Home  |  Contact
Entry: PS51642

General information about the entry

Entry name [info] HEMOPEXIN_2
Accession [info] PS51642
Entry type [info] MATRIX
Date [info] 01-MAY-2013 CREATED;
01-OCT-2013 DATA UPDATE;
18-SEP-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC00023
Associated ProRule [info] PRU01011

Name and characterization of the entry

Description [info] Hemopexin repeat profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=47;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=47;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1196651; R2=0.0077764; TEXT='NScore';
/CUT_OFF: LEVEL=0; SCORE=821; N_SCORE=8.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=564; N_SCORE=6.5; MODE=1; TEXT='RR';
/DEFAULT: M0=-21; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -46, -79, -15,  17, -24,   9,  38, -50, -34, -26, -40, -37,  86, -48, -17, -15, -20,  14, -79, -52;
/M: SY='D';  M= -21, -28,  36,   5, -51,  25,  -3, -13,   4, -44, -65,  25,  -9,  -4, -26,  31,   4, -32,  17,  -1;
/M: SY='P';  M= -23,  10, -19,   1, -73,   4,  45, -33,  36, -38, -33,  28,  46, -10,  10,   3, -23, -22, -48, -39;
/M: SY='C';  M= -56,  58, -71, -77,  33, -72, -77,  49, -65,  14, -11, -73, -42, -50, -59, -44,  -3,  57, -74, -44;
/M: SY='D';  M= -64, -79, 107, -11, -84, -11,   4, -82, -50, -58, -77,  -8, -67,  -4, -62, -14, -14, -79, -96, -53;
/M: SY='A';  M=  82,  -4, -19, -60, -76,  14, -53, -62, -63, -70, -64, -48,  -6, -59, -68,  15,  -5, -48, -10, -71;
/M: SY='A';  M=  72, -65, -43, -53,   8, -52, -43,   3, -49, -29, -54, -12, -56, -63, -69,  -5, -25,  36, -75, -55;
/M: SY='F';  M= -12, -70, -78, -74,  75, -78, -63, -14, -70,  26,  12, -62, -60, -71, -19, -36,   3,  21, -54,  53;
/M: SY='E';  M= -31,  38,  11,  40, -18, -53,   0, -55, -36, -38, -42, -21, -14,  24,  19,  24,  -1,  14, -23,  28;
/I:         I=-24; MD=-60;
/M: SY='W';  M= -18,  55,  23, -37,  14, -40, -23, -10, -57, -18,  29,   6, -77, -47,  -4,   1,   0, -14,  72,  17; D=-24;
/I:         I=-24; MD=-60;
/M: SY='E';  M= -48, -60,  40,  41, -69, -43,  21, -48, -25, -71, -33, -47,  40, -41, -14, -22, -27, -44, -28, -39; D=-24;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='Q';  M= -42, -44, -13, -29, -56, -21, -20, -38,  -4,   0, -45, -19,   6,   9, -26, -24, -50, -65,-100, -86; D=-24;
/I:         I=-24; DM=-60;
/M: SY='R';  M= -45, -83,  28, -21, -42,  10,  12, -49, -24, -48, -72,  39, -22,   5,  48, -16,  -5, -58, -87, -28; D=-24;
/I:         I=-24; DM=-60;
/M: SY='G';  M= -35, -78,  36,  16, -82,  63,  26, -84,   3, -82, -72,  24,   1,   2, -21, -17, -62, -57, -82, -66; D=-24;
/I:         I=-24; DM=-60;
/M: SY='H';  M= -25, -76, -33,  37,  -6,  13,  61, -59,  43, -45, -56,   4, -59,  -6,  14, -10,  -5, -64, -44,  21;
/M: SY='V';  M=   1, -68, -69, -70,  19, -74,  22,  30, -62,  11,  12, -30, -73, -55, -61,  -5,  37,  48, -74,  -3;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='Y';  M= -69,  22, -74, -73,  55, -79,  47, -12, -58,   8,  -4, -70, -81, -66, -41, -67, -35, -24, -12, 101;
/M: SY='F';  M= -11,  25, -83, -79,  95, -79, -70,  26, -76,  12,  -3, -74, -81, -79, -75, -14, -61,  -1, -54, -28;
/M: SY='F';  M= -32,  -6, -85, -81, 110, -81, -68,  18, -77, -27, -18, -75, -83, -83, -75, -45, -49, -25, -46,   4;
/M: SY='K';  M= -28, -61, -57, -48, -71, -60,  30, -29,  76, -42, -61,   9, -67,  24,  32,  19, -38, -20, -75, -14;
/M: SY='G';  M= -30, -77,  51,  -2, -83,  87, -65, -88, -48, -84, -76, -17, -67, -38, -42, -47, -64, -82, -41, -75;
/M: SY='N';  M= -27, -41,  43,  -8, -77, -15,  37, -67,  -4, -46, -66,  50,  19,  28,  36,  13,  -7, -74, -35, -65;
/M: SY='H';  M= -59, -78, -14,   0,  29, -23,  59, -29,  32, -42,  -6, -21, -70,  49,  23,   6, -60, -57,  36,  28;
/M: SY='Y';  M= -61,  16, -77, -64,  63, -80, -22,  13, -55,   6, -25, -72, -81,  18, -68, -67, -46,  23, -48,  85;
/M: SY='W';  M= -32, -86, -87, -77,  38, -74, -50, -49, -71, -16, -30, -82, -80, -69, -72, -24, -64, -56, 151,  70;
/M: SY='R';  M=  -8, -76,  -1,   4, -24, -71,  -6, -41,  33,  -7, -18, -26, -71, -13,  69,  -2, -44,   6,  19, -41;
/M: SY='Y';  M= -62, -73, -79, -76,  68, -23, -62,  18, -35,  13, -14, -73, -72, -49, -33, -55, -32,  30,  19,  69;
/I:         I=-36; MI=0; MD=-90; IM=0; DM=-90;
/M: SY='D';  M= -30, -76,  80, -28, -32,  -1,  38, -43, -19, -63, -70,  38, -34,   0,   9,  10,  -4, -74, -88, -64;
/I:         I=-17; MD=-44;
/M: SY='P';  M= -48, -82, -36,  20, -19,  15, -46, -39, -15, -13, -10,  13,  63, -38, -44,   4, -23, -28, -27, -27; D=-17;
/I:         I=-17; MD=-44;
/M: SY='H';  M= -27, -81, -22,  -4, -13, -15,  49, -62,  14, -42,   9,  38, -76,  30,   1, -10, -28, -15, -22,   2; D=-17;
/I:         I=-17; MD=-44;
/M: SY='T';  M= -20, -81, -20, -40, -81, -41, -59, -62,  15, -15, -57,   4, -78,   6,  23,  21,  42, -51, -91, -76; D=-17;
/I:         I=-17; MI=0; MD=-44; IM=0; DM=-44;
/M: SY='M';  M= -29,   7, -63, -63, -61, -78, -44, -28, -30,  17,  46,  -1, -44, -34, -42, -66, -42,  33, -92, -15; D=-17;
/I:         I=-17; DM=-44;
/M: SY='D';  M= -51, -85,  38,  23, -61, -32,  13, -31,  18,  -9, -15, -42,  -5,  19,   3, -35, -34, -17, -85,  -6; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P';  M=  -2, -80,  -1,  11, -77, -10, -57, -28,  15, -34,  -6,  -8,  58, -23,   8,   5, -33, -10, -82, -33; D=-17;
/I:         I=-17; DM=-44;
/M: SY='G';  M= -24, -47,  21, -43,  -9,  48, -26, -13, -12, -31, -54, -31,   6,  -1, -29,  -9,   6,   4,  18, -53; D=-17;
/I:         I=-17; DM=-44;
/M: SY='Y';  M= -52, -81, -21,   7,  -6,  -4,  17, -44,  -3, -45, -61, -45,  22, -32, -21, -11,  -3, -22, -20,  87; D=-17;
/I:         I=-17; DM=-44;
/M: SY='P';  M= -31, -84, -27, -19, -27, -55, -16, -23, -18, -31, -57, -67,  97, -55,  24,  -2, -40, -11, -80, -72; D=-17;
/I:         I=-17; DM=-44;
/M: SY='K';  M= -27, -77, -13,  -6, -20, -21,   7, -32,  65, -23,  15, -13, -50,  -8,  39, -18, -15, -31,  20, -44; D=-17;
/I:         I=-17; DM=-44;
/M: SY='L';  M= -34, -73,  -2, -12, -23, -28, -39, -55,  -4,  39, -17, -16,  37,   9,  12,  20,   8, -23, -75, -17;
/M: SY='I';  M=  -1, -72, -26, -39, -41, -73, -17,  71,   0,   7,  -3, -20, -72, -51, -21, -16,  -2,  26, -77, -59;
/I:         I=-45; MD=-115;
/M: SY='S';  M=  14, -72,  -2,  12, -57, -26,  22, -35,  18, -27, -62,   4, -35,  18,  -1,  45,  15, -28, -47, -29; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='E';  M=   4, -73,  31,  39, -47, -41,  -2, -52,  20, -37, -65,  23, -24,  16,   8,  29,   5, -39, -80, -27;
/M: SY='Y';  M= -54, -49,  28,  15,  25,   7,  -1, -54,   1,   7,  -8, -32, -45, -27, -13,   7,  11,  -3,  20,  30;
/M: SY='W';  M= -45, -79, -73, -49,  74,  10, -76, -33, -55, -18, -37, -58, -66, -57, -60, -35,  -4, -22, 131,  -3;
/M: SY='P';  M= -54, -78, -67, -37,  28,  -6, -44,  -4,  -5,  12,  33, -39,  79, -35,  -7,  -9, -22, -43,  33, -57;
/M: SY='G';  M= -18, -23, -13,  13,  -9,  51, -11, -35, -27, -51, -43,  11,  32,  31, -15,   5,   9, -50, -45, -66;
/M: SY='C';  M= -20,  85, -67, -52,   0, -46, -70,  25, -43,  30,  -7, -47,  36,  31, -42, -51, -49,   7, -77, -62;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_08 which contains 560'823 sequence entries.


Total number of hits 433 in 104 different sequences
Number of true positive hits 433 in 104 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 8
Feature key [info] REPEAT
Feature description [info] Hemopexin
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
104 sequences

ALB2_LATSA  (D4AEP7    ), ALB2_PEA    (P08688    ), D2MP_DROME  (Q8MPP3    ), 
HEMO_BOVIN  (Q3SZV7    ), HEMO_DANRE  (Q6PHG2    ), HEMO_HUMAN  (P02790    ), 
HEMO_MOUSE  (Q91X72    ), HEMO_PIG    (P50828    ), HEMO_PONAB  (Q5R543    ), 
HEMO_RABIT  (P20058    ), HEMO_RAT    (P20059    ), HE_HEMPU    (P91953    ), 
HE_PARLI    (P22757    ), MMP10_HUMAN (P09238    ), MMP10_MOUSE (O55123    ), 
MMP10_RAT   (P07152    ), MMP11_HUMAN (P24347    ), MMP11_MOUSE (Q02853    ), 
MMP11_RAT   (Q499S5    ), MMP11_XENLA (Q11005    ), MMP12_HUMAN (P39900    ), 
MMP12_MOUSE (P34960    ), MMP12_RABIT (P79227    ), MMP12_RAT   (Q63341    ), 
MMP13_BOVIN (O77656    ), MMP13_HORSE (O18927    ), MMP13_HUMAN (P45452    ), 
MMP13_MOUSE (P33435    ), MMP13_RABIT (O62806    ), MMP13_RAT   (P23097    ), 
MMP13_XENLA (Q10835    ), MMP14_BOVIN (Q9GLE4    ), MMP14_HUMAN (P50281    ), 
MMP14_MOUSE (P53690    ), MMP14_PIG   (Q9XT90    ), MMP14_PONAB (Q5RES1    ), 
MMP14_RABIT (Q95220    ), MMP14_RAT   (Q10739    ), MMP15_HUMAN (P51511    ), 
MMP15_MOUSE (O54732    ), MMP16_HUMAN (P51512    ), MMP16_MOUSE (Q9WTR0    ), 
MMP16_RAT   (O35548    ), MMP17_HUMAN (Q9ULZ9    ), MMP17_MOUSE (Q9R0S3    ), 
MMP18_XENLA (O13065    ), MMP19_HUMAN (Q99542    ), MMP19_MOUSE (Q9JHI0    ), 
MMP1A_MOUSE (Q9EPL5    ), MMP1B_MOUSE (Q9EPL6    ), MMP1_BOVIN  (P28053    ), 
MMP1_HORSE  (Q9XSZ5    ), MMP1_HUMAN  (P03956    ), MMP1_LITCT  (Q11133    ), 
MMP1_PIG    (P21692    ), MMP1_RABIT  (P13943    ), MMP20_BOVIN (O18767    ), 
MMP20_HUMAN (O60882    ), MMP20_MOUSE (P57748    ), MMP20_PIG   (P79287    ), 
MMP21_CYNPY (Q90YC2    ), MMP21_DANRE (A0A0N9E2K8), MMP21_HUMAN (Q8N119    ), 
MMP21_MOUSE (Q8K3F2    ), MMP21_XENLA (O93470    ), MMP24_HUMAN (Q9Y5R2    ), 
MMP24_MOUSE (Q9R0S2    ), MMP24_RAT   (Q99PW6    ), MMP25_HUMAN (Q9NPA2    ), 
MMP25_MOUSE (Q3U435    ), MMP27_HUMAN (Q9H306    ), MMP27_TUPBE (Q9GKE1    ), 
MMP28_HUMAN (Q9H239    ), MMP2_BOVIN  (Q9GLE5    ), MMP2_CHICK  (Q90611    ), 
MMP2_HUMAN  (P08253    ), MMP2_MOUSE  (P33434    ), MMP2_RABIT  (P50757    ), 
MMP2_RAT    (P33436    ), MMP3_CANLF  (Q6Y4Q5    ), MMP3_HORSE  (Q28397    ), 
MMP3_HUMAN  (P08254    ), MMP3_MOUSE  (P28862    ), MMP3_RABIT  (P28863    ), 
MMP3_RAT    (P03957    ), MMP8_HUMAN  (P22894    ), MMP8_MOUSE  (O70138    ), 
MMP8_RAT    (O88766    ), MMP9_BOVIN  (P52176    ), MMP9_CANLF  (O18733    ), 
MMP9_HUMAN  (P14780    ), MMP9_MOUSE  (P41245    ), MMP9_RABIT  (P41246    ), 
MMP9_RAT    (P50282    ), MMPA_CAEEL  (G5EGM1    ), MMPC_CAEEL  (G5EBU3    ), 
MMP_HVAVE   (A4KX75    ), MMP_TNAVC   (Q06VC5    ), PRG4_HUMAN  (Q92954    ), 
PRG4_MOUSE  (Q9JM99    ), VTNC_HUMAN  (P04004    ), VTNC_MOUSE  (P29788    ), 
VTNC_PIG    (P48819    ), VTNC_RABIT  (P22458    )
» more

UniProtKB/Swiss-Prot
'Partial' sequences
1 sequence

ALB2_LENCU  (P86782    )

		
PDB
[Detailed view]
24 PDB

1CK7; 1FBL; 1GEN; 1GXD; 1HXN; 1ITV; 1PEX; 1QHU; 1QJS; 1RTG; 1SU3; 2CLT; 2JXY; 2MQS; 3BA0; 3C7X; 3LP9; 4AUO; 4FU4; 4FVL; 4G0D; 4RT6; 6CLZ; 6CM1
» more

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission