PROSITE entry PS51859
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General information about the entry
| Entry name [info] | RHO_BD |
| Accession [info] | PS51859 |
| Entry type [info] | MATRIX |
| Date [info] |
25-APR-2018 CREATED;
26-FEB-2020 DATA UPDATE; 08-NOV-2023 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC51859 |
| Associated ProRule [info] | PRU01206 |
Name and characterization of the entry
| Description [info] | Rho-binding (RhoBD) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=66; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=61; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.2628765; R2=0.0052755; TEXT='-LogE'; /NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9114.9658203; R2=1.8029594; PRIORITY=1; TEXT='Heuristic 5.0%'; /CUT_OFF: LEVEL=0; SCORE=1751; H_SCORE=12272; N_SCORE=12.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=614; H_SCORE=10222; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-66; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='T'; M= -47, -58, 33, 25,-152,-103, 22, -22, 22, -44, -13, 23,-145, 3, -59, -45, 71, -40,-165,-145; /M: SY='K'; M= 7,-154, -17, 9,-154,-122,-140, -45, 73, -43, -27, -20,-146, 17, -1, 25, -30, -8,-158,-146; /M: SY='D'; M= 11,-154, 76, -9,-158,-143, -68, -19, 34, -85, -67, 36,-147, 2, -38, 0, 8,-112,-167,-148; /M: SY='V'; M= -73, -3, -72,-156, -32,-162,-154, 44, -95, 41, 15, 4,-159,-152,-155, -66, -50, 64,-158, -46; /M: SY='E'; M= 39,-154, 21, 63,-161, -18,-137,-157, 1,-156, -52, 28,-144, 24, -10, 8, -50,-150,-161,-151; /M: SY='N'; M= -91,-155, -31, 33, -56,-147, 32, -26, -30, 5, 2, 72,-150, 71, -49, -39, -30, -58,-161, -58; /M: SY='L'; M=-146,-153,-156, -54, -46,-163,-147, 20, 36, 75, -15,-153,-158, -53, -25,-152, -80, -55, -4, -14; /M: SY='A'; M= 42, -70, -38, 20,-116, -83, 3, -48, -21, -34, -16, 21,-147, 6, 28, 29, 21, -52,-159, -46; /M: SY='K'; M= -45,-153,-134,-131, -71, -48,-135,-148, 68, -23,-142, 60,-148, 39, -11, 31, -17, -36,-156, -18; /M: SY='E'; M= -55,-160, -6, 103,-162,-153, -29,-160, -13, -72,-149, -83,-139, 44,-130, -54, -50, -99,-160,-151; /M: SY='K'; M= -71, -20, -48, 1,-146,-149, -76,-115, 80, 15, -72, 53, -42, -4, -29, -90, -83, -61, -56, 5; /M: SY='E'; M= -49,-158, 48, 96,-160, -86,-135,-158,-127, -76,-151, -55,-140, 2,-135, -4, 4, -78,-162, -48; /I: I=-45; MD=-115; /M: SY='E'; M=-105,-160, 52, 98,-163, -90,-135,-162,-127,-156, -1, -79,-140, -12, -58, -7, -25,-156,-165,-152; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='L'; M= -32,-150, -89, -29, -72,-162,-148, 3, -35, 84, 25,-157,-159, -31,-150,-151, -75, -41, 10,-134; /M: SY='N'; M= -41,-150, -20, -50,-151, -62,-133, -45, 2, -27, 19, 82,-148, 50, -15, 39, 7, -40,-162,-105; /M: SY='N'; M= -61, -73, 8, 32,-154, -59, -46, -83, 16, -25, -60, 73,-148, 62, 24, -36, -59, -15,-162,-146; /M: SY='Q'; M= -30,-157, -51, -8,-160,-145, 30,-156, 69, -85, -67, -15, -52, 89, 4, 15,-136,-153,-156,-142; /M: SY='L'; M= -55, -36,-154,-150, -45, -82, 42, 19, -81, 67, 64, -1,-156, -55,-148, -1, -90, -16,-154, -87; /M: SY='K'; M= -76,-156, -20, 11,-158,-147, -17,-105, 88,-119, -58, 10,-144, 48, 26, -11, -10,-152,-156,-144; /M: SY='H'; M= -22,-155, 11, 50,-152, -82, 52, -1, 50, -31, -38, 1,-144, 26, -3, 1, -28, -79,-159,-142; /M: SY='L'; M= 34, -75,-148, -18,-118,-146, -61, -14, -46, 53, 39,-145, -53, 45, -22, -7, -10, -19,-154,-139; /M: SY='Q'; M= -47, -19, -30, 35,-155, -94, -36, -72, -12, -15, 8, 33,-146, 100, -30, 18,-135, -62,-157,-143; /M: SY='E'; M= -45,-158, 38, 89,-159, -77, 7, -29, -21,-152,-146, -43,-140, 53, -13, -48, -18, -71,-160,-147; /M: SY='E'; M= -71,-158, 30, 86,-159,-124, -96,-158, 29, -74,-146, -26,-140, 62, -3, -20,-137, -93,-157, -39; /M: SY='L'; M= -8, -77,-153, -28, -22,-101, -24, 28, -86, 63, 32, -38,-156, 7,-147, -37, -51, -17,-145, 40; /M: SY='Q'; M= 22, -87, -9, 51,-152, -48,-136,-104, 22, -29, -37, -3, -80, 51, 10, 7, 20, -70,-156, -22; /M: SY='K'; M= -4,-151, -6, -3, -60, -71, -17, -92, 55, -1, -13, 25,-146, 41, 9, 34, -24, -50,-157,-142; /I: I=-9; MD=-24; /M: SY='M'; M= 26,-153,-150, -8,-103,-101, -91, 14, 14, 33, 43, -89,-154, 31, -75, -15, -65, 1,-154, -3; D=-9; /I: I=-9; MD=-24; /M: SY='K'; M= -61, -88,-135, 26,-111,-152,-139, -79, 78, -95,-148, 5,-148, 48, 23, -9, -21,-156,-160,-150; D=-9; /I: I=-9; MD=-24; /M: SY='E'; M= -32,-164, 25, 67, -79, -47,-146, -97, -54, -67, -99, 2,-153, -24, -59, 12, 11, -62,-169, -13; D=-9; /I: I=-9; MI=0; MD=-24; IM=0; DM=-24; /M: SY='E'; M= 7,-159,-109, 51,-161,-104, -18, -52, -23, -27,-115, 17,-151, 33, -6, 35, 9,-151,-167,-153; D=-9; /I: I=-9; DM=-24; /M: SY='E'; M= -34, -47, 28, 44,-108,-130, -62, -32, 35, -9, -34, 37, 1, 34, -32, -3, -25,-109, 22, -97; D=-9; /I: I=-9; DM=-24; /M: SY='E'; M= -9,-155, 38, 45, -50,-113, 17, 22, 7, -25, 24, -6, -82, 28, -98, -14, -35, 1,-161,-142; D=-9; /I: I=-9; DM=-24; /M: SY='E'; M= -1, -21, 18, 69,-158, 1,-135,-158, 15,-140, -91, 53,-144, 12,-133, 13, -47,-116,-161, -34; D=-9; /I: I=-9; DM=-24; /M: SY='E'; M= -34, -72, -10, 81,-158,-119, -86, -18, -22,-117,-146, 27,-142, 53, -9, 9, 3, -97,-161, -83; D=-9; /I: I=-9; DM=-24; /M: SY='I'; M= -84,-155,-161,-155,-133,-164, -67, 79, -4, 14, 60,-153,-156, -39,-151, -42, -25, 25,-156, -43; D=-9; /I: I=-9; DM=-24; /M: SY='K'; M= -11,-157, 23, 54, -51,-116, -63,-124, 68,-100,-148, -28,-145, -24, 19, -33, 0, -60,-160,-105; D=-9; /I: I=-9; MI=0; MD=-24; IM=0; DM=-24; /M: SY='Q'; M= -13,-153, 41, 7, -50, -59, -7,-154, 56, -86,-103, 10,-144, 64, 33, 21, -28,-139,-156, -89; /M: SY='L'; M=-146, -7,-158, -58, 48,-161,-140, -15,-153, 81, -25, -72,-161,-148,-150,-152,-141,-112,-135, 57; /M: SY='E'; M=-137,-154, -39, 77,-155, -84, -17, -67, 54, -55, -87, 16,-140, 21, 32, -13, 13, -95,-157,-144; /M: SY='K'; M= 4,-152, -42, 10,-153, -44,-136,-149, 94, -73, -24, 2,-142, -43, 12, -22, -33, -27,-153,-144; /M: SY='Q'; M= -44,-153, -82, -60,-153,-143,-132, -30, 65, -36, -10, 19,-144, 96, -15, 19, -28, -40,-153,-141; /M: SY='L'; M=-143, 16,-160,-154, -28,-161,-144, -1,-154, 87, -24,-157,-160,-148,-152, -67, -56, -21, 16, 31; /M: SY='E'; M= -36,-106, 14, 58,-153, -60, 25,-150, 56, -13,-140, 43,-142, 49,-103, 3,-133, -70,-157,-111; /M: SY='Q'; M= -76,-124, -48, -21,-148,-142, 7, -68, 18, 3,-135, 59, -81, 65, -1, 9, 63, -92,-159,-117; /I: I=-24; MI=0; MD=-60; IM=0; DM=-60; /M: SY='E'; M=-138,-158, -47, 119,-160,-153,-131, -71, -34,-108,-149,-134,-133,-112,-128,-134, -89,-100,-158,-150; /M: SY='R'; M= -62,-155, -28,-126,-151,-150,-134, -5, 64, -87, -7, -90,-146, 50, 83, -49, 8, -29,-153,-140; /M: SY='T'; M= 5,-144, -89,-144,-133,-151, -31, -17, -40, 46, 74,-140,-147, -40, -88,-131, 77, 1,-156,-136; /M: SY='L'; M=-143,-148,-155,-148, -22,-159, 46, -60, -6, 87, 42,-151,-157,-143,-145, -56, -34, -88,-150,-129; /M: SY='K'; M=-140,-154,-133,-120,-155,-148,-136, -63, 118, -71,-141,-126,-141, -72, -72,-135,-135, -72,-150,-142; /M: SY='Q'; M= -34,-149, -23, -44,-146,-102, -59, 18, 14, -20, 30, -12,-144, 77, 2, -63, 71, -51,-156,-140; /M: SY='Q'; M= 6,-155,-133, 10, -88,-143,-131,-143, -87,-145,-136,-130,-143, 122, -57, -6, 6, 3,-153,-140; /M: SY='A'; M= 100,-140,-147,-140,-151,-130,-148,-136,-142,-141, -11,-141,-146,-138,-146, -19, -49, 11,-155,-148; /M: SY='V'; M=-134,-147,-162,-157,-131,-164,-164, 64,-154,-116,-119,-156,-156,-155,-156,-147,-131, 98,-162,-139; /M: SY='N'; M= -71,-146, -48, -44,-153,-131, -60,-149, -54, -73, -30, 126,-151,-129, -48, -35, -48, -41,-172,-149; /M: SY='K'; M=-141,-155,-133, -42,-157,-148,-136,-158, 118,-156,-144,-126,-141,-118,-102,-135,-136,-153,-151,-144; /M: SY='L'; M=-145,-148,-161, -46,-119,-164,-146,-111,-155, 99,-107,-161,-162,-148,-153,-155,-142,-118,-150,-132; /M: SY='A'; M= 86,-144,-134, 52,-153,-135, -14, -54,-135,-145,-140, -41,-142,-131,-141, -25, 12, -30,-157,-148; /M: SY='E'; M=-138,-160,-112, 115,-162,-153,-131,-162,-119,-154,-150,-134,-135, 29, -23, -61,-139,-155,-158,-150; /M: SY='I'; M=-138,-152,-154, 18,-131,-165,-159, 90, -78, -46,-119,-152,-152,-148,-154,-147, -62, 65,-157,-138; /M: SY='M'; M=-140,-148,-161,-151,-129,-155,-134, -41,-144, -11, 150,-149,-150,-137, -41,-148, -50, -60,-153,-129; /M: SY='N'; M= 33,-145,-122,-136, -46,-131, -87,-148, -79, -31,-142, 116,-150, 2,-137, -31, -26,-147,-164, -39; /M: SY='R'; M= -66, -34, -44, -14,-153,-152, -26,-157, 26,-151, 5, -31,-150, 0, 108,-137, -51,-152,-154, -37; /M: SY='K'; M= -64,-157,-137,-123,-156,-150,-135,-157, 98,-153, -11,-130, -39, -34, 75,-136, -77,-152,-152,-143; /M: SY='D'; M= -65, -18, 97, 33,-158, -22,-135, -32, -32, -71,-147, -64,-145, 53,-137, -82, -33, -6,-167,-147; /M: SY='F'; M= -55,-150, -18, -62, 61, -77,-143, 6, -91, -6, 60, 20, 47,-144,-108, -6, 27, 8, -15, -74; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 13 in 13 different sequences |
| Number of true positive hits | 13 in 13 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Feature key [info] | DOMAIN |
| Feature description [info] | RhoBD |
| Version [info] | 3 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
13 sequences
ROCK1_BOVIN (Q8MIT6), ROCK1_HUMAN (Q13464), ROCK1_MOUSE (P70335), ROCK1_PANTR (P61584), ROCK1_RABIT (O77819), ROCK1_RAT (Q63644), ROCK2_BOVIN (Q28021), ROCK2_HUMAN (O75116), ROCK2_MOUSE (P70336), ROCK2_PIG (M3TYT0), ROCK2_RAT (Q62868), ROCK_CAEBR (A8WVU9), ROCK_CAEEL (P92199)» more
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| PDB [Detailed view] |
4 PDB
1S1C; 1UIX; 5F5P; 8P0S |