PROSITE entry PS51497

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51497
Entry name [info]	UMA
Accession [info]	PS51497
Entry type [info]	MATRIX
Date [info]	01-JUN-2010 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51497
Associated ProRule [info]	PRU00830

Name and characterization of the entry

Description [info]

UMA domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=48;
/DISJOINT: DEFINITION=PROTECT; N1=5; N2=44;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3741412; R2=0.0063080; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=5720.6245117; R2=1.4007252; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=972; H_SCORE=7082; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=655; H_SCORE=6638; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-25; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='M';  M=-51,-57,-72,-64,-33,-70,-53, 17,-61, 63, 92,-66,-66,-54,-59,-61,-48, 12,-61,-40;
/M: SY='D';  M=-49,-66, 92, 46,-72,-28, -8,-71,-38,-68,-64,-29,-51, 25,-46, 20,-43,-67,-79,-57;
/M: SY='D';  M=-22,-66, 80,-38,-72, 74,-50,-75,-50,-72,-66,-31,-55,-48,-58,-39,-50,-70,-72,-62;
/M: SY='V';  M=-43,-57,-72,-67,-40,-74,-73, 62,-64,-24,-27,-65,-65,-64,-66,-56,-40, 83,-70,-47;
/M: SY='P';  M=-53,-78,-15, -3,-74,-56,-55,-62,-48,-71,-58,-57,120,-13,-60,-50,-47,-67,-67,-69;
/M: SY='F';  M=-58,-58,-75,-70,108,-71,-58,-10,-66,-14,-35,-65,-72,-74,-64,-60,-51, 29,-34,-12;
/M: SY='K';  M=-28,-60,-43, 36,-57,-60,-47,-21, 62,-34, 51,-42,-51,-11,  8,-42, 37, -1,-65,-51;
/M: SY='I';  M=-52,-60,-72,-67, 11,-74,-63, 66,-65, 51, 28,-66,-66,-61,-65,-61,-33, 23,-59,-40;
/M: SY='N';  M=  7,-56,  3,-47,-61, 28, 50,-39,-46,-60,-52, 55,-56,-42,-51, 55,-36,  3,-73,-52;
/M: SY='P';  M=-18,-70, 27, 57,-70,-57,-49,-60,  6,-64,-57,-47, 86, -8,-16,-46,-46,-15,-68,-62;
/M: SY='R';  M=-28,-65,-46, -7,-62,-19, 47,-62, 56,-47, 34,-39,-55, 26, 63,  1,-47,-59,-64,-48;
/M: SY='F';  M=-33,-59,-70,-66, 85,-69,-50,-13,-63, 40,-30,-65,-23,-64,-61,-59,-52, -4,-36, 53;
/M: SY='K';  M= 27,-10,-45, 23,-60,-29,-47,-54, 48, -2,-47,-43,-54, 33, 22, 15,-22,-24,-63,-53;
/M: SY='P';  M=  7, 52,-49,-47,-62, -3,-52,-56, -6,-35,-52, 14, 61,-18, 10, 20, 36,-28,-69,-59;
/M: SY='P';  M= -3,-64, 23,-41,-58,-54,-50, -9, 23,-54, 16, -4, 76,-12,-29,  8,-13,  1,-65, -3;
/M: SY='P';  M=  2,-63, 24, -6,-62,-25,-46,-37,-41,-36,-53,  4, 60, 37, -1, 45,-21,-39,-66,-13;
/M: SY='K';  M= 17,  8,-46,  2,-31,  9,-49,-31, 42,-31,-51, -8, 20,  4, 31, 16,-11,-54,-64,-54;
/M: SY='V';  M=-41,-58,-13,-31, -5, 23,  8,-18, -7,-23,-10, -9,-59,-23,-52, 33,-16, 51,  1, 13;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='Y';  M=-63,-77,-37,-29, -2,-70,  0,-69,-58,-45,-62, -2,-74, 31,-26, 17, 24,-68,  5, 44; D=-21;
/I:         I=-21; DM=-53;
/M: SY='Q';  M=-23,-68, 20, 14,-70,  8, 11,-62,-17,-63,-56,-29, 19, 62, -2,  0, 17,-15,-72,-58; D=-21;
/I:         I=-21; DM=-53;
/M: SY='L';  M=-31,-57,-67,-61, 21,-69,-56, 14,-60, 63, 38,-24,-67,  1,-59,-57,-20, 23,-58,-39;
/M: SY='P';  M=-34,-70, 27,  0,-46,-54,-51,-42,-45,-65,-56,  3, 99, 16,-54, -6, 13,-41,-69,-62;
/I:         I=-19; MD=-47;
/M: SY='M';  M=-10,-71,  5,-66,  1,-40,-69, 28,-69,  8, 34,-66,-19,-36,-72,-18,-56, 19,-74,-56; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='G';  M=-30,-67, 17, -5,-61, 41, -1,-54,-50, 17,-49, 16,-63, 37,-10,-24,-53,-15,-71,-58; D=-19;
/I:         I=-19; DM=-47;
/M: SY='F';  M= 21,-63,-67,-63, 32,-62,-59, 29,-60, 23, -1,-60,-67,-58,-26, 17,-13,-37, 27, 18; D=-19;
/I:         I=-19; DM=-47;
/M: SY='T';  M=-19, 16,-19,-43,-29,-57, 46,-12, 17, 10,-41,-41,-24, 31,  9, 15, 49,-24,-68,-47;
/M: SY='I';  M=-35,-60,-66,-60,  4,-69,  2, 48,-12, 44,  4,-60,-65,-30,-24,-28,-47, 25,-53, 36;
/M: SY='K';  M=-49,  5,-42,-39,-57,-52,-44,-60, 58,-63,-53, 47, 55, -9, -2, -3, 26,-58,-61, 22;
/M: SY='D';  M=-44,-61, 59, 15,-64,-51,-44,-62,-12,-40,-56, -5,-11,-36, 45, 44, 34,-57,-73,-55;
/M: SY='P';  M=-22, 41,-59,-25,  1,-43,-55, 12,-54, 44,-32,-30, 47, 30,-57,-22,-15,  1,-62,-47;
/M: SY='S';  M= 28,-57, 20,-16,-55,-18, -1,-37,-45,  9, -1,-12,  6, 16,-18, 49,-20,-30,-66,-23;
/M: SY='Q';  M= -9,-63, 27, 60,-66,-33,-15,-64, -5,-62,-55,-37,-50, 60,-11, 29, 12,-59,-67,-24;
/M: SY='I';  M= -8,-59,-22,-61, 14,-46,-61, 60,-60, 25,-11,-19,-31,-58,-62,-17,-15, 36,-60, -8;
/I:         I=-16; MD=-40;
/M: SY='D';  M=-25,-63, 52, 49,-51,-43,-47,-16,-32, 30,-42,  4,-57,-23,-12,-34,-47,  5,-68,-14; D=-16;
/I:         I=-16; MI=0; MD=-40; IM=0; DM=-40;
/M: SY='K';  M=-23,-65,  7,-12,-61,-59,-14,-56, 32,  7,-17, -4,  2,  4, 25, 25,  2,-37,-71,-56; D=-16;
/I:         I=-16; DM=-40;
/M: SY='E';  M= 26,-61, 21, 58,-66,-51,-15,-61,  0,-61,-55, 10,  3,  8, 21, 12,-16,-26,-69,-57;
/M: SY='Y';  M=-27,-63,-56, 21, 33,-66,-41,-37,-32, 32,  5,-60,-34,-49,-53,-24,-37,-12,-37, 85;
/M: SY='Q';  M=-50,  4, 35, 40,-68,-54, 32,-67,  9,-65,-56, 51,-55, 60,-15,-19, -4,-65, 20,-53;
/M: SY='Y';  M=-59,-70,-59,-62, 11,-32, 11,-46,-54,-42,-39,-59,-71,-50,-52,-54,-55,-51,-18,124;
/M: SY='D';  M=-49, -2, 89,-31,-66, -5,-21,-68,-43,-67,-63, 10,-56,-43, -4, 16, 26,-63,-79, -9;
/M: SY='F';  M=-63,  2,-75,-71,109,-71,-54,-38,-66,-31,-40,-65,-74,-74,-64,-62,-56,-17, 31, 37;
/M: SY='Q';  M=  8,-60,  6, -6,-62,-31, 26,-53,-39,-34,-49, -3,-55, 60,  7, 27, 37, -2,-71,-52;
/M: SY='L';  M=-30,-58,-64,-56,-38,-69,  1,-25,-56, 65,-25,-60,-66, 24,-21,-54, 15, 28,-65,-45;
/M: SY='E';  M=-48,-69,-21,103,-71,-31,-43,-68,-31,-64,-60,-46,-45,-24,-41,-46,-49,-27,-69,-62;
/M: SY='R';  M=-42,-69,-45,-15,-64,-29, 41,-68, 25,-40,-52, 30, -8,  0, 86,-46,-51,-64,-68,-51;
/M: SY='S';  M=  7,-17,-47,-22, -3,-31,-48,-58, -2,-45,-52,-16,-54, 44,  5, 63, 34,-52,-66,-51;
/M: SY='V';  M= 34,-55,-66,-60,-46,-61,-65, 17,-59, -1, 30,-60,-63,-58,-62,-29, -5, 69,-70,-51;
/M: SY='L';  M= 24,-59,-65,-54,-10,-63,-56, 10,-57, 60,-27,-62, -9, 37,-57,-52,-49, -3,-61,-45;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	15 in 15 different sequences
Number of true positive hits	15 in 15 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	UMA
Version [info]	5

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

15 sequences

MB12A_BOVIN (Q3T0N1), MB12A_CHICK (Q5ZJX7), MB12A_DANRE (Q7SXX7),

MB12A_HUMAN (Q96EY5), MB12A_MOUSE (Q78HU3), MB12A_RAT   (Q6P777), 
MB12A_XENLA (Q7ZYJ7), MB12B_HUMAN (Q9H7P6), MB12B_MOUSE (Q6KAU4), 
UBA1L_HUMAN (F5GYI3), UBAP1_DANRE (F6P6X0), UBAP1_HUMAN (Q9NZ09), 
UBAP1_MOUSE (Q8BH48), UBAP1_RAT   (Q5XIS7), UMAD1_HUMAN (C9J7I0)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

1 PDB

6VME