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PROSITE entry PS51859


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General information about the entry

Entry name [info] RHO_BD
Accession [info] PS51859
Entry type [info] MATRIX
Date [info] 25-APR-2018 CREATED;
26-FEB-2020 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC51859
Associated ProRule [info] PRU01206

Name and characterization of the entry

Description [info] Rho-binding (RhoBD) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=66;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=61;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.2628765; R2=0.0052755; TEXT='-LogE';
/NORMALIZATION: MODE=-1; FUNCTION=LINEAR; R1=9114.9658203; R2=1.8029594; PRIORITY=1; TEXT='Heuristic 5.0%';
/CUT_OFF: LEVEL=0; SCORE=1751; H_SCORE=12272; N_SCORE=12.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=614; H_SCORE=10222; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-66; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='T';  M= -47, -58,  33,  25,-152,-103,  22, -22,  22, -44, -13,  23,-145,   3, -59, -45,  71, -40,-165,-145;
/M: SY='K';  M=   7,-154, -17,   9,-154,-122,-140, -45,  73, -43, -27, -20,-146,  17,  -1,  25, -30,  -8,-158,-146;
/M: SY='D';  M=  11,-154,  76,  -9,-158,-143, -68, -19,  34, -85, -67,  36,-147,   2, -38,   0,   8,-112,-167,-148;
/M: SY='V';  M= -73,  -3, -72,-156, -32,-162,-154,  44, -95,  41,  15,   4,-159,-152,-155, -66, -50,  64,-158, -46;
/M: SY='E';  M=  39,-154,  21,  63,-161, -18,-137,-157,   1,-156, -52,  28,-144,  24, -10,   8, -50,-150,-161,-151;
/M: SY='N';  M= -91,-155, -31,  33, -56,-147,  32, -26, -30,   5,   2,  72,-150,  71, -49, -39, -30, -58,-161, -58;
/M: SY='L';  M=-146,-153,-156, -54, -46,-163,-147,  20,  36,  75, -15,-153,-158, -53, -25,-152, -80, -55,  -4, -14;
/M: SY='A';  M=  42, -70, -38,  20,-116, -83,   3, -48, -21, -34, -16,  21,-147,   6,  28,  29,  21, -52,-159, -46;
/M: SY='K';  M= -45,-153,-134,-131, -71, -48,-135,-148,  68, -23,-142,  60,-148,  39, -11,  31, -17, -36,-156, -18;
/M: SY='E';  M= -55,-160,  -6, 103,-162,-153, -29,-160, -13, -72,-149, -83,-139,  44,-130, -54, -50, -99,-160,-151;
/M: SY='K';  M= -71, -20, -48,   1,-146,-149, -76,-115,  80,  15, -72,  53, -42,  -4, -29, -90, -83, -61, -56,   5;
/M: SY='E';  M= -49,-158,  48,  96,-160, -86,-135,-158,-127, -76,-151, -55,-140,   2,-135,  -4,   4, -78,-162, -48;
/I:         I=-45; MD=-115;
/M: SY='E';  M=-105,-160,  52,  98,-163, -90,-135,-162,-127,-156,  -1, -79,-140, -12, -58,  -7, -25,-156,-165,-152; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='L';  M= -32,-150, -89, -29, -72,-162,-148,   3, -35,  84,  25,-157,-159, -31,-150,-151, -75, -41,  10,-134;
/M: SY='N';  M= -41,-150, -20, -50,-151, -62,-133, -45,   2, -27,  19,  82,-148,  50, -15,  39,   7, -40,-162,-105;
/M: SY='N';  M= -61, -73,   8,  32,-154, -59, -46, -83,  16, -25, -60,  73,-148,  62,  24, -36, -59, -15,-162,-146;
/M: SY='Q';  M= -30,-157, -51,  -8,-160,-145,  30,-156,  69, -85, -67, -15, -52,  89,   4,  15,-136,-153,-156,-142;
/M: SY='L';  M= -55, -36,-154,-150, -45, -82,  42,  19, -81,  67,  64,  -1,-156, -55,-148,  -1, -90, -16,-154, -87;
/M: SY='K';  M= -76,-156, -20,  11,-158,-147, -17,-105,  88,-119, -58,  10,-144,  48,  26, -11, -10,-152,-156,-144;
/M: SY='H';  M= -22,-155,  11,  50,-152, -82,  52,  -1,  50, -31, -38,   1,-144,  26,  -3,   1, -28, -79,-159,-142;
/M: SY='L';  M=  34, -75,-148, -18,-118,-146, -61, -14, -46,  53,  39,-145, -53,  45, -22,  -7, -10, -19,-154,-139;
/M: SY='Q';  M= -47, -19, -30,  35,-155, -94, -36, -72, -12, -15,   8,  33,-146, 100, -30,  18,-135, -62,-157,-143;
/M: SY='E';  M= -45,-158,  38,  89,-159, -77,   7, -29, -21,-152,-146, -43,-140,  53, -13, -48, -18, -71,-160,-147;
/M: SY='E';  M= -71,-158,  30,  86,-159,-124, -96,-158,  29, -74,-146, -26,-140,  62,  -3, -20,-137, -93,-157, -39;
/M: SY='L';  M=  -8, -77,-153, -28, -22,-101, -24,  28, -86,  63,  32, -38,-156,   7,-147, -37, -51, -17,-145,  40;
/M: SY='Q';  M=  22, -87,  -9,  51,-152, -48,-136,-104,  22, -29, -37,  -3, -80,  51,  10,   7,  20, -70,-156, -22;
/M: SY='K';  M=  -4,-151,  -6,  -3, -60, -71, -17, -92,  55,  -1, -13,  25,-146,  41,   9,  34, -24, -50,-157,-142;
/I:         I=-9; MD=-24;
/M: SY='M';  M=  26,-153,-150,  -8,-103,-101, -91,  14,  14,  33,  43, -89,-154,  31, -75, -15, -65,   1,-154,  -3; D=-9;
/I:         I=-9; MD=-24;
/M: SY='K';  M= -61, -88,-135,  26,-111,-152,-139, -79,  78, -95,-148,   5,-148,  48,  23,  -9, -21,-156,-160,-150; D=-9;
/I:         I=-9; MD=-24;
/M: SY='E';  M= -32,-164,  25,  67, -79, -47,-146, -97, -54, -67, -99,   2,-153, -24, -59,  12,  11, -62,-169, -13; D=-9;
/I:         I=-9; MI=0; MD=-24; IM=0; DM=-24;
/M: SY='E';  M=   7,-159,-109,  51,-161,-104, -18, -52, -23, -27,-115,  17,-151,  33,  -6,  35,   9,-151,-167,-153; D=-9;
/I:         I=-9; DM=-24;
/M: SY='E';  M= -34, -47,  28,  44,-108,-130, -62, -32,  35,  -9, -34,  37,   1,  34, -32,  -3, -25,-109,  22, -97; D=-9;
/I:         I=-9; DM=-24;
/M: SY='E';  M=  -9,-155,  38,  45, -50,-113,  17,  22,   7, -25,  24,  -6, -82,  28, -98, -14, -35,   1,-161,-142; D=-9;
/I:         I=-9; DM=-24;
/M: SY='E';  M=  -1, -21,  18,  69,-158,   1,-135,-158,  15,-140, -91,  53,-144,  12,-133,  13, -47,-116,-161, -34; D=-9;
/I:         I=-9; DM=-24;
/M: SY='E';  M= -34, -72, -10,  81,-158,-119, -86, -18, -22,-117,-146,  27,-142,  53,  -9,   9,   3, -97,-161, -83; D=-9;
/I:         I=-9; DM=-24;
/M: SY='I';  M= -84,-155,-161,-155,-133,-164, -67,  79,  -4,  14,  60,-153,-156, -39,-151, -42, -25,  25,-156, -43; D=-9;
/I:         I=-9; DM=-24;
/M: SY='K';  M= -11,-157,  23,  54, -51,-116, -63,-124,  68,-100,-148, -28,-145, -24,  19, -33,   0, -60,-160,-105; D=-9;
/I:         I=-9; MI=0; MD=-24; IM=0; DM=-24;
/M: SY='Q';  M= -13,-153,  41,   7, -50, -59,  -7,-154,  56, -86,-103,  10,-144,  64,  33,  21, -28,-139,-156, -89;
/M: SY='L';  M=-146,  -7,-158, -58,  48,-161,-140, -15,-153,  81, -25, -72,-161,-148,-150,-152,-141,-112,-135,  57;
/M: SY='E';  M=-137,-154, -39,  77,-155, -84, -17, -67,  54, -55, -87,  16,-140,  21,  32, -13,  13, -95,-157,-144;
/M: SY='K';  M=   4,-152, -42,  10,-153, -44,-136,-149,  94, -73, -24,   2,-142, -43,  12, -22, -33, -27,-153,-144;
/M: SY='Q';  M= -44,-153, -82, -60,-153,-143,-132, -30,  65, -36, -10,  19,-144,  96, -15,  19, -28, -40,-153,-141;
/M: SY='L';  M=-143,  16,-160,-154, -28,-161,-144,  -1,-154,  87, -24,-157,-160,-148,-152, -67, -56, -21,  16,  31;
/M: SY='E';  M= -36,-106,  14,  58,-153, -60,  25,-150,  56, -13,-140,  43,-142,  49,-103,   3,-133, -70,-157,-111;
/M: SY='Q';  M= -76,-124, -48, -21,-148,-142,   7, -68,  18,   3,-135,  59, -81,  65,  -1,   9,  63, -92,-159,-117;
/I:         I=-24; MI=0; MD=-60; IM=0; DM=-60;
/M: SY='E';  M=-138,-158, -47, 119,-160,-153,-131, -71, -34,-108,-149,-134,-133,-112,-128,-134, -89,-100,-158,-150;
/M: SY='R';  M= -62,-155, -28,-126,-151,-150,-134,  -5,  64, -87,  -7, -90,-146,  50,  83, -49,   8, -29,-153,-140;
/M: SY='T';  M=   5,-144, -89,-144,-133,-151, -31, -17, -40,  46,  74,-140,-147, -40, -88,-131,  77,   1,-156,-136;
/M: SY='L';  M=-143,-148,-155,-148, -22,-159,  46, -60,  -6,  87,  42,-151,-157,-143,-145, -56, -34, -88,-150,-129;
/M: SY='K';  M=-140,-154,-133,-120,-155,-148,-136, -63, 118, -71,-141,-126,-141, -72, -72,-135,-135, -72,-150,-142;
/M: SY='Q';  M= -34,-149, -23, -44,-146,-102, -59,  18,  14, -20,  30, -12,-144,  77,   2, -63,  71, -51,-156,-140;
/M: SY='Q';  M=   6,-155,-133,  10, -88,-143,-131,-143, -87,-145,-136,-130,-143, 122, -57,  -6,   6,   3,-153,-140;
/M: SY='A';  M= 100,-140,-147,-140,-151,-130,-148,-136,-142,-141, -11,-141,-146,-138,-146, -19, -49,  11,-155,-148;
/M: SY='V';  M=-134,-147,-162,-157,-131,-164,-164,  64,-154,-116,-119,-156,-156,-155,-156,-147,-131,  98,-162,-139;
/M: SY='N';  M= -71,-146, -48, -44,-153,-131, -60,-149, -54, -73, -30, 126,-151,-129, -48, -35, -48, -41,-172,-149;
/M: SY='K';  M=-141,-155,-133, -42,-157,-148,-136,-158, 118,-156,-144,-126,-141,-118,-102,-135,-136,-153,-151,-144;
/M: SY='L';  M=-145,-148,-161, -46,-119,-164,-146,-111,-155,  99,-107,-161,-162,-148,-153,-155,-142,-118,-150,-132;
/M: SY='A';  M=  86,-144,-134,  52,-153,-135, -14, -54,-135,-145,-140, -41,-142,-131,-141, -25,  12, -30,-157,-148;
/M: SY='E';  M=-138,-160,-112, 115,-162,-153,-131,-162,-119,-154,-150,-134,-135,  29, -23, -61,-139,-155,-158,-150;
/M: SY='I';  M=-138,-152,-154,  18,-131,-165,-159,  90, -78, -46,-119,-152,-152,-148,-154,-147, -62,  65,-157,-138;
/M: SY='M';  M=-140,-148,-161,-151,-129,-155,-134, -41,-144, -11, 150,-149,-150,-137, -41,-148, -50, -60,-153,-129;
/M: SY='N';  M=  33,-145,-122,-136, -46,-131, -87,-148, -79, -31,-142, 116,-150,   2,-137, -31, -26,-147,-164, -39;
/M: SY='R';  M= -66, -34, -44, -14,-153,-152, -26,-157,  26,-151,   5, -31,-150,   0, 108,-137, -51,-152,-154, -37;
/M: SY='K';  M= -64,-157,-137,-123,-156,-150,-135,-157,  98,-153, -11,-130, -39, -34,  75,-136, -77,-152,-152,-143;
/M: SY='D';  M= -65, -18,  97,  33,-158, -22,-135, -32, -32, -71,-147, -64,-145,  53,-137, -82, -33,  -6,-167,-147;
/M: SY='F';  M= -55,-150, -18, -62,  61, -77,-143,   6, -91,  -6,  60,  20,  47,-144,-108,  -6,  27,   8, -15, -74;
/I:         E1=0; IE=-380; DE=-380;
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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2024_03 which contains 571'609 sequence entries.


Total number of hits 13 in 13 different sequences
Number of true positive hits 13 in 13 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] RhoBD
Version [info] 3

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
13 sequences

ROCK1_BOVIN (Q8MIT6), ROCK1_HUMAN (Q13464), ROCK1_MOUSE (P70335), 
ROCK1_PANTR (P61584), ROCK1_RABIT (O77819), ROCK1_RAT   (Q63644), 
ROCK2_BOVIN (Q28021), ROCK2_HUMAN (O75116), ROCK2_MOUSE (P70336), 
ROCK2_PIG   (M3TYT0), ROCK2_RAT   (Q62868), ROCK_CAEBR  (A8WVU9), 
ROCK_CAEEL  (P92199)
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PDB
[Detailed view]
4 PDB

1S1C; 1UIX; 5F5P; 8P0S