M: SY='T';  M= -38,  -6, -92, -95, -99,-100, -95,   2,  -7, -59,  24, -26, -96,  -7, -56,  11,  94,  25,-115, -95;
/M: SY='D';  M= -25, -44,  76, -87,-103, -92, -92,-103, -30, -81,-106,  71, -98, -93, -11,  69, -89,-102,-117,-103;
/M: SY='P';  M= -39, -99, -24,  -2,-100, -97,  22,  12,  -8,   0,-101, -17,  85, -94, -94,  12,   0,  26,-109, -95;
/M: SY='E';  M= -75, -93,  47,  70,-107, -99,   1,-107,  13, -59, -49,  22, -55,  14,  48,  -5, -30, -59,-104, -97;
/M: SY='N';  M= -94, -92, -83, -91, -95, -93,  -4, -27, -34,  -9, -96, 120,-106, -37, -16, -47, -89, -45,-124, -35;
/M: SY='L';  M=-101, -89, -93, -93, -79,-103, -92, -13,-100,  93, -84, -98,-106, -99, -99, -98, -92, -35,-102,  -6;
/M: SY='C';  M=  63,  98, -90, -88,-101,   7, -27, -99, -57, -98,-101, -91, -98, -93, -93,  55, -27, -71,-107,-111;
/M: SY='Q';  M=   0, -17, -74,   0,-100,-101, -31, -56,  15, -18,   0, -47, -44,  85,  50,  -4, -18,   5,-102, -93;
/M: SY='M';  M=  -7,  43, -98, -92, -98, -57,  30,  -2, -88,   3, 122, -43,-106, -95, -92, -14,  21, -37,-108, -94;
/M: SY='Y';  M=-106,-107,  50, -59,  61, -60, -92,-100, -31, -53,-103,-102, -13, -98, -87, -95,-102, -58,  72, 106;
/I:         I=-9; MI=0; MD=-18; IM=0; DM=-18;
/M: SY='P';  M=   1,  24, -63,  17,  -5, -44, -31,  49, -54, -19, -21, -42,  55,  14, -56, -19, -39,  22,-105, -95;
/M: SY='G';  M= -18,-104, -91, -66,-103,  91, -97, -98, -95, -10,-102, -43, -94, -99, -97, -16,  24,-103,  56,-100;
/M: SY='W';  M=-117, -92,-109, -93,  13, -86,-107,-107, -67, -98,-109,-127,-103, -97, -88, -73,-120, -76, 177,  19;
/M: SY='M';  M=   3,  80, -67, -17,-100, -21,  57, -67, -50, -19,  92, -92,-100,  18, -62,  17,   1, -75,-102,   6;
/M: SY='P';  M=  48,-104, -89, -85,-109, -79, -84,-105, -61,-105,-111,-100, 112, -38, -92,  16, -92,-104,-109,-105;
/M: SY='W';  M= -69, -97,-108, -98,  74, -94, -24,-100, -99, -30, -60, -63,-105, -57, -88, -99, -33,-100, 151,  59;
/M: SY='W';  M= -69, -28,-101, -96,  39, -98, -49,  11, -98,  47,  43, -60,-107, -58, -93, -98, -54,   9, 118,  22;
/I:         E1=0; IE=-105; DE=-105;

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Post-processing [info]

PROMOTED_BY

PS51189

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	73 in 72 different sequences
Number of true positive hits	73 in 72 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	2
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	FATC
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

72 sequences

ATM_ARATH   (Q9M3G7), ATM_ASPFU   (Q4WVM7), ATM_ASPOR   (Q2U639),

ATM_CAEEL   (Q9N3Q4), ATM_CANAL   (Q5ABX0), ATM_CANGA   (Q6FRZ9), 
ATM_CRYNB   (P0CP61), ATM_CRYNJ   (P0CP60), ATM_DEBHA   (Q6BV76), 
ATM_DROME   (Q5EAK6), ATM_EMENI   (Q5BHE2), ATM_EREGS   (Q751J3), 
ATM_GIBZE   (Q4IB89), ATM_HUMAN   (Q13315), ATM_KLULA   (Q6CP76), 
ATM_MOUSE   (Q62388), ATM_NEUCR   (Q7RZT9), ATM_PIG (Q6PQD5), 
ATM_SCHPO   (O74630), ATM_YARLI   (Q6CAD2), ATM_YEAST   (P38110), 
ATR1_DICDI  (Q54ER4), ATR_ARATH   (Q9FKS4), ATR_CAEEL   (Q22258), 
ATR_CANAL   (Q59LR2), ATR_CANGA   (Q6FX42), ATR_DROME   (Q9VXG8), 
ATR_ENCCU   (Q8SSE7), ATR_EREGS   (Q75DB8), ATR_HUMAN   (Q13535), 
ATR_KLULA   (Q6CT34), ATR_MOUSE   (Q9JKK8), ATR_ORYSI   (A2YH41), 
ATR_ORYSJ   (Q5Z987), ATR_XENLA   (Q9DE14), ATR_YEAST   (P38111), 
MTOR_HUMAN  (P42345), MTOR_MOUSE  (Q9JLN9), MTOR_RAT(P42346), 
PRKDC_CANLF (Q8WN22), PRKDC_CHICK (Q8QGX4), PRKDC_DICDI (Q54UC0), 
PRKDC_HUMAN (P78527), PRKDC_MOUSE (P97313), PRKDC_XENLA (Q9DEI1), 
RAD3_SCHPO  (Q02099), SMG1_CAEBR  (Q61CW2), SMG1_CAEEL  (O01510), 
SMG1_DANRE  (C5J7W8), SMG1_DICDI  (Q553E9), SMG1_DROME  (Q70PP2), 
SMG1_HUMAN  (Q96Q15), SMG1_MOUSE  (Q8BKX6), TOR1_SCHPO  (O14356), 
TOR1_YEAST  (P35169), TOR2_SCHPO  (Q9Y7K2), TOR2_YEAST  (P32600), 
TOR_ARATH   (Q9FR53), TOR_CAEEL   (Q95Q95), TOR_DICDI   (Q86C65), 
TOR_DROME   (Q9VK45), TOR_ORYSJ   (Q0DJS1), TRA1_DICDI  (Q54T85), 
TRA1_DROME  (Q8I8U7), TRA1_SCHPO  (Q9HFE8), TRA1_YEAST  (P38811), 
TRA2_SCHPO  (Q10064), TRR1_CAEBR  (A8WTE8), TRR1_CAEEL  (G5EEV2), 
TRRAP_DANRE (A0A0R4ITC5), TRRAP_HUMAN (Q9Y4A5), TRRAP_MOUSE (Q80YV3)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

129 PDB

pdb_00001w1n; pdb_00002kio; pdb_00002kit; pdb_00003jbz; pdb_00004jsn; pdb_00004jsp; pdb_00004jsv; pdb_00004jsx; pdb_00004jt5; pdb_00004jt6; pdb_00005flc; pdb_00005h64; pdb_00005luq; pdb_00005np0; pdb_00005np1; pdb_00005ojs; pdb_00005w1r; pdb_00005wbu; pdb_00005wby; pdb_00005x6o; pdb_00005y3r; pdb_00005y81; pdb_00005yz0; pdb_00005zcs; pdb_00006bcu; pdb_00006bcx; pdb_00006emk; pdb_00006hka; pdb_00006ig9; pdb_00006jxa; pdb_00006jxc; pdb_00006k9k; pdb_00006k9l; pdb_00006l53; pdb_00006l54; pdb_00006s8f; pdb_00006sb0; pdb_00006sb2; pdb_00006syt; pdb_00006t9i; pdb_00006t9j; pdb_00006z2w; pdb_00006z2x; pdb_00006z3a; pdb_00006z3r; pdb_00006zfp; pdb_00006zh2; pdb_00006zh4; pdb_00006zh6; pdb_00006zh8; pdb_00006zha; pdb_00006zhe; pdb_00006zwm; pdb_00006zwo; pdb_00007k0y; pdb_00007k10; pdb_00007k11; pdb_00007k19; pdb_00007k1b; pdb_00007k1j; pdb_00007k1k; pdb_00007k1n; pdb_00007ktr; pdb_00007lt3; pdb_00007nfc; pdb_00007nfe; pdb_00007ni4; pdb_00007ni5; pdb_00007ni6; pdb_00007otm; pdb_00007otp; pdb_00007otv; pdb_00007otw; pdb_00007oty; pdb_00007owg; pdb_00007pe7; pdb_00007pe8; pdb_00007pe9; pdb_00007pea; pdb_00007peb; pdb_00007pec; pdb_00007pqh; pdb_00007pw4; pdb_00007pw5; pdb_00007pw6; pdb_00007pw7; pdb_00007pw8; pdb_00007pw9; pdb_00007sgl; pdb_00007sic; pdb_00007sid; pdb_00007su3; pdb_00007sud; pdb_00007tyr; pdb_00007tzo; pdb_00007uxc; pdb_00007uxh; pdb_00007vvy; pdb_00007vvz; pdb_00007wzr; pdb_00007wzw; pdb_00007yfn; pdb_00007yfp; pdb_00007z87; pdb_00007z88; pdb_00008bh3; pdb_00008bhv; pdb_00008bhy; pdb_00008bot; pdb_00008era; pdb_00008esc; pdb_00008ez9; pdb_00008eza; pdb_00008ezb; pdb_00008h7g; pdb_00008oxm; pdb_00008oxo; pdb_00008oxp; pdb_00008oxq; pdb_00008qri; pdb_00008rch; pdb_00008rck; pdb_00008rcn; pdb_00008rd4; pdb_00008xvg; pdb_00008xvv; pdb_00009c47; pdb_00009f44; pdb_00009f45
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