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Entry: PS51860

General information about the entry

Entry name [info] REM_1
Accession [info] PS51860
Entry type [info] MATRIX
Date [info] 25-APR-2018 CREATED;
25-APR-2018 DATA UPDATE;
03-JUL-2019 INFO UPDATE.
PROSITE Doc. [info] PDOC51860
Associated ProRule [info] PRU01207

Name and characterization of the entry

Description [info] REM-1 domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=78;
/DISJOINT: DEFINITION=PROTECT; N1=1; N2=78;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1723568; R2=0.0081206; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1272; N_SCORE=12.5; MODE=1; TEXT='R';
/CUT_OFF: LEVEL=-1; SCORE=657; N_SCORE=7.5; MODE=1; TEXT='R?';
/DEFAULT: M0=-49; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='N';  M=  14,-124,  35, -55,-129, -62,  40, -17,  22,-126,-119,  45, -11,-106,-110,  37,  18,-118,-139,-119;
/M: SY='L';  M= -53,-125, -73, -37,  12, -64, -28,-102,   1,  45,  40, -53,  29,-114,-117,  14,   3, -62,-119,  32;
/M: SY='P';  M= -23,-132,  50,  32, -25, -43,-114, -22,-105, -39,-117, -52,  61, -22,  31, -23, -55, -27,-134,-120;
/M: SY='P';  M=  17,  15,-114, -53, -30, -15,-116,-122,  42,-123,   7, -38,  53,  31, -48,  -3,  28, -62,-130,-120;
/M: SY='P';  M= -59,-134,-106,  45,-133, -24,   6,-127,   1, -31,-117,-110,  72,  69,-107,  14,-111,-127,-131,-122;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='Q';  M= -48, -23,-115, -39,-120, -47, -10, -28, -19, -13, -14, -44,  21,  51,  41,  17,  28, -25,   1, -22;
/M: SY='R';  M= -39,   1, -36,  21,-121,  -5,-114, -40,-101,   8, -25,-112,  -9,  32,  55,  11, -19,  -7,-131,-118;
/M: SY='R';  M=   5, -13, -35,   2, -54, -12,-110, -19,  24, -20,  40,-107, -11,  41,  49,  14, -48,-113,-126,-114;
/M: SY='M';  M=  -6,-120, -38, -39, -32,   3,-107, -56,  24, -55,  71, -34,  20,  43, -14,  53, -12, -50,  -6,-110;
/M: SY='K';  M=  -8,  -3, -38,-102,  -4, -51,-106,-110,  53,  22, -13,  28,  -4,  23,  32,   8,   8,-110,-122,-108;
/M: SY='L';  M= -58,-121, -25, -14,  -7, -56,-115,  43,-114,  62, -88,  15,  34,-112,  -4, -56,-107, -15,-121,-105;
/M: SY='Q';  M=  -6,-125,  41,  44,-126,-113,-101,-120,   3, -16,-110, -21, -26,  91,  -7,  13, -49,-118,-126,-113;
/M: SY='Q';  M=-108,-124,  25,  27, -19, -44,  49,-115, -20,  13,-106,  26,  12,  63,  -2,  22, -36,-116,-125, -25;
/M: SY='R';  M= -14,-123, -33,  22,-115,-120,   4, -27,  52,   3,  54, -49,-116,  39,  56,-106, -39, -22,-124,-109;
/M: SY='I';  M= -52,-121,  29, -47,-103, -72,-115,  55,  -1,  45, -17,  -9,-122,-109,  26, -55,-106,  21,-125,-107;
/M: SY='E';  M=  38,  46,  30,  54,-124, -63, -14,-120, -68, -50, -17,  12,-113,  50, -18,  -3,   3,-114,  -1,-115;
/M: SY='E';  M=  11,-124,  52,  64,-123, -42,  -8, -47, -95, -58, -29,  20,-113,  37,  27,  -2,-104, -42,-128, -29;
/M: SY='L';  M= -55,-119,-130,-124, -90,-132,-116,  56,-122,  74,  19,-126,-128,-117, -36,-121,-108,   1,-115,  30;
/M: SY='Q';  M=-108,-126, -97,  42,-123,-115,  18,-123,  23,-120,-110,  41,-114,  87,  48,  -2, -37, -53,-123,   2;
/M: SY='R';  M=-112,-127,-105,   9,  25, -50,  56,-124,  61,-117, -10,-101,-117,  41,  79,-106,-110,-121,-120,-102;
/M: SY='K';  M= -45,-127,  10,  42,-128, -70,  39,-128,  83,-123,-113, -96,-111,  69,   2,-102,-107,-124,-124,-111;
/M: SY='I';  M=  -8,-120,-130,-125,   6,-131,-121,  78, -38,  59,  -3,-124,-125,-119,-122,-119,-107, -19,-117, -38;
/M: SY='Q';  M= -25,-126,  59,  63,-127,-116,  -2, -62, -59, -33,-113, -22,-113,  68,  40,   1,-106,-120,-129,-113;
/M: SY='K';  M=-109,-123,-114,-103,  -4,-124,  39,  35,  71, -42, -99,-106,-118,  20,  39,-110,-106,  42,-122,-104;
/M: SY='E';  M=  23,-125, -82, 113,-130,-119,-103,-129, -91,-123,-118,-105,-104, -34,-101,-102,-107,-120,-127,-121;
/M: SY='M';  M=  -4,  -6,-111,  13, -22,-119,   2,  25,  23,  30,  61,   9,-118, -23, -12,   7, -12, -32,-123,-106;
/M: SY='K';  M=  31,-123,  41, -16,-128,-112,-103,-125,  60,-123,-113, -33,-114,  58,  58, -20,-105,-119,-125,-114;
/M: SY='M';  M=-108,  -7,   0,-111,-100, -48,-110,  26,   6,   9,  82,-113,-121,  42,-109, -37,-105,  47,-118,  38;
/M: SY='R';  M=   2,-124,-111,-100,-117,-120,-108,  34,  67, -52,-104,-104,-117,  -4,  79, -23,-106, -29,-122,-110;
/M: SY='E';  M= -10,-124,  42,  77,-127,-116, -11,-124, -18, -63,-114,  11,-110,  46,  21, -41,  18, -75,-130,-115;
/M: SY='G';  M=  40,-120,-110,-118,-128,  95,-115,-131,-114,-129,-119,  21,-116,-111,-121, -95,-110,-122,-123,-124;
/M: SY='A';  M=  80,-113,-120,-115, -31,-109,-119,  40,-115,  22, -26,  -9,-119,-112,-118,-100,-102,   3,-122,-110;
/M: SY='E';  M=-107,  32, -90,  88,-121, -55,-104,-124,  38, -62,-116,  29,-109, -25, -97,  -2,  13,-119,  33, -18;
/M: SY='N';  M=   5,-119, -14, -97,-125,-106, -99,-124,  73,-126,-115,  96,-116, -35,   7, -42, -34,-121,-130,-116;
/M: SY='M';  M=-110,-117, -16, -19, -97,-127,-109, -36, -34,  54, 119,-119,-122,-109,-114,-118,-107,  21,-123,-101;
/M: SY='R';  M= -64,-121,-119,-109,-103,-125,-111,  21,  36,  37,  47,-113,-121,   9,  47, -49, -20,  31,-121, -14;
/M: SY='Q';  M=  -3,-124,  29, -48,-126,-112,  24,-123,  50,-122,-112,  -7,-115,  70,  55,  29,-103, -46,-126,-111;
/M: SY='V';  M=  42,-113,-117,-112,-106,-114,-116, -89, -49,  38,  15, -29,-119,   0,-114,  21,  32,  47,-126,-109;
/M: SY='Y';  M=  -9,  38,-116,-116, -27,-119,-102,-100,-113,  32, -96,-111,-122,-111,-115,   6,  63,-101,-101,  96;
/M: SY='S';  M=  -9,-117, -10,  13,-120,   0,-105,-118,  22, -35,-112,  24,-112,  31, -29,  59,  45,-113,-126, -18;
/M: SY='N';  M= -50,-119,  49, -32,-123, -53,-100, -26,  40,-119,  25,  80,-115,  24, -48,  25,  10,-116,-133,-114;
/I:         I=-25; MD=-63;
/M: SY='N';  M= -29,-147, -16,  -6,-152,  26, -24,-151,-130, -61,-143,  50,-143, -52, -69, -36, -21,-148,-159,-145; D=-25;
/I:         I=-25; MD=-63;
/M: SY='P';  M= -70, -20,-139,-135, -37,  -2, -29,-152,   1,-154,-145, -48,  54,-134, -42,  13, -27,-149,-154,-145; D=-25;
/I:         I=-25; MI=0; MD=-63; IM=0; DM=-63;
/M: SY='D';  M=-134,-152,  74,   1,-158,-137,-122,-152, -14,-148,-141,-112,-135,  69,-120,-123,-129,-150,-156,-137; D=-25;
/I:         I=-25; DM=-63;
/M: SY='R';  M= -29,-124,-108,   0,-117, -47,   5,-112,  41,   0,  57,  -2,  23,  27,  68, -42, -50, -54,-124,-110;
/M: SY='K';  M= -28,-125, -19,  50,-124,  27,-106,-124,  76, -63,  14,-100,-112, -25,  27, -47, -40,-120,   0,-114;
/M: SY='D';  M=   8,-118,  56,-100,-114,-112,  -2, -45,-107,  11,-102,  16,-118,  43,-111,  44, -99,  44,-132,-111;
/M: SY='L';  M= -25,-122,-117,-107,-107,-122,  31,  -8,  22,  52, -93,-113,  48,  17,  35, -23,-107,   4,-124,-107;
/M: SY='S';  M=  41,-117,-106,  12,-118,   4,-108,-113,  29,  15,-106, -34,-114,  39, -13,  49, -35,-109,-124,-113;
/M: SY='D';  M=   8,-122,  47,  41,-124,-112,  31,-124,  36,-122,-114, -26,  -1,  29,   2,  25,  13,-118,-127, -16;
/M: SY='A';  M=  70,  52,-122,-115,-108,-112,-120, -92,-114,  27, -26,-117,-122,-113, -18,-102, -27,  48,  17,-111;
/M: SY='Q';  M=  11,-122,  44,  39,-124, -68,  35, -44, -38, -63,-109,   8,-113,  73, -27,  -1,  13,  -5,-130,-112;
/M: SY='Q';  M=  28,-121, -34,  -6,-121,   0, -17, -44,  18,   2,-105, -23,  18,  74, -32,   9,   5, -59,-124,-113;
/M: SY='N';  M=-107,-122,-101,  21,-116, -30,-102, -55,  40,  11,  52,  55, -26,  52,  18,   8, -56, -75,-125,-111;
/M: SY='L';  M= -55,-118,-128,-121, -20,-128,-114,  39,-117,  74,  52,-122,-126,-113,   2,   5,-107, -51,-118, -35;
/M: SY='Q';  M=  21,-120,   1, -15,-118, -54,-106,  -3,  16, -23,  40,  -4,-116,  59,  38,  16, -11, -16,-125,-111;
/M: SY='E';  M= -64,-124,  49,  81,  -5, -47,-105, -24, -19, -36,-110,-102,-111,   6,-105,  -6, -33,  13,-124,   2;
/M: SY='S';  M= -14,  62,-108,-111,-114,   9,-110, -63,-109, -84,-111,  15,-116,-105,-114,  85,  10,  11,-127,  11;
/M: SY='N';  M=  -9,-118, -38, -42,-123, -29,-101,-120,  47, -57, -18,  82,-115,  12,  22,  36,   6,-117,-129,-115;
/M: SY='Q';  M=   4,-121,-103,   9,-120, -69,  -1,-117,  21,  -8,-107,   3,-114,  77,  32,  41,   6,-114,-123, -26;
/M: SY='K';  M=-110,-123, -10, -31,-125,-112,-100,-125,  86,-125, -10,  74,-115, -90,  52, -44,-103,-123,-127,-114;
/M: SY='I';  M=-112,-121,-133,-128, -93,-136,-125,  86,-126,  61, -11,-127,-126,-121,-126,-122,-107,  13,-121,-103;
/M: SY='D';  M=  -2,-124,  68,  59,-126, -40,-102, -48, -15, -32, -25,  10,-112,  68,-101, -61, -19, -66,-130,-115;
/M: SY='L';  M=  -2,-121,-115,  -1,  14,-122,-105, -33,  -3,  51,  22, -29,-122,  39,  19, -27,-108, -39,-111,  48;
/M: SY='L';  M=-115,-119,-130,-124,   9,-133,-111,   2,-124,  88, -79,-129,-131,-118,-121,-123,-111, -88,-108,  53;
/M: SY='R';  M=-109,-125,-101,  35,-123,-119,  42,-120,  56,-116,  38, -32,-114,  53,  67, -35,  -2, -48,-125,-109;
/M: SY='M';  M=   4,-121, -40,  54, -52,  -2,  -5,-110,  14, -12,  70, -22,-114,  30, -10,  14,-105, -47,-121,   6;
/M: SY='Q';  M=  14,-123, -28,  67,-128,-112, -33,-125,  27,-122,-114,   8,-110,  71,   0,  30, -35,-119,-126,-115;
/M: SY='L';  M= -30,-117,-129,-123, -93,-129,-118,  47,-123,  80,  18,-125,-127,-117,-122,  -9, -62, -25,-120,-103;
/M: SY='Q';  M= -63,-127,  12,  56,-120,-118,  39, -55,  30, -38,-109,  -4,-114,  74,  39, -29,-107,-120,-122,  16;
/M: SY='K';  M= -53,-125,  -9,  54,-126, -27,-103,-126,  72, -55,-114, -24,-112,  28,  49,   5,-105,-121,-124,-114;
/M: SY='L';  M=  14,-119,-121,-115,  22,-122,-107, -40,-108,  62, -90, -17,-126, -22,  37, -50, -36, -52,-108,  60;
/M: SY='N';  M=-107,-121, -34,  50,-119,-114,  35,-114,  36,   5,  -8,  57,-114,  46, -20,  14,  -8, -42,-128,-111;
/M: SY='A';  M=  39,-119,  12,  37,-118,  18,-109,   2, -47,   2, -15, -18,-114,  32, -36,  23, -26, -49,-126,-114;
/M: SY='W';  M= -13,-123,-108,  39,  -7, -71,  40, -46, -46,  23, -30, -39,-117,  36,  24,  18, -15, -22,  85,-101;
/M: SY='L';  M=-108, -47,-116,-112,-102, -31,  44,  10, -19,  54,  -7,  15,-123,  15,  11,   3, -42,  22,-123, -17;
/M: SY='A';  M=  36,-120,  13,  13,-117,  -7,-112,  -1,-104, -21, -13,  -4,  34,   9,  12,  -3, -38,  28,-127,-115;
/M: SY='E';  M= -17,-121,  31,  46, -30, -13,-109, -56, -28,  12,  -6,   4,  25,  -5, -23, -44,  30,  10,-127,-112;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2019_06 which contains 560'459 sequence entries.


Total number of hits 96 in 66 different sequences
Number of true positive hits 96 in 66 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 3
Feature key [info] DOMAIN
Feature description [info] REM-1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
66 sequences

CIP4_DANRE  (Q5U3Q6    ), CIP4_HUMAN  (Q15642    ), CIP4_MOUSE  (Q8CJ53    ), 
CIP4_PONAB  (Q5RCJ1    ), CIP4_RAT    (P97531    ), FBP1L_HUMAN (Q5T0N5    ), 
FBP1L_MOUSE (Q8K012    ), FBP1L_RAT   (Q2HWF0    ), FBP1L_XENLA (Q6DCZ7    ), 
FBP1L_XENTR (Q6GUF4    ), FNBP1_HUMAN (Q96RU3    ), FNBP1_MOUSE (Q80TY0    ), 
FNBP1_RAT   (Q8R511    ), FNBP1_XENLA (Q6GNV5    ), KPC1_ASPNG  (Q00078    ), 
KPC1_CANAX  (P43057    ), KPC1_COCHE  (O42632    ), KPC1_HYPJE  (Q99014    ), 
KPC1_NEUCR  (P87253    ), KPC1_YEAST  (P24583    ), NOSTN_BOVIN (Q2KJB5    ), 
NOSTN_HUMAN (Q8IVI9    ), NOSTN_MOUSE (Q6WKZ7    ), NOSTN_RAT   (Q5I0D6    ), 
PCK1_SCHPO  (P36582    ), PCK2_SCHPO  (P36583    ), PKN1_BOVIN  (A1A4I4    ), 
PKN1_HUMAN  (Q16512    ), PKN1_MOUSE  (P70268    ), PKN1_RAT    (Q63433    ), 
PKN2_DANRE  (A7MBL8    ), PKN2_HUMAN  (Q16513    ), PKN2_MOUSE  (Q8BWW9    ), 
PKN2_RAT    (O08874    ), PKN3_HUMAN  (Q6P5Z2    ), PKN3_MOUSE  (Q8K045    ), 
PKN_DROME   (A1Z7T0    ), RHN2A_XENLA (Q6DJJ6    ), RHN2B_XENLA (Q63ZR5    ), 
RHPN1_HUMAN (Q8TCX5    ), RHPN1_MOUSE (Q61085    ), RHPN2_BOVIN (A4FUC9    ), 
RHPN2_CANLF (Q8HXG3    ), RHPN2_DANRE (Q6TNR1    ), RHPN2_HUMAN (Q8IUC4    ), 
RHPN2_MOUSE (Q8BWR8    ), RICTR_SCHPO (Q09743    ), ROCK1_HUMAN (Q13464    ), 
ROCK1_MOUSE (P70335    ), ROCK1_PANTR (P61584    ), ROCK1_RABIT (O77819    ), 
ROCK1_RAT   (Q63644    ), ROCK2_BOVIN (Q28021    ), ROCK2_HUMAN (O75116    ), 
ROCK2_MOUSE (P70336    ), ROCK2_PIG   (M3TYT0    ), ROCK2_RAT   (Q62868    ), 
RTKN2_DANRE (Q5XIZ9    ), RTKN2_HUMAN (Q8IZC4    ), RTKN2_MOUSE (Q14B46    ), 
RTKN2_XENLA (Q5XGX5    ), RTKN_HUMAN  (Q9BST9    ), RTKN_MOUSE  (Q8C6B2    ), 
RTKN_RAT    (Q6V7V2    ), TOCA1_CAEEL (Q19253    ), TOCA2_CAEEL (Q9XUS7    )
» more

PDB
[Detailed view]
6 PDB

1CXZ; 1URF; 2KE4; 2RMK; 4NKG; 5FRG

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