PROSITE entry PS51944

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PURL: https://purl.expasy.org/prosite/signature/PS51944

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General information about the entry

Entry name [info]	COV_NSP3D_UBL
Accession [info]	PS51944
Entry type [info]	MATRIX
Date [info]	10-FEB-2021 CREATED; 10-FEB-2021 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC51943
Associated ProRule [info]	PRU00214

Name and characterization of the entry

Description [info]

Coronavirus Nsp3d Ubl domain profile.

Matrix / Profile [info]

/GENERAL_SPEC: ALPHABET='ABCDEFGHIKLMNPQRSTVWYZ'; LENGTH=56;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=51;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.4896872; R2=0.0206079; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=413; N_SCORE=11.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=195; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-8; D=-50; I=-50; B1=-500; E1=-500; MI=-105; MD=-105; IM=-105; DM=-105;

...

                A   B   C   D   E   F   G   H   I   K   L   M   N   P   Q   R   S   T   V   W   Y   Z
/I:         B1=0; BI=-105; BD=-105;
/M: SY='A';  M=  1, -8, -2,-12,-10, -7,-18,-15, -8,-13, -8, -7, -6,-17,-10,-14, -2, -3, -2,-27,-12,-10;
/M: SY='K';  M=-11,  1,-22,  2,  4,-24,-13, -9,-25, 18,-22,-13,  1,-11,  1, 17, -5, -5,-17,-26,-14,  2;
/M: SY='T';  M= -4,  0,-19, -5, -2,-19,-17,-11,-13,  3,-16, -9,  3, -9,  2, -1,  8, 15, -8,-29,-13,  0;
/M: SY='I';  M= -6,-23,-24,-26,-20, -8,-30,-25, 22,-14,  2,  6,-18, -9,-17,-17,-11, -3, 20,-25, -8,-21;
/M: SY='K';  M= -8,  1,-23,  3,  2,-22,-21,-14,-13,  8,-16, -9, -4, -8, -2,  0, -2,  2, -5,-28,-13,  0;
/M: SY='V';  M= -4,-27,-17,-31,-27, -1,-32,-28, 32,-23, 13, 11,-24,-25,-24,-22,-11,  2, 36,-26, -6,-27;
/M: SY='F';  M=-11,-19,-22,-21,-15, 11,-26,-13,  1, -4,  7,  3,-16,-24,-15, -5,-17, -8,  3,-11, 10,-15;
/M: SY='V';  M= -4,-24, -9,-27,-24, -1,-29,-26, 19,-21, 15,  8,-23,-25,-23,-19, -9,  7, 27,-28, -8,-24;
/M: SY='T';  M=  0, -3,-11,-11,-11, -9,-19,-20, -7,-12, -7, -8, -2,-12,-11,-11, 17, 41,  2,-30,-10,-11;
/M: SY='E';  M= -7,-10,-22, -7, 11,-15,-25,-10,  0, -4, -3, -2,-13,-15, -2, -8, -7, -7,  5,-28,-12,  4;
/M: SY='D';  M=-20, 50,-30, 70, 20,-40,-10,  0,-40,  0,-30,-30, 20,-10,  0,-10,  0,-10,-30,-40,-20, 10;
/M: SY='G';  M= -3, -1,-19, -5,-15,-27, 43,-14,-33,-15,-28,-18, 10,-20,-13,-15,  3,-11,-27,-26,-26,-14;
/I:         I=-15; MD=-32;
/M: SY='V';  M= -6,-19,-18,-21,-19, -7,-25,-20, 13,-10,  0,  3,-15,-16,-16, -4, -8, -1, 21,-26,-10,-19; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='N';  M= -7, 25,-20, 12,  1,-21, -4,  2,-21,  7,-29,-18, 39,-16,  1,  4, 11,  3,-24,-36,-18,  1;
/M: SY='F';  M=-11,-27,-18,-30,-25, 30,-29,-14, 12,-22, 11,  6,-23,-29,-26,-17,-16, -7, 17, -8, 16,-25;
/M: SY='R';  M=-12, -2,-26, -4,  3,-21,-19, 16,-23, 14,-20, -7,  3,-16,  8, 22, -3, -4,-17,-26, -5,  3;
/M: SY='T';  M= -3, 12,-19, 12,  2,-23,-12, -9,-23,  2,-23,-17,  9,-11, -2,  0, 14, 15,-14,-33,-15,  0;
/M: SY='V';  M= -4,-22, -9,-23,-22, -7,-27,-21, 17,-14,  2,  5,-19,-27,-17,-12, -8, -3, 30,-29,-11,-20;
/M: SY='V';  M= -5,-13,-12,-13,-14, -5,-24,-21,  7,-15,  0, -1,-14,-21,-17,-16, -4,  2, 15,-28, -9,-16;
/M: SY='V';  M= -3,-29,-13,-29,-26,  2,-30,-27, 26,-22, 20, 12,-29,-29,-26,-20,-14, -1, 37,-27, -7,-26;
/M: SY='D';  M=  0, 10,-21, 11, 10,-25,-11, -8,-22,  3,-23,-17,  7, -5,  0, -5,  8,  2,-16,-32,-18,  5;
/M: SY='T';  M=  1, -7,-20, -9, -6,-13,-15,-14, -7,-10,-11, -4, -6,  5, -9,-14,  3,  6, -5,-28,-15, -8;
/M: SY='S';  M=  2,  3,-19,  3, -6,-23, 11,-15,-23,-10,-23,-17,  3,-14, -9,-13, 13,  6,-13,-31,-20, -8;
/M: SY='E';  M= -3,  3,-22,  3,  8,-23,-17, -7,-14,  5,-14, -3, -2,-12,  8, -2, -1, -2,-10,-27,-13,  8;
/M: SY='T';  M=  1, -1,-12, -5, -7,-14,-14,-17,-11,-10,-16,-13,  1, -7, -8,-11, 21, 31, -2,-33,-14, -8;
/M: SY='Y';  M=-13,-26,-25,-30,-23, 30,-30, -7, 12,-22, 17,  7,-22,-28,-21,-18,-21,-10,  3,  4, 34,-23;
/M: SY='G';  M= -5, -5,-30, -3,-10,-29, 45,-15,-38, -7,-28,-19,  1,-18,-12, -4, -2,-17,-28,-22,-25,-11;
/I:         I=-15; MD=-32;
/M: SY='Q';  M= -3, -3,-20, -2, 10,-22,-15, -5,-13, 11,-16, -6, -3,-10, 15,  5,  1, -4,-10,-21,-11, 12; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='Q';  M= -8, -1,-28, -2, 15,-36,-20,  6,-16,  6,-18, -1,  0,-10, 50,  6,  2, -6,-25,-22,-10, 32;
/M: SY='L';  M=-11,-30,-20,-32,-23, 21,-31,-21, 19,-29, 38, 16,-27,-29,-24,-21,-26,-10, 11,-15,  6,-23;
/M: SY='G';  M=  2, -7,-28, -8,-16,-29, 56,-18,-36,-14,-29,-19,  3,-19,-16,-16,  1,-17,-27,-21,-27,-16;
/M: SY='S';  M=  1, -3,-18, -3, -3,-24, -7,-11,-17, -8,-22,-14,  1,  5, -1,-10,  7,  1,-14,-31,-20, -3;
/M: SY='V';  M= -1,-19, 12,-23,-22, -9,-25,-25,  4,-15, -4, -3,-17,-25,-21,-15, -2,  7, 19,-33,-14,-22;
/M: SY='F';  M= -5,-23,-16,-29,-23, 32,-24,-19,  5,-22,  4,  0,-18,-25,-27,-18, -8, -1, 11, -9, 12,-23;
/I:         I=-14; MD=-29;
/M: SY='V';  M= -2,-18, 11,-21,-21, -2,-24,-20,  5,-18,  1, -1,-18,-25,-21,-18, -8, -2, 14,-24, -5,-21; D=-14;
/I:         I=-14; MI=0; MD=-29; IM=0; DM=-29;
/M: SY='D';  M=-14, 28,-28, 32, 13,-31, -8,  4,-32, 12,-29,-20, 21,-12,  3,  3, -1, -9,-28,-33,-16,  8;
/M: SY='G';  M= -9, 13,-29, 17, -1,-32, 24,-10,-37,  1,-30,-21,  9,-15, -7, -5, -1,-14,-28,-27,-22, -4;
/M: SY='V';  M=  2,-11,-18,-15, -9,-14,-21,-15,  0, -3, -7, -2,-10,-16, -7, -8,  0,  7,  8,-26,-10, -9;
/M: SY='D';  M=-13, 23,-24, 31,  4,-25,-15, -8,-17, -5,-16,-15,  9,-16, -7,-11, -3, -6,-10,-35,-16, -2;
/M: SY='V';  M= -7,-28, -9,-31,-27, 11,-30,-25, 19,-23,  9,  6,-25,-28,-26,-21,-14, -5, 25,-15,  2,-27;
/M: SY='T';  M=  1,  2,-12, -3, -6,-11,-13,-15,-15,-10,-17,-14,  4,-11, -7,-10, 23, 34, -5,-32,-12, -6;
/I:         I=-13; MD=-27;
/M: SY='D';  M= -8, 16,-24, 18,  8,-27, -2, -5,-27, 14,-25,-16, 13,-11,  2,  4, -1, -8,-22,-25,-15,  5; D=-13;
/I:         I=-13; MI=-27; MD=-27; IM=-27; DM=-27;
/M: SY='V';  M= -1,-10,-11,-14,-11,-12,-14, -9, -1, -9, -4, -1, -6,-17, -6,-10, -2, -1,  1,-24, -9, -9; D=-13;
/I:         I=-13; DM=-27;
/M: SY='K';  M= -8,-12,-20,-13, -9, -7,-22, -8, -1,  6, -4,  1, -9,-18, -7,  3,-11, -7,  4,-17,  0, -9; D=-13;
/I:         I=-13; DM=-27;
/M: SY='P';  M= -2,-20,-11,-17, -9,-23,-20,-22,-14,-14,-19,-14,-20, 44,-15,-21, -8, -8,-14,-31,-26,-15;
/M: SY='D';  M= -8, 12,-21, 17,  1,-22,-14,  4,-20, -8,-19,-13,  5, -9, -4,-10,  8,  7,-12,-35,-12, -2;
/I:         I=-15; MD=-32;
/M: SY='D';  M= -2,  8,-20, 11,  0,-19,-15,-12, -9, -9,-11,-11,  1,-12, -9,-13, -1, -4, -3,-31,-15, -5; D=-15;
/I:         I=-15; MI=-32; IM=-32; DM=-32;
/M: SY='V';  M= -3, -8,-18,-13,-12, -5,-18,-15,  1, -6, -6, -3, -2,-20,-12, -8,  0,  1,  5,-26, -9,-12;
/M: SY='H';  M=-14,  5,-27,  6,  5,-12,-20, 15,-12, -6, -9, -1,  2,-17,  1, -7, -8,-10,-15,-22,  4,  2;
/M: SY='D';  M= -3, 11,-22, 14, 10,-25,-11,-10,-22,  3,-20,-16,  3,-11, -1, -5,  4,  1,-13,-31,-17,  5;
/M: SY='G';  M= -4,  0,-24,  1, -4,-25, 21, -6,-27,-11,-24,-16,  4,-16, -6,-12,  5, -7,-19,-28,-20, -5;
/M: SY='E';  M= -3, -3,-24, -2, 15,-23,-21, -8,-15, 12,-16, -9, -5,-10,  5,  3, -3, -4, -9,-25,-13, 10;
/M: SY='V';  M= -1,-16,-16,-20,-17, -8,-24,-18,  9,-11, -1,  1,-13,-19,-15,-13,  0, 10, 18,-28, -9,-17;
/M: SY='F';  M= -9,-23,-18,-28,-23, 23,-27,-19, 13,-25, 22,  8,-18,-28,-25,-19,-18, -7, 11,-16,  4,-23;
/M: SY='F';  M=-11,-22,-19,-27,-23, 29,-28,-12,  6,-19,  3,  1,-18,-26,-23,-16, -9,  2, 10, -3, 24,-23;
/M: SY='V';  M=  1,-14,-21,-15, -7,-17,-22,-17, -2,  2, -8, -1,-14, -9, -3, -4, -6, -3,  4,-24,-12, -6;
/I:         E1=0; IE=-105; DE=-105;

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Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_03 which contains 573'661 sequence entries.

Total number of hits	59 in 59 different sequences
Number of true positive hits	59 in 59 different sequences
Number of 'unknown' hits	0
Number of false positive hits	0
Number of false negative sequences	0
Number of 'partial' sequences	0

Precision (true positives / (true positives + false positives))	100.00 %
Recall (true positives / (true positives + false negatives))	100.00 %

Comments [info]

Taxonomic range [info]	Eukaryotic viruses
Maximum number of repetitions [info]	1
Matrix type [info]	protein_domain
Scaling database [info]	reversed
Author [info]	CJA_Sigrist
Feature key [info]	DOMAIN
Feature description [info]	Ubiquitin-like
Version [info]	1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences

59 sequences

R1AB_BC133  (P0C6W1), R1AB_BC279  (P0C6V9), R1AB_BC512  (P0C6W0),

R1AB_BCHK3  (P0C6W2), R1AB_BCHK4  (P0C6W3), R1AB_BCHK5  (P0C6W4), 
R1AB_BCHK9  (P0C6W5), R1AB_BCRP3  (P0C6W6), R1AB_CVBEN  (P0C6W7), 
R1AB_CVBLU  (P0C6W8), R1AB_CVBM   (P0C6W9), R1AB_CVBQ   (P0C6X0), 
R1AB_CVH22  (P0C6X1), R1AB_CVHN1  (P0C6X2), R1AB_CVHN2  (P0C6X3), 
R1AB_CVHN5  (P0C6X4), R1AB_CVHNL  (P0C6X5), R1AB_CVHOC  (P0C6X6), 
R1AB_CVM2   (P0C6X8), R1AB_CVMA5  (P0C6X9), R1AB_CVMJH  (P0C6Y0), 
R1AB_CVPPU  (P0C6Y5), R1AB_FIPV   (Q98VG9), R1AB_IBVB   (P0C6Y1), 
R1AB_IBVBC  (P0C6Y2), R1AB_IBVM   (P0C6Y3), R1AB_MERS1  (K9N7C7), 
R1AB_PEDV7  (P0C6Y4), R1AB_SARS   (P0C6X7), R1AB_SARS2  (P0DTD1), 
R1A_BC133   (P0C6F7), R1A_BC279   (P0C6F5), R1A_BC512   (P0C6F6), 
R1A_BCHK3   (P0C6F8), R1A_BCHK4   (P0C6T4), R1A_BCHK5   (P0C6T5), 
R1A_BCHK9   (P0C6T6), R1A_BCRP3   (P0C6T7), R1A_CVBEN   (P0C6T8), 
R1A_CVBLU   (P0C6T9), R1A_CVBM(P0C6U0), R1A_CVBQ(P0C6U1), 
R1A_CVH22   (P0C6U2), R1A_CVHN1   (P0C6U3), R1A_CVHN2   (P0C6U4), 
R1A_CVHN5   (P0C6U5), R1A_CVHNL   (P0C6U6), R1A_CVHOC   (P0C6U7), 
R1A_CVM2(P0C6U9), R1A_CVMA5   (P0C6V0), R1A_CVMJH   (P0C6V1), 
R1A_CVPPU   (P0C6V2), R1A_IBVB(P0C6V3), R1A_IBVBC   (P0C6V4), 
R1A_IBVM(P0C6V5), R1A_MERS1   (K9N638), R1A_PEDV7   (P0C6V6), 
R1A_SARS(P0C6U8), R1A_SARS2   (P0DTC1)

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Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
[Clustal format, color, condensed view] [Clustal format, color]
[Clustal format, plain text] [Fasta format]
Retrieve the sequence logo from the alignment

PDB
[Detailed view]

106 PDB

pdb_00002fe8; pdb_00003e9s; pdb_00003mj5; pdb_00004m0w; pdb_00004mm3; pdb_00004ovz; pdb_00004ow0; pdb_00004r3d; pdb_00004wur; pdb_00004x2z; pdb_00004ypt; pdb_00005bz0; pdb_00005e6j; pdb_00005wfi; pdb_00005y3e; pdb_00005y3q; pdb_00006w9c; pdb_00006wrh; pdb_00006wuu; pdb_00006wx4; pdb_00006wzu; pdb_00006xa9; pdb_00006xaa; pdb_00006xg3; pdb_00006yva; pdb_00007cjd; pdb_00007cjm; pdb_00007cmd; pdb_00007d47; pdb_00007d6h; pdb_00007d7k; pdb_00007d7l; pdb_00007e35; pdb_00007jir; pdb_00007jit; pdb_00007jiv; pdb_00007jiw; pdb_00007jn2; pdb_00007jrn; pdb_00007koj; pdb_00007kok; pdb_00007kol; pdb_00007krx; pdb_00007lbr; pdb_00007lbs; pdb_00007lfu; pdb_00007lfv; pdb_00007llf; pdb_00007llz; pdb_00007los; pdb_00007m1y; pdb_00007nfv; pdb_00007nt4; pdb_00007ofs; pdb_00007oft; pdb_00007ofu; pdb_00007qcg; pdb_00007qch; pdb_00007qci; pdb_00007qcj; pdb_00007qck; pdb_00007qcm; pdb_00007rbr; pdb_00007rbs; pdb_00007rzc; pdb_00007sdr; pdb_00007sgu; pdb_00007sgv; pdb_00007sgw; pdb_00007sqe; pdb_00007thh; pdb_00007tzj; pdb_00007uv5; pdb_00007ybg; pdb_00008cx9; pdb_00008eua; pdb_00008fwn; pdb_00008fwo; pdb_00008g62; pdb_00008iho; pdb_00008jux; pdb_00008uob; pdb_00008uuf; pdb_00008uug; pdb_00008uuh; pdb_00008uuu; pdb_00008uuv; pdb_00008uuw; pdb_00008uuy; pdb_00008uvm; pdb_00008vec; pdb_00008yx2; pdb_00008yx3; pdb_00008yx4; pdb_00008yx5; pdb_00008z4w; pdb_00009brv; pdb_00009brw; pdb_00009brx; pdb_00009csy; pdb_00009dnu; pdb_00009dnv; pdb_00009do1; pdb_00009do3; pdb_00009do5; pdb_00009doi
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