PROSITE entry PS51544
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General information about the entry
| Entry name [info] | PI3K_ABD |
| Accession [info] | PS51544 |
| Entry type [info] | MATRIX |
| Date [info] |
01-JUL-2011 CREATED;
10-MAY-2017 DATA UPDATE; 13-SEP-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51544 |
| Associated ProRule [info] | PRU00877 |
Name and characterization of the entry
| Description [info] | Phosphatidylinositol 3-kinase adaptor-binding (PI3K ABD) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=90; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=85; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5546300; R2=0.0088578; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=14533.8183594; R2=3.2977803; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=954; H_SCORE=17680; N_SCORE=11.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=446; H_SCORE=16005; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-32; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-255; BD=-255; /M: SY='S'; M= -3, -78, -66, 28, -7, -73, -70, -63, -68, 5, 31, 11, -2, -63, -73, 40, -16, -7, -86, -70; /M: SY='H'; M= -67, 4, -12, 29, -82, 0, 47, -81, 35, -30, 26, -62, 21, -58, -60, 17, -66, -79, -89, -72; /M: SY='Q'; M= -30, -77, -56, 32, -82, 19, -62, -77, -57, -76, 8, 23, -22, 56, -62, 25, 42, -73, -85, -73; /M: SY='W'; M= -24, -75, 11, -63, -62, -70, 17, -6, -14, 3, 19, -61, 24, -62, -29, 40, 14, 7, 44, 7; /M: SY='I'; M= 9, -72, -77, -13, 47, -79, -77, 48, -73, -21, -49, -72, -76, -73, -76, -10, 12, 45, -73, -53; /M: SY='D'; M= -24, -76, 63, -21, -76, -68, -64, -23, -1, -44, 5, 10, 35, -59, -64, 19, 31, -4, -90, -71; /M: SY='I'; M= -65, -75, -88, -83, 25, -90, -83, 69, -81, 30, -40, -81, -82, -79, -81, -75, -61, 51, -75, -55; /M: SY='D'; M= -66, 26, 64, 28, -69, -76, -64, 30, -20, 6, 15, 0, -71, -59, -67, -61, 27, -56, -88, -68; /M: SY='C'; M= -69, 99, -86, -83, 86, -84, -77, 10, -79, -27, -56, -74, -87, -86, -81, -70, 4, -10, -63, -42; /M: SY='L'; M= -68, -73, -88, -81, 26, -88, -74, 25, -80, 68, 34, -83, -84, -75, -78, -78, -64, 18, -72, -52; /M: SY='L'; M= -69, 37, -87, -80, 7, -86, -69, -38, -79, 76, 66, -83, -85, -73, -77, -78, -66, -45, -74, -54; /M: SY='P'; M= -66, -90, -68, -56, -82, -69, -69, -70, -63, -77, 33, -73, 125, -66, -75, -64, -59, -75, -79, -80; /M: SY='N'; M= -59, -66, 15, -57, 8, -58, -52, -68, -53, -72, -66, 96, -68, -55, -61, -1, 67, -66, -87, -64; /M: SY='G'; M= -50, -75, -62, -68, -9, 89, 31, -84, -65, -80, -71, -50, -68, 13, -70, 27, -62, -79, -74, -67; /I: I=-18; MI=0; MD=-45; IM=0; DM=-45; /M: SY='V'; M= -58, -71, -70, -3, 39, -5, -67, 30, -66, 0, 36, -65, -73, 10, -69, 14, 5, 40, -68, 9; /M: SY='M'; M= -60, -71, -73, -70, -10, -5, -63, 28, -11, 31, 59, -65, -73, -62, 1, -7, 28, 1, -66, 40; /M: SY='I'; M= 14, -71, -71, 12, -55, -78, -74, 66, -5, 22, -42, -69, -71, -64, -68, -62, 5, 33, -77, -61; /M: SY='T'; M= -60, -72, -2, 12, -67, -69, -60, -11, -56, 17, -54, 48, 41, 41, -62, -52, 51, -1, -82, -66; /M: SY='L'; M= -63, -71, -79, -73, 32, -83, 51, 11, -70, 57, -38, -74, -80, -69, -5, -71, -60, 49, -73, -48; /M: SY='E'; M= -17, -76, -3, 56, -73, -70, 30, -64, -47, -19, -61, 24, 38, -48, 46, -19, -15, 10, -82, -66; /M: SY='C'; M= -57, 86, -76, -71, -7, -79, -73, 9, -65, -50, -50, -68, -78, 7, 7, -61, 24, 68, -80, 6; /M: SY='S'; M= -7, -71, -57, -55, -75, -13, -59, -71, 40, -46, 14, 31, 43, -50, -16, 70, -47, -68, -79, -68; /M: SY='G'; M= -56, -75, -67, -64, -69, 48, -67, 3, -14, -14, -58, -58, 36, -59, 46, 5, 11, 19, -78, -67; /M: SY='N'; M= -18, -71, -12, 40, -61, -65, 31, -65, -11, 9, -58, 42, -67, -50, -6, 35, 24, -63, -74, 34; /M: SY='T'; M= 39, -69, 26, 2, -16, -7, -61, 14, -59, -64, -61, 1, -66, 7, -64, 27, 40, -55, -75, 13; /M: SY='T'; M= -53, -64, -54, -59, -69, -63, -62, -57, 2, -65, -61, 53, -64, -57, -60, 29, 88, 15, -87, -66; /M: SY='L'; M= -65, -72, -78, -77, 6, -83, -69, 57, -75, 62, -35, 14, -80, -71, -75, -72, -60, 11, -69, 11; /M: SY='E'; M= -25, 40, -46, 65, -8, -28, -57, -37, -5, -72, -67, 28, -64, 31, -55, 50, -18, -69, -79, -66; /M: SY='D'; M= -61, -76, 61, 46, -70, -70, -55, -61, -50, -12, 3, 13, -67, 48, 0, -55, 17, 9, -81, -1; /M: SY='M'; M= -64, -72, -85, -79, 13, -85, -73, 68, -76, 46, 70, -77, -77, -71, -76, -73, -60, 21, -71, -51; /M: SY='K'; M= -63, -78, -56, -43, -79, -70, -58, -79, 104, -78, -66, -50, 18, -41, 15, -57, -58, -75, -73, -66; /M: SY='H'; M= 8, -75, 27, 46, -76, -65, 69, -70, -8, -35, -62, 20, -65, 57, -53, -4, -3, -19, -84, -61; /M: SY='Q'; M= -60, -78, -3, 51, -67, -4, -56, -14, -17, -19, 10, 2, -68, 61, 29, -57, -60, 15, -74, 11; /M: SY='L'; M= -61, -68, -84, -77, -45, -85, -73, 4, -76, 71, 22, -81, -81, -72, -75, -73, -58, 57, -76, -56; /M: SY='W'; M= -14, -84, -93, -79, 46, -75, -89, -52, -73, -23, -60, -87, -80, -74, -75, -74, -73, 30, 155, -32; /M: SY='E'; M= -61, -76, -10, 55, -4, -72, 37, -3, 31, 9, -56, 1, -66, 39, -15, -3, -1, -62, -76, -59; /M: SY='E'; M= -17, -78, -50, 62, -73, -71, 33, -71, -41, 3, -59, -55, -66, 53, 58, 16, -59, -69, -78, -63; /M: SY='A'; M= 80, -64, -72, -66, -60, -59, -70, 3, -67, 3, -51, -68, -71, -64, -70, -50, -54, 29, -72, 16; /M: SY='Q'; M= 34, -72, -55, 37, 1, -64, 12, -66, 22, 5, -58, 1, -67, 46, 7, 18, -56, -63, -74, -60; /M: SY='E'; M= -23, -77, -51, 45, -71, -17, -55, -75, 43, -73, -65, -5, 14, 38, 36, -20, 25, -71, -72, 23; /M: SY='Y'; M= -62, -72, -66, 3, -4, -72, -51, -49, -63, 27, 80, -4, -74, -58, -64, 21, 3, -53, -55, 82; /M: SY='P'; M= -62, -80, -60, -55, 3, -64, -63, -72, 19, -78, -68, 37, 103, -59, -62, 15, 5, -73, -77, -70; /M: SY='W'; M= -15, -72, 8, -69, 38, -76, -69, -5, -72, 55, 14, -72, 8, -69, -73, -4, -60, 13, 60, -49; /M: SY='F'; M= -10, -73, -67, -67, 67, 23, 22, -58, -4, -57, -56, 0, -74, 2, -63, -1, -2, -2, -54, 63; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='H'; M= -14, 21, 43, -12, -70, 10, 57, -74, -10, -30, -64, 15, -68, 24, -58, 41, 6, -70, -81, 6; /M: SY='H'; M= -63, -72, -63, 15, 9, -76, 66, -15, -61, 32, 35, 8, -72, -58, -8, -60, 30, 13, -72, 22; /M: SY='L'; M= -61, -70, -76, -71, -45, -76, -63, -5, -67, 73, 16, -71, -78, -63, 0, 35, -57, -44, -69, 18; /M: SY='K'; M= -65, -78, -65, -57, -9, 5, 47, -62, 59, 10, 10, -2, -74, 37, -49, -62, -63, -6, -73, 17; /M: SY='D'; M= -63, -79, 53, 34, -84, -10, -57, -83, 28, -83, -74, 46, 7, 9, 4, 6, -18, -79, -87, -73; /M: SY='P'; M= 16, 14, -71, -29, -7, -71, -69, 10, 23, -3, 35, -68, 69, 3, -63, -5, -60, -59, -77, -66; /M: SY='D'; M= -60, 21, 76, -47, -85, -8, -58, -83, -58, -83, -76, 24, 13, 39, -64, 48, -54, -79, -92, -73; /M: SY='S'; M= -7, -73, 33, -9, -78, -13, -62, -70, -59, -73, 15, 2, 11, 22, -64, 65, -1, -13, -86, -70; /M: SY='Y'; M= -73, -85, -72, -75, -25, -16, 33, -62, -68, -58, -54, -71, -84, -63, -65, -68, -69, -67, -34, 126; /M: SY='H'; M= -5, -76, -74, -71, -3, -19, 60, 37, -70, 3, 12, -3, -77, 3, -71, -10, -61, 33, 49, -55; /M: SY='F'; M= -75, -74, -90, -85, 104, -87, -73, 21, -82, 18, -47, -81, -87, -87, -79, -77, -68, -12, -51, -30; /M: SY='M'; M= 7, 19, -2, -65, -14, -71, -66, -49, -64, 23, 39, -65, -77, 8, 4, 33, -57, 27, -76, 7; /M: SY='C'; M= -17, 75, 30, -62, -10, 15, -64, -69, -65, -18, 16, 7, -75, 17, -69, 13, 28, -66, -80, 10; /M: SY='V'; M= -62, 29, -87, -82, 8, -89, -84, 55, -80, 22, -42, -81, -82, -80, -81, -73, -59, 66, -80, -58; /M: SY='N'; M= 6, -71, -49, -60, -73, -13, -53, -76, 1, -80, -70, 93, -73, -54, -17, 35, -22, -74, -83, 16; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='D'; M= -19, 20, 43, -53, -75, -67, 13, -67, -1, -38, 22, 35, -71, 31, -8, 7, 42, -18, -89, -67; /M: SY='N'; M= -64, -78, 30, 16, 28, -69, -58, -73, 0, -71, 14, 34, 9, 27, 32, 15, 7, -72, -78, -61; /M: SY='G'; M= 38, 26, -64, -70, -79, 66, -68, -77, -67, -22, -69, 42, 12, -66, -74, -52, -62, -72, -81, -77; /I: I=-30; MD=-77; /M: SY='E'; M= -66, -85, 27, 77, -84, -77, -59, -6, -18, -75, -70, 0, -67, 54, -5, -61, -64, -26, -86, -73; D=-30; /I: I=-30; MI=-77; IM=-77; DM=-77; /M: SY='W'; M= -66, -80, 5, -19, -61, -79, -66, 44, 17, 2, 20, -64, -74, 25, 31, -14, -17, -25, 57, 1; /M: SY='E'; M= -63, -79, -46, 82, -62, -77, -56, -65, -53, -25, -64, 11, -66, -48, -60, -59, 22, 2, -70, 54; /M: SY='E'; M= -63, -81, 15, 84, -77, -77, -60, -4, -52, -19, -65, 0, 1, 12, -60, -60, -9, -6, -84, -72; /M: SY='L'; M= -68, -75, -82, -76, 8, -84, -67, 36, -75, 63, 15, -78, -82, 7, -74, -8, -63, -43, -67, 32; /M: SY='Y'; M= -68, -76, -2, 10, 40, -79, 21, -11, -65, 8, 8, -2, -78, -64, -25, -65, 12, 10, -60, 67; /M: SY='D'; M= -67, -81, 103, 11, -88, -65, -55, -87, -56, -86, -83, 39, -69, -54, -64, -1, -57, -84,-102, -74; /M: SY='E'; M= -65, -83, 49, 87, -85, -76, -58, -29, 39, -79, -74, -54, -62, -42, -50, -60, -62, -76, -85, -74; /I: I=-24; MI=0; MD=-61; IM=0; DM=-61; /M: SY='S'; M= -57, 32, 7, -62, -81, -66, -67, -74, -62, -79, -73, 12, -74, 11, -10, 70, 30, -10, -93, -74; D=-24; /I: I=-24; DM=-61; /M: SY='Q'; M= -65, 20, -2, 26, -85, -74, -55, -83, 38, -77, -67, -55, -70, 84, 59, -58, -65, -79, -79, -68; /M: SY='R'; M= -67, 10, -69, -60, -59, -78, 23, -63, -49, 26, -54, -64, 13, 43, 62, -24, 1, -65, -70, 44; /M: SY='L'; M= -69, -73, -88, -81, 4, -90, -74, 33, -81, 77, -34, -85, -85, -75, -79, -79, -65, -5, -73, -55; /M: SY='C'; M= -61, 63, 25, -59, -16, -73, 8, 3, -59, -17, -59, -59, -76, 50, 8, 28, -8, 9, -80, 7; /M: SY='D'; M= -65, 33, 69, 38, -82, -68, -58, -77, 2, -79, -74, 46, -1, -53, -5, -21, -1, -21, -93, -74; /M: SY='L'; M= -65, -75, -80, -73, -52, -86, -72, 37, -5, 44, -42, -75, -80, -68, 22, -70, -6, 42, -76, 7; /M: SY='R'; M= -67, -85, -58, 5, -83, -74, -54, -83, -1, -78, -66, 18, -11, 70, 87, -59, -65, -80, -79, -67; /M: SY='P'; M= 9, -80, -78, -70, -59, -76, -71, -5, -73, 47, -51, -78, 74, -71, -78, -6, -63, -56, -75, 16; /M: SY='F'; M= -74, -81, -80, -74, 68, -85, 33, 13, 15, -4, -54, -73, -83, -70, 3, -74, -69, -16, 58, 52; /I: I=-21; MI=0; MD=-53; IM=0; DM=-53; /M: SY='F'; M= -26, 2, -10, -66, 53, -77, -69, -58, 22, 23, 7, -67, 9, -19, -21, 11, -6, -26, -71, -54; /M: SY='P'; M= -10, -85, -67, -65, -9, 25, 24, -80, -67, -83, -73, 25, 89, -67, -75, 2, -62, -80, 32, -72; /M: SY='W'; M= -70, -81, -83, -73, 52, -83, -71, 30, 21, -25, 69, -75, -80, 13, -65, -74, -67, 3, 78, 1; /M: SY='L'; M= -72, -75, -90, -83, 20, -91, -74, 27, -82, 74, 26, -86, -87, -77, -80, -81, -68, -42, -73, -54; /M: SY='K'; M= -20, 6, -62, -53, 7, -71, 30, -80, 80, -77, -69, -1, -72, -50, 16, 13, -60, -76, -78, -63; /M: SY='M'; M= -66, 19, -87, -81, 19, -85, -73, 8, -79, 49, 70, -80, -84, -74, -78, -11, -63, 29, -77, -56; /M: SY='V'; M= -5, 23, -80, -77, -59, 6, 17, 41, -12, -21, -52, -73, -80, -73, -74, -67, -62, 55, -79, 20; /M: SY='E'; M= -63, -83, -42, 91, -87, -77, -58, -84, -48, -79, -73, -59, -63, 56, -55, -10, 14, -78, -84, -75; /M: SY='R'; M= -69, -86, -67, -55, -81, -78, -63, -77, 51, -79, -69, -62, 49, -50, 81, -64, -18, -17, -81, -71; /M: SY='S'; M= -26, -79, 8, -1, -73, -17, 30, -74, 32, -75, -68, -55, -72, 34, 10, 38, -7, -11, -79, 18; /I: E1=0; IE=-255; DE=-255;» more |
Numerical results [info]
| Total number of hits | 15 in 15 different sequences |
| Number of true positive hits | 15 in 15 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DOMAIN |
| Feature description [info] | PI3K-ABD |
| Version [info] | 4 |
Cross-references [info]