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Entry: PS51530

General information about the entry

Entry name [info] CYSTATIN_FETUIN_B
Accession [info] PS51530
Entry type [info] MATRIX
Date [info] 01-MAR-2011 CREATED;
01-OCT-2013 DATA UPDATE;
12-AUG-2020 INFO UPDATE.
PROSITE Doc. [info] PDOC00966
Associated ProRule [info] PRU00862

Name and characterization of the entry

Description [info] Fetuin-B-type cystatin domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=112;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=107;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.9357021; R2=0.0074100; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=3383; N_SCORE=28.0; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=482; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-48; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='M';  M=   9, -90, -77,  35, -80,  27, -77, -76, -72,  -9,  43, -76, -85,  33,  12,   8,  11,   3, -89,  28;
/M: SY='A';  M=  44, -87,  21,   9, -89,  26, -81, -79, -73,  -8, -77, -73, -85,  28,  12, -66,  40,   3, -97, -85;
/M: SY='C';  M= -76, 128, -90, -88, -88,   5, -89, -89, -81, -11, -81, -79,  21, -86,  23,   8,  11, -83,-106, -92;
/M: SY='P';  M=  25, -96, -84, -75, -97, -80, -86, -83, -80, -93, -84, -83, 110, -80, -89,  36, -70,   1, -97, -94;
/M: SY='D';  M= -76, -92,  95, -60, -94,   0, -75, -92, -72, -12, -88, -60, -85, -72,  14,  40,  19, -89,-107, -85;
/M: SY='C';  M=   0, 128, -89, -90, -85, -87, -91, -73, -87, -80, -79,  26, -99, -90, -92,  18, -71,  44,-111, -91;
/M: SY='P';  M= -81,-100, -86, -75, -87, -87, -84, -77, -80,  37, -72, -87, 108,  32, -87,   7, -75, -82, -94, -88;
/M: SY='T';  M=  -1, -83, -87, -85, -77,   1, -86, -60, -83,  24,  48, -78, -87, -81, -87,  34,  56,  45, -98, -80;
/M: SY='P';  M=  -3, -94,  16, -71, -93,   2,  41, -88, -77, -10, -81, -72,  80,  27, -82,  55, -70, -87, -98, -85;
/M: SY='I';  M=  -3, -92,  46,   7, -78,  -1, -87,  50, -84,  24, -66, -80,  20, -82, -90, -80, -76,  30, -97, -81;
/M: SY='P';  M=  25,  47,  49, -68, -97, -81, -81, -92,  13, -94, -86, -72,  79, -75,  11,   8,  12, -87,-101, -90;
/M: SY='C';  M= -79, 125, -88,   7, -81, -94, -90, -78, -86,  31, -73, -83,  22, -88, -92, -77,  41, -75,-105, -89;
/M: SY='D';  M= -79, -93,  89, -58, -98, -79,  42, -97,   9, -96, -89,  57, -84,  34, -72,   7,  14, -94,-110, -83;
/M: SY='D';  M= -78, -93,  96,  13, -99, -78,  43,-100, -71, -99, -93,  50, -84, -68, -78,  41, -69, -96,-113, -84;
/M: SY='P';  M=  42, -89,  16,  10, -94, -76, -81, -84,   6, -90, -84, -73,  66, -72, -79,  56, -67,   0, -98, -89;
/M: SY='N';  M=  42, -86, -78, -80, -80,   2, -76, -75, -71, -82, -77,  50, -89, -74,  40,   7,  12,  27, -90,  41;
/M: SY='V';  M=  -3, -86, -93, -90,  19, -95,  44,  10, -88, -62, -63, -87, -93, -88, -89, -79,  14,  83, -91,  31;
/M: SY='Q';  M= -77, -90, -76,  52, -76, -90, -76, -68, -74,  56,  48, -80, -87,  57, -77,  33, -74, -72, -92, -77;
/M: SY='E';  M=  -1, -93,  28,  73, -95, -86, -75, -88,  53, -90, -85, -70, -80, -60,  15,   8, -73,   2, -97, -86;
/M: SY='A';  M=  70, -82, -87, -83, -80, -80, -89,  19, -83,  18, -67, -80, -86, -81, -87, -65,  56,   4, -95, -82;
/M: SY='A';  M=  84, -81, -81,  10, -89, -73, -86, -73, -79, -80, -76, -78, -84, -75, -84,   8,  12,  29, -96, -87;
/M: SY='D';  M=  25, -89,  44,  16, -94, -80, -75, -85,  35, -89, -82,  34, -84,  26,  13,   9,  12,   2,-100, -85;
/M: SY='M';  M=  -1, -90,  27,  54, -75, -92, -77, -67,   9,  54,  69, -81, -87, -70, -77, -81, -78, -71, -94, -78;
/M: SY='S';  M=  62, -82, -81, -79, -88,   2, -85,  17, -79, -82, -78, -71, -83, -75, -84,  62,  42, -70, -96, -85;
/M: SY='L';  M= -82, -87, -94,   9, -62,-101, -83, -51, -89,  81,  71, -96, -96, -82, -88, -91, -79,   4, -91, -72;
/M: SY='R';  M=  24, -91, -67,  55, -96, -82, -73, -93,  10, -91, -83,  22, -82,  40,  57,   9,  12, -86, -96, -85;
/M: SY='K';  M= -81, -96,  27, -59, -86, -88, -71, -89,  86,  -9, -77, -68, -84,  75, -52, -74, -77, -88, -86,  28;
/M: SY='I';  M=  -2, -93, -98, -96,  63, -99, -82,  75, -92,  -3, -60, -92, -96, -90, -92, -86, -79, -54, -69,  74;
/M: SY='N';  M= -80, -85, -54, -73, -95, -69, -61, -94,  11,-101, -87, 126, -90, -66, -70, -62, -65, -96,-111, -89;
/M: SY='N';  M=  43, -88, -70,  36, -83, -78, -73, -85,   7, -10, -78,  49, -85, -66,  25,  34, -70, -81, -90,  31;
/M: SY='E';  M= -81, -97,  75,  83, -98, -87, -72,   5,   8, -91, -88,  24, -79, -61, -72, -74, -75, -87,-104, -88;
/M: SY='R';  M= -73, -90, -73, -72, -93, -78, -70, -96, -54, -95, -85,  50, -88, -62,  89,  71, -67, -90, -98, -83;
/M: SY='Q';  M=  -2, -91, -69,  38, -96,   1, -75, -91,  20, -91, -82,  21,  21,  58,  15, -65,  56, -86, -97, -86;
/I:         I=-28; MI=0; MD=-71; IM=0; DM=-71;
/M: SY='E';  M= -79, -93,  27,  55,  16, -92, -81, -81,   9,  -9, -80, -74, -86,  29, -76,   5,  40,   1, -97, -80; D=-28;
/I:         I=-28; DM=-71;
/M: SY='G';  M=  -1, -89, -79, -84, -92,  76, -83, -91, -82, -10, -83,  21,  20, -79, -88,  34,  14, -87, -95, -90;
/M: SY='Y';  M= -84, -95, -78, -78,  22, -88,  89, -84,  34, -79, -73,  21, -92, -71, -70,   6, -78, -86, -68, 100;
/M: SY='Y';  M= -81, -94, -89, -81, -64, -97, -77,  52,  33,  -7, -63, -84, -93,  29,  14, -82, -77,  36, -77,  75;
/M: SY='F';  M= -90, -90,-102, -98, 104,-100, -79, -62, -94,  40, -61, -95,-103, -96, -91, -91, -84, -68, -61,  60;
/M: SY='S';  M=  41, -81, -75,   8, -90, -73, -81, -80, -75, -86, -82, -68, -81, -70, -81,  82,  43,   2, -99, -85;
/M: SY='L';  M= -83, -88,-100, -93, -62,-102, -88,  11, -94,  85, -49, -99,  20, -89, -93, -93, -79,   7, -90, -73;
/M: SY='N';  M=  -3, -88,  16, -80,  20, -85,  44, -66, -80,  34, -67,  72, -94, -79, -83, -76, -73,  27, -90,  29;
/M: SY='R';  M= -82, -94, -69, -68, -94, -83, -68, -97,  53, -96, -84,  77, -89, -60,  90, -72, -75, -94, -97, -83;
/M: SY='I';  M= -77, -90,-102, -98, -68,-105,-102,  86, -95,  -2, -55, -95, -94, -93, -97, -88, -73,  70, -96, -76;
/M: SY='T';  M= -72, -82, -75, -80,  17, -83, -78, -77, -76, -80, -77,  23, -81, -78, -82,  20, 103, -72, -91,  36;
/M: SY='R';  M=  -4, -92,  50, -66, -96, -80, -69, -97,  10, -96, -86,  68, -88, -64,  79,   7, -72, -92,-102, -84;
/M: SY='A';  M=  77, -82, -89, -84, -86,  28, -92, -65, -85, -76, -74, -82, -88, -83, -89, -66, -71,  58, -96, -87;
/M: SY='H';  M= -76, -91, -78, -71,  17, -84,  73, -87,  15, -82,  39, -68, -86,  27,  61,  50,  14, -85, -94, -70;
/M: SY='M';  M=  24, -89, -71,  57, -84, -82, -75,   6, -72,  -3,  69,  20, -83,  28, -77,  34, -71, -72, -95, -81;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='Q';  M= -77, -99, -68,  23,-102,   1,  44, -96,  15, -91, -79,  24, -83, 113, -61, -68, -78, -96, -94, -79;
/M: SY='W';  M=  33, -96, -91,   7, -75,  26, -92,   7, -79, -78,  42, -87, -89, -79,  12, -78, -83,   1, 129, -68;
/M: SY='V';  M=  -1, -91,  46,  37, -85,  11, -87,   8, -80, -74, -74, -78,  20, -78, -87, -76, -73,  65,-102, -85;
/M: SY='M';  M=  24, -84, -85, -86,  18,   5, -85,   9, -83,   4,  42,  22, -88, -82, -87,   6,  40,  29, -93, -76;
/M: SY='G';  M= -67, -93, -83, -92, -96,  99, -89,   9, -87, -95, -87, -69, -86, -84, -94,   9, -81, -89, -92, -92;
/M: SY='P';  M= -75, -92, -78, -73, -91, -82, -79, -80,  34, -86,  42,  27,  79, -72,  13,  40,  15,   1, -98, -86;
/M: SY='H';  M=  40, -86, -89, -85,  18, -84,  48,  10, -85,   4, -66, -82, -91, -81, -86,  33, -71,  44, -87,  31;
/M: SY='Y';  M= -89, -95, -91, -92,  68, -97,  45, -71, -86,  -1, -65, -88,-100, -83, -83, -86, -83, -76, -53, 117;
/M: SY='Y';  M= -85, -94, -81, -82,  64, -89,  75, -79, -79, -74, -71,  22, -95,  28, -78,   6, -79, -83, -63,  99;
/M: SY='V';  M= -77, -85,-102, -95,  31,-102, -94, -43, -94,  56, -55, -98, -99, -93, -93, -88, -74,  80, -92, -69;
/M: SY='E';  M= -75, -91,  17,  88, -92, -91, -77,   4, -67, -85, -82, -70, -76, -63, -76, -67,  74, -77,-101, -87;
/M: SY='F';  M= -89, -90,-100, -96,  84,-101, -76, -60, -93,  58, -57, -96,-102, -91, -90, -91, -83, -66, -64,  76;
/M: SY='D';  M=  -2, -90,  92, -64, -83, -87, -79,   5, -79,  33, -74, -66, -87, -78, -85, -73,  39, -73,-105, -82;
/M: SY='V';  M= -75, -89,-102, -98, -69,-105,-103,  80, -94, -53, -57, -95, -94, -94, -97, -87, -71,  83, -99, -77;
/M: SY='Q';  M= -80, -92, -84, -70, -76, -93,  42, -66,  35,  58, -60, -79, -91,  84, -68, -79, -79,   2, -92, -74;
/M: SY='E';  M=   3, -97,  18, 109,-101, -90, -72,-100, -61, -94, -90, -73, -74, -54, -71, -72, -77, -92, -99, -91;
/M: SY='T';  M=  -1, -79, -75, -77, -87, -79, -83, -79, -75, -84, -80, -64, -78, -76, -82,  51, 105, -71,-103, -84;
/M: SY='E';  M= -73, -93, -70,  52, -95,  11, -78, -86,  34, -90, -83, -72,  50,  34, -70,  34,  14,   0, -96, -87;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='H';  M= -80, -95, -72, -67, -90, -86, 121, -97,  52, -89, -76, -63, -84,  29,  14,   7,  11, -94,-105, -66;
/M: SY='V';  M= -71, -86, -82, -80, -83,   0, -85, -60,  34, -74, -72,  20, -88, -77,  14,   9,  40,  69,-101, -82;
/I:         I=-24; MD=-61;
/M: SY='L';  M= -90, -99,  15, -94, -81,-102, -94,  36, -96,  48, -70,  20,-103, -93, -99,   3,  11, -70,-107, -88; D=-24;
/I:         I=-24; MI=-61; MD=-61; IM=-61; DM=-61;
/M: SY='S';  M= -73, -95, -83, -85,-104, -79, -86,-103, -85,-107, -99,  21,  22, -79, -90,  93, -67, -97,-112, -97; D=-24;
/I:         I=-24; DM=-61;
/M: SY='K';  M= -90,-107, -87,   7,-104,-101, -89, -95,  51,-100, -92, -85,  49, -76,  50, -86,  11,   0,-106, -96; D=-24;
/I:         I=-24; DM=-61;
/M: SY='Q';  M=  24,-102, -86,   8,-103, -95, -88,   2,  34, -94, -88, -83, -94,  55,  19, -79,  23, -87,-104, -94; D=-24;
/I:         I=-24; DM=-61;
/M: SY='D';  M= -74, -89,  59, -65, -88, -80, -74, -84,  37,  16, -78,  23, -85,  29, -70,  54,  14, -83,-100, -82;
/M: SY='W';  M=  -2, -99,-102, -88, -65, -91,-100,   8, -86,  16, -72, -96, -93,  25, -88, -85,  12,   2, 150, -58;
/M: SY='K';  M=  -3, -90,  43, -64, -95, -80, -75, -94,  67, -94, -85, -64, -83, -64,  43,  51,  12, -87, -97, -84;
/M: SY='Q';  M= -74, -90,  18, -62, -97, -76, -69, -94,  51, -95, -84,  70, -84,  72, -62,  52, -67, -92, -99, -84;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='E';  M=  27, -91, -64,  77, -97, -82, -77, -93,  10, -93, -86, -73,  50, -63, -73,  34,  12, -86, -97, -90;
/M: SY='V';  M= -78, -90, -97, -89, -71, -99, -94,  12, -90,  46, -59, -96,  67, -90, -94, -87, -74,  70, -97, -80;
/I:         I=-30; MI=0; MD=-77; IM=0; DM=-77;
/M: SY='M';  M= -81, -95,  21, -67, -85, -90, -74, -78,  51,  17,  70, -74,  20,  56,  47, -78, -78, -80, -93, -78;
/M: SY='P';  M=  -2, -94,  42,  10,  16, -85,  41,  41,   9, -79, -77, -72,  50, -74, -79,  35, -72, -73, -95, -77;
/M: SY='C';  M=  -2,  75, -82,   9,  29,   6, -82, -81, -81,  -8,  40, -76,  23, -77, -86,  61, -70, -79, -92, -78;
/M: SY='H';  M= -80, -97,  44,  74, -98, -84,  78,-100, -64, -94, -85,  53, -81,  55, -69, -71, -76, -97,-105, -80;
/M: SY='S';  M= -75, -88,  15,  43,  46, -86, -76, -76, -77,  21, -73, -74, -86, -73, -81,  49,  39, -76, -84,  31;
/M: SY='A';  M=  69, -86, -79,   8, -93, -75, -83, -80, -76, -85, -79, -77,  53,  26, -82,  19,  13,   3, -96, -88;
/M: SY='H';  M=  28, -90, -88, -81, -80, -89,  71,   8,   8,  -9, -67, -83,  50, -80, -82, -77, -74,  60,-100, -77;
/M: SY='Y';  M= -77, -90, -84, -80,  25, -89, -75,   8,  50, -73, -71, -77, -89, -75, -71,  33,  13,  29, -74,  79;
/M: SY='G';  M= -67, -94, -82, -94,-100, 106, -89,-108, -87,-104, -93, -68, -86, -85, -95, -67, -86,-102, -91, -95;
/M: SY='Q';  M= -83, -92, -83, -75,  74, -91, -75,   5,   9,  -5, -69,  20, -91,  76, -74, -76,  18, -74, -75,  31;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='K';  M= -78, -93, -68,  17, -97, -84, -73, -96,  99, -95, -84,  21, -81,  28, -48,   6, -72, -92, -92, -84;
/M: SY='G';  M=  57, -85, -84, -85, -91,  65, -89, -78, -83, -85, -80, -74, -85, -81, -89,   8,  12,  29, -95, -89;
/M: SY='S';  M= -67, -85, -78,  10,  17, -79, -82,  39, -78, -76, -75, -71, -84, -73, -83,  86,  14,   4, -94, -76;
/M: SY='H';  M=  -3, -87, -93, -89,  53, -95,  70,   9, -88,  20,  43, -84, -93, -85, -87, -81,  11,  47, -89, -63;
/M: SY='Y';  M= -76, -89, -88, -87,  21, -91,  44,   7, -84,  -7, -66, -81, -93, -81, -85,  36,  15,  45, -76,  79;
/M: SY='I';  M=  -3, -91, -85, -82, -72, -91,  41,  54, -77,  -1,  42,  22, -90,  25,  14, -77,  11,   4, -89,  31;
/I:         I=-26; MD=-65;
/M: SY='N';  M=  -5,-100, -79, -91,-108, -87,  42,-107, -87,-110,-100,  81,-102, -85, -92,  33,  12,-103,-124, -98; D=-26;
/I:         I=-26; MI=0; MD=-65; IM=0; DM=-65;
/M: SY='T';  M= -76, -89,  43,  16,  17, -86, -76, -88,  42, -87, -82, -65, -81,  27,  15,   7,  69, -83, -95, -78;
/M: SY='P';  M= -76, -94, -78,  20, -88, -85,  44, -77, -78, -11,  42, -79,  88, -75, -84,  36,  12,   2, -99, -83;
/M: SY='W';  M= -80, -93,  16,  37, -86, -88,  43, -89,  42, -12, -80,  22, -84, -65,  40, -72,  43, -86,  72, -76;
/I:         I=-19; MD=-47;
/M: SY='H';  M= -91,-110, -82,  34,-106,  25,  71,-114,   8,-105, -95, -81, -97, -73,  62, -86, -94,-109,-109, -90; D=-19;
/I:         I=-19; MD=-47;
/M: SY='I';  M=-107,-118,-130,-127,  15,-132,-127,  64,-122, -79, -83,-121,-121,-122,-124,-116,-102,  28,-115, -95; D=-19;
/I:         I=-19; MI=0; MD=-47; IM=0; DM=-47;
/M: SY='E';  M=  24, -90, -69,  65,  29, -86, -79,  11,  51, -81, -79, -74, -81, -65, -68,   6,  13, -76, -89, -77;
/M: SY='H';  M=  -2, -95, -75,  10, -76, -88,  72, -84,  64, -84, -76, -72, -86,  29,  16, -75, -78,  -1, -82,  64;
/M: SY='L';  M= -77, -86, -88, -87,  21, -91,  42, -57, -87,  64, -58,  21, -95, -82, -87,  33, -73,  32, -92, -69;
/M: SY='Y';  M= -79, -93, -80,   8, -72, -91,  44, -63, -78,  -8, -69,  20,  57,  33, -81, -79, -75,  56, -87,  57;
/M: SY='S';  M=  10, -84,  14, -71, -92, -74, -78, -88,   9, -91, -84, -64, -81, -68,  13,  80,  57, -80,-100, -84;
/M: SY='Y';  M= -79, -91, -94, -93, -51, -99, -73,  12, -88, -62, -63, -93, -98, -86, -87, -84, -75,  73, -66, 108;
/M: SY='N';  M= -72, -87,  16,  37, -95, -76, -70, -92,   7, -94, -86,  73, -82,  28, -71,  51,  41, -88,-103, -86;
/M: SY='C';  M= -79, 157, -99, -99, -89, -94, -99, -96, -94, -86, -87, -85,-109,-102,-101, -81, -79, -83,-119,-100;
/M: SY='E';  M=   0, -88,  19,  74, -94, -81, -74, -91, -67, -91, -86,  49, -78, -64, -76,  14,  61, -84,-103, -88;
/I:         E1=0; IE=-255; DE=-255;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2020_04 which contains 563'082 sequence entries.


Total number of hits 8 in 4 different sequences
Number of true positive hits 8 in 4 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Feature key [info] DOMAIN
Feature description [info] Cystatin fetuin-B-type
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
4 sequences

FETUB_BOVIN (Q58D62    ), FETUB_HUMAN (Q9UGM5    ), FETUB_MOUSE (Q9QXC1    ), 
FETUB_RAT   (Q9QX79    )
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PDB
[Detailed view]
3 PDB

6HPV; 6HT9; 6SAZ

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission