PROSITE entry PS51546
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General information about the entry
| Entry name [info] | PI3K_RBD |
| Accession [info] | PS51546 |
| Entry type [info] | MATRIX |
| Date [info] |
01-AUG-2011 CREATED;
10-MAY-2017 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51546 |
| Associated ProRule [info] | PRU00879 |
Name and characterization of the entry
| Description [info] | Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=93; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=88; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.0174348; R2=0.0095898; TEXT='NScore'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=13497.8076172; R2=3.9518487; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=937; H_SCORE=17201; N_SCORE=11.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=468; H_SCORE=15347; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-21; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='N'; M=-30,-37, 20,-14,-74, 6, 1,-23, 18,-27, -4, 46, 38, -9,-20, 1, 11,-43,-83,-32; /M: SY='T'; M= 1,-72,-49,-13,-71, 27,-51, -6, -6,-38,-62, 21,-31, -7, -2, 21, 44, -5,-80,-21; /M: SY='S'; M=-16, 8, -5,-22,-20,-36, 12,-33, 34,-72,-66, 31, -9, 11, 4, 38, 20,-35,-80,-16; /M: SY='I'; M=-53, 5,-46,-24, 48,-86,-18, 53,-42, 37,-26,-76,-80,-74,-76,-53,-62, 28,-69,-22; /M: SY='K'; M=-26,-11,-67,-18, 34,-75,-65, 9, 41, 13,-33, -3,-52,-43,-10, 1, 16, -2,-70, 3; /M: SY='I'; M=-27, -3,-59,-79,-53,-86,-81, 67,-58, 12, -2,-49,-79,-75,-35,-71,-58, 61,-80,-25; /M: SY='N'; M=-17,-19, 16,-14,-71,-67,-31,-15, 12,-48, 26, 43,-70,-24, 20, 17, 31, 15,-86,-67; /M: SY='V'; M=-10, -2,-78,-74, -7,-42,-77, 49,-37, 3, -6,-32,-18,-25,-42,-36, 1, 56,-80,-61; /M: SY='W'; M=-51, -6,-24, 11, 14,-59, 71,-71, 22,-25,-61,-11,-55, 29, -2,-56,-27,-57, 94, 35; /M: SY='Y'; M=-53, 14,-25,-50, 43,-59,-65, 26,-34, 15,-51, -9, 4,-25,-11,-20, 11, -5,-13, 45; /M: SY='E'; M=-16,-77, 25, 34,-36,-17,-40, 1,-30,-18,-62,-19, 7, 30, 14, 21, -2, -9,-82,-67; /I: I=-14; MD=-34; /M: SY='W'; M=-21,-95, -3,-40, -8,-50,-33,-36,-14,-26,-79, -8, -7,-60,-86,-16,-17, 2, 13,-81; D=-14; /I: I=-14; MI=0; MD=-34; IM=0; DM=-34; /M: SY='N'; M=-60,-89, 4,-15,-56, 18,-72,-21, 0,-60,-55, 57,-26,-19,-63, 2,-48,-65,-33,-83; D=-14; /I: I=-14; DM=-34; /M: SY='S'; M=-14, 2, 40, -8,-25,-26,-64,-29,-31,-39,-28, 16,-46,-28,-27, 44,-16,-40,-83, 17; D=-14; /I: I=-14; DM=-34; /M: SY='Q'; M=-47, 5, 12, 13,-52, -7,-32,-23, 18,-56, 8, 38, 8, 48, 3, -9, 15,-38,-82,-47; /M: SY='Q'; M=-51, 17, 12, 9,-43,-72, -1, 1, -6,-24, 19, 1,-16, 47,-17, -1, 34, 3,-81,-12; /M: SY='S'; M=-17, 4, 13,-17,-32,-18,-64,-11, 22,-59,-13,-14, 37,-12,-18, 41, 23,-19,-81,-41; /M: SY='F'; M=-24,-74,-70,-48, 42,-76, 0, 23, 25, 2, -3, 17,-38, -7,-34,-32, 2, 24,-69, 5; /M: SY='T'; M=-22,-41,-43,-13,-71,-67, 1,-54, 5,-32,-18,-25,-21,-35, 16, 40, 75,-26,-85,-66; /M: SY='F'; M=-33,-73,-84,-79, 74,-63,-72, 41,-59, 31, 17,-45,-81,-31,-37,-72,-38, 16,-62,-26; /M: SY='Q'; M=-24,-75, -4, 4,-50,-52, -1,-15, 32,-55, 3, -1,-23, 46, 19, 4, 36, -7,-81,-45; /M: SY='C'; M=-25, 94,-80,-76, 17,-81,-27, 41,-43, -4,-50,-29,-20,-15,-55,-67,-59, 46,-81,-61; /M: SY='D'; M= -7, -2, 45, 0,-71,-32, 10,-67,-27,-22, 9, 38, 14,-16,-46, 36, -6,-22,-83, -2; /M: SY='P'; M= -6, 28,-69,-36, 0,-53, 47, 22,-30, 1,-26,-11, 52,-65,-38,-28, 14, 12,-26,-15; /M: SY='N'; M=-60,-73, 48, -8,-50,-23,-21,-68, 1,-21, -9, 60,-69, 23,-37, 14, 29,-24,-28,-17; /M: SY='D'; M= -4, 24, 37, 1,-30,-24, -8,-11,-32,-17, 11,-37,-35, -4,-65, 35, 35,-29,-79, 11; /M: SY='T'; M=-47,-34,-48,-48,-12,-31,-31,-23, -1, 5,-32, -8, -3,-61,-16, 19, 77, -8,-81,-33; /M: SY='P'; M= 29,-10,-73,-65,-69,-70,-18, -5,-51,-59, 12,-48, 78,-44,-73,-27,-25, 50, 4,-69; /M: SY='D'; M=-12,-76, 54, 36,-15, 0,-20, 3, -2,-22,-63,-25,-51, 8,-25, 6, -7,-23,-80,-23; /M: SY='E'; M=-12,-40, 36, 47,-37,-57, 26,-19, 20,-15,-25, 10,-67, 35,-37, -2, -9,-41,-82,-44; /M: SY='L'; M= 16,-71,-82,-76, 8,-80,-74, 38,-57, 48,-40,-77,-80,-72,-75,-54,-44, 43,-71, 10; /M: SY='I'; M=-49,-10,-77,-56,-53,-82,-47, 73,-16, 29, 39, 2,-50,-48,-72,-50, -8, 10,-78,-59; /M: SY='E'; M= 32,-25, -3, 37,-47,-50, -8,-61, 21,-36, -1, 2,-69, 8, 2,-15,-15, 18,-78, -6; /M: SY='Q'; M=-41, 6,-24, 23,-67,-36, 18, -1, 4, 0, 35, 26,-69, 50, 5, 14, -8,-37,-79,-25; /M: SY='I'; M= 39,-31,-23,-71, 21,-60,-74, 49,-71, 14,-15,-68,-73,-69,-74,-32, 21, 23,-74,-34; /M: SY='L'; M=-44,-72,-79,-31, 52,-82,-69, 34,-55, 59, 6,-22,-80,-71,-74,-29,-48, -9,-23, -1; /M: SY='C'; M= -9, 55,-48, 11,-41,-55, 19,-24, 29,-60,-39, 14,-70, 19, 46, 18, 14,-49,-80,-39; /M: SY='K'; M= -1, 19,-58, 20,-19,-43,-61,-72, 72,-45,-28,-55,-45,-22, -5, 15, -4,-46, 29, 8; /M: SY='M'; M=-20, 14,-70,-19, 34,-63, 8, 16, 24, 23, 45, -7,-75,-15, -1,-64,-19, 1, -8, -7; /M: SY='H'; M= 19,-72,-21, 14,-21,-23, 38,-26,-11,-10,-16, 22,-34, 19, -9, 16, 11,-31,-74, 22; /M: SY='N'; M=-46, 11, 27, -2,-72,-20, -5,-28, 28,-18, 9, 38,-51, 12, 16, 5, 32,-45,-83,-40; /M: SY='Q'; M=-19,-74, 29,-14, -5,-24, 15, 12, 20,-12, -6,-31,-22, 29,-23, 17, 16, -3,-78,-37; /M: SY='H'; M=-15,-74, -6,-61, 9,-37, 41, -8, 0, 36, 19, -9,-35, 33,-15,-36, -9, 3,-73, -1; /M: SY='K'; M=-30, 12, 9,-11,-70, 13, 1,-39, 30, 2, 11, 29, -4, 9, 16, 6,-23,-16,-80,-65; /M: SY='M'; M= -6,-72, 2,-13, 7,-26, 0, -3, -9, 14, 26, 4, 4, 23,-44, -1, 12, 10,-74,-10; /M: SY='N'; M=-12,-40, 14, 13,-31,-26,-30, -2,-11,-21, 8, 34, 28, -5, 20, 15, -3, -3,-80,-45; /M: SY='P'; M=-18,-22, 27, 27,-18,-21,-37,-15, 4, -7,-36, -4, 32,-22,-10, 0, 1, 13,-78,-12; /I: I=-18; MD=-45; /M: SY='E'; M=-30,-83, 28, 37,-50,-61, -1, -1, 4,-20,-45,-20,-12, 21,-16, -6,-64, 8,-88,-71; D=-18; /I: I=-18; MD=-45; /M: SY='Q'; M=-26,-92, 25, 10,-58,-45,-76,-33, -8, -9,-74,-39, 10, 29,-15,-38,-15,-35,-32,-80; D=-18; /I: I=-18; MI=0; MD=-45; IM=0; DM=-45; /M: SY='N'; M=-20,-56, 27,-30,-86,-77,-18,-67, -1,-65,-48, 31, 4, 5,-30, 13, -5,-36,-95, -9; D=-18; /I: I=-18; DM=-45; /M: SY='P'; M= 0,-55,-16,-12,-88,-37,-74,-47,-27,-69,-76,-18, 78, 11,-41, 5,-45,-35,-89,-31; D=-18; /I: I=-18; DM=-45; /M: SY='N'; M=-23, -6, -4, 27,-62, 12,-20,-42, 9,-45,-37, 38,-71, -2,-51, 35, 12,-72,-84,-14; D=-18; /I: I=-18; DM=-45; /M: SY='D'; M=-52,-78, 80, 37,-79,-33,-30,-35, 13,-61,-19, 23,-66, 29,-17, -1,-33,-74,-14,-32; /M: SY='Y'; M=-73,-29,-75,-74, 73,-79, 41,-43,-50,-30,-51,-71,-53,-33,-66,-69,-67,-61, 56,105; /M: SY='V'; M= -2,-10,-50,-72,-34, -5,-76, 42,-41, 12,-30,-70,-76,-33,-13,-52, -4, 62,-79,-37; /M: SY='L'; M=-52,-70,-85,-78, 32,-85,-70, 2,-78, 82,-19,-82,-84,-73,-76,-55,-63,-14,-68,-49; /M: SY='K'; M=-61,-78,-58,-45,-76,-70,-57,-33, 82,-35,-61,-32,-67, 63, 32, -2,-45,-28,-13,-63; /M: SY='V'; M=-36,-72,-82,-77,-54,-85,-28, 61,-75, 5,-23,-76,-15,-26,-77,-59,-32, 74,-82,-60; /M: SY='C'; M= -8, 99,-49,-48,-27,-70,-39,-17,-18,-31, -6, -3,-20, 17, 11, 5, 30,-16, 14, -5; /M: SY='G'; M=-50,-22,-51,-60,-83,100,-45,-90,-69,-86,-75,-34,-36,-67,-77,-33,-68,-84,-75,-78; /M: SY='R'; M=-55, 22,-66,-25, 17,-73,-36,-21,-27, 13,-14,-59,-73, 20, 64, 21, 28,-59, -9, 10; /M: SY='D'; M=-19,-76, 49, 47,-38,-46, 14,-73, -9,-28, -3, 31,-67, 19, 25, 11,-29,-52,-10,-31; /M: SY='E'; M=-18,-16, 17, 98,-81,-73,-56,-35,-45,-51,-35,-55,-59, 15,-54,-27,-19,-71,-81,-72; /M: SY='Y'; M=-50,-34,-75,-75, 68,-79, 32,-18,-70,-37,-50,-72,-83,-68,-67,-68,-65, -4, 16,108; /M: SY='L'; M=-36,-70,-84,-78, -5,-85,-72, 39,-77, 72, 19,-80,-81,-72,-76,-49,-61, 21,-72,-54; /M: SY='Q'; M= 8,-27,-30,-27, 35,-72, -8, 11,-53, 13,-50,-46,-73, 46,-29, 1, 18, 4,-65, 37; /I: I=-16; MI=0; MD=-40; IM=0; DM=-40; /M: SY='G'; M=-33,-76,-10, 1,-78, 68,-37,-76,-16,-43,-19, 42, 37,-58,-20,-13,-18,-41,-80,-73; /M: SY='D'; M=-54,-77, 76, 13,-81,-45, 7,-80, 19,-79,-15, 49, 5, 0, -2, 9,-19,-77,-90,-69; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='H'; M=-40,-31,-20,-15, 20,-73, 80, 18,-32,-33,-53,-33,-73, 13,-32, 7, 9, -4, -8, 61; /M: SY='P'; M=-14, 24,-35,-23,-52,-57,-64,-42, 7,-15,-62,-46, 83, 7, 20, 12,-10,-28,-76, -1; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='L'; M=-58,-71,-85,-77,-44,-86,-70, 33,-77, 78, 47,-81,-82,-35,-75,-76,-62,-11,-73,-55; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='I'; M=-28, 38,-47,-67,-64, 31,-20, 40, -2, 1,-22, 1,-72,-20,-10, 28, 4,-16,-79,-48; /M: SY='Q'; M=-48,-33, 47, 15,-54,-52, 9,-77,-49,-76,-68, 37,-67, 71,-17, 52,-15,-56,-85,-66; /M: SY='Y'; M=-55,-21,-73,-73, 74,-78, 58,-24,-69, -4,-50,-11,-61,-42,-67,-49,-45,-24,-45, 90; /M: SY='E'; M=-40,-22, 46, 49,-47,-54,-20,-29, 26,-16, 0,-30,-35, 46, -6,-31,-26, -7,-80,-29; /M: SY='Y'; M=-52, 36,-72,-70, 2,-45, 31, -5,-62,-42,-11,-68,-80,-19, 9,-14,-50,-19, 51,105; /M: SY='I'; M=-60,-73,-83,-79, 1,-87,-28, 75,-56,-32,-41,-76,-77,-28,-77,-69,-25, 70,-78,-57; /M: SY='R'; M=-50, -6,-60,-37,-47,-28, 38,-77,-26,-57,-62, 5,-74, 63, 91,-48,-64,-37,-78,-61; /M: SY='Q'; M=-42,-75, 11, 24,-75,-66, 38,-43, 19,-38,-14, 36,-45, 61, 2, 24, -1,-27,-81,-35; /M: SY='C'; M=-19,124,-20,-27, -8,-70,-16,-35,-17,-61, -2, -2,-80,-28, -3, 23,-40,-65,-29,-69; /M: SY='L'; M=-44,-47,-79,-60, 3,-82,-23, 39,-13, 61,-21,-74,-79,-67, -4,-18,-39, 17,-73,-39; /M: SY='K'; M=-15,-41,-42, 3,-69,-60, 6,-30, 48, 2, 21,-55,-55, 10, 45, 32, -9,-43,-77,-39; /M: SY='R'; M=-53,-75,-16,-52, 24,-20, -3,-47, 19, 1,-30, 35,-39, 25, 43, 14,-12, -8, 13,-56; /M: SY='G'; M=-28,-59, 29, 21,-71, 38, 4, -8, 8,-55, -9, 5,-45, 21, 7, 1,-28,-35,-76, 14; /M: SY='Q'; M=-23,-34,-16, 35,-74,-29, -4,-26, 50,-25,-15,-46,-44, 52, 25,-44, 12,-40, 12,-44; /M: SY='P'; M=-54,-12, 38, 27,-30,-58, 22, -4, 4, -5, 9, 5, 40,-56,-36,-20, 29,-16,-82,-41; /M: SY='P'; M=-52,-79,-76,-60, 2,-61, 15, 62,-45, 2,-40,-51, 72,-70,-50,-55,-34, 26,-76,-60; /M: SY='H'; M=-40,-10, 23, 11,-70,-41, 67,-32, 18,-14, 16, 23,-50, 32, 23,-14, -9,-47,-21,-19; /M: SY='L'; M=-66,-71,-59,-72, 32,-82,-34,-12,-54, 69,-37, -7,-82, 7,-33,-56,-47, 22,-70,-51; /M: SY='T'; M=-30,-23,-34, 5, -7,-30,-67, 13, -3,-18, 21,-42,-50, 3,-20, 17, 43, 38,-79,-40; /M: SY='L'; M=-57,-70,-77,-52,-12,-81,-68, -4,-58, 66, 33,-16,-10,-68,-34,-30, 3, 22,-75,-41; /M: SY='V'; M=-41, 21, 3, -4,-21,-18,-69, 36,-33, 1, 26,-64,-58,-14, 8,-48, 21, 40,-79,-28; /M: SY='H'; M= -5,-59, 24, 28,-42,-68, 52,-22, -5,-18,-28, 18, 31, 7, 7, 6, -8,-27,-82,-38; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 25 in 25 different sequences |
| Number of true positive hits | 25 in 25 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | PI3K-RBD |
| Version [info] | 4 |
Cross-references [info]