PROSITE entry PS51529
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General information about the entry
| Entry name [info] | CYSTATIN_FETUIN_A |
| Accession [info] | PS51529 |
| Entry type [info] | MATRIX |
| Date [info] |
01-MAR-2011 CREATED;
01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00966 |
| Associated ProRule [info] | PRU00861 |
Name and characterization of the entry
| Description [info] | Fetuin-A-type cystatin domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=113; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=108; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.8541539; R2=0.0089748; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=2134; N_SCORE=22.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=318; N_SCORE=5.7; MODE=1; TEXT='R?'; /DEFAULT: M0=-48; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='K'; M= 4, -96, 23, -13, -86, -89, 9, -86, 63, -53, -80, -73, -37, 28, 31, -75, -20, -2, -90, 36; /M: SY='R'; M= -4, -91, 6, -78, -2, -88, -10, -32, 19, 15, -72, 28, -93, -76, 36, 18, -74, 33, -98, -79; /M: SY='C'; M= -25, 133, -92, -20, -89, 3, -92, -90, -18, 2, -82, -45, -40, 4, -58, -81, -81, -84,-108, -94; /M: SY='P'; M= -40,-103, -3, -73, -96, -87, -43, -83, -80, -5, -81, -86, 112, 26, -53, -24, -77, -20, -98, -93; /I: I=-17; MI=0; MD=-42; IM=0; DM=-42; /M: SY='D'; M= -7, -94, 67, 9, -99, 13, 0, -99, 29, -98, -90, 48, -86, -1, 17, -35, -12, -94,-104, -87; /M: SY='C'; M= -80, 155,-100,-100, -90, -96,-100, -97, -96, -88, -88, -86,-111,-104,-102, -83, -80, -85,-120,-101; /I: I=-21; MD=-53; /M: SY='P'; M= -57,-129,-110, -99, -8,-109,-112,-113,-105,-119,-110,-114, 99,-109,-116, -48,-101,-117, 13,-111; D=-21; /I: I=-21; MI=-53; MD=-53; IM=-53; DM=-53; /M: SY='L'; M=-105,-114, -10,-110, -92, -31, 23, 24,-114, 43, -80,-108,-118,-107,-114, -24,-102, -83,-118, -97; D=-21; /I: I=-21; DM=-53; /M: SY='L'; M=-109,-111,-126,-118, -82,-128,-110, -73,-120, 72, -70,-125,-126,-112,-117,-119,-105, -81,-113, -95; D=-21; /I: I=-21; DM=-53; /M: SY='A'; M= 37,-107,-115,-109, -96,-108,-111, -14,-110, 35, -84,-110,-114,-107,-113, -96, 12, -84,-116,-103; D=-21; /I: I=-21; DM=-53; /M: SY='P'; M=-106,-129,-105, -97,-126,-108,-108,-116, -99,-125,-111, -22, 99,-103, -10, -31, -99,-120,-121,-121; D=-21; /I: I=-21; DM=-53; /M: SY='L'; M=-109,-112,-124,-116, 28,-124,-110, -79,-117, 56, -77,-121, 5,-114,-116, -58,-104, -53,-107, -89; D=-21; /I: I=-21; DM=-53; /M: SY='N'; M= -82, -92, 65, -65, -98, -75, 43, -98, -68,-100, -89, 103, -89, 32, -51, -32, -70, -99,-114, -85; /M: SY='D'; M= -81, -96, 102, 32,-102, -43, 21,-102, -41,-100, -96, 8, -84, -69, -79, 9, -13, -98,-114, -87; /M: SY='P'; M= -77, -92, 2, -34, -95, -85, -84, -87, 2, -92, -85, -10, 87, -78, -34, -8, 78, -67,-103, -91; /M: SY='Q'; M= -80, -98, 34, 55,-100, -26, 36,-100, 16, -96, -86, 33, -84, 59, 37, -12, -77, -97,-101, -84; /M: SY='V'; M= 41, -85, 19, -83, -84, 11, -93, -35, -86, -73, -73, -80, -89, -86, -90, -71, 35, 71,-103, -85; /M: SY='V'; M= -31, -89, -78, 45, -79, -95, -85, -59, 32, 27, -67, 18, -90, -75, -76, -80, -74, 64, -99, -82; /M: SY='H'; M= -3, -97, 54, 40, -93, -86, 100, -29, -34, -90, -81, 4, -85, 47, -73, -73, -31, -92,-105, -22; /M: SY='W'; M= 74, -84, -88, -82, -4, -75, -89, -79, -83, -24, -78, -81, -87, -80, -87, 35, 16, -15, 83, -77; /M: SY='V'; M= 67, -83, -93, -87, -82, -83, -95, -4, -87, -69, -69, -87, -90, -86, -90, -70, 9, 72,-100, -85; /M: SY='D'; M= -82, -94, 54, 51, -85, -90, -75, -80, 28, 42, -73, 28, -87, 7, -73, -29, -77, -82, -99, -83; /M: SY='A'; M= 63, -85, -42, -1, -37, -81, -84, -9, -81, -39, -10, -80, -86, -22, -85, -15, 44, 18, -90, 31; /M: SY='A'; M= 90, -81, -86, -80, -93, -5, -88, -80, -82, -85, -80, -79, -86, -78, -87, 16, -70, 4, -96, -89; /M: SY='L'; M= -81, -88, -95, 3, -66, -54, -89, -23, -91, 74, -53, -97, -98, -18, -91, -90, -78, 48, -94, -76; /M: SY='D'; M= 48, -90, 56, -68, -94, -44, 43, -50, -71, -35, -82, 35, -87, 32, 19, -21, -4, -84,-103, -83; /M: SY='Y'; M= 41, -90, -3, -77, 29, -44, -18, -81, 35, -79, -75, -4, -89, -75, -73, -24, 7, -71, -69, 90; /M: SY='F'; M= -86, -91, -98, -96, 90,-100, 44, 65, -93, 7, -61, -89, -97, -93, -92, -16, -80, -57, -73, -3; /M: SY='N'; M= -80, -85, -53, -74, -94, -68, -60, -94, -65,-101, -87, 129, -91, -67, -74, -62, -64, -96,-114, -90; /M: SY='E'; M= 48, -89, -13, 54, -97, -16, -74, -92, 14, -91, -83, 44, -81, 53, -70, -24, -1, -85, -97, -87; /M: SY='H'; M= -80, -96, -58, -1, -63, -2, 98, -98, 25, -91, -78, 56, -85, 84, -42, -69, -78, -97,-101, -73; /M: SY='N'; M= -78, -87, -68, -76, -56, -79, 80, -80, 12, 25, -72, 86, -89, -70, -73, 28, -6, -47,-104, -75; /I: I=-30; MD=-77; /M: SY='H'; M=-103,-114, -22,-100,-103, -25, 47, -96, -98, 16, -91, -2, 16, -59, 4, -98, 8, -34,-122, -99; D=-30; /I: I=-30; MI=-77; IM=-77; DM=-77; /M: SY='H'; M= -67, -92, -27, -72, -87, -78, 107, -92, -71, -20, -77, 85, -18, 14, -28, 11, -73, -94, 47, -70; /M: SY='G'; M= -69, -93, -7, -37, -97, 91, -86, -97, 24, -97, -88, -67, -84, -79, -66, -67, 13, -21, -94, -91; /M: SY='Y'; M= -52, -89, -81, -83, -3, -85, 51, -74, -80, -76, -73, -74, -89, -76, -81, 49, 50, 5, -71, 97; /M: SY='Y'; M= -83, -95, -78, -72, -38, -90, 15, -32, 80, -80, -74, 6, -89, -67, -17, -78, -77, -7, -70, 94; /M: SY='F'; M= -88, -92, -90, -85, 97, -95, 58, -72, -84, -13, -68, -29, -97, 41, -82, -82, -9, -76, -65, 63; /M: SY='K'; M= 31, -90, -77, 17, -89, -86, -80, 17, 60, -79, 1, -74, -83, 47, 2, -71, 12, 8, -94, -82; /M: SY='L'; M= -83, -86,-102, -95, 32,-103, -87, -49, -95, 84, 23, -99,-101, -90, -92, -93, -79, 17, -86, -66; /M: SY='N'; M= -80, -88, -74, 6, 1, -87, 31, -64, -79, 11, 41, 84, -94, -77, -83, -77, -73, 48,-102, -77; /M: SY='E'; M= -77, -98, -61, 89, -98, -92, -74, -42, -62, -89, -84, -75, -81, 61, 14, 11, -77, 4, -98, -87; /M: SY='I'; M= -82, -96,-101, -96, -71,-107,-100, 99, -39, -36, -57, -93, -93, 19, -94, -90, -77, 30, -95, -77; /M: SY='S'; M= -30, -92, 59, 24,-100, 40, -78,-100, 12,-100, -93, -22, -84, -70, -78, 62, -70, -94,-102, -90; /M: SY='R'; M= -81, -98, -23, 20, -95, -40, -73, -24, 17, -93, -84, 4, -89, -24, 94, 18, -78, -91, -97, -84; /M: SY='A'; M= 56, -88, -92, -88, -10, 4, -90, 38, -82, -71, 24, -22, -91, -83, 16, -74, -75, 40, -95, -81; /M: SY='Q'; M= -75, -20, -76, -64, -97, -85, 33, -88, 38, -89, -79, -69, -86, 95, 8, 36, 9, -8, -97, -80; /M: SY='V'; M= 2, -88, -87, -87, -31, -90, 44, 14, -30, 22, -65, 24, -58, -83, -86, 4, 10, 54,-101, -77; /M: SY='W'; M= -79, -96, -88, 2, -76, -96, -86, -27, 8, 2, -70, -86, -92, 71, -76, -81, -32, 57, 94, -3; /M: SY='P'; M= -33,-105, -89, -80, -39, -11, -86, -12, 11, -93, -85, -87, 92, -4, -85, 2, -81, -90, 70, 42; /M: SY='W'; M= -84, -98, -84, 25, -18, -34, 2, -79, 2, 15, 41, -84, 10, 3, 41, -20, -32, -15, 51, 0; /M: SY='P'; M= 14, -99, 13, -76, 2, -16, -84, -94, -75, -96, -88, -9, 80, -7, 33, -2, 10, -91, -99, -89; /I: I=-22; MD=-57; /M: SY='P'; M= -42,-119, 22, -97, -17, 20,-105,-113,-104,-115, -9, -25, 60,-103,-112, -10, -98, -67,-119,-109; D=-22; /I: I=-22; MI=0; MD=-57; IM=0; DM=-57; /M: SY='G'; M= -89,-109, -97, -37,-107, 50,-103, -97,-101, -42, -99, 17, -14, -99,-107, 1, -19, 12, -1,-106; D=-22; /I: I=-22; DM=-57; /M: SY='E'; M= -40, 50, 4, 56, -94, -69, -84, -40, -36, -36, -82, -5, 45, 27, -24, -80, -79, 30,-104, -91; /M: SY='S'; M= 17, -90, -83, 13, -88, -86, -86, 28, -4, -53, 25, -79, -88, 10, -82, 54, 2, 17,-100, -85; /M: SY='Y'; M= -47, -92, -96, -95, 60,-100, 11, -31, -91, -48, -70, -89, -99, -92, -91, -82, 38, 48, -74, 77; /M: SY='Y'; M= -86, -97, -38, 23, 55, -98, 32, -15, -82, -23, -73, -86, -96, 15, -17, -6, -82, 12, -75, 74; /M: SY='V'; M= -5, -89,-102, -96, 15,-100, -95, 3, -95, 42, 29, -97, -99, -93, -95, -27, -28, 63, -96, -76; /M: SY='E'; M= -80,-102, -58, 99,-105, 16, -76,-106, -3, -99, -93, -29, -80, 16, -73, -76, -83, -99,-100, -94; /M: SY='F'; M= -90, -94,-106,-103, 89, -32, -91, 42, -99, 27, -64, -98,-103,-101, -98, -94, -85, -8, -74, 16; /M: SY='D'; M= 48, -90, 63, -17, -95, -82, -84, -39, -38, -88, -85, 26, -88, -79, -85, -69, 38, 13,-108, -90; /M: SY='I'; M= -83, -92, -98, -23, -2,-105, -96, 62, -94, 42, -2, -93, -96, -91, -96, -86, 36, 22, -96, -76; /M: SY='L'; M= 30, -90, -93, 12, -75, -94, -89, -6, -89, 51, 42, -93, -95, -84, -91, -16, -78, 28, -97, -50; /M: SY='E'; M= 38, -96, -62, 92,-102, 1, -80, -99, -70, -96, -91, -79, -81, -63, -79, -20, -79, -59,-100, -94; /M: SY='T'; M= -73, -84, -81, -83, -88, -90, -90, -30, -81, -82, -79, -71, -30, -84, -88, 9, 105, 8,-109, -87; /M: SY='N'; M= -29, -93, 54, 41,-100, -83, -74, -97, -1, -99, -92, 77, -86, -70, -77, -69, 46, -92,-112, -92; /M: SY='C'; M= -83, 153,-103,-103, -93, -98,-103,-100, -99, -91, -91, -89,-114,-106,-105, -85, -83, -88,-123,-104; /M: SY='H'; M= -32, -94, -80, -79, -89, -89, 112, -43, -21, -86, -78, -71, 13, -76, -80, 19, 47, 12,-112, -73; /M: SY='A'; M= 55, -89, -90, -86, -85, -56, -92, 17, 10, -33, -75, 4, -92, -83, -85, 7, -74, 41, 42, -85; /M: SY='Q'; M= -30, -95, -88, -2, -11, -97, -83, -68, 42, 42, 8, -87, -33, 44, -74, -84, -81, 20, -90, 12; /M: SY='D'; M= -82, -99, 76, 64,-103, -87, -75, -97, -36, -98, -93, 32, -85, 30, -77, -1, -77, -18,-110, -91; /M: SY='P'; M= 48, -96, 0, -79, -97, -52, -91, -53, -85, -60, -84, -87, 91, -86, -93, -39, -16, 12,-102, -96; /M: SY='T'; M= -27, -90, -1, -76, -91, -89, 38, -85, 22, -52, -82, -26, 8, -3, -49, -29, 87, -44,-105, -38; /M: SY='P'; M= -48,-106, 62, -5,-106, -87, -83, -97, -78, -59, -92, -77, 98, 27, -87, -2, -78, -98,-105, -96; /I: I=-20; MD=-50; /M: SY='V'; M= 4, 27, 20, -83, -85, -63, -89, -67, -37, 25, -73, 23, 37, -4, -90, -39, -77, 44,-105, -88; D=-20; /I: I=-20; MI=0; MD=-50; IM=0; DM=-50; /M: SY='A'; M= 59, 34, 20, 48, -97, -83, 44, -88, -45, -90, -85, -77, -39, -74, -83, -30, -21, -3,-105, -89; /M: SY='N'; M= 19, -92, -72, -73, -96, -53, 21, -89, 41, -49, -83, 79, -91, 48, -40, -22, -74, -11,-104, -87; /M: SY='C'; M= 4, 145,-101,-100, -92, -72,-101, -13, -97, -88, -87, -89,-109,-102,-103, -83, -82, -82,-117,-101; /M: SY='H'; M= -45, -93, 3, -21, -94, -83, 64, -93, 7, -22, -84, 59, 14, -10, -44, 33, 29, -91,-108, -84; /M: SY='V'; M= -2, -92, -97, -91, -80, -9, -96, -29, -89, 26, -68, -92, 37, -91, -22, -82, 18, 62,-102, -86; /M: SY='R'; M= -31, -98, -90, -83, -80, -13, -79, -79, -65, 45, -70, -1, -42, -74, 83, -85, -85, -81, -94, 0; /M: SY='C'; M= 23, 66, -33, -36, -97, -28, -86, -39, -44, -40, -17, -81, 58, 64, -84, -74, 24, -56,-102, -92; /M: SY='E'; M= -2, -99, -16, 52, -42, 14, -81, -88, 11, 8, -81, -80, 8, 51, -11, -78, -83, -38, -97, -88; /M: SY='K'; M= 36, -93, 21, -22, -97, 1, 47, -29, 47, -92, -51, -72, -87, -20, -25, -32, 33, -85,-102, -86; /M: SY='Q'; M= -81,-102, -66, 67, -99, -90, -9, -97, -38, -95, -86, 25, -8, 89, -70, -5, -80, -46, -97, 2; /M: SY='H'; M= -3, -96, 11, -78, -76, -17, 98, -92, -80, -87, -79, -41, -91, 2, -81, -18, 45, -89, -89, 69; /M: SY='A'; M= 58, -90, -84, -82, -96, 37, 44, -91, 11, -52, -84, -16, -89, -77, -1, 3, -28, -27,-100, -88; /M: SY='V'; M= -18, -91,-100, -96, 53, -31, -93, 11, -93, -66, -69, -93, -99, -24, -94, -5, -76, 72, -86, 30; /I: I=-24; MD=-61; /M: SY='E'; M= -17,-111, -79, 70,-110, 32, -95, -45, -86,-108,-103, -90, -95, -81, -95, -86, 3,-104,-110, -23; D=-24; /I: I=-24; MD=-61; /M: SY='G'; M= 3,-120,-115, -45,-117, 47,-114,-112,-115, -30, 44,-106,-117,-110,-119,-101,-111,-110,-122,-116; D=-24; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='D'; M=-104,-113, 83, -77, 52,-105, -93, -45, 10,-100,-103, -80,-106, -94, -94, -95, -95,-104,-108, -84; D=-24; /I: I=-24; DM=-61; /M: SY='C'; M= -82, 147,-101, -99, -91, -98,-101, -92, -96, -50, -87, -89,-111, -7,-102, -85, -82, -16,-120,-100; /M: SY='D'; M= -5, -97, 73, -64,-102, -86, -77, -99, 63,-100, -92, 41, -89, -70, 6, -75, -24, -47,-107, -90; /M: SY='A'; M= 49, 28, -95, -91, 40, -5, -94, -30, -91, -75, 7, -87, -95, -89, -94, 17, -75, 46, -94, -78; /M: SY='T'; M= -38, -91, -79, -75, -94, -87, 45, -89, 46, -92, -84, -36, -8, -13, 9, 35, 67, -30,-104, -84; /M: SY='V'; M= -81, -92,-103, -96, -72,-106, -99, 48, 5, 34, 4, -97, -99, -92, -91, -92, -78, 67,-100, -80; /M: SY='F'; M= -11, -91, -93, -88, 44, -94, -88, 12, -26, 19, 33, -30, -95, 13, -88, 15, 27, 14, -92, -72; /M: SY='K'; M= -57, -98, -76, 6, -2, -1, 45, -99, 61, -96, -87, 5, -9, 15, 25, 11, -24, -96, -97, -82; /M: SY='Q'; M= -48, -96, 25, -25, -37, -40, -82, -25, 26, 5, -78, 11, 25, 45, -46, 17, -77, 12,-101, -86; /M: SY='H'; M= 0, -6, 26, 43, -90, -54, 44, -20, -80, 9, -78, 22, 25, -76, -86, -78, -4, -1,-106, -86; /M: SY='G'; M= 12, -96, -40, 29, -99, 75, -85,-102, -82, -60, -91, -13, -88, 10, -88, -7, -38, -96, -96, -21; /M: SY='Q'; M= -12, -96, -81, -48, -97, 18, -84, -15, 27, -91, -84, -3, 36, 51, -45, 8, 34, -14,-100, -90; /M: SY='F'; M= 4, -95, -4, 41, 70, -51, -86, -75, -83, 5, -76, -86, -10, 15, -87, -82, -9, 0, -86, -68; /M: SY='E'; M= -2, -95, 12, 64, -95, -89, 4, -39, 4, -44, -85, -75, -85, -19, -18, 26, 16, 0,-104, -88; /I: I=-19; MD=-47; /M: SY='V'; M= -96,-111, 14, 27,-107,-114,-104, -84, 7, -97, -96, -96,-106, -25, -47, -95, 7, 46,-124,-105; D=-19; /I: I=-19; MI=0; MD=-47; IM=0; DM=-47; /M: SY='V'; M= -31, -94, 9, 40, -89, -95, -88, -15, -30, -50, -41, -16, -91, -14, -6, 8, 7, 55,-107, -88; D=-19; /I: I=-19; DM=-47; /M: SY='F'; M= -14, -93,-105,-100, 67,-102, -89, 34, -96, 11, 45, -98,-101, -96, -96, -91, -70, 34, -80, 35; /M: SY='Y'; M= -27, -99, 4, 21, 43, -11, 16, -21, -4, -82, -9, 4, -20, 28, -4, -61, -83, -27, -83, 51; /M: SY='C'; M= 20, 85, -90, -6, -90, -44, -95, -73, -88, -82, -13, -85, -9, -88, -94, 18, 28, 45,-109, -92; /M: SY='Q'; M= -33,-101, 48, -62,-106, -29, -7,-102, 63, -99, -89, -34, -88, 79, -63, -16, -37, -99,-102, -88; /M: SY='C'; M= -84, 119, -93, -87, -94, -96, -94, -91, -26, -13, -85, -85, 44, 32, -92, -80, 37, -86,-111, -96; /M: SY='H'; M= -7, -96, 33, 29, -25, -93, 62, -77, -3, -13, -79, 8, -92, -77, -82, -41, -14, 34,-104, -10; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 34 in 17 different sequences |
| Number of true positive hits | 34 in 17 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 2 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Cystatin fetuin-A-type |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
17 sequences
FETAF_PROFL (P29695), FETCA_GLOBR (Q5KQS3), FETCB_GLOBR (Q5KQS2), FETC_GLOBR (Q5KQS4), FETHP_PROFL (Q5KQS5), FETJ_GLOBL (Q5KQS1), FETUA_BOVIN (P12763), FETUA_CAVPO (O70159), FETUA_HUMAN (P02765), FETUA_MERUN (P97515), FETUA_MOUSE (P29699), FETUA_PANTR (Q9N2D0), FETUA_PIG (P29700), FETUA_RABIT (P80191), FETUA_RAT (P24090), FETUA_SHEEP (P29701), FTE46_BOTJA (Q9DGI0)» more
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