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PROSITE entry PS51702


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General information about the entry

Entry name [info] HTH_MU
Accession [info] PS51702
Entry type [info] MATRIX
Date [info] 01-JAN-2014 CREATED;
10-MAY-2017 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51702
Associated ProRule [info] PRU01039

Name and characterization of the entry

Description [info] Mu-type HTH domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=67;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=62;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.2966406; R2=0.0093798; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=10213.0000000; R2=0.0000000; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=662; H_SCORE=10213; N_SCORE=8.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=449; H_SCORE=10213; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-87; D=-100; I=-100; B1=-1000; E1=-1000; MI=-255; MD=-255; IM=-255; DM=-255;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-255; BD=-255;
/M: SY='M';  M= -19, -61,  -8,  44, -13,-106, -72, -15,  -2, -49,  99,   8, -43, -23, -36,  -4,  25,  -7,-255,-236;
/M: SY='W';  M= -61,-256, -42, -36, -77, -39,  61,-248,  58, -26, -19,   0, -85,  18,   5,  11, -38,-249, 115,  16;
/M: SY='E';  M= -49, -22,  22,  69,  45, -64, -39,  -3,-235,  -8,  22,-239, -71,   1,-103, -85, -27, -57,  42,  53;
/M: SY='W';  M=   7,-255, -80, -68, -73,-110,-254,-246, -82, -66,-245, -43, -61,-239, -64,  47,  46,-247, 154, -60;
/M: SY='Y';  M=  38, -39,-255,-250,  58,-251, -78,  21,-249,  24, -39,-250, -16,-247,-249, -74,-108,  35,-235,  63;
/M: SY='T';  M=  35,-243,-236, -42,-247, -94,-241,-104, -14, -39, -40, -51, -12,  13, -56,  49,  85, -43,-259,-243;
/M: SY='E';  M=  69, -31, -43,  74,-252,-239,-241, -79, -69, -85,-240,-236,   4,-227,-239, -32,  23,  -3,-257,-248;
/M: SY='Q';  M= -22,-251, -69, -58, -59, -89,-237,   7,  60,  47, -21, -29,-248,  65, -16,   3, -64,-110,-250,-237;
/M: SY='E';  M=  45,-251,  34,  86,-252, -96,-236,-243, -58,  -1,-239,-234,-240,  23, -76, -89,-235, -16,-257,-246;
/M: SY='L';  M=  12,  57,  -2,  24, -60, -30,-244,  22, -25,  60, -71, -73,-251,  -6,-244, -40,-236, -43,-253,-238;
/M: SY='A';  M=  61,-244,-250, -19,  -3,-245, -63,  -4, -91,  42,  57,-246,-249,-240, -46, -48,  -8,  18,-251,-235;
/M: SY='G';  M= -11, -63,  18,  20, -89,  71,  20,-258,  15,-256,-246,  10, -32,  26,   2, -35, -53, -76,-256,-246;
/M: SY='L';  M=  -8, -14,-257,-250, -66,-257,-246,  16, -39,  80,  13,-253, -55, -52, -55, -47, -74,   5,-250, -51;
/M: SY='P';  M= -10,-257,  14,  -9, -69, -10, -39, -33, -63,   6,  -3, -87, 100,  -8, -64, -10, -26, -69,-256,-247;
/M: SY='G';  M=-230,  26,  16,   0,-256,  91, -57, -87, -11,-256, -32,   2,-245,-238,-245, -12, -50, -47,-255, -61;
/M: SY='M';  M=-241,-247,-261,-253,  43,-260,-245,   3, -76,  68,  87,-254,-257, -50,-249,-250, -74,  28,-245,-225;
/M: SY='P';  M= -51,-261,-242,-233,-259, -60, -34,-250,-239,-102,-246,-243, 125,-240,-250,  32, -10,-252,-257,-255;
/M: SY='T';  M= -21, -55,   1, -15,-249,  20, -20, -68,  20, -58, -39,  32,-244, -23,  15,  44,  51, -20,  -5,-243;
/I:         I=-28; MD=-71;
/M: SY='T';  M= -10,-250,  -5, -63,-254, -57, -17,-250, -25, -62,-247, -66,-247, -79, -51,  59,  82,-243,-266, -33; D=-28;
/I:         I=-28; MD=-71;
/M: SY='P';  M=  13,-261,   2,  26,-256, -79, -14,  -8,  26, -62, -45, -73,  37,   0,  -4, -58, -54,  16,-264, -54; D=-28;
/I:         I=-28; MI=-71; IM=-71; DM=-71;
/M: SY='Q';  M= -27,-254, -52,-225, -66,-106, -49, -90,  30,-249, -22, -19,  -3,  78,  77,  25,   6, -83,-254,-240;
/M: SY='G';  M=  31,-248,-236,-243, -56,  80,-240,-255, -57,-255, -43,  55,-246,-236,  11,  -6,  -3,-249, -21,-248;
/M: SY='I';  M= -43,  -6,-260,-256,-228,-261,-258,  81,-253,   5,  12,-253,-254,-251,-255,-246, -40,  72, -12, -59;
/M: SY='R';  M= -46,-252, -29,   5,-246, -87,  58,  -7, -88,  -9, -43,  44,-247,  38,  67,   3,  25, -70,-258, -61;
/M: SY='R';  M= -10,-254,   7,   3, -47, -96,   0, -15,  55,   1, -42,   0,-247,  29,  57, -43, -93, -99,-248,  25;
/M: SY='R';  M= -76, -67,-240, -83,  -4,-251,  49, -57,  58, -27,  47, -61,-249,  13,  84,-109,-239, -38,-250, -18;
/M: SY='A';  M=  99,-240,-248,-241, -64, -87,-247,  -9,-243,  21,-230,-243,-246,-239,-246,-224,-231, -82,-252,-243;
/M: SY='K';  M=  -6,-252,   8,  32,-254, -39, -29,-251,  74, -68,-242,  30,-242,  19,  35, -31,  -5, -50,-256,-244;
/M: SY='R';  M=  -6,-253, -65,  10,-252,-247, -47,-101,  65, -64,-240,  12,-245, -10,  84, -36, -19, -30,-254,-242;
/M: SY='E';  M= -52,-254,   6,  92, -46, -85, -10,-248, -66,   3,-239,  25,-240,  40,-232,  -8,-235, -94, -17,  -1;
/M: SY='G';  M=  19, -78, -43, -50, -69,  72, -21,-255, -30,-256,-247,  68,-246,  -7, -87,  30,-232, -78, -14, -72;
/M: SY='W';  M= -62,-271,-267, -18,-222, -47, -48,-248,-246, -99,-249,-263,-254,-245, -73, -23, -71, -51, 179,-209;
/M: SY='Q';  M=  -9,-253, -25,  20,-251, -14,-234, -62,  18, -18, -34,  29,  40,  73,  18, -55,  13, -50,-254, -64;
/M: SY='K';  M= -13,  37, -29, -33,  44, -48,  23,-245,  51, -86, -13,  29,-248, -62,  12,  27,   0,-243,  23,  27;
/I:         I=-14; MI=0; MD=-35; IM=0; DM=-35;
/M: SY='R';  M= -56,-259,-238,  -5,-253,-252, -45, -86, -25, -95,-240,-233,-250,  32, 116, -76,-241, -60,-253,-240;
/M: SY='K';  M= -48, -37, -38,  28,-254,-247, -56, -44,  75, -58, -32, -19,  28,  51,  50, -49,-103, -83,-253,-243;
/M: SY='R';  M= -43, -43, -62, -29,-249,-252,-235, -40,  20, -93,-236, -91, -82, -10, 104, -76, -51,  31,-255,-240;
/I:         I=-20; MD=-50;
/M: SY='E';  M=  26,-252, -13,  38, -35, -46, -37, -79,  21,-114, -36, -86,  36,  33,   3,  16,  18, -19,-256, -62; D=-20;
/I:         I=-20; MD=-50;
/M: SY='G';  M=  -9,  20,-244,-251,-260,  99,-249,-265, -21,-262,-252,-231,-248, -74, -35, -40, -74,-106,-255,-255; D=-20;
/I:         I=-20; MD=-50;
/M: SY='R';  M= -71,-264,-252,-242,-257, -48, -40, -32,  34, -89, -64, -85, -17,  -2,  78, -49, -37,  28,-265,-251; D=-20;
/I:         I=-20; MI=0; MD=-50; IM=0; DM=-50;
/M: SY='G';  M= -88, -27,-240,-248, -56,  99, -34,-259, -38, -96,-248,-227,-245,-241,-249,  15,  16, -87,-252,-250;
/M: SY='G';  M=-233,-254,-238, -30,-254,  74,  -6, -40,  68,-252,-243, -45,  -8,-230,  24,-100, -67,  -5,-253,-246;
/M: SY='G';  M=  53,-247,-242,-242,-253,  74,-244, -85, -51, -74,-242, -80,-245,  -5,  15,  -2,  -7, -12,-253,-248;
/M: SY='F';  M=-242, -43, -72, -57,  61,-254, -15,  -2,  26,  -6,  -2,   7,-253,-237,  40, -87, -28,  24,  55,  47;
/M: SY='E';  M= -46,-256,-213, 115, -83,-253,-232,-252, -54,  -6,-243,-236,-235,-214, -36,-235,-238,-107,-255, -52;
/M: SY='Y';  M=-249,-258,-252,-252,  46,-255,-220,-233,-245, -85,-228,-251,-261,-242,-242,-245,-244, -87,  75, 135;
/I:         I=-24; MD=-61;
/M: SY='H';  M=  16, -76, -42, -48,-243,-247, 132, -52,-101,  -4,-232, -19, -22, -74, -26, -24, -87, -83,-266,  -8; D=-24;
/I:         I=-24; MI=0; MD=-61; IM=0; DM=-61;
/M: SY='I';  M= -35,-252,-260,-256,  30,-261, -44,  71,-251,  23, -23, -52, -79,-250, -46, -84, -81,  44,  31,  24; D=-24;
/I:         I=-24; DM=-61;
/M: SY='S';  M=  18, -55,  25, -41,-252, -63, -38,-250, -44,-115, -42,  33, -62, -10, -24,  80,  20, -86, -33, -40; D=-24;
/I:         I=-24; DM=-61;
/M: SY='S';  M=   5,  24,  -2,-238,-241,-105,-240, -18,-239,  10, -18,   5,-247,-234,-243,  89,-222,  20,-258, -56;
/M: SY='L';  M= -83,-247,-262,-254,  52,-261,-244, -42,-253,  86,  63,-257, -32,-248,-251,-252,-240,-219,-242,-223;
/M: SY='P';  M=-242,-267, -80,-232,-263, -81, -40,-251, -67,-261,-247,-248, 133,-242,-251, -35,-235,-256,-257,-259;
/M: SY='E';  M=  28,-251, -17,  56,-247, -71, -21, -20,   7, -16,  -4,  -9,  34,  30, -52, -18,  -3,  -7,-255, -37;
/M: SY='E';  M=  19,-251,  28,  71,-250, -59,  -2, -37, -21, -65, -39, -16,  -2, -22,  -9,  20, -13,  -4,-257, -34;
/M: SY='T';  M=  54,-243, -80, -78,-238,-244,-249,  35,-242, -24,  -3,-239,-245, -15,-246, -58,  67,  40,  -5, -46;
/M: SY='Q';  M= -90,-258, -80, -92, -36, -86, -44, -51,  14, -43, -39, -84,-248, 101,  86, -87,-239, -47,-251,-237;
/M: SY='A';  M=  57,-247,  -3,  23,-249,-104, -30,-106, -10,  -5, -27, -15,-244,  49,   1,  17,  13, -27,-256,-243;
/M: SY='A';  M=  68,-248, -57,  41, -35, -88,  -3, -24,  -5, -62, -40, -84, -80,  31,  19, -20, -66, -49,-249,   9;
/M: SY='L';  M=-243,-249,-261,-255, -12,-264,-248,  66,-253,  75, -36,-257,-257,-249, -66,-251, -88,  -4,-245,  13;
/M: SY='R';  M=  27,-249, -80,  -8,-238,   1,-241,  18, -38,  33,  30, -17,-249, -28,  44, -19,  -5, -10, -20, -66;
/M: SY='E';  M=  24,-250, -29,  38,  -4,   1, -45, -36,  34,  11,   0, -14, -50,  -8,   4, -14, -61,  -4, -35, -58;
/M: SY='R';  M=  16, -76, -30, -29, -85, -35,  47, -32,  37, -49, -11,   9, -36,  30,  62,   9,  -9,-107,-255, -70;
/M: SY='Q';  M=  13,-251, -20,  45,   9, -48,  32, -58, -23,  -5,  22,  -9, -54,  53,  -4, -27,  -1, -31,-248,  17;
/M: SY='A';  M=  31,-248, -28,  18,-240,  23, -51,  -2,  -9,  13,  -7, -34, -26,  -8, -24,  10, -11,   3,-251,   5;
/M: SY='Q';  M=  34,-249, -12,   1,-249, -27,-238, -20,  26,  -5,-235, -38,  12,  49,  21,   9,  24, -43,-255,-243;
/M: SY='Q';  M=  29,-250, -37,  32, -98, -41, -11,   8,  -7, -62, -23,   1,  13,  55, -27,  -1,  15,  11, -54, -73;
/M: SY='A';  M=  49,-248, -21,  26,-244, -61,   2, -16,  -6,  11, -40,  -3,  34,  -3, -94, -14, -12,  11,-256, -91;
/I:         E1=0; IE=-255; DE=-255;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.


Total number of hits 4 in 4 different sequences
Number of true positive hits 4 in 4 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Bacteriophages, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] HTH Mu-type
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
4 sequences

REPC_BPD10  (P07040), REPC_BPMU   (P06019), TNPA_BPMU   (P07636), 
TRA_HAEIN   (O05069)
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PDB
[Detailed view]
4 PDB

1G4D; 1QPM; 1TNS; 1TNT