Home  |  Contact
Due to scheduled maintenance work, this service will not be available from Tuesday August 23rd 06:00 pm until Wednesday August 24th 08:00 am CEST. Apologies for the inconvenience.
Entry: PS51998

General information about the entry

Entry name [info] DEK_C
Accession [info] PS51998
Entry type [info] MATRIX
Date [info] 03-AUG-2022 CREATED;
03-AUG-2022 DATA UPDATE;
03-AUG-2022 INFO UPDATE.
PROSITE Doc. [info] PDOC51998
Associated ProRule [info] PRU01342

Name and characterization of the entry

Description [info] DEK C-terminal (DEK-C) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=56;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=51;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3463306; R2=0.0071021; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1360; N_SCORE=12.0; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=585; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-32; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='E';  M=  -1,-106,  20,  37, -32,   8, -30, -42, -18,  -9,  31,  -5,  36, -18, -22,  15, -24, -24,-110, -74;
/M: SY='P';  M= -11, -84,  -3,  15, -32, -49, -40,   1, -45, -24,  -6, -55,  87,  -8, -40, -14, -32,  17,-109, -53;
/M: SY='T';  M= -33, -99,  14,  -4, -15, -52, -68, -27, -37,  -8, -13, -11, -35, -18, -46,  59,  63, -47, -42, -45;
/M: SY='D';  M= -40, -51,  70,  51, -88, -71, -32, -51,  22, -40, -42,  -7,  -7,  12,  12, -18, -17, -28, -64, -98;
/M: SY='E';  M=  22,-105,  35,  62, -51, -43, -29, -71,  17, -60, -52,   1, -30,  21,   6,   8, -23, -45,-111, -98;
/M: SY='E';  M=  -6,-106,  25,  64, -78, -71, -43, -41,  18, -14, -24, -12, -63,  49,   9, -30,   0, -18,-110, -96;
/M: SY='I';  M= -69, -31, -65,-108, -22,-101, -84,  71,-106,  56,  15, -83, -87,-102,-106, -79, -90,  20, -98,  26;
/M: SY='R';  M=  -3, -48, -68,  31, -42,-101, -18, -10,  42, -22,  -5, -18, -59,   5,  55,  -5,   2,  -9, -51, -17;
/M: SY='E';  M=  21, -72,   8,  39, -66, -48, -33, -55,  33, -48, -30,  14,  13,  13,  11,  18,   4, -37, -45, -64;
/M: SY='A';  M=  38, -46, -13,  35, -36, -43,  10, -18,  23, -40, -37, -32, -60,   1,  13,  -1,  32, -24, -23, -53;
/M: SY='I';  M= -41, -51, -91,-108, -73, -99, -79,  77,-106,  38, -13,-107, -85,-103, -79, -76, -57,  57,-107, -88;
/M: SY='R';  M= -24, -34,  17,   8, -11, -54,  -1, -31,  38, -15, -21, -27, -50,  22,  67, -18, -23, -36, -59, -31;
/M: SY='E';  M=  13, -57,  41,  58, -74, -44, -11, -62,  20, -64, -44,   4, -67,  25,  10,  15, -23, -52, -34, -54;
/M: SY='I';  M= -60, -47,-113, -81, -14,-116,-106,  89,-105,  30,   1,-106,-107, -57, -59,-102, -65,  25, -54,   9;
/M: SY='L';  M= -62, -62,-114,-106, -27,-114,-100,  31, -81,  77,  61,-109, -60,-100,-104,-104, -77,  14,-102, -83;
/M: SY='R';  M=  24,-104,  -2,  15, -69, -38,  -6, -82,  41, -46,  19, -16, -35,  31,  47,  11,  -9, -48, -47, -63;
/M: SY='E';  M=  -7, -47,  17,  41,-105,  10,  25, -69,   7, -85, -75,  27, -95,  13, -13,  26,  38, -24,-112, -45;
/M: SY='A';  M=  57,  -1, -43,  -4, -16, -35, -23, -59, -33, -49,  -6, -29, -46,   0, -70,  46, -42,  32,-108, -52;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='D';  M= -59,-107, 109, -15,-115, -12, -83,-113, -70,-113,-109,  54, -58, -59, -70, -38, -39, -97,-127,-101;
/M: SY='L';  M= -53,-100, -97, -66,   6, -85, -69,  -3, -92,  83,  42,-109, -52, -57, -70, -67, -69, -21, -30, -46;
/M: SY='E';  M= -14, -73,  54,  65,-107, -71, -25,-104, -17,-102,  31,  32, -74,  20, -47,  28,   4, -84,-113, -51;
/M: SY='T';  M= -36, -99,  -2,  39, -79, -78, -26, -66,  24, -50, -43,  20, -93,  20, -35,  24,  69,  -3,-113, -96;
/M: SY='V';  M=  -8, -48, -79, -64, -39,-109, -75,  42,-102,  38,  48,-102,-105,-100,-103, -82,  30,  59,-108, -88;
/M: SY='T';  M= -79, -92, -87, -71,-100, -63, -94, -93, -52, -97, -49, -43, -91, -87, -93,  65, 104, -70,-116, -96;
/M: SY='M';  M=  14,  -7, -77,  28, -17, -80, -93, -19,  36,  -2,  46, -62,   1, -49,  -2,  25,   2,   7,-106, -77;
/M: SY='K';  M= -72,-106, -66, -67, -35, -26, -47, -90,  91, -88, -70,  -8, -97, -30,  58, -10, -20, -77,-103, -33;
/M: SY='Q';  M= -19,-105,  21,  -1, -83, -36, -11, -19,  51, -58,  24, -11, -96,  72,  -8,   9,   7, -40,-107, -52;
/M: SY='V';  M= -28, -48,-113,-108, -29,-114,-110,  68,-106,  17,  12,-107,-107,-104,-107, -87, -66,  75,-108, -87;
/M: SY='R';  M= -96,  18, -95, -84, -65,-107, -40, -13,  -7, -39, -10, -88,-105, -17, 109, -69, -53, -39,-105, -30;
/M: SY='K';  M=  -7, -80, -12,  38,-105, -55, -10, -74,  54, -35,  -3,   7, -96,  52,  40, -25,   1, -50,-107, -79;
/M: SY='Q';  M=  23, -64, -21,  32,-101, -33,  21, -48,  32,  -3,  22, -43, -97,  68,  10, -17, -32, -67,-106, -48;
/M: SY='L';  M=  -6, -41,-113,-106, -75, -86,-101,   8,-106,  80,  -3,-110,-111,-101,-105,-101, -90,  34,-104, -64;
/M: SY='E';  M=  16, -41, -48,  85, -39, -28, -55, -65, -12, -69, -34, -62, -66,  33, -62,  28, -33, -64,-106, -14;
/M: SY='E';  M=  22, -57,  36,  59, -84, -62, -39, -82,  32, -59, -96,  -6, -71,  42, -11,   6,  -3, -50,-110, -86;
/M: SY='K';  M= -19, -81,  -2,  33, -40, -83,  45, -41,  53, -20, -13, -35, -78,  17,  47, -34, -26, -28, -25,  -5;
/M: SY='F';  M= -60, -53, -66, -92,  87, -88, -33, -30,-103,  46,  35, -94, -57, -48, -87,-101, -41, -18, -81,  54;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='G';  M= -24, -48,  40,   2, -88,  56, -24,-107,  19, -71, -43,  46, -30,  13, -21,  -3, -22, -57,-111, -71;
/M: SY='V';  M=  -9,  31, -28,  -3,   4, -23, -11,   7, -33,  16,  38, -49, -44, -10, -24, -53,   4,  42,-103,  15;
/M: SY='D';  M= -30,-105,  94,   8, -26, -54, -86, -78, -28, -62,-103,  22,  -8, -49, -65,  41, -59, -53, -44, -52;
/M: SY='L';  M= -57,-100, -72, -26,  17, -57, -56,   7,-102,  75,  41, -44,-109, -30, -80, -60, -59,   2,-100, -44;
/M: SY='S';  M=  -7, -59,  25,   3, -87, -18, -11, -68,  42, -48, -28,  -5, -16, -19,  -5,  50,  36, -54,-111, -60;
/M: SY='P';  M=  -2, -57,  39,  45,-107, -22,  29, -75, -17, -81, -66,   6,  46,   8, -64,  40, -14, -47, -60, -37;
/M: SY='H';  M= -96, -33, -91, -30,   6, -77,  71, -55,  43, -71, -48, -48, -74,  27,  69, -44, -82, -54,   6,  58;
/M: SY='K';  M= -67,-107, -60, -59,-106, -79, -65, -79, 104, -76, -59, -53, -71, -60,  38, -74, -28, -53, -43, -68;
/M: SY='K';  M=  25, -63,  36,  24, -82, -16, -20, -63,  48, -44, -95,  -2, -11,  20, -10,  14,  -7, -73,-109, -56;
/M: SY='F';  M=   2, -84, -30,  39,  72, -93, -39, -30, -30,   3,  -1, -71, -58,   8, -47, -42, -18, -14,  32,  34;
/M: SY='I';  M= -93,-104,-114, -95, -22,-118,-112,  95, -93,   7, -10, -79,-106,-105,-110, -61, -63,  43,-105, -86;
/M: SY='K';  M= -75,-106,  61, -32,-110, -43, -43, -81,  62,-109,-100,  58, -98, -21,  38,   0, -30, -75,-114, -83;
/M: SY='E';  M=  18, -84,  30,  54, -79, -15,  -4, -81,  11, -70, -51,  -1, -95,  40,  11,   9,   7, -71,-111, -57;
/M: SY='L';  M=   2,  25, -60,  21,  -9, -70, -20,  25, -29,  27,  20, -77, -83,  24, -54, -58,  21,  15,   4, -22;
/M: SY='I';  M= -49,-103, -88, -96, -73, -99,-109,  80, -80,  11,  40, -83,-106, -82, -76, -70, -22,  56, -62, -66;
/M: SY='M';  M= -35,-105,  49,  33, -48, -36, -22, -17,  17,  -6,  50, -12, -79,  29,  -2, -16,   9, -36,-110, -45;
/M: SY='E';  M=   7,-105,  29,  59, -72, -69,  -9, -48,  22, -43, -35,   1, -64,   5,   6,  22,  -9, -28,-110, -34;
/M: SY='I';  M=  10,  19, -78,   2,  40, -91, -16,  42, -49,  -2, -39, -60,-105, -67,   4, -56, -15,  30, -21,  30;
/M: SY='L';  M= -66, -49,-113, -74,  32,-114, -71,  35, -94,  63,  51, -66,-110, -68, -74, -71, -56,  19, -98,   2;
/M: SY='Q';  M=  10,-105,  31,  34, -49,   2, -14, -55, -10, -29, -41,  29, -98,  35, -12,   7,  10, -31,-112, -50;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2022_03 which contains 568'002 sequence entries.


Total number of hits 26 in 26 different sequences
Number of true positive hits 26 in 26 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Feature key [info] DOMAIN
Feature description [info] DEK-C
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
26 sequences

CHS4_CRYNH  (J9VF17    ), CHS5_CRYNH  (J9VNT4    ), CHS6_USTMA  (O13395    ), 
CHS8_USTMA  (Q4P9K9    ), DEKP1_ARATH (Q9SMM8    ), DEKP2_ARATH (Q84JB7    ), 
DEKP3_ARATH (Q9SUA1    ), DEKP4_ARATH (F4K4Y5    ), DEK_HUMAN   (P35659    ), 
DEK_MOUSE   (Q7TNV0    ), DEK_RAT     (Q6AXS3    ), HMGL_TRYBR  (P26586    ), 
KELP_ARATH  (O65155    ), MDA3_ARATH  (Q9FHX8    ), SSH1_HUMAN  (Q8WYL5    ), 
SSH1_MOUSE  (Q76I79    ), SSH2_HUMAN  (Q76I76    ), SSH2_MOUSE  (Q5SW75    ), 
SSH3_HUMAN  (Q8TE77    ), SSH3_MOUSE  (Q8K330    ), SSH3_RAT    (Q5XIS1    ), 
SSH_DROME   (Q6NN85    ), SSH_XENLA   (Q6IVY4    ), TRI1_YEAST  (Q05024    ), 
UAF30_SCHPO (O74503    ), UAF30_YEAST (Q08747    )
» more

PDB
[Detailed view]
1 PDB

1Q1V

View entry in original PROSITE format
View entry in raw text format (no links)
Direct ScanProsite submission