PROSITE entry PS51844

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General information about the entry

Entry name [info]	SH3_LIKE
Accession [info]	PS51844
Entry type [info]	MATRIX
Date [info]	22-NOV-2017 CREATED; 26-FEB-2020 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51844
Associated ProRule [info]	PRU01190

Name and characterization of the entry

Description [info]

Myosin N-terminal SH3-like domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=50;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=45;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.6695542; R2=0.0069741; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=6366.6386719; R2=1.6386719; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1123; H_SCORE=8207; N_SCORE=10.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=550; H_SCORE=7268; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-40; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;

...

                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='D';  M= -39, -16,  73,  35,-103, -72, -30, -27,  -4, -51,   5, -43, -95, -29,   1,  27,  42, -74,-114, -26;
/M: SY='V';  M=  29,-101,  30,  33,-100,  -9, -94, -18,  27, -38, -89, -86, -97,  -8, -20,  15, -84,  42,-111, -97;
/M: SY='K';  M= -88, -24, -46, -84, -34,  60, -91, -55,  83,-105, -96, -31, -97, -81,   4, -54, -34, -56,-100,   9;
/M: SY='T';  M= -21, -99, -11, -42, -98, -96, -91, -90,  55,   2, -16, -21, -96, -20,   3,  38,  62, -12,-110, -94;
/M: SY='W';  M= -30,  11, -28, -11, -54, -55,  47, -12,   9,   5, -33,   6, -12,  17,  51,  13, -90, -94,  79,   3;
/M: SY='C';  M= -41,  97,-112,-107, -21,-111,-112, -16,-105, -26, -77,-104,-111,-108,-107, -51, -84,  90,-117, -93;
/M: SY='W';  M=-104,-123,-129,-111,  50,-105,-124, -95,-103, -93, -97,-122,-110,-104,-106,-110,-112, -24, 173, -36;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='V';  M= -10, -15,   3,-102, -48,-110,-104,  60,-100, -72, -74,-101,-106,-101, -34, -94, -29,  77,-104,  36;
/M: SY='P';  M= -20,-113, -89,  35,-110, -23, -96, -96, -24,-104, -33, -95, 106,   0, -15, -19, -87,   7,-109,-105;
/M: SY='D';  M= -45,-107, 101,  -7,  -7, -94,  60,-107, -43, -45,-101,  13, -98, -83, -91,  17, -85, -55,-122, -91;
/M: SY='P';  M=  10,-107,   8,  39,-111, -53, -91,-105,  19,-108, -99,  -7,  87, -29, -88,  36, -20,-102,-110,-104;
/M: SY='E';  M= -46,-106,  38,  61,-106, -37, -24,-103,  60, -19, -95,  34, -94,  18, -19, -85, -19, -43,-111, -97;
/M: SY='E';  M=  -3,-106,  27,  79,-106,   6,  13,-101, -41, -10, -94,   6, -93,  24, -15, -27, -42, -34,-111, -98;
/M: SY='G';  M=  41,-100, -90,   3,-105,  63,  -5, -96, -91, -99,  10, -13, -97,  16, -96,  32, -85,  10,-108, -99;
/M: SY='W';  M=-104,-116,-116,-106,  72,-107, -96, -91,-100, -86, -89,-111,-111,   3,-100,-104,-105, -99, 148,  83;
/M: SY='I';  M= -43,  26, -31,  24, -88,-111,  -6,  65, -13,   0, -75, -97,-102,  10, -19, -94, -41,  51,-109, -91;
/M: SY='K';  M=  17,  13,  30,   9,-104,  12,  -4,-100,  57,  -8,  -2, -32,  -6, -20, -27,  17, -86, -71,-109, -97;
/M: SY='G';  M=  67, -10, -96, -97,-108,  77,-100,-104, -96,-105, -98, -85, -98, -93,-102,   5, -88, -41,-106,-104;
/M: SY='E';  M= -47,-106,  -1,  84, -38,-100, -88, -82,  36, -71,  10, -25, -91, -73,  -7,   7,  12, -24,  34, -95;
/M: SY='I';  M= -90,-102,-111, -16, -80,-117,-111,  81,-105,  24, -67,-107,-106,-103,-107,-101, -86,  65,-108, -88;
/M: SY='Q';  M= -51,-102, -95, -25, -92,-105,  -5,  24,  41,  11,   9, -89, -99,  52, -34, -86,  48,  36,-108, -90;
/M: SY='S';  M= -42,-103,  21,  51,-109, -15, -87,-108,  58,-108,-100,  -7, -92, -41, -26,  65, -27,-102,-110, -98;
/M: SY='D';  M= -37, -12,  38,  38, -97,-100,  11,  32, -19, -31, -88,  18, -45, -82,  29,  -2,  34, -24,-111, -16;
/M: SY='E';  M= -36,-105,  28,  48, -42,   3, -30, -50,  25, -42, -94,  32,  -2,  -8, -20,  11,  -5, -42,-103,  31;
/M: SY='G';  M= -21,-105,  15,  26,  -6,  70, -94, -50,   0, -67, -98,   0,  16, -87, -42,  -4, -20, -33,-106, -99;
/M: SY='D';  M= -89,-107,  66,  42, -51,  43, -88, -59,  21, -59,-100,  17, -16,  11, -37, -23, -27, -54,-112, -99;
/M: SY='K';  M= -34,-106,  30,  54,-108,  28, -87, -59,  60,-106, -99,  23, -94,   0, -77,   5, -40, -52,-108, -42;
/M: SY='V';  M=  13,-100,  31, -42,   9,  13, -98,   4, -32, -14, -82,  -8,-103, -19, -59, -12, -41,  60,-107, -28;
/M: SY='T';  M= -87,-100, -40,  21, -96, -45,  14, -15,  47, -52, -39, -84, -95, -83,   3, -48,  74,  28,   6, -29;
/M: SY='V';  M=   7,  -3,-107,-102,  -1,-107, -13,  32, -38, -49, -76,-100,-105, -34,-101, -24,  -8,  81,-105,  19;
/M: SY='K';  M= -90,-104, -36,  46,   1, -62,  37, -51,  52,  -1, -17, -28, -98,  10, -27, -35, -14,  39,-107, -88;
/M: SY='T';  M= -46,  44, -98, -20, -88, -55, -96, -18, -90,  47,  14, -93,   7,   4,  10, -42,  65, -12,-109, -92;
/M: SY='E';  M=   6,-101,   7,  59, -95, -69, -29, -86, -50,  24, -85, -41, -39,   7, -39,  -3,  42,   7,-109, -30;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='D';  M= -35,-105,  81,  18,-112, -10, -21,-111, -32,-112,-105,  62, -98, -11, -56,  30, -10,-107,-121, -70; D=-20;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='G';  M= -25,-106,  20,   6,-109,  88, -93,-115, -90,-112,-103,  23, -97, -22, -19, -21, -54,-109,-106, -22;
/M: SY='K';  M=   7,-104, -38,  25,-105, -97, -88, -99,  77, -39, -93,  22, -27,   7,  23, -31,   6, -23,-107, -96;
/M: SY='T';  M= -88,-101,  30,  22, -96,-103, -38,  25,  26, -31, -25, -84, -96, -24, -21, -17,  68,  27,-113, -94;
/M: SY='V';  M= -59,-101, -33, -37, -13,-112,-102,  30, -34,  39, -71,-103,-108, -19,  12, -98, -87,  72,-106, -26;
/M: SY='T';  M= -61,-100,   9,   6, -43, -73, -93, -13,  27, -61,   8, -37,  -2,   7, -14,   4,  73,  20,-112, -94;
/M: SY='V';  M=  13,  -6,-108,-103, -82,-108, -16,  38, -37, -10, -74,-103,-106,-100, -34, -93, -31,  81,-106,  22;
/M: SY='K';  M= -61, -38,  19,  12,-106, -41,   3, -55,  72, -43, -96,  57,  17, -76,   5,   0, -30,-102,-111, -97;
/M: SY='E';  M= -89,-105, -30,  57, -31, -43, -91,  17,  32,  -5,  -6, -41,  28, -81, -21,  13,  18, -19,-105, -17;
/M: SY='D';  M= -49, -13,  92,  47, -43, -94, -84,-111,   4,-109,-104,  17, -95,   9, -86,  21, -50,-106,-117, -38;
/M: SY='Q';  M= -63,-107,  67,  28, -50, -97, -11, -58,  18, -41, -94,  17, -16,  73, -45,  -9,  -4, -22,-113, -95;
/M: SY='V';  M= -17, -20,-111,-103,  -9,-112,-106,  58, -31,  39, -25,-105, -46,  -6,-102, -98, -58,  61,-106, -87;
/M: SY='Q';  M= -95,-106, -14,  21,  66,-103,   8, -89, -50, -16,  -3,  23, -37,  71, -22, -89,  -9, -33, -89,  47;
/M: SY='P';  M= -45,-110, -23,   1,-109, -34, -88,-105,  33,-108, -19,  39,  88,  39,  -1,  10, -86,-105,-108, -27;
/M: SY='M';  M=  22,-101, -13,   1, -94, -98, -87, -81,  27, -52, 100, -30, -98,  37,  12, -38, -19,  11,-105, -15;
/M: SY='N';  M= -93,  -6,  44,  -9,-106, -46, -78,-103,  -2, -34, -98, 113,-101, -80, -39, -79, -81, -48,-122,-100;
/M: SY='P';  M=  -4,-113,  16, -21,-110, -97, -96, -39, -89,-105, -14, -15, 113, -18, -41, -88,  -3, -28,-111,-106;
/I:         E1=0; IE=-380; DE=-380;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_05 which contains 572'214 sequence entries.

Total number of hits	120 in 120 different sequences
Number of true positive hits	120 in 120 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotes
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Myosin N-terminal SH3-like
Version [info]	3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

120 sequences

MY18A_HUMAN (Q92614), MY18A_MOUSE (Q9JMH9), MY18A_RAT   (D3ZFD0),

MYH10_BOVIN (Q27991), MYH10_HUMAN (P35580), MYH10_MOUSE (Q61879), 
MYH10_RAT   (Q9JLT0), MYH11_CHICK (P10587), MYH11_HUMAN (P35749), 
MYH11_MOUSE (O08638), MYH11_RABIT (P35748), MYH13_CANLF (Q076A3), 
MYH13_HUMAN (Q9UKX3), MYH14_HUMAN (Q7Z406), MYH14_MOUSE (Q6URW6), 
MYH15_HUMAN (Q9Y2K3), MYH16_CANLF (F1PT61), MYH1B_CHICK (P02565), 
MYH1_BOVIN  (Q9BE40), MYH1_CANLF  (Q076A6), MYH1_HORSE  (Q8MJV0), 
MYH1_HUMAN  (P12882), MYH1_MOUSE  (Q5SX40), MYH1_PIG(Q9TV61), 
MYH2_BOVIN  (Q9BE41), MYH2_CANLF  (Q076A7), MYH2_HORSE  (Q8MJV1), 
MYH2_HUMAN  (Q9UKX2), MYH2_MOUSE  (G3UW82), MYH2_PIG(Q9TV63), 
MYH3_HUMAN  (P11055), MYH3_MOUSE  (P13541), MYH3_RAT(P12847), 
MYH4_CANLF  (Q076A5), MYH4_HUMAN  (Q9Y623), MYH4_MOUSE  (Q5SX39), 
MYH4_PIG(Q9TV62), MYH4_RABIT  (Q28641), MYH4_RAT(Q29RW1), 
MYH6_HUMAN  (P13533), MYH6_MESAU  (P13539), MYH6_MOUSE  (Q02566), 
MYH6_RAT(P02563), MYH7B_HUMAN (A7E2Y1), MYH7B_MOUSE (A2AQP0), 
MYH7_BOVIN  (Q9BE39), MYH7_CANLF  (P49824), MYH7_HORSE  (Q8MJU9), 
MYH7_HUMAN  (P12883), MYH7_MESAU  (P13540), MYH7_MOUSE  (Q91Z83), 
MYH7_PIG(P79293), MYH7_RAT(P02564), MYH8_CANLF  (Q076A4), 
MYH8_HUMAN  (P13535), MYH8_MOUSE  (P13542), MYH9_CANLF  (Q258K2), 
MYH9_CHICK  (P14105), MYH9_HUMAN  (P35579), MYH9_MOUSE  (Q8VDD5), 
MYH9_RAT(Q62812), MYO10_ARATH (F4IVR7), MYO11_ARATH (F4HWY6), 
MYO12_ARATH (F4IRU3), MYO13_ARATH (F4IUG9), MYO14_ARATH (F4JM19), 
MYO15_ARATH (Q0WPU1), MYO16_ARATH (Q9M2K0), MYO17_ARATH (F4K5J1), 
MYO1_ARATH  (Q9LHE9), MYO1_CAEEL  (P02567), MYO1_YEAST  (P08964), 
MYO2A_NAUCC (Q875X3), MYO2B_NAUCC (Q875X4), MYO2_ARATH  (F4K0A6), 
MYO2_CAEEL  (P12845), MYO2_LACK1  (Q875Q8), MYO2_SACU7  (Q876G9), 
MYO2_SCHPO  (Q9USI6), MYO2_YEAST  (P19524), MYO3_ARATH  (F4I507), 
MYO3_CAEBR  (Q60LV4), MYO3_CAEEL  (P12844), MYO3_SCHPO  (O14157), 
MYO4_ARATH  (F4JIU4), MYO4_CAEEL  (P02566), MYO4_YEAST  (P32492), 
MYO51_SCHPO (O74805), MYO52_SCHPO (O94477), MYO5A_CHICK (Q02440), 
MYO5A_HUMAN (Q9Y4I1), MYO5A_MOUSE (Q99104), MYO5A_RAT   (Q9QYF3), 
MYO5B_HUMAN (Q9ULV0), MYO5B_MOUSE (P21271), MYO5B_RAT   (P70569), 
MYO5C_HUMAN (Q9NQX4), MYO5_ARATH  (Q39160), MYO6_ARATH  (Q9LKB9), 
MYO6_BOVIN  (E1BPK6), MYO6_CHICK  (Q9I8D1), MYO6_HUMAN  (Q9UM54), 
MYO6_MOUSE  (Q64331), MYO6_PIG(Q29122), MYO7_ARATH  (F4I5Q6), 
MYO8_ARATH  (F4I460), MYO9_ARATH  (F4HXP9), MYOH_DICDI  (P54696), 
MYOJ_DICDI  (P54697), MYOM_DICDI  (Q9TW28), MYS2_DICDI  (P08799), 
MYS9_DROME  (Q01989), MYSA_DROME  (P05661), MYSN_ACACA  (P05659), 
MYSN_DROME  (Q99323), MYSS_CHICK  (P13538), MYSS_CYPCA  (Q90339), 
MYS_ARGIR   (P24733), OP1_MAIZE   (K7U9N8), Y4A0_ENCCU  (Q8SS35)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

172 PDB

1B7T; 1BR1; 1BR2; 1BR4; 1D0X; 1D0Y; 1D0Z; 1D1A; 1D1B; 1D1C; 1DFK; 1DFL; 1FMV; 1FMW; 1G8X; 1I84; 1JWY; 1JX2; 1KK7; 1KK8; 1KQM; 1KWO; 1L2O; 1LVK; 1M8Q; 1MMA; 1MMD; 1MMG; 1MMN; 1MND; 1MNE; 1MVW; 1O18; 1O19; 1O1A; 1O1B; 1O1C; 1O1D; 1O1E; 1O1F; 1O1G; 1OE9; 1QVI; 1S5G; 1SR6; 1VOM; 1W7I; 1W7J; 1W8J; 1W9I; 1W9J; 1W9K; 1W9L; 1YV3; 2AKA; 2BKH; 2BKI; 2DFS; 2JHR; 2JJ9; 2MYS; 2V26; 2VAS; 2VB6; 2W4A; 2W4G; 2W4H; 2W4T; 2W4V; 2W4W; 2X51; 2X9H; 2XEL; 2XO8; 2Y0R; 2Y8I; 2Y9E; 3BZ7; 3BZ8; 3BZ9; 3DTP; 3J04; 3L9I; 3MJX; 3MKD; 3MNQ; 3MYH; 3MYK; 3MYL; 4AE3; 4ANJ; 4DB1; 4DBP; 4DBQ; 4DBR; 4P7H; 4PA0; 4PD3; 4PJK; 4ZG4; 4ZLK; 5HMP; 5I4E; 5JLH; 5M05; 5N69; 5N6A; 5O2L; 5T45; 5TBY; 5W1A; 6BIH; 6BNP; 6BNQ; 6BNV; 6BNW; 6FSA; 6QDJ; 6X5Z; 6YSY; 6Z2S; 6Z7T; 6Z7U; 7B1A; 7DHW; 7JH7; 7MF3; 7NEP; 7PLT; 7PLU; 7PLV; 7PLW; 7PLX; 7PLY; 7PLZ; 7PM0; 7PM1; 7PM2; 7PM5; 7PM6; 7PM7; 7PM8; 7PM9; 7PMA; 7PMB; 7PMC; 7PMD; 7PME; 7PMF; 7PMG; 7PMH; 7PMI; 7PMJ; 7PML; 7QIN; 7QIO; 7YV9; 8ACT; 8EFD; 8EFE; 8EFH; 8EFI; 8ENC; 8EXW; 8G4L; 8Q6T; 8QYP; 8QYQ; 8QYR; 8QYU; 8SYF; 8W41
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