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Entry: PS51777

General information about the entry

Entry name [info] RH2
Accession [info] PS51777
Entry type [info] MATRIX
Date [info] 01-OCT-2015 CREATED;
13-FEB-2019 DATA UPDATE;
13-FEB-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC51777
Associated ProRule [info] PRU01113

Name and characterization of the entry

Description [info] RH2 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=77;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=72;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.5714810; R2=0.0063112; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=10833.6210938; R2=2.9783344; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1494; H_SCORE=15283; N_SCORE=12.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=623; H_SCORE=12689; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-39; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='R';  M= -44,-111, -91,   6,-106,-105,  13,-106,  25, -62,  12, -21, -33,  -4,  95, -30, -28, -56,-109, -94;
/M: SY='P';  M= -35,  15, -95, -84, -48, -54, -96,-108,  59,-111,-100, -93,  99, -86,  20,  -6, -90,-107,-109,-105;
/M: SY='R';  M= -96,  57, -96, -88, -39, -41, -21,-110, -33,-105, -96, -16, -34, -42, 103, -13, -94, -56,  -3, -31;
/M: SY='F';  M=-107,-105,-118,-114, 120,-115, -95, -45,-109, -74, -82,-108,-118,-117,-106,-105, -99, -86, -71,  47;
/M: SY='T';  M= -82, -94, -89, -91,-101, -95, -98, -94, -29, -99, -94, -78, -92, -90, -95,  50, 107, -86,-118, -98;
/M: SY='R';  M= -52,-107,-101, -91, -20,-110, -92, -51,  37,  44,  30, -95,-107, -83,  78, -96,  -8, -51,-105, -90;
/M: SY='Q';  M=  27,-105,  -4,  37,-103, -44, -90, -34,  -2, -46,  -2, -37, -99,  60,  11,  20, -87,   9,-108, -16;
/M: SY='E';  M= -92,-113, -18, 114,-115,-108, -85,-115, -74,-107, -16, -88, -88, -67, -84, -89, -93,-108,-113,-105;
/M: SY='M';  M= -93, -99,-114,-105, -75,-111, -92, -62,-102,  68, 118,-107,-107, -95,-100,-104, -91,   0,-103, -82;
/M: SY='R';  M=  50,-104, -90, -12,-107, -94, -87,-104,  38,-101,  -1, -85, -98,  47,  77,  -4, -87, -96,-105, -95;
/M: SY='R';  M= -41,-111,  44,  59,-108,-102,  22,-109,  -9,-104, -96, -36, -97,  43,  77, -86, -60, -51,-109, -31;
/M: SY='V';  M= -39, -99,-113,-108, -82,-114,-112,  56,-105,   4,   1,-108,-108,-105,-107, -98, -84,  89,-112, -89;
/M: SY='L';  M= -95,-100,-115,-108, -73,-117,-102,  40,-108,  86, -60,-112,-112,-102,-106,-106, -91,  10,-103, -84;
/M: SY='M';  M= -20, -24, -96, -88,   8, -20,  58,   5, -17,   5,  89,   7,-101,  67, -88, -53,  -2, -84,-104, -82;
/M: SY='E';  M= -91,-111,  38, 112,-114,-104, -83,-115, -73,-107,-104, -83, -86, -66, -83, -86, -90,-107,-112,-103;
/M: SY='R';  M= -95,-111, -91, -79,-106,-105, -83,-112,  47,-106, -94, -84,-102, -70, 112, -29, -93,-106,-105, -93;
/M: SY='N';  M= -92, -98, -33, -37,-105, -82, -74, -32, -33,-108,   1, 127,-102, -80, -86, -76, -78,-104,-124,-101;
/M: SY='Q';  M= -23,-109, -19,  72,-103, -51,  14, -22,  27, -56,  14, -84, -93,  77, -21, -30, -90, -98,-103,   8;
/M: SY='Y';  M= -98,-103,-108,-104, -28,-112, -84, -70, -39,  75, -15,-108,-113, -96, -98,-102, -94, -77, -79,  97;
/M: SY='K';  M= -93,-107, -85, -22,-108,-100, -20,-108, 111, -57, -94, -79, -93,  -7, -14, -87, -88,-104,-103, -95;
/M: SY='E';  M=  39, -18, -78,  78, -26, -26, -91, -45, -82, -62, -15, -86, -92, -23, -90,  30,  27, -39,-108, -97;
/M: SY='R';  M= -93,-108, -20, -44,-108, -99, -82,-109,  61,-106, -95,  39, -99,  43,  86, -20, -34,-105,-107, -94;
/M: SY='L';  M= -93,  18,-113,-107,  -1,-115,-100,  12,-106,  71, -65,-109,-112,-103,-105,-102, -37,  49, -99,  21;
/M: SY='M';  M= -37,-101, -37,-101,  71,-104, -93,  22, -99,  16,  95, -22,-105, -13, -99,  13, -38, -46,  20, -72;
/M: SY='E';  M= -32,-106,  26,  84, -27,-104, -87, -90, -27,  24,  -6, -27, -95,  24, -26, -89, -90,  -2,-108, -94;
/M: SY='L';  M=   0,   6,-113,-105, -23,-111,-101, -13,-106,  83,  -6,-110,-111,-101,-105,-101, -90,  20,-103, -85;
/M: SY='Q';  M= -90,-112, -75,  75, -32,-101, -81,-106, -20,-102, -93, -31, -93, 106,  12, -82, -35, -62,-105, -94;
/M: SY='E';  M= -91,-111,  66, 103,-115,-102, -83,-114, -74,-108,-105, -80, -88, -10, -84, -36, -89,-108,-115,-102;
/M: SY='E';  M=  41,-103, -74,  86,-109, -94,  -3,-107, -30,-103, -97, -85, -91, -11,  15,  25,  -9, -98,-109, -99;
/M: SY='L';  M= -94,-100,-114,-107, -73,-115,-100,  38,-106,  76,  41,-110,-111,-101,-105,-104, -90,  30,-102,  -7;
/M: SY='R';  M=  29,-105, -15,  36, -31, -96, -21,-105,  29,-101,  -2,  -8, -97,  39,  67,   5, -58, -99,-106, -94;
/M: SY='W';  M= -16,  34, -29, -35,   0,-101,   3, -87, -93,  19, -84, -17,-106, -28,  -6,  10, -12, -20, 108,  73;
/M: SY='Y';  M= -27,  31,-101, -99,  27,-103, -22, -80, -96,  18,  41, -94,-105, -32, -97,   6,  48, -11, -85,  87;
/M: SY='Q';  M= -91,-110, -34,  61,-109, -61, -21, -33,  55,-101,  -5, -82, -94,  77,  39, -35, -29,-101,-106, -95;
/M: SY='M';  M=   8,   5, -93, -89, -99, -28, -89, -14, -31, -45,  72,  30,  37,  -4,  52,  18,  20, -89,-109, -95;
/M: SY='E';  M= -24, -41, -11,  47, -21,  13, -92,  21,  10,   9, -23, -88, -98,  34,  17,   3, -89, -21, -12, -92;
/M: SY='R';  M= -26, -17, -16,   4, -98,   4, -89,  -4,   5,   2, -89,  -1,   3, -20,  66,  22, -14, -62,-106, -25;
/M: SY='A';  M=  45,-100,   0, -24, -17, -21, -94,   0, -21,  18, -32,  20, -18,   9,  -6, -18, -38,  15,-106, -36;
/M: SY='N';  M= -30, -17,  14,  -3, -50, -19, -25, -50,  18, -15,   8,  38,  31,   6,  13,  35,   4, -40,   0, -95;
/M: SY='Q';  M= -21,-106,  33,  27, -48, -47, -31,-101,  48, -32, -93, -18, -29,  51,  36,  -1,  -5, -39,-106, -16;
/M: SY='P';  M=  -3,  -8,  -4,  51,-100, -57, -92, -12,  23, -15,  29, -47,  52, -81,   7,   7, -27, -38,  22, -96;
/M: SY='E';  M=  -8,-106,  -1,  42, -56,  -3, -21, -49, -51, -52,  -9,  22,  32,  41,  23,  15, -53, -10,-105,  13;
/M: SY='H';  M=   4,  27,  11, -15,-102,   1,  49, -49,   3, -61, -16,  -9,  17,  18,  16,  38, -45,   2,-111, -36;
/M: SY='P';  M=   7,-105,   6,  14,-101, -38, -92, -26,  18,   2, -26,   7,  60,  32, -42,  -7, -12,   8,-109, -97;
/M: SY='S';  M= -17, -25,  20,  29,-104,   3,  -8, -39,  13, -33,   9, -14,   1,  35, -20,  39,  19, -34,-110, -96;
/M: SY='E';  M=  16,-102,   7,  36, -43, -45, -92,  -7, -16,   7, -86, -24,  -1,  35, -13,  23,   7,   7,-108, -94;
/I:         I=-10; MD=-24;
/M: SY='D';  M=  -2,-106,  33,  25,  13,-101, -23, -17,  -3,  21,   3,  -6,   9, -88, -26,  22, -12, -91,   1, -91; D=-10;
/I:         I=-10; MD=-24;
/M: SY='P';  M= -98,-114,  24,   2,-107,  -4,-102, -20,   2,  -2, -21, -20,  36, -95, -12,  11,  -3,  -7, -14,-105; D=-10;
/I:         I=-10; MD=-24;
/M: SY='E';  M= -72,-120,   0,  39, -41, -44,-101,-114,  24, -39,  -4,  18,-111, -32,  18,  -9, -16, -53, -11,-108; D=-10;
/I:         I=-10; MD=-24;
/M: SY='K';  M=  -2,-120,  13, -12,-123,  12,-106,-118,  30, -43,-111,   2, -23,   4, -21,  -3,-102, -48,-125,-115; D=-10;
/I:         I=-10; MD=-24;
/M: SY='M';  M= -22,-122, -16,  15,-120, -42,-112, -24,  14,-112,  30, -45, -18,-102, -25,   3,   4, -13,-130,-116; D=-10;
/I:         I=-10; MD=-24;
/M: SY='K';  M= -46,-129, -54, -27, -23, -27,-117,-117,  27,-122,-117, -50,  14, -41, -12, -10, -21,  -6,   3, -21; D=-10;
/I:         I=-10; MI=0; MD=-24; IM=0; DM=-24;
/M: SY='V';  M= -15,-118, -19, -37,-111, -70,-119, -43, -50,   1, -24, -43,   8,-113,-118, -30,  20,  36,-131,-114; D=-10;
/I:         I=-10; DM=-24;
/M: SY='Q';  M=-109,-124,-112,-106,  13, -23,-109, -27,-107, -21,  11,   9,  43,  53,-111, -69,   0, -23,-120,-106; D=-10;
/I:         I=-10; DM=-24;
/M: SY='Q';  M= -98,-117,-107,-103, -41,  41,-109, -27,   4,-110,-105, -97,-112,  44,-103,   2,  33,   0,-120, -50; D=-10;
/I:         I=-10; DM=-24;
/M: SY='P';  M= -25,  37,  -7, -95, -56, -14,-105, -55,  -5, -74,-105, -98,  60,  11,  33, -34,  16,-109,  51,-105; D=-10;
/I:         I=-10; DM=-24;
/M: SY='P';  M= -66,-110,  29, -18,-104,  -1,  -6,  10,   6, -16,  28,  -7,  47,  24, -94,  31, -42, -95,  -7, -99; D=-10;
/I:         I=-10; DM=-24;
/M: SY='P';  M= -35,-106, -94, -57, -17, -54, -94,  14, -49, -23, -87,  16,  77,  24,  28,  36, -84,  13,-107, -95;
/M: SY='R';  M=  -6,-105, -29,  15,   2, -40, -89, -52,  21, -21,  13,   3,  35, -18,  44, -21,  15, -30,  34,  16;
/M: SY='P';  M=   6, -21, -85,  48, -54, -96, -21,-103,  36, -63, -96, -89,  77,   1,  -7,  18, -53, -67,  26, -26;
/M: SY='P';  M=  21,-106, -18,   2,  13, -23,  -3, -25,  25, -29, -92, -22,  68,   5,   5,  -1, -15, -95,   9, -92;
/M: SY='E';  M=  -6,-106,  41,  46,  -3, -65, -93,  17, -60, -61, -13, -13,  30,   6,  -9,  -9,  16, -12,  24, -93;
/M: SY='S';  M=  -6,-103,  36,  24,   4, -94, -90,-101,  33, -68, -97,  -6,  29, -43, -45,  50,  28, -55,-109, -49;
/M: SY='K';  M=  34, -13,  39, -22,-106, -22,  -3,-101,  47, -34, -95,   0,   5, -82,  20,  16, -33, -30,-112, -98;
/M: SY='P';  M=  -1,-104, -10,  -1, -35,   6, -24,  -9,  16,  10,   1,  -2,  27, -86,  24,  13, -52,   4,-107, -50;
/M: SY='W';  M= -29,-105, -27, -58,   1,   5, -93, -55, -50, -28,  34, -40,  42, -14, -28,  50,   2, -26,  76,  33;
/M: SY='W';  M= -52,-104, -94, -94,  23,  15, -34, -92,  -3,  12, -89,  39,  46, -91, -38,  37,  -7, -22,  72, -87;
/M: SY='W';  M= -42,-105, -12, -30, -98,   7,  10, -13,  22, -22, -92, -19,   7, -85,  36,  26,  40, -44,  77, -91;
/M: SY='P';  M= -50,-105,  14, -84, -45, -23, -39, -43,  47,  -8, -92,   8,  50,   1,  -6,  11,  38, -36,-111, -97;
/M: SY='P';  M=   2,-107, -43,  11, -13, -29,  25,-105,  24,-105, -97,  36,  52,  10,  16,  36, -85, -52,-108, -23;
/M: SY='E';  M= -19,-108, -17,  63, -19, -39, -87,-105,  -3, -31, -96,  17,  15,  54,  13,   4,   1,-102,-109, -97;
/M: SY='S';  M= -57,-101, -89,  -1,-101, -25, -91, -95, -10,   7, -92, -17, -32,   6,  23,  80,  -5, -25,-111, -96;
/M: SY='G';  M= -10,-107, -94, -91, -45,  53,  11, -38,   7, -41, -37, -45,  37,  19,  30, -23,  29, -99,-107, -39;
/M: SY='I';  M= -92,  24,-101,  -2, -91, -26,  -1,  69, -29,  -9, -79, -96,  -2, -36,  22,   4, -17,  17,-110, -93;
/M: SY='R';  M= -89,-107,   7, -16,  -8, -99,   0, -35,  40,-100, -94, -84,  16,  20,  53,  44,  -6,  -2,-109, -93;
/M: SY='K';  M=  -5,-106,  -6, -84,-104,   3,  14, -32,  65, -97,  58, -84,  19, -12,   5,  16,  -9, -49,-109, -95;
/M: SY='F';  M= -33,-104,  -4, -29,  55, -61, -97,  13, -31,  43,  15, -24,  13,   2, -45, -15,  -9, -31, -99, -81;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_02 which contains 559'228 sequence entries.


Total number of hits 25 in 25 different sequences
Number of true positive hits 25 in 25 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] RH2
Version [info] 4

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
25 sequences

JIP3_DROME  (Q9GQF1    ), JIP3_DROPS  (Q29EP6    ), JIP3_HUMAN  (Q9UPT6    ), 
JIP3_MOUSE  (Q9ESN9    ), JIP3_RAT    (E9PSK7    ), JIP4_HUMAN  (O60271    ), 
JIP4_MOUSE  (Q58A65    ), JIP_CAEEL   (P34609    ), RILP_HUMAN  (Q96NA2    ), 
RILP_MOUSE  (Q5ND29    ), RIPL1_BOVIN (Q17QG3    ), RIPL1_DANRE (A0PJT0    ), 
RIPL1_HUMAN (Q5EBL4    ), RIPL1_MOUSE (Q9JJC6    ), RIPL1_RAT   (D3ZUQ0    ), 
RIPL1_XENLA (Q0IHE5    ), RIPL1_XENTR (A0PJP4    ), RIPL2_BOVIN (A4IFK7    ), 
RIPL2_DANRE (A4IGC3    ), RIPL2_HUMAN (Q969X0    ), RIPL2_MOUSE (Q99LE1    ), 
RIPL2_RAT   (Q6AYA0    ), RIPL2_XENLA (Q6IP02    ), RIPL2_XENTR (Q0P4J3    ), 
RIPL_DROME  (O76878    )
» more

PDB
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1 PDB

1YHN

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