PROSITE entry PS51544

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General information about the entry

PURL [info]	https://purl.expasy.org/prosite/signature/PS51544
Entry name [info]	PI3K_ABD
Accession [info]	PS51544
Entry type [info]	MATRIX
Date [info]	01-JUL-2011 CREATED; 10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51544
Associated ProRule [info]	PRU00877

Name and characterization of the entry

Description [info]

Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=90;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=85;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5546300; R2=0.0088578; TEXT='NScore';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=14533.8183594; R2=3.2977803; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=954; H_SCORE=17680; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=446; H_SCORE=16005; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-32; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='S';  M=  -3, -78, -66,  28,  -7, -73, -70, -63, -68,   5,  31,  11,  -2, -63, -73,  40, -16,  -7, -86, -70;
/M: SY='H';  M= -67,   4, -12,  29, -82,   0,  47, -81,  35, -30,  26, -62,  21, -58, -60,  17, -66, -79, -89, -72;
/M: SY='Q';  M= -30, -77, -56,  32, -82,  19, -62, -77, -57, -76,   8,  23, -22,  56, -62,  25,  42, -73, -85, -73;
/M: SY='W';  M= -24, -75,  11, -63, -62, -70,  17,  -6, -14,   3,  19, -61,  24, -62, -29,  40,  14,   7,  44,   7;
/M: SY='I';  M=   9, -72, -77, -13,  47, -79, -77,  48, -73, -21, -49, -72, -76, -73, -76, -10,  12,  45, -73, -53;
/M: SY='D';  M= -24, -76,  63, -21, -76, -68, -64, -23,  -1, -44,   5,  10,  35, -59, -64,  19,  31,  -4, -90, -71;
/M: SY='I';  M= -65, -75, -88, -83,  25, -90, -83,  69, -81,  30, -40, -81, -82, -79, -81, -75, -61,  51, -75, -55;
/M: SY='D';  M= -66,  26,  64,  28, -69, -76, -64,  30, -20,   6,  15,   0, -71, -59, -67, -61,  27, -56, -88, -68;
/M: SY='C';  M= -69,  99, -86, -83,  86, -84, -77,  10, -79, -27, -56, -74, -87, -86, -81, -70,   4, -10, -63, -42;
/M: SY='L';  M= -68, -73, -88, -81,  26, -88, -74,  25, -80,  68,  34, -83, -84, -75, -78, -78, -64,  18, -72, -52;
/M: SY='L';  M= -69,  37, -87, -80,   7, -86, -69, -38, -79,  76,  66, -83, -85, -73, -77, -78, -66, -45, -74, -54;
/M: SY='P';  M= -66, -90, -68, -56, -82, -69, -69, -70, -63, -77,  33, -73, 125, -66, -75, -64, -59, -75, -79, -80;
/M: SY='N';  M= -59, -66,  15, -57,   8, -58, -52, -68, -53, -72, -66,  96, -68, -55, -61,  -1,  67, -66, -87, -64;
/M: SY='G';  M= -50, -75, -62, -68,  -9,  89,  31, -84, -65, -80, -71, -50, -68,  13, -70,  27, -62, -79, -74, -67;
/I:         I=-18; MI=0; MD=-45; IM=0; DM=-45;
/M: SY='V';  M= -58, -71, -70,  -3,  39,  -5, -67,  30, -66,   0,  36, -65, -73,  10, -69,  14,   5,  40, -68,   9;
/M: SY='M';  M= -60, -71, -73, -70, -10,  -5, -63,  28, -11,  31,  59, -65, -73, -62,   1,  -7,  28,   1, -66,  40;
/M: SY='I';  M=  14, -71, -71,  12, -55, -78, -74,  66,  -5,  22, -42, -69, -71, -64, -68, -62,   5,  33, -77, -61;
/M: SY='T';  M= -60, -72,  -2,  12, -67, -69, -60, -11, -56,  17, -54,  48,  41,  41, -62, -52,  51,  -1, -82, -66;
/M: SY='L';  M= -63, -71, -79, -73,  32, -83,  51,  11, -70,  57, -38, -74, -80, -69,  -5, -71, -60,  49, -73, -48;
/M: SY='E';  M= -17, -76,  -3,  56, -73, -70,  30, -64, -47, -19, -61,  24,  38, -48,  46, -19, -15,  10, -82, -66;
/M: SY='C';  M= -57,  86, -76, -71,  -7, -79, -73,   9, -65, -50, -50, -68, -78,   7,   7, -61,  24,  68, -80,   6;
/M: SY='S';  M=  -7, -71, -57, -55, -75, -13, -59, -71,  40, -46,  14,  31,  43, -50, -16,  70, -47, -68, -79, -68;
/M: SY='G';  M= -56, -75, -67, -64, -69,  48, -67,   3, -14, -14, -58, -58,  36, -59,  46,   5,  11,  19, -78, -67;
/M: SY='N';  M= -18, -71, -12,  40, -61, -65,  31, -65, -11,   9, -58,  42, -67, -50,  -6,  35,  24, -63, -74,  34;
/M: SY='T';  M=  39, -69,  26,   2, -16,  -7, -61,  14, -59, -64, -61,   1, -66,   7, -64,  27,  40, -55, -75,  13;
/M: SY='T';  M= -53, -64, -54, -59, -69, -63, -62, -57,   2, -65, -61,  53, -64, -57, -60,  29,  88,  15, -87, -66;
/M: SY='L';  M= -65, -72, -78, -77,   6, -83, -69,  57, -75,  62, -35,  14, -80, -71, -75, -72, -60,  11, -69,  11;
/M: SY='E';  M= -25,  40, -46,  65,  -8, -28, -57, -37,  -5, -72, -67,  28, -64,  31, -55,  50, -18, -69, -79, -66;
/M: SY='D';  M= -61, -76,  61,  46, -70, -70, -55, -61, -50, -12,   3,  13, -67,  48,   0, -55,  17,   9, -81,  -1;
/M: SY='M';  M= -64, -72, -85, -79,  13, -85, -73,  68, -76,  46,  70, -77, -77, -71, -76, -73, -60,  21, -71, -51;
/M: SY='K';  M= -63, -78, -56, -43, -79, -70, -58, -79, 104, -78, -66, -50,  18, -41,  15, -57, -58, -75, -73, -66;
/M: SY='H';  M=   8, -75,  27,  46, -76, -65,  69, -70,  -8, -35, -62,  20, -65,  57, -53,  -4,  -3, -19, -84, -61;
/M: SY='Q';  M= -60, -78,  -3,  51, -67,  -4, -56, -14, -17, -19,  10,   2, -68,  61,  29, -57, -60,  15, -74,  11;
/M: SY='L';  M= -61, -68, -84, -77, -45, -85, -73,   4, -76,  71,  22, -81, -81, -72, -75, -73, -58,  57, -76, -56;
/M: SY='W';  M= -14, -84, -93, -79,  46, -75, -89, -52, -73, -23, -60, -87, -80, -74, -75, -74, -73,  30, 155, -32;
/M: SY='E';  M= -61, -76, -10,  55,  -4, -72,  37,  -3,  31,   9, -56,   1, -66,  39, -15,  -3,  -1, -62, -76, -59;
/M: SY='E';  M= -17, -78, -50,  62, -73, -71,  33, -71, -41,   3, -59, -55, -66,  53,  58,  16, -59, -69, -78, -63;
/M: SY='A';  M=  80, -64, -72, -66, -60, -59, -70,   3, -67,   3, -51, -68, -71, -64, -70, -50, -54,  29, -72,  16;
/M: SY='Q';  M=  34, -72, -55,  37,   1, -64,  12, -66,  22,   5, -58,   1, -67,  46,   7,  18, -56, -63, -74, -60;
/M: SY='E';  M= -23, -77, -51,  45, -71, -17, -55, -75,  43, -73, -65,  -5,  14,  38,  36, -20,  25, -71, -72,  23;
/M: SY='Y';  M= -62, -72, -66,   3,  -4, -72, -51, -49, -63,  27,  80,  -4, -74, -58, -64,  21,   3, -53, -55,  82;
/M: SY='P';  M= -62, -80, -60, -55,   3, -64, -63, -72,  19, -78, -68,  37, 103, -59, -62,  15,   5, -73, -77, -70;
/M: SY='W';  M= -15, -72,   8, -69,  38, -76, -69,  -5, -72,  55,  14, -72,   8, -69, -73,  -4, -60,  13,  60, -49;
/M: SY='F';  M= -10, -73, -67, -67,  67,  23,  22, -58,  -4, -57, -56,   0, -74,   2, -63,  -1,  -2,  -2, -54,  63;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='H';  M= -14,  21,  43, -12, -70,  10,  57, -74, -10, -30, -64,  15, -68,  24, -58,  41,   6, -70, -81,   6;
/M: SY='H';  M= -63, -72, -63,  15,   9, -76,  66, -15, -61,  32,  35,   8, -72, -58,  -8, -60,  30,  13, -72,  22;
/M: SY='L';  M= -61, -70, -76, -71, -45, -76, -63,  -5, -67,  73,  16, -71, -78, -63,   0,  35, -57, -44, -69,  18;
/M: SY='K';  M= -65, -78, -65, -57,  -9,   5,  47, -62,  59,  10,  10,  -2, -74,  37, -49, -62, -63,  -6, -73,  17;
/M: SY='D';  M= -63, -79,  53,  34, -84, -10, -57, -83,  28, -83, -74,  46,   7,   9,   4,   6, -18, -79, -87, -73;
/M: SY='P';  M=  16,  14, -71, -29,  -7, -71, -69,  10,  23,  -3,  35, -68,  69,   3, -63,  -5, -60, -59, -77, -66;
/M: SY='D';  M= -60,  21,  76, -47, -85,  -8, -58, -83, -58, -83, -76,  24,  13,  39, -64,  48, -54, -79, -92, -73;
/M: SY='S';  M=  -7, -73,  33,  -9, -78, -13, -62, -70, -59, -73,  15,   2,  11,  22, -64,  65,  -1, -13, -86, -70;
/M: SY='Y';  M= -73, -85, -72, -75, -25, -16,  33, -62, -68, -58, -54, -71, -84, -63, -65, -68, -69, -67, -34, 126;
/M: SY='H';  M=  -5, -76, -74, -71,  -3, -19,  60,  37, -70,   3,  12,  -3, -77,   3, -71, -10, -61,  33,  49, -55;
/M: SY='F';  M= -75, -74, -90, -85, 104, -87, -73,  21, -82,  18, -47, -81, -87, -87, -79, -77, -68, -12, -51, -30;
/M: SY='M';  M=   7,  19,  -2, -65, -14, -71, -66, -49, -64,  23,  39, -65, -77,   8,   4,  33, -57,  27, -76,   7;
/M: SY='C';  M= -17,  75,  30, -62, -10,  15, -64, -69, -65, -18,  16,   7, -75,  17, -69,  13,  28, -66, -80,  10;
/M: SY='V';  M= -62,  29, -87, -82,   8, -89, -84,  55, -80,  22, -42, -81, -82, -80, -81, -73, -59,  66, -80, -58;
/M: SY='N';  M=   6, -71, -49, -60, -73, -13, -53, -76,   1, -80, -70,  93, -73, -54, -17,  35, -22, -74, -83,  16;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='D';  M= -19,  20,  43, -53, -75, -67,  13, -67,  -1, -38,  22,  35, -71,  31,  -8,   7,  42, -18, -89, -67;
/M: SY='N';  M= -64, -78,  30,  16,  28, -69, -58, -73,   0, -71,  14,  34,   9,  27,  32,  15,   7, -72, -78, -61;
/M: SY='G';  M=  38,  26, -64, -70, -79,  66, -68, -77, -67, -22, -69,  42,  12, -66, -74, -52, -62, -72, -81, -77;
/I:         I=-30; MD=-77;
/M: SY='E';  M= -66, -85,  27,  77, -84, -77, -59,  -6, -18, -75, -70,   0, -67,  54,  -5, -61, -64, -26, -86, -73; D=-30;
/I:         I=-30; MI=-77; IM=-77; DM=-77;
/M: SY='W';  M= -66, -80,   5, -19, -61, -79, -66,  44,  17,   2,  20, -64, -74,  25,  31, -14, -17, -25,  57,   1;
/M: SY='E';  M= -63, -79, -46,  82, -62, -77, -56, -65, -53, -25, -64,  11, -66, -48, -60, -59,  22,   2, -70,  54;
/M: SY='E';  M= -63, -81,  15,  84, -77, -77, -60,  -4, -52, -19, -65,   0,   1,  12, -60, -60,  -9,  -6, -84, -72;
/M: SY='L';  M= -68, -75, -82, -76,   8, -84, -67,  36, -75,  63,  15, -78, -82,   7, -74,  -8, -63, -43, -67,  32;
/M: SY='Y';  M= -68, -76,  -2,  10,  40, -79,  21, -11, -65,   8,   8,  -2, -78, -64, -25, -65,  12,  10, -60,  67;
/M: SY='D';  M= -67, -81, 103,  11, -88, -65, -55, -87, -56, -86, -83,  39, -69, -54, -64,  -1, -57, -84,-102, -74;
/M: SY='E';  M= -65, -83,  49,  87, -85, -76, -58, -29,  39, -79, -74, -54, -62, -42, -50, -60, -62, -76, -85, -74;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='S';  M= -57,  32,   7, -62, -81, -66, -67, -74, -62, -79, -73,  12, -74,  11, -10,  70,  30, -10, -93, -74; D=-24;
/I:         I=-24; DM=-61;
/M: SY='Q';  M= -65,  20,  -2,  26, -85, -74, -55, -83,  38, -77, -67, -55, -70,  84,  59, -58, -65, -79, -79, -68;
/M: SY='R';  M= -67,  10, -69, -60, -59, -78,  23, -63, -49,  26, -54, -64,  13,  43,  62, -24,   1, -65, -70,  44;
/M: SY='L';  M= -69, -73, -88, -81,   4, -90, -74,  33, -81,  77, -34, -85, -85, -75, -79, -79, -65,  -5, -73, -55;
/M: SY='C';  M= -61,  63,  25, -59, -16, -73,   8,   3, -59, -17, -59, -59, -76,  50,   8,  28,  -8,   9, -80,   7;
/M: SY='D';  M= -65,  33,  69,  38, -82, -68, -58, -77,   2, -79, -74,  46,  -1, -53,  -5, -21,  -1, -21, -93, -74;
/M: SY='L';  M= -65, -75, -80, -73, -52, -86, -72,  37,  -5,  44, -42, -75, -80, -68,  22, -70,  -6,  42, -76,   7;
/M: SY='R';  M= -67, -85, -58,   5, -83, -74, -54, -83,  -1, -78, -66,  18, -11,  70,  87, -59, -65, -80, -79, -67;
/M: SY='P';  M=   9, -80, -78, -70, -59, -76, -71,  -5, -73,  47, -51, -78,  74, -71, -78,  -6, -63, -56, -75,  16;
/M: SY='F';  M= -74, -81, -80, -74,  68, -85,  33,  13,  15,  -4, -54, -73, -83, -70,   3, -74, -69, -16,  58,  52;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='F';  M= -26,   2, -10, -66,  53, -77, -69, -58,  22,  23,   7, -67,   9, -19, -21,  11,  -6, -26, -71, -54;
/M: SY='P';  M= -10, -85, -67, -65,  -9,  25,  24, -80, -67, -83, -73,  25,  89, -67, -75,   2, -62, -80,  32, -72;
/M: SY='W';  M= -70, -81, -83, -73,  52, -83, -71,  30,  21, -25,  69, -75, -80,  13, -65, -74, -67,   3,  78,   1;
/M: SY='L';  M= -72, -75, -90, -83,  20, -91, -74,  27, -82,  74,  26, -86, -87, -77, -80, -81, -68, -42, -73, -54;
/M: SY='K';  M= -20,   6, -62, -53,   7, -71,  30, -80,  80, -77, -69,  -1, -72, -50,  16,  13, -60, -76, -78, -63;
/M: SY='M';  M= -66,  19, -87, -81,  19, -85, -73,   8, -79,  49,  70, -80, -84, -74, -78, -11, -63,  29, -77, -56;
/M: SY='V';  M=  -5,  23, -80, -77, -59,   6,  17,  41, -12, -21, -52, -73, -80, -73, -74, -67, -62,  55, -79,  20;
/M: SY='E';  M= -63, -83, -42,  91, -87, -77, -58, -84, -48, -79, -73, -59, -63,  56, -55, -10,  14, -78, -84, -75;
/M: SY='R';  M= -69, -86, -67, -55, -81, -78, -63, -77,  51, -79, -69, -62,  49, -50,  81, -64, -18, -17, -81, -71;
/M: SY='S';  M= -26, -79,   8,  -1, -73, -17,  30, -74,  32, -75, -68, -55, -72,  34,  10,  38,  -7, -11, -79,  18;
/I:         E1=0; IE=-255; DE=-255;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.

Total number of hits	15 in 15 different sequences
Number of true positive hits	15 in 15 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	PI3K-ABD
Version [info]	4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

15 sequences

AGE1_CAEBR  (P0C5E7), AGE1_CAEEL  (Q94125), PI3K1_DICDI (P54673),

PK3CA_BOVIN (P32871), PK3CA_HUMAN (P42336), PK3CA_MOUSE (P42337), 
PK3CA_RAT   (A0A0G2K344), PK3CB_HUMAN (P42338), PK3CB_MOUSE (Q8BTI9), 
PK3CB_RAT   (Q9Z1L0), PK3CD_HUMAN (O00329), PK3CD_MOUSE (O35904), 
PK3CG_HUMAN (P48736), PK3CG_MOUSE (Q9JHG7), PK3CG_PIG   (O02697)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

111 PDB

2RD0; 2V1Y; 2Y3A; 3HHM; 3HIZ; 4A55; 4JPS; 4L1B; 4L23; 4L2Y; 4OVU; 4OVV;
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