PROSITE entry PS51536

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51536
Entry name [info]	TFG
Accession [info]	PS51536
Entry type [info]	MATRIX
Date [info]	01-MAY-2010 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51512
Associated ProRule [info]	PRU00869

Name and characterization of the entry

Description [info]

TFG box profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=21;
/DISJOINT: DEFINITION=PROTECT; N1=3; N2=19;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3437343; R2=0.0096206; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=1793.7653809; R2=0.3868313; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=900; H_SCORE=2142; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=433; H_SCORE=1961; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-103; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='N';  M=  -1,-252,  40, -20, -40,  16,  19, -58,  10,-251, -34,  58,  -8,  49,  22,  -9,  -3,-135,-258,-242;
/M: SY='Q';  M= -55,-254,  -5,  -2, -88,  56, -32, -21,  12, -23, -10,   0,   0,  57,  25, -23,  -2,-245,-254,-244;
/M: SY='R';  M= -49,-256,-236,-229, -32, -20,  45,-254,  32, -76,-241,  14,  42,  26,  87,   0, -96,-251,-254,-239;
/M: SY='M';  M=   8,-248, -11,  13, -59, -21,-237, -18, -28, -38,  69,  25,  -6,  40,-237,  21,  42, -21, -10,-240;
/M: SY='W';  M= -38, -51,  43,   2, -55, -42,-234, -70, -35, -46,-241,  30,-246,  61,  64, -19,  19,-248,  74,-237;
/M: SY='W';  M= -58,-258,-250,-240,  64, -93,  23,-244, -27, -16,-236, -24, -61, -27,  85,-243,-245,-246, 115, -35;
/M: SY='R';  M=  40,-250, -44,  30,-250,  -2, -21,-249, -70,-247,  33,  14,  19,   3,  45,  42, -68,-244,-253,  -2;
/M: SY='E';  M= -24,-255,  23,  86,-258,  -7, -31,-255,  45,-253,-246, -19,-238,  41, -93, -28, -55, -46,-257,-246;
/M: SY='Q';  M= -58,-256,-221,  87,-255,-248,  43,-249,-221, -39,  31,  13,-240,  89,  -8,-232,-238, -74,-256,-240;
/M: SY='R';  M=-241,-256,-237, -17,-250,-250,-230, -69,  40,-142,  63,   9,-248,  -9, 103, -23,-106,-246,-253,-239;
/M: SY='R';  M= -31,-254, -72,  44,-251,-247, -37, -44,  58, -46,  26,  -1,-244,  38,  66,  -4, -41,-109,-254,-241;
/M: SY='L';  M= -27,-250,-250,-241,-232,-255, -61,  42,  12,  52,  31,-243, -60,  27,  35,-240,  19,  -5, -35,-235;
/M: SY='N';  M=-241,-250,  92,-222,-256,-235,-226,-249,-229,-256,-250, 108,-248,-230,-238,-227,-228,  -2,-276,-248;
/M: SY='M';  M=  -2,-246,-246,-240,-107, -97, -67,  19,  11,   5,  79,-238,  19,   9,-239,  -6,  64,   6,-255,-238;
/M: SY='E';  M=   1,-255,  52, 105,-258,-247,-232,-256,-223, -46, -38, -27,-236, -49,-232, -71,-236,-250,-260,-249;
/M: SY='T';  M=   6,-238,-235,-238,-245,-243,-245,-236,-235,-241,-237,-225,-237,-239,-243,-213, 124,-228,-264,-243;
/M: SY='F';  M=-253,-249,-265,-261, 133,-260,-245,-226,-256,-218,-228,-254,-263,-267,-253,-251,-245,-231,-218,-196;
/M: SY='G';  M= -25,-253,-242,-252,-259, 109,-248,-264,-247,-261,-251,-228,-245,-244,-254,-226,-244, -70,-251,-254;
/M: SY='Q';  M=  11,-249,  22,  16, -24, -56, -29, -11, -27, -67, -49,  41, -79,  55, -71,  27,  12,  22, -10,-240;
/M: SY='F';  M=  22,-247, -67,   2,  41,  14,-239, -44,-238, -26,  39,  36,   7,   8,-243,  18,  31, -13,-250,-234;
/M: SY='S';  M=  42,-245, -31,-239,  22,  16, -53, -58,-239, -53,  32, -36,  22, -57, -77,  67,  -9, -42,-250, -24;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	18 in 18 different sequences
Number of true positive hits	18 in 18 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	MOTIF
Feature description [info]	TFG box
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

18 sequences

DCP5L_ARATH (Q9FH77), DCP5_ARATH  (Q9C658), L14AA_XENLA (A0A8M2),

L14AB_XENLA (Q8AVJ2), L14BA_XENLA (Q68FI1), L14BB_XENLA (Q498K9), 
LS14A_BOVIN (Q3MHF8), LS14A_HUMAN (Q8ND56), LS14A_MOUSE (Q8K2F8), 
LS14A_PONAB (Q5R4R4), LS14A_XENTR (Q6NVR8), LS14B_HUMAN (Q9BX40), 
LS14B_MOUSE (Q8CGC4), LS14B_XENTR (Q566L7), LS14H_CAEEL (Q9XW17), 
LSM14_PLEWA (Q9YH12), SCD6_YEAST  (P45978), SUM2_SCHPO  (Q9HGL3)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

1 PDB

6F9S