PROSITE entry PS52081
View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS52081
Direct ScanProsite submission
General information about the entry
| Entry name [info] | CPH |
| Accession [info] | PS52081 |
| Entry type [info] | MATRIX |
| Date [info] |
10-JUN-2026 CREATED;
10-JUN-2026 DATA UPDATE; 10-JUN-2026 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52081 |
| Associated ProRule [info] | PRU01426 |
Name and characterization of the entry
| Description [info] | CPH (CUL7, PARC, and HERC2) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=78; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=73; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7969024; R2=0.0090898; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=848; N_SCORE=10.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=408; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-29; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='Y'; M= -72, -80, -79, -77, 75, -80, -55, -58, -72, -27, 20, -73, -85, -2, -70, 11, -66, -62, -44, 93; /M: SY='R'; M= -26, -83, -15, -57, -74, 6, 3, -71, 35, 17, -61, -62, 20, 29, 57, -64, -67, -72, -80, -68; /M: SY='W'; M= -20, -82, -70, -62, -65, -74, 29, -12, 17, -71, -66, -63, 1, 21, 21, -4, 43, -69, 101, 12; /M: SY='R'; M= -67, -85, -69, -59, -72, -74, -64, -27, 27, -28, -67, -64, 54, -54, 68, 24, -63, -73, 49, -4; /M: SY='S'; M= 18, -72, 11, -61, -78, 3, -65, -78, -8, -80, -74, 36, -71, -58, -65, 63, 16, -72, 49, -70; /M: SY='D'; M= -66, 63, 80, 0, -86, 7, -64, -82, -9, -82, -78, -51, 1, -5, -4, -24, -63, -26, -95, -76; /M: SY='F'; M= -21, -76, -9, -81, 103, 6, -72, -55, -79, -50, 12, -74, -85, -85, -79, -72, -69, -12, -54, -33; /M: SY='A'; M= 47, 24, -11, -60, -73, -66, 34, -71, 18, -12, -63, -60, -11, -4, -3, 3, 17, -65, -82, -9; /M: SY='S'; M= -14, -74, 26, -57, -77, -64, -64, -21, 14, -27, -68, 17, 2, -56, 5, 60, 18, -67, -87, -71; /M: SY='C'; M= 23, 53, 0, 44, -16, -9, 3, -26, -54, -75, -70, 25, -11, -56, 35, -59, -63, -71, -85, -71; /M: SY='E'; M= 14, -80, 44, 57, -78, -14, -62, -83, -9, -80, -75, -18, -68, -52, -19, 26, -60, -77, 49, -4; /M: SY='E'; M= -23, -82, 44, 65, -87, 0, -60, -85, -52, -83, -76, 2, 3, 21, -5, 9, -26, -80, -87, -76; /M: SY='Y'; M= -72, -85, -72, -10, -31, -20, -47, -12, -66, -59, -56, -74, -84, -64, -4, -69, -69, -15, -40, 117; /M: SY='A'; M= 52, -71, -73, -69, 19, 3, -74, -58, -70, -66, -64, -65, 4, -67, -74, 42, -55, 31, -79, -66; /M: SY='Q'; M= -30, -79, -56, 43, -75, -73, -61, -18, -6, -13, 1, 43, 2, 43, 6, -16, -60, 10, -84, -70; /M: SY='Y'; M= -71, -84, -74, -10, -2, -20, -50, -60, -70, -21, -56, -75, -84, -66, -69, -24, -68, -14, 49, 113; /M: SY='V'; M= -17, -72, -85, -77, -57, -85, -80, -7, -12, 27, 41, -80, -82, -75, -74, -71, -59, 75, -85, -64; /M: SY='S'; M= -17, 10, -66, -58, -1, -68, -61, -72, 17, -73, -67, -58, -74, 41, 50, 55, -56, -16, -76, 7; /M: SY='D'; M= 28, -77, 67, 21, -78, 1, -61, -78, -61, -28, -73, 22, -71, -58, -68, 17, -59, -73, -86, 0; /M: SY='N'; M= -24, 45, -57, 15, -75, -15, 55, -19, -58, -70, -64, 65, -76, -5, 7, -58, -16, 21, -93, -68; /M: SY='I'; M= -19, 11, -5, -14, -59, 5, -78, 68, -77, 26, 11, -73, -79, -73, -80, -71, -64, -11, -81, -65; /M: SY='K'; M= -22, 15, -10, -58, -77, -72, -67, -62, 40, -71, -65, 14, 27, 7, 20, 4, 15, 28, -86, -72; /M: SY='P'; M= -16, 22, -73, -63, -72, -73, -70, -17, -62, -61, 51, -71, 87, 6, 9, -17, -58, 34, -82, -71; /M: SY='G'; M= -15, -77, -64, -9, -80, 89, -71, -82, -12, -22, -71, -54, -69, -65, -72, -52, -5, -77, -77, -76; /M: SY='M'; M= -61, -72, -76, -68, -56, -74, 24, -45, -10, -12, 122, -65, -72, -57, -3, 5, 2, -19, -76, -4; /M: SY='R'; M= -23, 23, -2, -60, -64, -75, 21, 3, -54, 24, -2, -60, -74, 37, 45, -20, 38, -57, 34, -60; /M: SY='V'; M= -14, -68, -77, -71, -58, -19, -77, -28, -10, -13, 22, -71, 0, -69, -70, -4, -52, 86, -84, -63; /M: SY='R'; M= -19, 23, -65, -54, -74, -16, -57, -74, 22, -35, 21, -58, 28, -3, 93, -60, -63, -71, -76, -65; /M: SY='C'; M= -2, 125, -78, -75, -62, -15, -73, -62, -72, 14, 46, -67, -82, -72, -76, 8, -59, -59, 49, -67; /M: SY='C'; M= -63, 107, -79, -72, 1, -80, -70, -15, -67, 46, 22, -72, -83, 13, 8, -68, -61, 10, -79, -60; /M: SY='E'; M= -17, -74, 0, 44, -2, -67, -57, -69, 34, -25, -63, 12, -66, 18, 38, 31, -13, -22, -77, -62; /M: SY='D'; M= 33, -72, 57, -10, -79, 10, -58, -71, -53, -74, -67, 32, 3, 27, 2, 1, 9, -18, -84, -70; /M: SY='Y'; M= -18, 79, -72, -69, 52, -74, -57, -60, -65, -28, -56, -67, 28, -12, -13, -23, 18, -61, -52, 83; /M: SY='E'; M= -57, -78, 4, 83, -80, 33, -58, -77, -46, -75, -70, -53, -61, -3, 20, -8, 2, -18, -80, -71; /M: SY='C'; M= -22, 53, 51, 45, -72, -29, 30, -66, -54, -6, 5, 20, 1, 11, -6, -56, -14, -15, -86, -66; /M: SY='V'; M= -56, -70, -74, -70, 2, -77, -70, 28, -65, -2, -45, 1, -77, 4, -5, 12, -53, 73, -75, 12; /M: SY='S'; M= 17, 32, 5, -11, -10, -63, -59, 10, -49, -65, 1, -3, -69, 41, 47, 49, -52, -60, -78, -62; /M: SY='W'; M= 45, -72, -62, 11, -66, 9, -66, -16, 2, -6, -59, 28, -15, -56, -7, -8, -57, -1, 77, -62; /M: SY='G'; M= -55, 53, -5, -64, -79, 79, -66, -81, -60, -27, -68, -54, 27, 29, 15, -54, -65, -77, -77, -74; /M: SY='D'; M= -60, 16, 87, 12, -74, -20, -56, -78, 14, -41, -72, -44, 5, -52, -58, 35, -54, -75, -82, 16; /M: SY='V'; M= -57, 25, -62, 44, -61, -78, -69, 47, -21, -20, 23, -65, -69, 9, -65, -11, 7, 50, -81, -63; /M: SY='G'; M= -54, -77, 24, -65, -73, 86, -66, -80, -9, -26, -69, -51, 1, -64, -70, -52, -6, -77, -73, 7; /M: SY='E'; M= -60, 25, -56, 53, -2, -24, -63, -16, 14, -21, -58, -61, 32, 1, 26, -58, 13, 22, -77, -64; /I: I=-29; MD=-75; /M: SY='V'; M= -23, -97, -11, -93, -92, -26,-101, -65, -91, -81, -81, -92,-103, -93, -10, -17, -81, 50,-114, -94; D=-29; /I: I=-29; MI=0; MD=-75; IM=0; DM=-75; /M: SY='W'; M= -19, -75, 11, 16, 46, -74, 14, 9, -15, -24, 22, -9, 2, -60, -5, -61, 5, 12, 49, 24; /M: SY='Y'; M= -23, -76, -67, -59, -55, -75, 10, 30, 43, 1, 19, -10, 0, 1, 38, -62, -59, 7, -67, 44; /M: SY='V'; M= -59, 10, -60, 31, -59, -75, 20, 23, 11, 12, -50, -5, -70, 30, -24, -10, -3, 35, -76, 3; /M: SY='D'; M= -57, -74, 46, 20, -70, 0, 35, -24, -14, -1, -59, -52, 10, 8, -61, 38, -3, 12, -84, -64; /M: SY='N'; M= -15, -71, -54, 11, -14, -20, -57, -17, -4, -67, -62, 54, -5, -52, 37, 36, 11, 9, -77, -2; /M: SY='D'; M= -16, -75, 59, 40, -73, 3, -56, -73, 11, -74, -69, 20, -66, -49, 16, 13, 3, -17, -79, 10; /M: SY='G'; M= -52, -74, 10, -16, -70, 74, -63, -74, -60, -1, -65, -51, -69, -58, 10, 38, -59, -72, -73, 6; /M: SY='Y'; M= -6, -71, -74, -71, 5, -75, 21, 24, -69, 28, 21, -69, 3, -66, -70, 3, 3, 37, -66, 47; /M: SY='H'; M= -65, -83, -62, -54, -67, -19, 88, -71, 23, -8, -58, -58, 85, 28, -56, -61, -62, -74, -74, 27; /M: SY='P'; M= -62, 32, 42, -54, -69, 7, -61, -68, -7, 3, -62, -7, 73, -1, -5, -19, 10, -69, -77, 10; /I: I=-29; MI=0; MD=-75; IM=0; DM=-75; /M: SY='V'; M= -31, -70, -76, -72, -56, -17, 19, 33, -71, -1, 22, -69, 9, -70, -73, -9, -3, 72, -82, -60; /M: SY='Q'; M= -62, -81, -16, 16, -15, -18, 14, -13, 24, -33, -58, -53, -68, 95, 44, -55, -62, -70, -73, -59; /M: SY='V'; M= -54, 30, -83, -76, -54, -83, -85, 16, -29, -42, -44, -77, -79, -76, -74, -67, -53, 94, 45, -60; /M: SY='Y'; M= -18, -74, 40, 6, 36, -71, -54, -59, -20, 21, -54, 17, -74, 6, 12, -15, -20, -61, -61, 60; /M: SY='W'; M= -26, -94, -95, -78, -2, -32, 11, -70, -71, -25, -68, -88, -78, -70, -74, -77, -82, -81, 170, -30; /M: SY='Q'; M= -21, -78, 17, 10, -81, -29, -52, -75, 53, -73, 12, 29, -66, 87, -5, -17, -57, -74, -77, -65; /I: I=-45; MD=-115; /M: SY='S'; M= 16, -71, -62, -59, -73, -21, 29, -12, -17, -69, -63, -3, -69, 13, 29, 65, -9, 1, -83, -65; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='T'; M= -3, -70, -65, -23, -59, -73, 40, 20, 21, 18, 8, -58, -68, -3, -15, -53, 60, 2, -77, -5; /M: SY='G'; M= -51, -75, -60, -16, -77, 78, -65, -15, -19, -32, -67, -10, 1, 22, -66, 34, -58, -71, -76, -72; /I: I=-45; MD=-115; /M: SY='R'; M= 11, 22, -68, -62, -71, -11, 5, 3, -17, -35, -63, -60, -5, -54, 73, 28, -60, -65, -78, -9; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='T'; M= -58, 17, -64, -63, -3, -72, 41, -7, -60, -60, 3, -55, 18, 0, -12, -12, 84, 4, -84, -60; /I: I=-45; MD=-115; /M: SY='Y'; M= -27, -80, -74, -73, 3, -78, -48, -57, -64, -5, 39, -71, -82, -63, 10, -27, -6, -60, -43, 110; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='W'; M= -73, -96, -93, -75, -2, -25, -92, -74, -18, -71, -72, -85, -78, 6, -71, -76, -18, -84, 168, -32; /M: SY='V'; M= -17, -70, -82, -75, -4, -81, -75, -3, -12, -42, 61, -76, -78, -71, -70, -67, -56, 81, 40, 8; /M: SY='H'; M= -65, 14, -57, 12, -72, -23, 91, -81, 3, -74, -63, -8, 18, 29, 55, -15, -63, -79, -80, 13; /M: SY='W'; M= -3, 16, -83, -13, 54, -75, -73, -64, -18, -21, -62, -80, -80, -69, -70, -72, -73, -69, 141, 49; /M: SY='H'; M= -31, -78, -64, -63, -1, 0, 111, 31, -64, -26, -52, -8, -5, 5, -63, -21, -63, -2, -85, -49; /M: SY='M'; M= -28, -75, -8, 4, -65, -71, 84, -55, -57, -52, 99, 31, -4, -2, -4, -61, -60, -1, -85, -55; /M: SY='I'; M= -24, 23, -82, -78, -51, -26, 12, 51, -77, 49, -39, -76, -80, -73, -77, -70, -60, 45, -79, -59; /M: SY='E'; M= -26, -80, -39, 95, -83, -23, -56, -78, -46, -75, -70, -57, -60, 44, -54, -10, -11, -31, -81, -72; /M: SY='I'; M= -63, 17, -83, -79, -8, -83, -75, 69, -76, 42, 43, -75, -78, -71, -77, 10, -58, 6, -75, -56; /M: SY='I'; M= -11, -72, -82, -78, -49, -22, -74, 59, -76, 47, 11, -75, -78, -72, -77, -68, -5, 27, -73, 4; /M: SY='G'; M= -52, -77, -9, 3, -82, 85, -69, -81, -66, -82, -74, -53, 13, -63, -74, 18, -62, -19, -78, -77; /M: SY='F'; M= -3, -76, -17, -21, 66, -2, -66, -61, -68, -5, -59, -66, 66, -68, -72, 7, -11, -63, -62, 21; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 9 in 9 different sequences |
| Number of true positive hits | 9 in 9 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | CPH |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
9 sequences
CUL7_HUMAN (Q14999), CUL7_MOUSE (Q8VE73), CUL7_PONAB (Q5RCJ3), CUL7_RAT(D3ZEF4), CUL9_HUMAN (Q8IWT3), CUL9_MOUSE (Q80TT8), HERC2_DROME (Q9VR91), HERC2_HUMAN (O95714), HERC2_MOUSE (Q4U2R1)» more
|
| PDB [Detailed view] |
8 PDB
pdb_00002jng; pdb_00002juf; pdb_00007z8b; pdb_00008q7e; pdb_00008q7h; pdb_00008rhz; pdb_00009l8y; pdb_00009l93 |