PROSITE entry PS51780

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General information about the entry

Entry name [info]	GW
Accession [info]	PS51780
Entry type [info]	MATRIX
Date [info]	01-NOV-2015 CREATED; 01-NOV-2015 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51780
Associated ProRule [info]	PRU01116

Name and characterization of the entry

Description [info]

GW domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=79;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=79;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4062796; R2=0.0083001; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1578; N_SCORE=15.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=494; N_SCORE=6.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-34; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='S';  M= -15,-100, -18, -12, -23, -54, -41, -38,  12, -66,  40,  32,  -4,  -5, -60,  58,  35, -38,-103,  29;
/M: SY='E';  M=  -1,-102,  26,  45, -62, -44, -88, -50, -24, -51, -93,  27,   8,  38, -47,  12,  43,   0,-111, -38;
/M: SY='K';  M= -33,-102, -41,   3,-101, -98, -20, -17,  70, -46, -20, -56, -57,  30, -17,  13,  53,  -5,-108, -94;
/M: SY='N';  M=  21,-101, -13,   8,-104, -58, -43, -38,  31,-100, -39,  44,  41, -82, -19,  30,  35, -18,-111, -50;
/M: SY='V';  M= -18, -99, -41, -59, -16, -68, -22,   4, -33,  -9,  25,  -2, -30, -24, -57, -30,  20,  71, -14,  20;
/M: SY='N';  M= -39, -99,  11, -84, -40, -63,  11, -50,   9, -51, -45,  81, -41,   7, -21,  41,  37, -40,-113, -29;
/M: SY='Y';  M=  -3,-104, -93, -48, -25,  21, -85, -61,  47,   8,   3,  -3,-102,   0, -11, -13, -24, -68, -36,  77;
/M: SY='T';  M= -22,-101,  19, -68,   5, -99, -14,  11,  23, -30, -51,  22, -44,  20, -17, -11,  56, -16,-100,  39;
/M: SY='A';  M=  58,-100, -43, -66,  -7,  27, -92, -27, -16, -43, -48, -41,-101, -54,  19,  -7, -36,   5, -96,  48;
/M: SY='Y';  M= -33,-102, -91, -39, -15, -38,  13,  -4,  34, -62, -85,   9, -99,  26,  12, -32,  52,  14, -96,  57;
/M: SY='I';  M= -89,-101,-107,-105, -17,-112,-108,  81,-101, -22, -71,   0,-104, -21, -67, -52,  16,  61,-108, -88;
/I:         I=-22; MD=-55;
/M: SY='N';  M=   1,-110,  -6, -32,-106, -26, -99, -16,  31, -33, -98,  50,-108, -26, -67, -22,  16,   6,-119, -18; D=-22;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='N';  M= -38,-107,  -1, -44, -75,  -4, -13, -34,   1, -49,-100,  69, -51, -25,  -3,  28,  28, -74,-118, -22; D=-22;
/I:         I=-22; DM=-55;
/M: SY='R';  M=   9,-103,  -8, -23,-104, -43, -40, -51,  49, -47, -93,  26,  10,  -1,  53,  11,  15, -21,-109, -96;
/M: SY='N';  M=  14,-102,  17,  -1,-106,   2, -39, -55,  34, -64, -96,  44,  22, -55,   8,  23,  28, -49,-112, -99;
/M: SY='N';  M= -13,-102,  66, -31, -42,  35, -85, -58,  -8,-107,-100,  72, -98, -55, -65,   2,  14, -66,-114, -26;
/M: SY='G';  M= -23,-104,  14,   6, -21,  49,  39,-105, -24,-104, -97,  47, -99,  12, -91,  26, -12, -53, -18,  32;
/M: SY='M';  M=  -7,-102, -31, -67,  -3,  39,   1,  -2,  -4,   2,  48,  27, -25, -56, -95,   7,   6,  -7,-104,   0;
/M: SY='Y';  M= -45, -50,-110,-108,  25,-113, -45,  62,-104,  22, -71,-105,-109,-101,-104, -69, -36,  29, -19,  81;
/M: SY='W';  M= -41,-110, -11, -67,  -7, -76, -28, -29, -43, -15, -85, -98, -60, -37, -19, -25,  17, -67, 111, 101;
/M: SY='N';  M=   0, -98,  17, -34,-102, -39, -44,-100,  -3, -81, -56,  67, -43, -39, -42,  54,  54, -73,-114, -16;
/M: SY='K';  M=  32,-100, -44, -44, -46,  22, -50, -16,  46,   1,   2, -13, -98, -41, -60,  -2,  28,  -3,-106, -48;
/M: SY='P';  M=  -5,-113, -59, -61,-104, -72,-101, -21, -95, -28, -91,-102, 114, -46,-104, -62, -49,  20,-109, -52;
/M: SY='W';  M= -24, -31, -29, -33,   8, -79,  -5, -46, -64, -39, -86,   9, -17, -54, -66, -19, -93,  -2, 105, 101;
/M: SY='G';  M= -27,-106,  29, -17, -51,  58,  -5, -58,  10, -28, -23,  36, -12, -10,  22, -33, -37, -75,-107, -21;
/M: SY='T';  M= -18, -99,  14, -10, -66, -29, -91, -63,  16, -26,  14,  23, -51,   4, -60,  -5,  77,  -5,-112, -29;
/M: SY='S';  M=   8,-101, -56,  18, -68, -65, -47, -28,  31,-100, -41,  36,  -7,  10, -32,  52,  27, -26,-107,   4;
/I:         I=-21; MD=-53;
/M: SY='G';  M= -24,-119, -18, -59,-119,  52, -45, -85, -35, -48,-112,  51,   1,-104, -53, -29, -75, -49, -34, -45; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='A';  M=  32, -24, -70, -70, -17, -82,-106, -60,  -1, -42,  16, -62, -68, -22, -53,  23,  -6, -18, -37,  27; D=-21;
/I:         I=-21; DM=-53;
/M: SY='Q';  M= -38,-114, -99, -31, -49, -64, -27,  -5,  43, -24, -54, -17,-107,  66, -47, -14,  22, -26,-115, -62; D=-21;
/I:         I=-21; DM=-53;
/M: SY='Q';  M=  -9,-110, -11, -10, -20, -31, -97, -20,  13, -17, -27, -17, -13,  32,   1,  23,  -9,  -9,  -2,  -4; D=-21;
/I:         I=-21; DM=-53;
/M: SY='V';  M=  -3,-104, -48, -41, -93, -27,-101,  28,   0,   4, -36,  27,-107, -40, -30, -33,   3,  50,-112, -19; D=-21;
/I:         I=-21; DM=-53;
/M: SY='G';  M=  17, -50,   3, -11, -43,  57, -20, -73,  10, -50, -95,  -8, -54, -52, -93,  20,  13,  -7,-105,   7;
/M: SY='S';  M=   3,-101,  27, -37, -64, -58, -33, -94,  21,  -3,  13,  38,  18,  14, -48,  41,  18, -42,-110, -23;
/M: SY='A';  M=  49, -98, -44, -62, -94,  21, -98, -22, -40,  24, -83,  -7, -44, -93, -99,  12,  23,  15,-108, -35;
/M: SY='K';  M=  -7, -50,  -7, -27, -55, -44, -27, -60,  50, -70, -44,  28,  13,  -7, -18,  49,  29, -43, -24, -36;
/M: SY='N';  M= -21,-105,  37,   0, -60, -21, -51, -50,  37, -40, -96,  45,  12,  19, -30,  23,   9, -33,-112, -33;
/M: SY='Y';  M= -43,-109,-102, -51,  51,-108,   6, -52, -14, -13, -39,-100, -39, -21, -94, -50, -28, -41,   4, 112;
/M: SY='N';  M=  21,-102,  12,  -1, -99, -24, -23, -37,  26, -28, -20,  64,-100,   1, -61, -13,  17, -13,-110,   4;
/M: SY='N';  M= -56, -48,  20, -18, -68,  70, -44,-114, -38,-113,-103,  75,-100,  22, -34, -26, -47,-111,-113,-103;
/M: SY='Q';  M=  -2, -46,   3, -19,-111, -44, -40, -61,  57, -84, -94, -12, -98,  85,  29, -29,  -4,-102,-107, -54;
/M: SY='T';  M= -10,-102,  -9,  17, -40,-101,  -9,  10,  -1, -25, -26,   9, -31,  21, -30, -12,  58,   3,-107,  14;
/M: SY='V';  M= -26,-101,-114,-109,  63, -83,-103,   8,-106,  18, -74,-109,-112,-107,-106,-100, -89,  72, -93,  37;
/M: SY='K';  M= -21,-105, -32,   4, -97, -99,  40,  -8,  49, -53, -11,  27, -69,  34,  -1, -34,  41, -56,   6,  19;
/M: SY='V';  M=  13,-101,-112,-107, -62,-110,-112,  63,-105, -17, -39, -67, -44,-104,-108, -37, -85,  77,-112, -92;
/M: SY='T';  M= -44,-100,  20, -21, -62, -61, -43,  16,  -1,  -1, -25,  16, -98, -11, -93,  25,  66,  -9, -30, -48;
/M: SY='K';  M= -15,-109, -28,  15,-108, -35, -88, -80,  76, -41, -95, -54, -98,  40,  58, -36, -60,-103, -32, -96;
/M: SY='Q';  M= -34,-108, -79,  70,-107,-101, -87, -36,  29, -82, -47, -85, -94,  72,  -8,   2,  22, -47,-107, -17;
/M: SY='A';  M=  60,-100,  -9,   0, -96, -40,   7, -40, -18, -57, -20,  -6,-100,  22, -25, -20, -10,  18,-105,  26;
/M: SY='T';  M= -89,-102, -43, -26, -61, -76, -41, -15,  57, -25, -88, -13, -97,  22, -26,  -4,  66,  14,-109, -11;
/M: SY='T';  M= -17, -98,  11, -54, -92,-102, -98,   8, -93,  -1, -83,  22,-100, -55, -42, -46,  77,  40,-114, -18;
/M: SY='N';  M=   2,-104,  32, -14, -69,  35, -88,-107,  22, -76,-100,  63, -21,   8, -34,  17,  -8, -77,-113, -58;
/M: SY='N';  M= -70,-107,  -8, -35,-106,  40,  18, -59,  30, -88, -98,  53,-101,  16,  43,   4, -17, -75,  22, -38;
/M: SY='G';  M=   2,-103, -10,  -3,-104,  50, -27, -75,   3, -64, -42,  39, -99,   2, -68,  29,   7, -10,-109, -10;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='T';  M= -35, -98, -43, -39, -94, -60, -98,   3,   2,  -2, -38, -14, -53,  -6, -93,   0,  85,  16,-113, -48;
/M: SY='W';  M= -69,-117,-113, -74,  28,-108, -89, -92,-101, -33, -88,-111,-113, -98,-100, -75, -73, -99, 140, 106;
/M: SY='Y';  M=  -1, -22, -66,-101, -34, -75, -32, -24, -97,   4, -80,   2,-110, -37, -68, -14, -65,  28, -79, 107;
/M: SY='Q';  M= -57,-109, -94, -24, -23,-105,  30, -90,  19,  35, -81, -13,-105,  65,  33, -35, -93, -93, -93,  65;
/M: SY='I';  M= -26, -49,-110,-110,  48,  38, -48,  60,-106,  18, -12,-101,-107,-105,-108, -96, -50,  23, -99, -83;
/M: SY='S';  M= -22,-102, -44, -10,-102, -95,  -5, -31,  40, -78, -93,  -9, -96,  47, -11,  54,  46, -31,-108,  -3;
/M: SY='V';  M= -33,-104,  27, -28,  13, -50, -38,  20, -52,  30, -46,   3,-107,  -7, -70, -27, -42,  39, -27,  31;
/I:         I=-28; MD=-70;
/M: SY='N';  M=  -6,-117,  23, -19, -45,  -8,-100, -77, -19, -89, -50,  59, -50, -18, -75,  -7, -31, -51,-124,   1; D=-28;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='N';  M= -42,-106,  33, -90,-113,  49, -41,-114, -17,-117,-106,  93, -46, -40, -94, -19, -60,-113,-120, -53; D=-28;
/I:         I=-28; DM=-70;
/M: SY='G';  M= -90,-108, -18, -21,-111,  54, -18, -40,  51,-110,-101,  41, -59,  10, -85, -21,  25, -63,-113,-103; D=-28;
/I:         I=-28; DM=-70;
/M: SY='Q';  M= -40,-106, -48,   1,-102,-103, -52,  -5,  39,  -8, -43,  17,  14,  47, -34, -18,  36,   8,-113, -98; D=-28;
/I:         I=-28; DM=-70;
/M: SY='I';  M= -44,-104,-104, -68, -34,-108,-101,  68, -15,  17, -41, -42,-103,   4,  -8,  -5,  37,   0,  28, -14;
/M: SY='G';  M= -22, -43,-100,-107,   2,  89, -99, -51,-102, -49, -95, -88,-103,-100,-107, -85, -64,   9, -98,  35;
/M: SY='W';  M=-107,-131,-133,-111, -72,-105,-132,-103,-103, -77,-104,-126,-111, -45,-107,-113,-118, -74, 180, -31;
/M: SY='I';  M= -91,-103,-113,-109, -13,-116,-110,  75, -62,   9,  24,-106,-107,-105,-107, -65,  -1,  62,-108, -60;
/M: SY='D';  M= -38,-108,  90, -17,-112, -38,  15,-111,  35, -59,-104,  50, -42, -13, -57, -17, -87, -75,-122, -99;
/M: SY='K';  M=  38,-101, -88,   9, -50, -92, -92, -58,  50, -83, -44, -18, -96,  34, -42,  46,  12, -40,  17, -40;
/M: SY='R';  M=  -1,-105, -27,  -2,-105, -17,   7,-103,  44, -54, -95,   9, -99,   2,  57,  30,  -2, -29,-109, -38;
/M: SY='A';  M=  65,-101,  63, -35, -60, -13, -92,-104, -33, -83, -99,  15, -99, -53, -95,  22, -61, -73,-112, -10;
/M: SY='L';  M= -44,-102,-115,-110,  41, -59,-105,  33,-109,  63, -28,-110,-112,-106,-108, -61, -47,  36,-101, -81;
/M: SY='T';  M=  -2,-101, -28, -15, -10, -61, -51, -30,  28, -53, -47,  24, -62,  12,   0,  42,  50, -28,-111, -95;
/M: SY='T';  M=   7,-103,   5, -15, -48,-101, -96,  29, -12,  -2, -24, -12, -22,  18, -70,  14,  35,   8,-108,   5;
/M: SY='Y';  M= -47,-108, -17, -18,  -8, -54, -44,  -5, -18,   7, -25,   8, -13,  26, -12,  21,   5,  -4,-103,  40;
/M: SY='Y';  M= -14,-110,   2,  -6, -35, -32, -95, -30,   7, -10, -95,  19,  16,   9,  -8,  13,  10, -33,-110,  20;
/M: SY='T';  M= -11,-109,  -2, -22, -11, -59,  11,  -8,  -2, -35,  -4, -13,  -9, -17, -27,   2,  42,  -9,-111,  14;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_06 which contains 572'619 sequence entries.

Total number of hits	99 in 16 different sequences
Number of true positive hits	99 in 16 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Prokaryotes (Bacteria)
Maximum number of repetitions [info]	8
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	GW
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

16 sequences

AMI_LISMG   (O33983), ATL_STAA1   (A7X0T9), ATL_STAA8   (Q2FZK7),

ATL_STAAC   (Q5HH31), ATL_STAAM   (Q931U5), ATL_STAAN   (Q99V41), 
ATL_STAAR   (Q6GI31), ATL_STAAS   (Q6GAG0), ATL_STAAU   (P0C5Z8), 
ATL_STAAW   (Q8NX96), ATL_STAEP   (O33635), ATL_STAEQ   (Q5HQB9), 
ATL_STAES   (Q8CPQ1), INLB_LISMG  (P0DQD3), INLB_LISMO  (P0DQD2), 
LYTG_BACSU  (O32083)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

3 PDB

1M9S; 4EPC; 7KWI