PROSITE entry PS51530
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General information about the entry
| Entry name [info] | CYSTATIN_FETUIN_B |
| Accession [info] | PS51530 |
| Entry type [info] | MATRIX |
| Date [info] |
01-MAR-2011 CREATED;
01-OCT-2013 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00966 |
| Associated ProRule [info] | PRU00862 |
Name and characterization of the entry
| Description [info] | Fetuin-B-type cystatin domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=112; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=107; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9357021; R2=0.0074100; TEXT='NScore'; /CUT_OFF: LEVEL=0; SCORE=3383; N_SCORE=28.0; MODE=1; TEXT='R'; /CUT_OFF: LEVEL=-1; SCORE=482; N_SCORE=6.5; MODE=1; TEXT='R?'; /DEFAULT: M0=-48; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='M'; M= 9, -90, -77, 35, -80, 27, -77, -76, -72, -9, 43, -76, -85, 33, 12, 8, 11, 3, -89, 28; /M: SY='A'; M= 44, -87, 21, 9, -89, 26, -81, -79, -73, -8, -77, -73, -85, 28, 12, -66, 40, 3, -97, -85; /M: SY='C'; M= -76, 128, -90, -88, -88, 5, -89, -89, -81, -11, -81, -79, 21, -86, 23, 8, 11, -83,-106, -92; /M: SY='P'; M= 25, -96, -84, -75, -97, -80, -86, -83, -80, -93, -84, -83, 110, -80, -89, 36, -70, 1, -97, -94; /M: SY='D'; M= -76, -92, 95, -60, -94, 0, -75, -92, -72, -12, -88, -60, -85, -72, 14, 40, 19, -89,-107, -85; /M: SY='C'; M= 0, 128, -89, -90, -85, -87, -91, -73, -87, -80, -79, 26, -99, -90, -92, 18, -71, 44,-111, -91; /M: SY='P'; M= -81,-100, -86, -75, -87, -87, -84, -77, -80, 37, -72, -87, 108, 32, -87, 7, -75, -82, -94, -88; /M: SY='T'; M= -1, -83, -87, -85, -77, 1, -86, -60, -83, 24, 48, -78, -87, -81, -87, 34, 56, 45, -98, -80; /M: SY='P'; M= -3, -94, 16, -71, -93, 2, 41, -88, -77, -10, -81, -72, 80, 27, -82, 55, -70, -87, -98, -85; /M: SY='I'; M= -3, -92, 46, 7, -78, -1, -87, 50, -84, 24, -66, -80, 20, -82, -90, -80, -76, 30, -97, -81; /M: SY='P'; M= 25, 47, 49, -68, -97, -81, -81, -92, 13, -94, -86, -72, 79, -75, 11, 8, 12, -87,-101, -90; /M: SY='C'; M= -79, 125, -88, 7, -81, -94, -90, -78, -86, 31, -73, -83, 22, -88, -92, -77, 41, -75,-105, -89; /M: SY='D'; M= -79, -93, 89, -58, -98, -79, 42, -97, 9, -96, -89, 57, -84, 34, -72, 7, 14, -94,-110, -83; /M: SY='D'; M= -78, -93, 96, 13, -99, -78, 43,-100, -71, -99, -93, 50, -84, -68, -78, 41, -69, -96,-113, -84; /M: SY='P'; M= 42, -89, 16, 10, -94, -76, -81, -84, 6, -90, -84, -73, 66, -72, -79, 56, -67, 0, -98, -89; /M: SY='N'; M= 42, -86, -78, -80, -80, 2, -76, -75, -71, -82, -77, 50, -89, -74, 40, 7, 12, 27, -90, 41; /M: SY='V'; M= -3, -86, -93, -90, 19, -95, 44, 10, -88, -62, -63, -87, -93, -88, -89, -79, 14, 83, -91, 31; /M: SY='Q'; M= -77, -90, -76, 52, -76, -90, -76, -68, -74, 56, 48, -80, -87, 57, -77, 33, -74, -72, -92, -77; /M: SY='E'; M= -1, -93, 28, 73, -95, -86, -75, -88, 53, -90, -85, -70, -80, -60, 15, 8, -73, 2, -97, -86; /M: SY='A'; M= 70, -82, -87, -83, -80, -80, -89, 19, -83, 18, -67, -80, -86, -81, -87, -65, 56, 4, -95, -82; /M: SY='A'; M= 84, -81, -81, 10, -89, -73, -86, -73, -79, -80, -76, -78, -84, -75, -84, 8, 12, 29, -96, -87; /M: SY='D'; M= 25, -89, 44, 16, -94, -80, -75, -85, 35, -89, -82, 34, -84, 26, 13, 9, 12, 2,-100, -85; /M: SY='M'; M= -1, -90, 27, 54, -75, -92, -77, -67, 9, 54, 69, -81, -87, -70, -77, -81, -78, -71, -94, -78; /M: SY='S'; M= 62, -82, -81, -79, -88, 2, -85, 17, -79, -82, -78, -71, -83, -75, -84, 62, 42, -70, -96, -85; /M: SY='L'; M= -82, -87, -94, 9, -62,-101, -83, -51, -89, 81, 71, -96, -96, -82, -88, -91, -79, 4, -91, -72; /M: SY='R'; M= 24, -91, -67, 55, -96, -82, -73, -93, 10, -91, -83, 22, -82, 40, 57, 9, 12, -86, -96, -85; /M: SY='K'; M= -81, -96, 27, -59, -86, -88, -71, -89, 86, -9, -77, -68, -84, 75, -52, -74, -77, -88, -86, 28; /M: SY='I'; M= -2, -93, -98, -96, 63, -99, -82, 75, -92, -3, -60, -92, -96, -90, -92, -86, -79, -54, -69, 74; /M: SY='N'; M= -80, -85, -54, -73, -95, -69, -61, -94, 11,-101, -87, 126, -90, -66, -70, -62, -65, -96,-111, -89; /M: SY='N'; M= 43, -88, -70, 36, -83, -78, -73, -85, 7, -10, -78, 49, -85, -66, 25, 34, -70, -81, -90, 31; /M: SY='E'; M= -81, -97, 75, 83, -98, -87, -72, 5, 8, -91, -88, 24, -79, -61, -72, -74, -75, -87,-104, -88; /M: SY='R'; M= -73, -90, -73, -72, -93, -78, -70, -96, -54, -95, -85, 50, -88, -62, 89, 71, -67, -90, -98, -83; /M: SY='Q'; M= -2, -91, -69, 38, -96, 1, -75, -91, 20, -91, -82, 21, 21, 58, 15, -65, 56, -86, -97, -86; /I: I=-28; MI=0; MD=-71; IM=0; DM=-71; /M: SY='E'; M= -79, -93, 27, 55, 16, -92, -81, -81, 9, -9, -80, -74, -86, 29, -76, 5, 40, 1, -97, -80; D=-28; /I: I=-28; DM=-71; /M: SY='G'; M= -1, -89, -79, -84, -92, 76, -83, -91, -82, -10, -83, 21, 20, -79, -88, 34, 14, -87, -95, -90; /M: SY='Y'; M= -84, -95, -78, -78, 22, -88, 89, -84, 34, -79, -73, 21, -92, -71, -70, 6, -78, -86, -68, 100; /M: SY='Y'; M= -81, -94, -89, -81, -64, -97, -77, 52, 33, -7, -63, -84, -93, 29, 14, -82, -77, 36, -77, 75; /M: SY='F'; M= -90, -90,-102, -98, 104,-100, -79, -62, -94, 40, -61, -95,-103, -96, -91, -91, -84, -68, -61, 60; /M: SY='S'; M= 41, -81, -75, 8, -90, -73, -81, -80, -75, -86, -82, -68, -81, -70, -81, 82, 43, 2, -99, -85; /M: SY='L'; M= -83, -88,-100, -93, -62,-102, -88, 11, -94, 85, -49, -99, 20, -89, -93, -93, -79, 7, -90, -73; /M: SY='N'; M= -3, -88, 16, -80, 20, -85, 44, -66, -80, 34, -67, 72, -94, -79, -83, -76, -73, 27, -90, 29; /M: SY='R'; M= -82, -94, -69, -68, -94, -83, -68, -97, 53, -96, -84, 77, -89, -60, 90, -72, -75, -94, -97, -83; /M: SY='I'; M= -77, -90,-102, -98, -68,-105,-102, 86, -95, -2, -55, -95, -94, -93, -97, -88, -73, 70, -96, -76; /M: SY='T'; M= -72, -82, -75, -80, 17, -83, -78, -77, -76, -80, -77, 23, -81, -78, -82, 20, 103, -72, -91, 36; /M: SY='R'; M= -4, -92, 50, -66, -96, -80, -69, -97, 10, -96, -86, 68, -88, -64, 79, 7, -72, -92,-102, -84; /M: SY='A'; M= 77, -82, -89, -84, -86, 28, -92, -65, -85, -76, -74, -82, -88, -83, -89, -66, -71, 58, -96, -87; /M: SY='H'; M= -76, -91, -78, -71, 17, -84, 73, -87, 15, -82, 39, -68, -86, 27, 61, 50, 14, -85, -94, -70; /M: SY='M'; M= 24, -89, -71, 57, -84, -82, -75, 6, -72, -3, 69, 20, -83, 28, -77, 34, -71, -72, -95, -81; /I: I=-26; MI=0; MD=-65; IM=0; DM=-65; /M: SY='Q'; M= -77, -99, -68, 23,-102, 1, 44, -96, 15, -91, -79, 24, -83, 113, -61, -68, -78, -96, -94, -79; /M: SY='W'; M= 33, -96, -91, 7, -75, 26, -92, 7, -79, -78, 42, -87, -89, -79, 12, -78, -83, 1, 129, -68; /M: SY='V'; M= -1, -91, 46, 37, -85, 11, -87, 8, -80, -74, -74, -78, 20, -78, -87, -76, -73, 65,-102, -85; /M: SY='M'; M= 24, -84, -85, -86, 18, 5, -85, 9, -83, 4, 42, 22, -88, -82, -87, 6, 40, 29, -93, -76; /M: SY='G'; M= -67, -93, -83, -92, -96, 99, -89, 9, -87, -95, -87, -69, -86, -84, -94, 9, -81, -89, -92, -92; /M: SY='P'; M= -75, -92, -78, -73, -91, -82, -79, -80, 34, -86, 42, 27, 79, -72, 13, 40, 15, 1, -98, -86; /M: SY='H'; M= 40, -86, -89, -85, 18, -84, 48, 10, -85, 4, -66, -82, -91, -81, -86, 33, -71, 44, -87, 31; /M: SY='Y'; M= -89, -95, -91, -92, 68, -97, 45, -71, -86, -1, -65, -88,-100, -83, -83, -86, -83, -76, -53, 117; /M: SY='Y'; M= -85, -94, -81, -82, 64, -89, 75, -79, -79, -74, -71, 22, -95, 28, -78, 6, -79, -83, -63, 99; /M: SY='V'; M= -77, -85,-102, -95, 31,-102, -94, -43, -94, 56, -55, -98, -99, -93, -93, -88, -74, 80, -92, -69; /M: SY='E'; M= -75, -91, 17, 88, -92, -91, -77, 4, -67, -85, -82, -70, -76, -63, -76, -67, 74, -77,-101, -87; /M: SY='F'; M= -89, -90,-100, -96, 84,-101, -76, -60, -93, 58, -57, -96,-102, -91, -90, -91, -83, -66, -64, 76; /M: SY='D'; M= -2, -90, 92, -64, -83, -87, -79, 5, -79, 33, -74, -66, -87, -78, -85, -73, 39, -73,-105, -82; /M: SY='V'; M= -75, -89,-102, -98, -69,-105,-103, 80, -94, -53, -57, -95, -94, -94, -97, -87, -71, 83, -99, -77; /M: SY='Q'; M= -80, -92, -84, -70, -76, -93, 42, -66, 35, 58, -60, -79, -91, 84, -68, -79, -79, 2, -92, -74; /M: SY='E'; M= 3, -97, 18, 109,-101, -90, -72,-100, -61, -94, -90, -73, -74, -54, -71, -72, -77, -92, -99, -91; /M: SY='T'; M= -1, -79, -75, -77, -87, -79, -83, -79, -75, -84, -80, -64, -78, -76, -82, 51, 105, -71,-103, -84; /M: SY='E'; M= -73, -93, -70, 52, -95, 11, -78, -86, 34, -90, -83, -72, 50, 34, -70, 34, 14, 0, -96, -87; /M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100; /I: I=-30; MI=0; MD=-77; IM=0; DM=-77; /M: SY='H'; M= -80, -95, -72, -67, -90, -86, 121, -97, 52, -89, -76, -63, -84, 29, 14, 7, 11, -94,-105, -66; /M: SY='V'; M= -71, -86, -82, -80, -83, 0, -85, -60, 34, -74, -72, 20, -88, -77, 14, 9, 40, 69,-101, -82; /I: I=-24; MD=-61; /M: SY='L'; M= -90, -99, 15, -94, -81,-102, -94, 36, -96, 48, -70, 20,-103, -93, -99, 3, 11, -70,-107, -88; D=-24; /I: I=-24; MI=-61; MD=-61; IM=-61; DM=-61; /M: SY='S'; M= -73, -95, -83, -85,-104, -79, -86,-103, -85,-107, -99, 21, 22, -79, -90, 93, -67, -97,-112, -97; D=-24; /I: I=-24; DM=-61; /M: SY='K'; M= -90,-107, -87, 7,-104,-101, -89, -95, 51,-100, -92, -85, 49, -76, 50, -86, 11, 0,-106, -96; D=-24; /I: I=-24; DM=-61; /M: SY='Q'; M= 24,-102, -86, 8,-103, -95, -88, 2, 34, -94, -88, -83, -94, 55, 19, -79, 23, -87,-104, -94; D=-24; /I: I=-24; DM=-61; /M: SY='D'; M= -74, -89, 59, -65, -88, -80, -74, -84, 37, 16, -78, 23, -85, 29, -70, 54, 14, -83,-100, -82; /M: SY='W'; M= -2, -99,-102, -88, -65, -91,-100, 8, -86, 16, -72, -96, -93, 25, -88, -85, 12, 2, 150, -58; /M: SY='K'; M= -3, -90, 43, -64, -95, -80, -75, -94, 67, -94, -85, -64, -83, -64, 43, 51, 12, -87, -97, -84; /M: SY='Q'; M= -74, -90, 18, -62, -97, -76, -69, -94, 51, -95, -84, 70, -84, 72, -62, 52, -67, -92, -99, -84; /M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100; /M: SY='E'; M= 27, -91, -64, 77, -97, -82, -77, -93, 10, -93, -86, -73, 50, -63, -73, 34, 12, -86, -97, -90; /M: SY='V'; M= -78, -90, -97, -89, -71, -99, -94, 12, -90, 46, -59, -96, 67, -90, -94, -87, -74, 70, -97, -80; /I: I=-30; MI=0; MD=-77; IM=0; DM=-77; /M: SY='M'; M= -81, -95, 21, -67, -85, -90, -74, -78, 51, 17, 70, -74, 20, 56, 47, -78, -78, -80, -93, -78; /M: SY='P'; M= -2, -94, 42, 10, 16, -85, 41, 41, 9, -79, -77, -72, 50, -74, -79, 35, -72, -73, -95, -77; /M: SY='C'; M= -2, 75, -82, 9, 29, 6, -82, -81, -81, -8, 40, -76, 23, -77, -86, 61, -70, -79, -92, -78; /M: SY='H'; M= -80, -97, 44, 74, -98, -84, 78,-100, -64, -94, -85, 53, -81, 55, -69, -71, -76, -97,-105, -80; /M: SY='S'; M= -75, -88, 15, 43, 46, -86, -76, -76, -77, 21, -73, -74, -86, -73, -81, 49, 39, -76, -84, 31; /M: SY='A'; M= 69, -86, -79, 8, -93, -75, -83, -80, -76, -85, -79, -77, 53, 26, -82, 19, 13, 3, -96, -88; /M: SY='H'; M= 28, -90, -88, -81, -80, -89, 71, 8, 8, -9, -67, -83, 50, -80, -82, -77, -74, 60,-100, -77; /M: SY='Y'; M= -77, -90, -84, -80, 25, -89, -75, 8, 50, -73, -71, -77, -89, -75, -71, 33, 13, 29, -74, 79; /M: SY='G'; M= -67, -94, -82, -94,-100, 106, -89,-108, -87,-104, -93, -68, -86, -85, -95, -67, -86,-102, -91, -95; /M: SY='Q'; M= -83, -92, -83, -75, 74, -91, -75, 5, 9, -5, -69, 20, -91, 76, -74, -76, 18, -74, -75, 31; /M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100; /M: SY='K'; M= -78, -93, -68, 17, -97, -84, -73, -96, 99, -95, -84, 21, -81, 28, -48, 6, -72, -92, -92, -84; /M: SY='G'; M= 57, -85, -84, -85, -91, 65, -89, -78, -83, -85, -80, -74, -85, -81, -89, 8, 12, 29, -95, -89; /M: SY='S'; M= -67, -85, -78, 10, 17, -79, -82, 39, -78, -76, -75, -71, -84, -73, -83, 86, 14, 4, -94, -76; /M: SY='H'; M= -3, -87, -93, -89, 53, -95, 70, 9, -88, 20, 43, -84, -93, -85, -87, -81, 11, 47, -89, -63; /M: SY='Y'; M= -76, -89, -88, -87, 21, -91, 44, 7, -84, -7, -66, -81, -93, -81, -85, 36, 15, 45, -76, 79; /M: SY='I'; M= -3, -91, -85, -82, -72, -91, 41, 54, -77, -1, 42, 22, -90, 25, 14, -77, 11, 4, -89, 31; /I: I=-26; MD=-65; /M: SY='N'; M= -5,-100, -79, -91,-108, -87, 42,-107, -87,-110,-100, 81,-102, -85, -92, 33, 12,-103,-124, -98; D=-26; /I: I=-26; MI=0; MD=-65; IM=0; DM=-65; /M: SY='T'; M= -76, -89, 43, 16, 17, -86, -76, -88, 42, -87, -82, -65, -81, 27, 15, 7, 69, -83, -95, -78; /M: SY='P'; M= -76, -94, -78, 20, -88, -85, 44, -77, -78, -11, 42, -79, 88, -75, -84, 36, 12, 2, -99, -83; /M: SY='W'; M= -80, -93, 16, 37, -86, -88, 43, -89, 42, -12, -80, 22, -84, -65, 40, -72, 43, -86, 72, -76; /I: I=-19; MD=-47; /M: SY='H'; M= -91,-110, -82, 34,-106, 25, 71,-114, 8,-105, -95, -81, -97, -73, 62, -86, -94,-109,-109, -90; D=-19; /I: I=-19; MD=-47; /M: SY='I'; M=-107,-118,-130,-127, 15,-132,-127, 64,-122, -79, -83,-121,-121,-122,-124,-116,-102, 28,-115, -95; D=-19; /I: I=-19; MI=0; MD=-47; IM=0; DM=-47; /M: SY='E'; M= 24, -90, -69, 65, 29, -86, -79, 11, 51, -81, -79, -74, -81, -65, -68, 6, 13, -76, -89, -77; /M: SY='H'; M= -2, -95, -75, 10, -76, -88, 72, -84, 64, -84, -76, -72, -86, 29, 16, -75, -78, -1, -82, 64; /M: SY='L'; M= -77, -86, -88, -87, 21, -91, 42, -57, -87, 64, -58, 21, -95, -82, -87, 33, -73, 32, -92, -69; /M: SY='Y'; M= -79, -93, -80, 8, -72, -91, 44, -63, -78, -8, -69, 20, 57, 33, -81, -79, -75, 56, -87, 57; /M: SY='S'; M= 10, -84, 14, -71, -92, -74, -78, -88, 9, -91, -84, -64, -81, -68, 13, 80, 57, -80,-100, -84; /M: SY='Y'; M= -79, -91, -94, -93, -51, -99, -73, 12, -88, -62, -63, -93, -98, -86, -87, -84, -75, 73, -66, 108; /M: SY='N'; M= -72, -87, 16, 37, -95, -76, -70, -92, 7, -94, -86, 73, -82, 28, -71, 51, 41, -88,-103, -86; /M: SY='C'; M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100; /M: SY='E'; M= 0, -88, 19, 74, -94, -81, -74, -91, -67, -91, -86, 49, -78, -64, -76, 14, 61, -84,-103, -88; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 8 in 4 different sequences |
| Number of true positive hits | 8 in 4 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 2 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | Cystatin fetuin-B-type |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
4 sequences
FETUB_BOVIN (Q58D62), FETUB_HUMAN (Q9UGM5), FETUB_MOUSE (Q9QXC1), FETUB_RAT (Q9QX79)» more
|
| PDB [Detailed view] |
5 PDB
6HPV; 6HT9; 6SAZ; 7AUW; 7UAI |