PROSITE entry PS51504

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General information about the entry

Entry name [info]	H15
Accession [info]	PS51504
Entry type [info]	MATRIX
Date [info]	01-JUL-2010 CREATED; 10-MAY-2017 DATA UPDATE; 08-NOV-2023 INFO UPDATE.
PROSITE Doc. [info]	PDOC51504
Associated ProRule [info]	PRU00837

Name and characterization of the entry

Description [info]

Linker histone H1/H5 globular (H15) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=73;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=73;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1323326; R2=0.0084606; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=7660.1591797; R2=2.9217172; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1120; H_SCORE=10932; N_SCORE=11.6; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=517; H_SCORE=9171; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-48; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='S';  M=  -2,-154,  11, -55, -75, -27, -41, -43,  14, -34, -52,  17,  20,  10,  13,  46,  19, -81,-161, -51;
/M: SY='H';  M= -71, -14, -69, -74, -69,   4, 100, -49,  29, -24,-140,  19,  10, -35, -19, -12,  14, -52, -27,-137;
/M: SY='P';  M= -48,-160, -48, -74, -73, -28, -26, -57,  11, -24, -33,-144,  98, -47, -77,   9,  -2,  -6,-158, -30;
/M: SY='P';  M= -16,-154,   4, -49, -66, -57, -44, -59,  18, -92,-147,  17,  64,-135,  16,  46,  31, -54,-162,-149;
/M: SY='Y';  M= -15, -76, -83, -66, -16,-157,-136, -23, -38,  15,  14,-151,-158, -65, -47, -84,  15,  13,  52,  98;
/M: SY='S';  M=   1, -59,  18,  -1, -28, -51, -58, -52,   4,  25,  25,   0, -33,  -3,  -2,  33, -59, -27,-156, -14;
/M: SY='D';  M= -22,-156,  52,  45, -93, -93, -56, -72,  19,-103,-147, -22,  -9,  35, -30,  12,  13,  -4,  -4, -58;
/M: SY='M';  M= -34,-149,-156, -77, -67,-100, -30,  -7,  15,  30, 126, -80,-151,-138, -58,-147, -69, -22,   8, -24;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='I';  M= -23,  -2,-161,-157,-130,-100, -12,  86,-154,   1,   2,-153,-154,-151,-156, -43,-135,  58,-157,-137;
/M: SY='K';  M= -26, -18, -34, -16,   3, -46, -14,  14,  37,  37,  30, -60, -26, -19, -43, -66,  12,   8,-150, -13;
/M: SY='E';  M=  21,-154,  33,  84,-156,-100,-135, -71, -15, -94, -28,  -8, -19,   4,   8, -31, -32, -48,-158, -45;
/M: SY='A';  M=  98,  -4,-145, -68,-149, -42,-146, -87, -77, -95,-139,-140,-146,-138,-145,  -7, -47, -34,-153,  -9;
/M: SY='I';  M=-142,-153,-161, -74, -11,-165,-155,  89,-154,  33,  31,-155, -15, -23,-155,-150,-137,  26,-151,-133;
/M: SY='E';  M=   4, -15, -38,  36,-106, -71, -39, -25,  35, -16, -31, -16, -51,  11,  11,  27,  26,  -5,  -8, -57;
/M: SY='A';  M=  54, -50,  32,  29,-153,  -4, -19, -81,   0,-148, -50, -24,-143,  -3, -41,  25,  24, -27,-159, -72;
/M: SY='L';  M= -52,  28, -84, -47,-127,-156, -18,   0, -35,  79,  37, -17,-156, -20, -54,  -9, -49, -79,-153,-134;
/M: SY='K';  M= -19, -19,  20,  -2, -81,  15, -28,-154,  68,-155, -49,  61,  12, -17, -30, -13, -87, -56,-158, -61;
/M: SY='E';  M= -69,-155,  66,  78,-157, -41, -39,-156, -39, -52,-149,  22, -21,  -8, -49,  18, -11,-106, -19,-147;
/I:         I=-11; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='R';  M= -60,   3, -52,  10, -74,  -7,   4, -73,  47,-154,-144,  -2,  57, -52,  77, -54,-138, -84,-155, -48;
/M: SY='K';  M= -38,-151, -17,  -2, -47,  27, -54, -67,  66, -93,-143,  48, -16,  -6, -49,  17,   9, -27,-156, -72;
/M: SY='G';  M=-129,-154, -62, -27, -43, 101,-147, -93, -82, -72, -46, -53,-147,-143, -75, -73, -44, -79,  27, -54;
/M: SY='S';  M=  37,  41,-143,-141,-145,-136,-144, -21,-140, -45,  -2, -49, -50,-135, -44,  84, -40,  31,-160,-144;
/M: SY='S';  M= -75, -43,   8,-133,-150,-131, -11, -35,-134,-151,-145,  22,-142,-129,-139, 102,  39,-141,-162, -68;
/M: SY='R';  M= -21,-151,-147, -19,  -7, -93,-141,   3,  24,  34,  30, -79, -24,  -7,  46, -22, -31,  27,-150, -13;
/M: SY='Q';  M=  21,-151,   9, -49, -18, -69, -22, -36,  25, -34, -54, -10,  20,  73, -15,  -3,   4,  -5,-151,   0;
/M: SY='A';  M=  80,-143, -25, -26, -74, -76,-141, -44,  17, -69,  -3, -11,-143, -16, -45,  31,   0, -88,-155,-145;
/M: SY='I';  M= -76,-153,-163,-160,-125,-166,-160, 107,-156,  24,-112,-155,-153,-152,-158,-151,-136,  -6,  -8,-133;
/M: SY='K';  M=  15, -13,-103,  16,  -6, -86, -53, -15,  64, -11,   1, -45,-146, -20,  29,  19, -78, -19, -17, -20;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='K';  M= -16,-152, -47,   0, -63,-101,  21, -89,  88, -91, -25,  25, -68, -37,  24, -12,   9, -65,-155,-141;
/M: SY='Y';  M= -15,-156, -76,-149,  65,-153,  35,-101, -73, -49,-130, -64, -39,-142, -37,-143, -76, -55,  71, 114;
/M: SY='I';  M=-140,-150,-161,-156, -67,-163,-154,  85, -48,  36,  42, -60,-154,-149, -76,-149,-135,  47,-153,-134;
/M: SY='E';  M=   2, -21, -33,  57, -27, -22, -47, -51,  43, -14, -34, -35,-143,  48,   4,  -1, -18, -48, -19, -59;
/M: SY='S';  M=  35, -44,  40,  40, -55, -21,  -4,-151,   5, -98,-144, -42, -73,  42, -17,  42,   1, -86,-158,-144;
/M: SY='N';  M= -21,-151, -32, -27, -70, -49,  51, -74,  62,-151,-141,  69, -80,  11,  31, -24,  17,-149,-156,  -3;
/M: SY='Y';  M= -49, -42, -78,-144,  28,   3,  72, -68, -72, -51,-133,  34, -38, -24, -49, -41, -27, -68,  49, 101;
/M: SY='P';  M= -55, -45,   7,   7, -49,  22,  26, -84,  49, -95,-142,  -2,  52,  -3,  11, -23, -28, -38,   0,  28;
/M: SY='V';  M=  -6, -42,  34,  -8, -64,  10,  -8,   6, -25,  -7, -52, -23, -43, -20, -46, -11,  16,  46, -37,   0;
/I:         I=-5; MD=-11;
/M: SY='V';  M= -88,-162, -11, -27,-153, -14, -13, -35,  11,  14, -47,   5, -65, -20, -68,   7, -11,  22, -38, -58; D=-5;
/I:         I=-5; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='D';  M= -54,-170,  49, -45, -28, -45, -32, -79, -54, -23,-158,  14,  -7, -37, -10, -12,  10, -41,-178, -62; D=-5;
/I:         I=-5; DM=-11;
/M: SY='P';  M= -26,-161, -14,  19,-158, -42, -48, -16,  -1, -84,  23, -14,  64,  35, -61,  -3,  -1,  -5,-164,-152; D=-5;
/I:         I=-5; DM=-11;
/M: SY='P';  M=  24,-154,  18,   6, -37, -39, -45,-149,  28,-152,-146,   9,  47,   8, -35,  18,  13, -22,   5, -51; D=-5;
/I:         I=-5; DM=-11;
/M: SY='N';  M= -14,-152,  12, -48,   1, -47,  -1, -37,  29, -45,  21,  62,  -9,   5,  34,  -8,   5, -75,  -7, -35; D=-5;
/I:         I=-5; DM=-11;
/M: SY='F';  M= -49, -49, -32, -57,  73, -86,  59,  -5, -31,  21,   1,  17,-154,  10,  -7, -36, -29,   1,-143, -23;
/M: SY='K';  M= -10,-152,  20,  -4,-152, -27,  -9, -33,  55, -67,  20,  26,  -6, -10,  41,  13, -14, -31,-157,-143;
/M: SY='S';  M=  10,-150, -43, -48, -32, -72,  32,-143,  30, -20,-138,  15,  23,  -6,  12,  43,  20, -28,-152,  23;
/M: SY='H';  M= -26,-151,-148, -65,  42, -95,  60, -35, -33,  43,  43, -23,-154,  29,  27, -28,-100,  -3,-147, -17;
/M: SY='L';  M= -33, -34,-162,-156,  35,-162,-150,  36,-155,  70,  -9,-157,-159,-152,-154,-150, -70,  35,-147, -46;
/M: SY='K';  M= -33,-152, -71, -76, -42, -57, -55, -87,  71, -53, -50,  43, -80, -21,  54,  19,  15,-147, -10, -16;
/M: SY='R';  M= -12,-151,-138, -59, -70, -59,  25, -50,  45,  -1,   9,   8, -30,  22,  45,  29,  15, -55,-154, -18;
/M: SY='A';  M=  75,   0, -72, -69, -70, -70,  49, -37, -20, -70, -56, -36,-147,  20, -55,  10,  -1, -25,-154,   4;
/M: SY='L';  M= -53,-149,-162,-156, -39,-163,-150,  45,-155,  79,   9, -70, -62,-150,-154,-152,-139,  17,-151, -61;
/M: SY='K';  M= -29, -21, -43,   9,-152, -42, -39, -60,  85, -32,-141,  18, -65,  -1,  43, -55, -57, -84,-154, -48;
/M: SY='K';  M= -13, -55, -28, -39, -76, -36,  16, -56,  66, -76,-142, -26, -81,  -5,  65,  28, -31, -57,-154, -35;
/M: SY='G';  M=  45,  24, -71, -56, -56,  53,   0, -51, -56,  42,  40,-141,-151, -64, -78, -50,-139,-134,-154,-142;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='V';  M=  -1,  14,-155, -54, -60,-157, -16,  20, -14,   8,  12, -78,-155,-146, -22, -59, -21,  78,-160,-139;
/M: SY='E';  M=  31,-152,  17,  61, -80, -70, -40, -70,  31, -40, -31,   8,-143,   8, -37,  22, -73, -21,-159,-146;
/M: SY='N';  M=   5,-150,   2,  21,-155, -68,   8, -94,  41, -70,-144,  49,-145,   9,  10,  42,  16, -61,-161,-145;
/M: SY='G';  M=-132,-156, -40,  -2,-161,  93, -43, -81,  24,-163,-152,   1,-147,-138, -33, -82, -75,-160,-155,-154;
/M: SY='K';  M= -58,-155,  18,  12, -27,-152,-140, -16,  46,   6, -26,-136,-149,  23,  34,  -8,  11,   1, -13, -23;
/M: SY='L';  M= -63,-151, -71,-157,  42, -85,-153,  49,-157,  67, -36,-158, -49,-153,-156, -53,-141,  11,-148,-129;
/M: SY='V';  M= -16,-153,-145,  24,-140,-156,  -1,  39,   9,  -7, -10, -24, -41,  27, -54, -65, -20,  51, -20, -35;
/M: SY='Q';  M= -56, -24, -43,-125, -18,-151,   1,-151,  61, -38,  12, -65,-104,  91,  46, -51,-141, -92,-153, -48;
/I:         I=-11; MD=-28;
/M: SY='P';  M= -31, -72, -88,-148,-152,-156, -41,  -5,   7, -96, -55, -15,  51,-149,-150,  -7,  50,  49,-170,-153; D=-11;
/I:         I=-11; MD=-28;
/M: SY='K';  M= -62, -63,-151, -80,-172,-161,-154,-171,  73,-171,-161,  -5, -35, -60,  11,  15,  13,-166,-173,-162; D=-11;
/I:         I=-11; MI=0; MD=-28; IM=0; DM=-28;
/M: SY='A';  M=  28, -59, -24, -17,  -6, -10,-164, -61,-160,   1,  -8, -85,  12, -62, -22, -53, -44, -73,-172,-160; D=-11;
/I:         I=-11; DM=-28;
/M: SY='S';  M= -13,-158, -23, -28,-164,  24,-146, -80, -22, -93, -34,  44,-155,  11,  -9,  50,  -2, -82,-169,-157; D=-11;
/I:         I=-11; DM=-28;
/M: SY='G';  M= -57, -53, -26, -31,-159,  81,   1, -93,  11, -52,-149,  38, -44, -12,  -2,-132, -71, -87,-158,-152;
/M: SY='S';  M= -84,  -6,-140, -81, -21,-142, -53, -53,   9,  -6, -22,   8, -40, -66,  39,  78,   8, -64,-158, -59;
/M: SY='Y';  M= -59,-155,-158, -71,  86,-160,-134, -38,-151, -69, -49,-154,-163,-152,-150, -70, -79,  17,-120, 104;
/M: SY='K';  M= -44,-157,-141, -85,-153, -50, -49, -38,  84, -41,  27,-134,-148,   5,  61, -91, -14, -46,-155,-143;
/M: SY='L';  M= -69,-152,-161, -62,  -2,-164,-150,  43, -24,  72,   8,-158, -46, -63, -52,-153,-141,   0,-151, -47;
/M: SY='P';  M=  27, -59, -48, -62,-154,  13, -14,-146,   5, -65, -14,  45,  46,-136, -44,  40,  -4,  -8,-162,-150;
/M: SY='P';  M=  34,-156, -10,   5, -64, -45, -10,-151,  52, -96, -39, -22,  57, -30, -39,  -4, -17, -37,-159, -67;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2023_05 which contains 570'420 sequence entries.

Total number of hits	160 in 148 different sequences
Number of true positive hits	160 in 148 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	1
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	99.38 %

Comments [info]

Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	3
Feature key [info]	DOMAIN
Feature description [info]	H15
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

148 sequences

B4_XENLA(P15308), H101_CHICK  (P08284), H103_CHICK  (P08285),

H10A_XENLA  (P22845), H10B_XENLA  (P22844), H10_BOVIN   (Q0IIJ2), 
H10_HUMAN   (P07305), H10_MOUSE   (P10922), H10_PONAB   (Q5NVN9), 
H10_RAT (P43278), H10_XENTR   (Q6NVM0), H110_CHICK  (P08286), 
H11E_PARAN  (Q99281), H11L_CHICK  (P08287), H11R_CHICK  (P08288), 
H11_ARATH   (P26568), H11_BOVIN   (G3N131), H11_DROVI   (Q24704), 
H11_GLYBA   (P40263), H11_GLYSA   (P40266), H11_HUMAN   (Q02539), 
H11_MOUSE   (P43275), H11_RAT (D4A3K5), H11_VOLCA   (Q08864), 
H11_WHEAT   (P15871), H12E_PARAN  (Q99282), H12_ARATH   (P26569), 
H12_BOVIN   (P02253), H12_CAEEL   (P15796), H12_DROVI   (Q94555), 
H12_GLYBA   (P40264), H12_HUMAN   (P16403), H12_MOUSE   (P15864), 
H12_VOLCA   (Q08865), H13E_PARAN  (Q99283), H13_BOVIN   (A7MAZ5), 
H13_CAEEL   (Q19743), H13_DROVI   (Q94972), H13_GLYBA   (P40265), 
H13_HUMAN   (P16402), H13_MOUSE   (P43277), H13_RABIT   (P02251), 
H14_CAEEL   (O17536), H14_HUMAN   (P10412), H14_MOUSE   (P43274), 
H14_RABIT   (P02252), H14_RAT (P15865), H15_CAEEL   (O01833), 
H15_HUMAN   (P16401), H15_MOUSE   (P43276), H15_RAT (D3ZBN0), 
H16_CAEEL   (O16277), H18_BOVIN   (Q3HNG7), H18_HUMAN   (Q8IZA3), 
H18_MOUSE   (Q8VIK3), H1A_CHITE   (P40275), H1A_OLILU   (P82898), 
H1A_PLADU   (P06894), H1A_XENLA   (P06892), H1B_CHITE   (P40276), 
H1B_OLILU   (P82899), H1B_PLADU   (P06895), H1B_STRPU   (P15869), 
H1B_XENLA   (P06893), H1C1_XENLA  (P15866), H1C2_XENLA  (P15867), 
H1C_CHITE   (P40277), H1D_STRPU   (P15870), H1E_CHIPA   (P40262), 
H1E_CHITE   (P40278), H1E_STRPU   (P19375), H1G_STRPU   (P07796), 
H1L1_OSTED  (Q86QH9), H1L2_OSTED  (Q86QI0), H1L5_ENSMI  (P27203), 
H1L_MYTCA   (P22974), H1L_MYTTR   (Q05831), H1L_SPISO   (P22975), 
H1O_CHITH   (Q07134), H1S_SPHGR   (Q99284), H1T_HUMAN   (P22492), 
H1T_MACMU   (P40286), H1T_MOUSE   (Q07133), H1T_PIG (P06348), 
H1T_RAT (P06349), H1X_CAEEL   (Q18336), H1X_HUMAN   (Q92522), 
H1_ANAPL(P09426), H1_ASCIM(Q9UV33), H1_CANGA(Q6FJX6), 
H1_CHICK(P09987), H1_CHITH(P21895), H1_DICDI(P54671), 
H1_DROHY(P17268), H1_DROME(P02255), H1_ECHCR(P02257), 
H1_EMENI(Q9P8F8), H1_EREGS(Q75C22), H1_EUPES(Q9M5W4), 
H1_LYTPI(P06144), H1_MAIZE(P23444), H1_NEUCR(Q8J0U2), 
H1_ONCMY(P06350), H1_PARAN(P02256), H1_PEA  (P08283), 
H1_PSAMI(P15868), H1_SALSA(P84408), H1_SALTR(P02254), 
H1_SOLLC(P37218), H1_SOLPN(P40267), H1_TIGCA(P35060), 
H1_WHEAT(P27806), H1_YEAST(P53551), H24_CAEEL   (P10771), 
H5_ANSAN(P02258), H5_CAIMO(P06513), H5_CHICK(P02259), 
HILS1_HUMAN (P60008), HILS1_RAT   (D3ZZW6), HMGYA_ARATH (Q43386), 
HMGYA_MAIZE (Q9FYS5), HMGYA_SOYBN (Q00423), HMGYB_SOYBN (Q10370), 
HP1B3_BOVIN (Q08DU9), HP1B3_CHICK (Q5ZM33), HP1B3_HUMAN (Q5SSJ5), 
HP1B3_MOUSE (Q3TEA8), HP1B3_RAT   (Q6P747), HSPL_MULSU  (Q08GK9), 
KAT6A_HUMAN (Q92794), KAT6A_MOUSE (Q8BZ21), KAT6A_RAT   (Q5TKR9), 
KAT6B_HUMAN (Q8WYB5), KAT6B_MACFA (Q8WML3), KAT6B_MOUSE (Q8BRB7), 
SHPRH_HUMAN (Q149N8), SHPRH_MOUSE (Q7TPQ3), SMH1_MAIZE  (Q6WS85), 
SMH2_MAIZE  (B4FT40), SMH3_MAIZE  (Q6WLH4), SMH4_MAIZE  (Q8W119), 
SMH5_MAIZE  (Q6WLH3), SMH6_MAIZE  (C0HIA3), TRB1_ARATH  (Q8VWK4), 
TRB2_ARATH  (Q9FJW5), TRB3_ARATH  (Q9M2X3), TRB4_ARATH  (F4I7L1), 
TRB5_ARATH  (F4IEY4)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

UniProtKB/Swiss-Prot
False negative sequences

1 sequence

HILS1_MOUSE (Q9QYL0)

PDB
[Detailed view]

56 PDB

1GHC; 1HST; 1UHM; 1USS; 1UST; 1YQA; 2LSO; 2RQP; 4QLC; 5NL0; 5WCU; 6HQ1; 6L9Z; 6LA2; 6LA8; 6LA9; 6LAB; 6N88; 6N89; 7COW; 7DBP; 7K5X; 7K5Y; 7K60; 7K63; 7KBF; 7PET; 7PEU; 7PEX; 7PEZ; 7PF0; 7PF2; 7PF3; 7PF5; 7PF6; 7PFA; 7PFC; 7PFD; 7PFE; 7PFT; 7PFU; 7PFV; 7PFW; 7PFX; 7XVL; 7XVM; 7XX5; 7XX6; 7XX7; 7Y43; 8AAG; 8E4V; 8H0V; 8H0W; 8H1T; 8H7A
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