PROSITE entry PS52088
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PURL: https://purl.expasy.org/prosite/signature/PS52088
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General information about the entry
| Entry name [info] | UPF1_HELICASE |
| Accession [info] | PS52088 |
| Entry type [info] | MATRIX |
| Date [info] |
10-JUN-2026 CREATED;
10-JUN-2026 DATA UPDATE; 10-JUN-2026 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52088 |
| Associated ProRule [info] | PRU01433 |
Name and characterization of the entry
| Description [info] | UPF1-type helicase core domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=457; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=452; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.1192443; R2=0.0085999; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1149; N_SCORE=12.0; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=510; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-33; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='Q'; M= -7, 30, 3, -4, -74, -12, 17, -25, 27, -73, -66, 20, -71, 37, 9, -4, 25, -35, -81, -4; /M: SY='L'; M= -68, -74, -83, -78, 18, -29, -67, -41, -78, 71, 12, -81, 0, -73, -76, -32, -65, -12, -66, 31; /M: SY='N'; M= -66, -72, 46, -54, -81, -56, -48, -80, -52, -86, -75, 112, -74, -54, -61, -49, -6, -81,-100, -75; /M: SY='E'; M= 0, -78, 38, 41, -77, -71, 34, -17, 23, -38, -66, -16, 4, -52, 6, -1, 0, -17, -86, -68; /M: SY='S'; M= -57, -74, 28, -4, -7, -64, -61, -29, 26, -75, -70, 8, 17, -54, -58, 63, 18, -69, -79, 4; /M: SY='Q'; M= -63, -88, -2, -37, -93, -70, -51, -79, -43, -74, -61, -52, -70, 126, -44, -52, -65, -81, -76, -64; /M: SY='K'; M= 5, 19, -65, -15, -68, -73, -64, 12, 59, 12, 4, 15, -73, 5, 18, -62, -61, -30, -79, -66; /M: SY='E'; M= -64, 1, -54, 62, -64, -78, -59, -12, 19, 6, -59, -22, -69, 27, -17, -60, 24, -33, -73, 33; /M: SY='A'; M= 87, -65, -67, -63, -74, -53, -68, -69, -64, -71, -65, 1, -70, -61, -69, 13, -54, -58, -76, 3; /M: SY='I'; M= -63, -74, -87, -82, -8, -88, -79, 63, -78, 8, 50, -80, -80, -76, -79, -74, -59, 61, -76, -2; /M: SY='K'; M= -26, 10, -1, 12, -17, -76, -62, -24, 41, 24, -12, -13, -74, 37, 19, -63, -28, -30, -76, -12; /M: SY='M'; M= 6, -12, -64, -27, 30, -70, 26, -63, 27, -6, 33, 24, -74, 22, 16, -5, 0, -36, -76, -57; /M: SY='I'; M= 41, 2, -75, -71, -66, 17, -76, 41, -13, -22, 8, -66, -73, -67, -72, 5, -15, 23, -80, -68; /I: I=-17; MI=0; MD=-42; IM=0; DM=-42; /M: SY='L'; M= -66, -74, -84, -79, -8, -29, -2, 0, -78, 62, 37, -78, -83, -72, -77, 7, -63, 16, -78, -58; D=-17; /I: I=-17; DM=-42; /M: SY='Q'; M= 0, -77, 22, -8, -79, -33, -61, -72, 2, -22, -67, 31, -72, 52, 3, 16, 25, -35, -86, -71; D=-17; /I: I=-17; MI=0; MD=-42; IM=0; DM=-42; /M: SY='C'; M= 7, 25, -79, -13, -10, 7, -83, -29, -32, -86, -82, -5, -88, -13, -36, 8, -3, -39, -96, -83; D=-17; /I: I=-17; DM=-42; /M: SY='K'; M= -67, -82, 11, 22, -20, -71, -57, -80, 52, -79, -70, 41, 43, -1, 42, -60, -61, -79, -78, -4; /M: SY='P'; M= -35, -82, 36, 23, -82, 42, 0, -82, -56, -39, -73, -11, 51, -56, 26, 7, -62, -79, -84, -74; /M: SY='L'; M= -17, -75, -11, -76, 46, -83, -68, 20, -77, 53, -42, -78, -13, -74, -76, -73, -65, 1, -63, 41; /M: SY='T'; M= 20, -71, -66, -63, -71, -66, -70, -15, -11, -68, -63, -59, 52, -63, -67, 34, 64, -5, -82, -11; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='I'; M= -67, -75, -88, -82, -49, -89, -76, 65, -80, 56, 52, -82, -81, -74, -79, -77, -63, 9, -77, -58; /M: SY='I'; M= -66, -78, -87, -85, -53, -26, -85, 92, -80, 1, 23, -78, -78, -77, -83, -75, -61, 20, -78, -60; /M: SY='H'; M= -66, -79, -62, -10, 34, -74, 78, -21, -58, -7, -55, 12, -75, 76, -58, -14, -63, -3, -74, 3; /M: SY='G'; M= -52, -79, -67, -78, -86, 98, -73, -93, -72, -89, -78, -53, -71, -69, -79, -11, -69, -86, -77, -80; /M: SY='P'; M= -67, -90, -72, -61, -82, -18, -71, -68, -67, -74, 50, -75, 116, -69, -77, -67, -62, -33, -82, -80; /M: SY='P'; M= -69, -89, -71, -62, 27, -73, -71, -72, -67, -77, -69, -74, 115, -71, -77, -65, 3, -76, -73, -5; /M: SY='G'; M= -53, -80, -67, -77, -86, 97, -73, -93, -68, -88, -78, -54, -72, -68, 1, -53, -71, -87, -77, -80; /M: SY='T'; M= -27, 56, -63, -65, -71, -71, -72, -64, -62, -67, -64, -52, -65, -66, -70, -14, 104, -55, -92, -70; /M: SY='G'; M= -52, -80, -67, -79, -86, 100, -74, -94, -73, -89, -78, -53, -71, -70, -80, -52, -71, -87, -77, -81; /M: SY='K'; M= -66, -80, -58, -44, -82, -73, -61, -82, 107, -81, -69, -51, -66, -43, -27, -60, -60, -78, -75, -68; /M: SY='T'; M= -53, -66, -60, -62, -72, -66, 31, -66, -60, -70, -65, -49, -64, -60, -67, 47, 97, -58, -91, -66; /M: SY='H'; M= -64, -76, -7, -12, 25, -76, 60, -27, 15, -57, 47, -60, -73, -18, -20, -8, 25, 21, -71, 36; /M: SY='T'; M= -57, -66, -67, -68, -64, -76, -74, -15, -65, -2, -54, -58, -68, -69, -72, -47, 96, 33, -89, -66; /M: SY='I'; M= -21, -75, -83, -80, -54, 1, -79, 68, -78, 40, 2, -75, -78, -74, -80, -32, -16, 13, -78, -61; /M: SY='C'; M= 21, 50, -78, -29, -60, -76, -78, 30, -74, 22, -48, -73, -78, -71, -76, 3, -19, 50, -84, -66; /M: SY='E'; M= -60, -78, -52, 56, -78, 16, 22, -14, 24, -71, 8, 0, -66, 39, -54, -9, 18, -31, -82, -68; /M: SY='I'; M= 39, -73, -82, -77, -56, -77, -78, 66, -76, 35, 3, -76, -77, -72, -78, -65, -19, 0, -78, -62; /M: SY='I'; M= -21, -75, -86, -82, -53, -86, -83, 77, -79, 26, -40, -79, -79, -76, -81, -22, -59, 43, -79, -61; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='Y'; M= -13, -75, -64, 15, -21, -41, -63, -22, 20, 17, -54, 1, -74, 12, 0, -3, -15, 24, -72, 29; /M: SY='Q'; M= -9, -79, -60, 9, -22, -72, 52, 11, -55, -20, -57, 23, -72, 75, -15, -25, -16, 5, 18, -59; /M: SY='L'; M= -32, -73, -84, -30, -15, -87, -74, 19, -79, 74, -35, -83, -84, -73, -78, -76, -64, 18, -75, -57; /M: SY='H'; M= -8, -75, -73, -68, -12, -78, 56, 2, -68, 25, -4, -68, -78, 32, -67, -28, -1, 29, -69, 51; /M: SY='H'; M= -13, -77, 7, 29, -25, -71, 32, -9, 31, -15, -62, 12, -70, -2, 18, 6, 14, -40, -82, -64; /M: SY='N'; M= -19, 5, -27, 15, -22, -69, 2, -74, 34, -30, -65, 44, -71, 30, 36, -8, 24, -71, -82, -66; /I: I=-5; MD=-13; /M: SY='N'; M= -71, -84, -71, -73, 10, -38, -72, -38, -16, -5, -72, 47, -10, 13, -74, 35, -2, -76, -90, -73; D=-5; /I: I=-5; MD=-13; /M: SY='P'; M= -43,-106, -85, -28, -96, -93, 28, -90, -18, -95, -85, -85, 64, 24, -29, -46, -83, -20, -99, -8; D=-5; /I: I=-5; MI=0; MD=-13; IM=0; DM=-13; /M: SY='K'; M= -70, -88, -65, 3, -92, 36, -72, -88, 44, -90, -81, 38, -16, -7, -27, -65, -19, -33, -91, -83; D=-5; /I: I=-5; DM=-13; /M: SY='W'; M= -34, -84, 5, -20, 18, -39, 0, -73, 22, 7, -66, 7, -24, 3, 4, -31, 5, -73, 27, -64; D=-5; /I: I=-5; DM=-13; /M: SY='R'; M= -67, -4, -64, -52, -81, -74, 1, -83, 57, -80, -69, -58, 45, -17, 79, -7, -63, -79, -80, -69; /M: SY='I'; M= -62, -75, -82, -78, -56, -87, -84, 78, -75, -22, -43, -74, -76, 0, -79, -67, 22, 53, -82, -62; /M: SY='L'; M= -69, -72, -88, -80, -44, -89, -72, -34, -81, 86, -32, -87, -87, -74, -78, -80, -65, 0, -75, -57; /M: SY='V'; M= -14, 31, -86, -81, -2, -85, -81, 47, -79, 26, -43, -80, -82, -78, -80, -71, -59, 63, -78, -13; /M: SY='C'; M= -11, 114, -78, -78, -63, -33, -77, -12, -75, -14, -59, -69, -82, -77, -79, -24, 24, 31, -86, 7; /M: SY='T'; M= 51, 53, -66, -65, -76, 2, -70, -71, -65, -73, -68, -56, -69, -62, -70, 49, 53, -61, -85, -73; /M: SY='P'; M= -17, -86, 19, -10, 6, -71, 55, -75, -62, -74, -67, -63, 87, 23, -67, -25, -63, -76, -71, 41; /M: SY='S'; M= -48, -67, -59, -60, -75, -58, -64, -72, -12, -76, -70, -48, -65, -54, -63, 89, 60, -65, -87, -69; /M: SY='N'; M= -66, -72, -41, -60, -77, -57, 62, -75, -53, -81, -69, 114, -76, -53, -60, -50, -52, -23,-100, -68; /M: SY='S'; M= 7, -73, -67, -63, 8, -36, 31, 26, -30, -20, -57, -58, -72, 30, -65, 58, -7, -24, -75, 6; /M: SY='A'; M= 83, -66, -68, -63, -79, -4, -70, -71, -65, -73, -67, -60, -69, -60, -69, 40, -52, -59, -80, -74; /M: SY='V'; M= 40, -69, -81, -74, -59, -74, -77, 1, -74, 21, 31, -75, -78, -71, -75, -14, -56, 64, -83, -64; /M: SY='D'; M= -69, -81, 107, -38, -87, -66, -55, -81, -57, -84, -82, 47, -71, -57, -66, -57, -58, -24,-105, -73; /I: I=-45; MD=-115; /M: SY='N'; M= -18, -76, -52, 30, -73, -69, 1, -20, -55, 3, -60, 71, -73, 45, -19, -55, 17, -19, -87, -69; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='I'; M= -67, -76, -87, -82, -9, -90, -76, 64, -80, 50, -38, -82, -83, -76, -80, -76, -62, 32, -71, 24; /M: SY='L'; M= -33, 43, -84, -80, 30, -85, -73, 22, -78, 56, 10, -79, -83, -76, -78, -72, -2, 12, -71, 7; /M: SY='E'; M= -36, -78, 10, 55, -65, -77, -62, 18, 14, 19, -56, -2, -70, -9, -12, -31, 3, -58, -77, 8; /M: SY='R'; M= -67, -82, -14, -14, -73, 0, -60, -19, 60, -18, -64, -57, -73, -48, 75, -63, -65, -71, -75, -10; /M: SY='L'; M= -23, -75, -86, -81, -45, -87, -72, 52, -80, 69, -35, -83, -83, -74, -79, -76, -65, -37, -70, 24; /M: SY='M'; M= 7, -76, -68, 0, -9, -22, 21, 18, 21, 18, 35, -65, -74, 3, 1, -29, -20, -54, -71, 20; /I: I=-19; MD=-47; /M: SY='H'; M= 0, -1, -22, -8, -87, -86, 50, -83, 10, -10, -74, -73, -17, -7, 12, -14, -76, -38, -98, -78; D=-19; /I: I=-19; MI=0; MD=-47; IM=0; DM=-47; /M: SY='N'; M= -34, -88, 29, 8, -89, -6, 24, -37, -26, -44, -78, 40, -82, -20, 7, 1, -69, -41, -99, -79; D=-19; /I: I=-19; DM=-47; /M: SY='C'; M= -69, 34, -72, -70, -5, 3, 10, 0, 12, 24, -57, 26, -82, 8, -4, -31, -30, -27, -80, -10; D=-19; /I: I=-19; DM=-47; /M: SY='P'; M= -65, 30, -8, -58, 17, 6, -64, -13, 35, -36, -6, -61, 53, 38, -58, -28, -2, -67, -71, 17; /M: SY='D'; M= -65, -81, 54, 20, 0, 11, 18, -45, 34, -77, -71, 22, -20, 31, -13, -25, -28, -77, -82, -65; /I: I=-45; MD=-115; /M: SY='P'; M= 14, -79, -67, 13, -69, -32, -70, 41, -61, 5, -56, 6, 44, -9, 16, -27, -20, -53, -81, -70; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='K'; M= -20, -75, -15, -4, -77, -30, 18, -76, 47, -40, -67, 23, -19, -9, 32, 22, 35, -71, -84, -68; /M: SY='I'; M= -67, -76, -85, -79, 43, -86, -76, 50, -78, 36, 23, -79, 26, -77, -79, -73, -6, 22, -71, -52; /M: SY='V'; M= -64, -74, -81, -3, 14, -87, -75, 36, -76, 39, 32, -80, -81, -73, -77, -74, -61, 55, -75, -8; /M: SY='R'; M= -70, -86, -64, -54, -80, -78, -54, -85, -28, -78, -67, -1, -78, 11, 109, -63, -68, -79, -79, -66; /M: SY='V'; M= -21, -73, -82, -79, 18, -83, -73, 25, -77, 48, -41, -2, -83, -75, -77, -71, -61, 49, -71, 20; /M: SY='G'; M= -56, -2, -68, -76, -71, 79, -69, -71, -71, -23, 8, 4, 1, -69, -76, -12, -65, -5, -75, 14; /M: SY='H'; M= 7, -74, -65, -63, 5, 0, 68, -68, -61, -43, 2, -25, 6, -9, -4, 48, 5, -20, -78, 1; /M: SY='P'; M= -7, -79, -23, 16, -71, 4, -66, -27, 27, 1, -62, -63, 54, -57, 20, -26, 2, -29, -77, -9; /M: SY='S'; M= 8, 31, 19, 12, -78, -65, 27, -73, 17, -75, -68, 13, -69, 11, -18, 42, 16, -17, -87, -69; /M: SY='R'; M= -17, -79, -12, 13, -79, -69, 18, -79, 38, -77, -68, 17, -71, -4, 68, 21, -31, -36, -83, -67; /M: SY='W'; M= -64, -80, 3, 22, -20, -78, -10, 41, -15, -4, -55, -68, -8, -63, -69, 17, -61, 23, 92, -57; /M: SY='H'; M= -4, -76, -24, 10, -64, -71, 53, 25, -13, 17, -54, 44, -11, -10, -64, 4, -58, -22, -82, -11; /M: SY='E'; M= -60, -79, -15, 48, -73, -73, -63, -8, 23, -69, -65, -59, 34, -8, 8, 30, -5, 12, -80, -5; /M: SY='D'; M= -18, -77, 47, 27, -6, -72, -1, -6, -1, 9, -1, -56, -14, -1, -62, 15, 11, -62, -79, -9; /M: SY='I'; M= -11, -74, -71, -14, -21, -18, -71, 34, -3, 8, -52, -15, -3, -65, -69, 12, 6, 33, -77, 5; /M: SY='P'; M= -27, -80, 6, -55, -72, -73, 8, 6, 37, -6, 19, -60, 42, 41, 12, 8, -60, -18, -81, -66; /M: SY='P'; M= -64, -82, 42, 20, -21, -8, -61, -72, 28, -76, -69, -1, 47, 46, -16, -13, -60, -1, -82, -70; /M: SY='H'; M= -36, 19, -22, 4, 53, -76, 63, -57, -68, 14, -54, -10, 5, -65, -69, -11, 3, -3, -70, 19; /M: SY='S'; M= -19, 27, -7, 7, -23, -71, -69, 9, -62, -3, -58, -61, -17, -61, 4, 46, 26, 17, -83, -66; /M: SY='L'; M= -69, -77, -9, -25, 7, -83, 26, 17, -8, 47, 10, -69, -16, -63, 32, -70, -10, -27, -74, -14; /M: SY='E'; M= -35, -82, 41, 42, -71, -15, 5, -75, -7, -46, 21, -11, 20, 36, 3, -27, -23, -74, -76, 30; /M: SY='Y'; M= 0, 2, -62, 38, -17, -21, -62, 11, -20, -19, -58, -65, 1, -4, -65, 23, -59, -3, -66, 57; /M: SY='C'; M= 0, 69, 12, -63, -68, 14, 36, -7, -60, 2, -3, -60, -77, 23, 26, -14, -63, -27, -81, -8; /M: SY='C'; M= -62, 69, -69, -67, 11, -73, -66, -23, -4, -14, 32, 30, 1, -19, 15, 18, -7, 20, -82, -63; /M: SY='Y'; M= -13, -78, -2, 6, 12, -75, 9, -4, 8, 14, -2, 17, -3, -14, 11, -63, -23, -26, 24, 29; /M: SY='T'; M= -10, -1, 0, -18, -20, -36, 30, 0, 25, -41, -62, 9, -71, -16, 14, -1, 39, -63, -75, 30; /M: SY='Q'; M= 3, -76, 26, 21, -78, -17, 2, -72, 1, -30, -66, 10, -70, 34, 23, 29, -5, -20, -84, -69; /M: SY='M'; M= -27, -75, 43, -23, -14, -70, 9, -7, -9, 3, 47, 14, -74, -59, -64, 27, -18, -30, -73, 41; /M: SY='I'; M= -9, -76, -63, 8, -6, -34, 8, 34, 22, -23, 18, 27, -73, -56, 26, 9, -59, -7, -79, -62; /I: I=-2; MD=-4; /M: SY='Q'; M= -14, -82, -25, -11, 5, 0, -66, -37, 16, -43, -68, -22, -23, 31, 9, 17, -7, -31, 20, 14; D=-2; /I: I=-2; MD=-4; /M: SY='K'; M= 2, -79, -4, -1, -80, -71, -65, -75, 45, -15, -68, 19, -74, 14, 19, 15, 1, -44, -86, -73; D=-2; /I: I=-2; MD=-4; /M: SY='N'; M= -15, 0, -20, -9, -7, -82, -73, 2, 10, 4, -5, 33, 10, -70, -72, -71, -68, 4, -85, -13; D=-2; /I: I=-2; MD=-4; /M: SY='P'; M= -12, -88, -10, 3, -80, 12, -78, 4, -17, -24, -71, -72, 40, -27, -77, 4, -69, -12, -88, -15; D=-2; /I: I=-2; MD=-4; /M: SY='S'; M= -18, -87, 11, -10, -23, -48, -75, -74, -14, 17, 1, -72, -86, -69, -8, 35, -69, -74, -88, -6; D=-2; /I: I=-2; MD=-4; /M: SY='H'; M= -24, 4, -23, -75, -80, -14, 67, -15, -34, -5, -69, -13, 18, 7, -78, -75, -77, -23, 41, -71; D=-2; /I: I=-2; MD=-4; /M: SY='E'; M= 13, -90, 28, 35, -87, -44, -76, -1, -70, -23, -75, 11, -27, -17, -28, -70, -73, -30, -97, -83; D=-2; /I: I=-2; MD=-4; /M: SY='Q'; M= -13, -90, -6, 21, -86, -85, -73, -6, -9, -40, 32, -71, -82, 39, 15, -14, -9, -74, -93, -79; D=-2; /I: I=-2; MD=-4; /M: SY='M'; M= -33, -92, 0, 6, -89, -25, -78, -80, 11, -33, 33, -73, -86, -13, 2, 15, -33, -24, -98, -83; D=-2; /I: I=-2; MD=-4; /M: SY='P'; M= -18, -96, -2, -70, -92, -28, 6, -84, 32, -50, 27, -75, 40, -18, -11, -38, -77, -39, -97, -84; D=-2; /I: I=-2; MD=-4; /M: SY='M'; M= -45, -94, 3, -7, -79, -93, 4, 20, -24, -38, 28, -23, -89, -19, 3, -44, -34, -4, -95, -10; D=-2; /I: I=-2; MD=-4; /M: SY='D'; M= -39, -90, 36, -72, -9, -87, -80, -29, 10, 0, 0, -21, -89, -76, -77, 3, 1, -33, -97, -78; D=-2; /I: I=-2; MD=-4; /M: SY='Q'; M= -13, -92, -10, -6, -89, -86, -77, -18, -6, -16, -75, -19, -86, 50, -20, -9, -6, -39, -97, -83; D=-2; /I: I=-2; MD=-4; /M: SY='T'; M= -18, -3, -8, 5, -87, -25, -83, -10, 14, -20, -76, -75, -86, -72, 0, -33, 16, -32, -98, -85; D=-2; /I: I=-2; MD=-4; /M: SY='Y'; M= -44, -92, -27, -6, -20, -32, -75, -80, -10, -5, -1, 14, -19, 1, -77, 9, -26, -81, -88, 17; D=-2; /I: I=-2; MD=-4; /M: SY='W'; M= -19, -92, -90, -33, 32, -94, -9, -10, -31, -8, -72, -84, -92, -84, -29, -35, 26, -31, 42, -68; D=-2; /I: I=-2; MD=-4; /M: SY='R'; M= -34, -96, -79, -27, -94, -10, -8, -88, 20, -43, -81, -21, -89, 12, 36, -74, 0, -25, -99, -85; D=-2; /I: I=-2; MD=-4; /M: SY='D'; M= -83, 17, 34, -32, -91, -39, -79, -38, -31, -44, -2, 5, -92, -8, 23, -38, -35, -25, 5, -85; D=-2; /I: I=-2; MD=-4; /M: SY='K'; M= 6, -95, -26, -29, -85, -46, -84, -10, 30, -19, -76, -80, -5, -75, -5, -78, -31, -34, -93, -9; D=-2; /I: I=-2; MD=-4; /M: SY='Y'; M= -83, -98, -39, -28, -78, -26, 6, -21, 21, -84, -4, -17, -92, -9, -30, -17, -22, -39, -86, 41; D=-2; /I: I=-2; MD=-4; /M: SY='T'; M= -81, -92, 6, -81, -23, -92, -85, 7, -27, -13, -74, -14, -92, -22, -85, 1, 31, -32, -97, -11; D=-2; /I: I=-2; MD=-4; /M: SY='K'; M= 11, -95, -20, -26, -41, -86, 14, -30, 27, -47, -82, -75, -89, -11, -5, 10, -77, -84, -99, -83; D=-2; /I: I=-2; MD=-4; /M: SY='D'; M= -84,-100, 16, 5, -95, -90, 15, -40, 7, -91, 2, -22, -26, 13, 15, -5, -79, -92,-101, -29; D=-2; /I: I=-2; MD=-4; /M: SY='Y'; M= -85, -97, -39, -9, -8, -44, 6, -37, -29, -6, -76, 4, -21, -77, -4, -10, -35, -83, -87, 29; D=-2; /I: I=-2; MD=-4; /M: SY='W'; M= -82, -16, -83, -9, -86, -93, -87, -32, 4, -21, -80, -15, -27, -23, -4, -7, 11, -24, 58, -82; D=-2; /I: I=-2; MD=-4; /M: SY='E'; M= -36, 18, -4, 37, -19, -95, 1, -51, -33, -50, -87, -6, -21, 0, -22, -81, -84, -92, -99, -20; D=-2; /I: I=-2; MD=-4; /M: SY='R'; M= -89,-103, -82, 2, -97, -98, -83, -30, 10, -35, 11, 8, -96, 6, 20, -39, -30, -89,-105, -91; D=-2; /I: I=-2; MD=-4; /M: SY='W'; M= -88,-106, -32, -89, -86, -17, -90, -92, -46, -44, -89, -88,-101, -2, -4, 5, -15, -27, 54, 16; D=-2; /I: I=-2; MD=-4; /M: SY='N'; M= 4, -99, -81, 5,-100, -90, -87, -51, -34, -24, -89, 27, -98, -80, -29, 11, -81, -90,-110, -97; D=-2; /I: I=-2; MD=-4; /M: SY='H'; M= -95,-105, -91, -16, 5, -28, 13, 6, -33, -11, -79, 7,-104, -88, -30, -93, -91, -82, -97, -7; D=-2; /I: I=-2; MD=-4; /M: SY='Y'; M= -91, 6, -30, -48, -81, -43, -89, -2, -39, -87, -85, -88,-101, -90, -6, -85, 26, -32, -94, 38; D=-2; /I: I=-2; MD=-4; /M: SY='M'; M= -48,-103, -14, -37, -10,-105, -96, -20, -39, -12, -4, -21,-105, -92, -26, -38, -24, -11,-108, -89; D=-2; /I: I=-2; MI=0; MD=-4; IM=0; DM=-4; /M: SY='Y'; M= -29,-108, -84, 26, -89,-101, -86, -13, -35, -96, -92, -27, -99, -30, -32, -6, -88, -92, -95, 33; D=-2; /I: I=-2; DM=-4; /M: SY='R'; M= -31,-107, -99, -91, -10,-105, -95, 4, 12, -20, -83, -25,-105, -20, 12, -50, -91, -83,-103, -88; D=-2; /I: I=-2; DM=-4; /M: SY='R'; M= -38,-105, -12, -7, -43, -99, -86,-103, -3, -49, -93, -6, -99, -76, 43, -36, -28, -99,-108, -93; D=-2; /I: I=-2; DM=-4; /M: SY='P'; M= -8,-102, -35, -38, -11, -96, -98, -34, -94, -24, -85, -93, 30, -92,-100, 5, -42, -13,-105, -91; D=-2; /I: I=-2; DM=-4; /M: SY='C'; M= -40, 8, -22, -91, 4, -99, -94, -34, -15, -14, -83, -24,-103, -90, -27, 4, -32, -25,-104, -86; D=-2; /I: I=-2; DM=-4; /M: SY='R'; M= -92,-107, -83, 15, -96, -14, -86, -32, -28, -36, -89, 12,-100, -78, 28, -88, -90, -46,-104, -18; D=-2; /I: I=-2; DM=-4; /M: SY='K'; M= -29,-101, -82, -3, -93, -96, -84, -91, 35, -4, -83, 7, -95, -73, 21, -85, -85, -91, 17, -88; D=-2; /I: I=-2; DM=-4; /M: SY='L'; M= -92,-101, -3, 10, 5,-101, -83, -80, -84, 14, -1, -1, -7, -83, -23, -90, -87, -84, -93, 6; D=-2; /I: I=-2; DM=-4; /M: SY='R'; M= -40,-103, -28, -84, -83,-102, 14, 0, 7, -25, -77, -86,-100, -78, 36, -88, -87, -18, -96, 9; D=-2; /I: I=-2; DM=-4; /M: SY='Q'; M= -11, -94, 8, 10, -89, -11, -74, -94, 6, -92, -85, -12, -85, 32, -27, -16, -13, -90, -90, 16; D=-2; /I: I=-2; DM=-4; /M: SY='W'; M= -11, -94, -88, -31, -15, -5, 0, -31, -10, 5, -70, -84, -93, -1, -25, -80, -82, -18, 42, 18; D=-2; /I: I=-2; DM=-4; /M: SY='W'; M= -80, -93, -26, 12, 10, -91, -77, -80, 17, -1, -73, -76, -87, -7, 16, -26, 4, -80, 42, -15; D=-2; /I: I=-2; DM=-4; /M: SY='N'; M= -81, -93, 24, 20, -9, -87, -73, -80, -29, 6, -74, 25, -14, -6, 21, -75, -33, -82, 17, -75; D=-2; /I: I=-2; DM=-4; /M: SY='Q'; M= -18, -92, -77, -30, -23, -36, -74, -82, 29, -82, 4, -72, -10, 42, 38, -35, -30, -24, -90, -77; D=-2; /I: I=-2; DM=-4; /M: SY='K'; M= -5, 4, 0, 27, -88, -80, -74, -33, 29, -82, -77, -19, 15, -14, -16, -2, -22, -11, -94, -82; D=-2; /I: I=-2; DM=-4; /M: SY='T'; M= 11, -82, 5, -29, -75, -78, -71, 0, -15, -17, 25, 15, -20, 16, -29, -63, 34, -65, -88, -10; D=-2; /I: I=-2; DM=-4; /M: SY='Y'; M= 2, -84, -75, -68, 19, -81, -66, -26, 17, 3, -62, 5, -84, 34, 24, -69, -70, -34, -71, 39; D=-2; /I: I=-2; DM=-4; /M: SY='K'; M= 29, -79, -64, 31, 8, -73, 26, -26, 37, -29, -68, -19, -74, -59, -60, -2, -4, -69, -83, -67; D=-2; /I: I=-2; DM=-4; /M: SY='L'; M= -23, -81, 4, -3, 4, -84, -2, 22, 5, 34, 16, -22, -82, -16, -70, -28, -67, -26, -82, -63; D=-2; /I: I=-2; DM=-4; /M: SY='L'; M= -68, 35, -88, -83, -49, -89, -76, 52, -81, 56, 42, -82, -84, -76, -80, -77, -64, 12, -77, -10; D=-2; /I: I=-2; DM=-4; /M: SY='Q'; M= -9, -77, -4, -25, -62, -32, -63, -2, 16, 23, -3, -13, -75, 30, 7, 2, -1, -30, -74, 23; D=-2; /I: I=-2; DM=-4; /M: SY='Q'; M= -32, -79, 32, 25, -79, -27, -58, -29, 28, -36, 5, 7, -69, 55, 25, 9, -19, -71, -82, -68; /M: SY='H'; M= 34, -74, -62, 17, -23, -67, 58, -64, -10, -27, -61, -60, 15, 8, -62, 21, 4, 1, -78, 12; /M: SY='R'; M= 1, -78, 36, -22, -8, -67, -57, -77, 16, -74, 5, 13, -72, 39, 56, 28, -58, -73, -81, -65; /M: SY='V'; M= -37, -76, 17, -69, -60, -83, 5, 50, -30, 3, -48, -70, -3, -69, 10, -69, -59, 58, -85, -63; /M: SY='I'; M= -62, -75, -87, -83, -54, -90, -88, 81, -80, -21, -41, -79, -79, -79, -82, -72, -18, 64, -82, -62; /M: SY='V'; M= 14, 40, -79, -77, -18, 32, 15, 28, -75, -16, 16, -69, -78, -73, -77, -63, -61, 51, -82, -64; /M: SY='C'; M= 19, 90, -76, -74, -3, -72, -75, -11, -71, -55, 50, -66, -77, -71, -75, 7, 34, 32, -85, -66; /M: SY='T'; M= -7, 32, -63, -65, -71, -69, -70, -62, -62, -65, 15, -52, -65, -65, -69, -1, 102, -55, -90, -69; /M: SY='C'; M= -20, 88, -66, -69, -66, -71, -71, -66, -66, -18, -63, 22, -73, -69, -72, -21, 79, -60, 58, -12; /M: SY='T'; M= -29, 6, -9, -69, -3, -74, -70, 16, -69, 38, 1, -10, -74, -67, -73, 18, 57, -25, -81, -61; /M: SY='S'; M= -9, -2, -61, -12, -77, 41, 49, -76, -61, -74, 24, -52, -69, 27, -65, 57, 17, -71, -84, -67; /M: SY='A'; M= 55, 35, -72, -70, -6, 18, -72, -7, -70, 7, -58, -64, -74, -66, -74, 29, -15, -27, -78, -67; /M: SY='S'; M= 25, -72, -62, -63, -4, 27, -63, -30, -13, -75, -68, 24, -14, -4, -14, 60, -52, -68, -77, -12; /M: SY='G'; M= 6, -74, 1, -17, -18, 37, 0, -72, -1, -5, -65, 10, -72, -58, 2, 30, 4, -69, -77, -4; /M: SY='H'; M= -20, -77, -19, -25, 4, -29, 49, -23, -13, 31, -53, -63, 20, -60, 16, 14, -6, -61, -73, 20; /M: SY='R'; M= -38, 35, -8, -6, -62, -33, -65, -5, -54, 35, -52, -19, -17, -59, 57, -14, -63, 0, -79, -14; /M: SY='Q'; M= -33, -77, -15, -21, 4, -9, 17, -22, -63, 32, 4, -3, 12, 59, -65, -27, -9, -6, -77, -60; /M: SY='L'; M= -17, -75, -8, -27, -15, -77, 20, 24, 5, 37, -49, 6, 20, -65, -67, -62, 28, -14, -80, -61; /M: SY='L'; M= -8, 7, 5, -21, -63, 10, -68, -25, 16, 40, -52, 13, -76, -13, -64, -25, -27, 14, -81, -66; /M: SY='K'; M= -63, -77, -64, 3, 4, -10, -13, -25, 31, 4, -3, 7, -74, 22, 29, -2, -23, 6, 25, -60; /M: SY='K'; M= -13, -80, 28, 34, -13, -72, -60, -73, 45, -19, 18, -15, 8, 10, 30, -16, -61, -71, -79, -66; /I: I=-26; MD=-67; /M: SY='R'; M= -20, -92, -83, -30, -18, -19, -81, -6, 10, -31, -73, -29, 10, -74, 16, -43, -25, 2, -89, -10; D=-26; /I: I=-26; MD=-67; /M: SY='G'; M= -80,-100, -1, -6, -95, 46, -86, -39, -79, -12, -85, -14, -93, -80, 10, -79, -86, -91,-100, -92; D=-26; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='F'; M= -74, 3, -86, -82, 102, -84, -69, -8, -78, -47, -54, -79, 27, -85, -78, -74, -67, -3, -49, 35; /M: SY='D'; M= -64, 19, 81, -47, -83, -68, -60, -81, -16, -81, -76, 14, 8, -56, 32, 10, 33, -76, -94, -72; /M: SY='H'; M= -8, 9, -66, -68, -14, -74, 73, 21, -67, -20, -53, 30, -76, -17, -68, -28, 20, 27, -77, 37; /M: SY='V'; M= -61, 59, -87, -82, -55, -88, -86, 50, -80, 12, -44, -80, -83, -80, -81, -72, -58, 73, -86, -64; /M: SY='I'; M= -67, -77, -87, -81, 21, -90, -81, 78, -79, 31, -39, -80, -80, 0, -80, -75, -62, 24, -73, -55; /M: SY='I'; M= -65, -76, -88, -83, -11, -90, -82, 76, -80, 22, 37, -81, -80, -77, -81, -75, -61, 45, -78, -58; /M: SY='D'; M= -69, -83, 106, 33, -87, -70, -56, -83, -56, -80, 27, -42, -68, -54, -65, -60, -61, -81,-100, -72; /M: SY='E'; M= -63, -83, -34, 106, -86, -77, -56, -87, -45, -80, -76, 12, -59, -38, -55, -59, -63, -80, -84, -77; /M: SY='A'; M= 83, 33, -71, -65, -4, -25, -72, -67, -67, -69, -64, -64, -72, -64, -71, 12, -55, -25, -78, -70; /M: SY='S'; M= 51, 3, -65, -63, -80, 33, -67, -76, -63, -77, -70, -55, -69, 17, -68, 61, 0, -66, -81, -73; /M: SY='Q'; M= -63, -85, -11, 6, -85, -70, 3, -75, -46, -26, -5, 13, -70, 115, -47, -54, -64, -77, -78, -64; /M: SY='A'; M= 51, 46, -78, -73, -64, -70, -77, 49, -72, -21, 11, -70, -75, -70, -76, -3, -5, 24, -82, -67; /M: SY='M'; M= -6, 10, -72, -69, -58, -70, -67, -50, -68, 30, 54, -64, -19, -64, -71, 48, 31, 6, -78, 5; /M: SY='E'; M= -64, -83, 4, 99, -79, -79, -57, -76, -48, -5, 1, -60, -62, -2, -57, -61, -64, -73, -83, -73; /M: SY='P'; M= 12, 58, -68, -13, -76, -27, -71, 2, -67, -15, -64, 0, 86, -67, -75, -2, -26, -64, -84, -77; /M: SY='E'; M= -14, -77, -26, 59, -72, -69, 32, -30, -54, -70, -66, -57, -9, 14, -8, 44, -8, 2, -80, 8; /M: SY='C'; M= 9, 86, -70, -71, -67, -70, -73, 23, -69, -4, -58, -17, -74, -68, -74, 25, 60, -52, -87, -70; /M: SY='W'; M= -69, -76, -87, -81, 0, -87, -76, 53, -78, 57, 41, -81, -81, -74, -78, -75, 2, -39, 71, -52; /M: SY='I'; M= -28, -75, -75, -75, -64, 23, -77, 61, -72, -28, 9, -66, 19, -70, -78, 13, 26, 16, -81, -67; /M: SY='P'; M= 11, -85, -72, -63, -78, -17, -74, 14, -68, -29, -64, -73, 106, -70, -78, -63, -19, -64, -81, -79; /M: SY='L'; M= -68, -73, -88, -81, -46, -89, -74, 29, -81, 77, 14, -85, -85, -74, -79, -79, -64, 9, -76, -57; /I: I=-26; MI=0; MD=-67; IM=0; DM=-67; /M: SY='F'; M= -44, -1, -86, -79, 24, -88, -78, -2, -32, 10, -5, -80, 10, 7, 7, -1, -27, -34, -81, -1; D=-26; /I: I=-26; DM=-67; /M: SY='Y'; M= -6, -75, -68, -65, 26, -34, 26, -61, 5, 8, -57, -13, 23, -13, -19, 14, 25, -29, -68, 41; /M: SY='G'; M= -29, -78, -1, -21, 1, 40, -63, -76, 11, -43, -68, -1, 2, 11, 33, 3, 17, -73, -76, -8; /I: I=-45; MI=0; MD=-115; IM=0; DM=-115; /M: SY='C'; M= 20, 73, -69, -29, 22, 33, -69, -28, -67, -10, -4, 18, -77, -67, -23, 14, -60, -25, -78, -65; /M: SY='E'; M= 1, -76, 8, 38, -80, -14, 5, -79, 32, -78, -70, 24, -67, -5, 27, -4, 33, -72, -84, -70; /M: SY='R'; M= -64, -81, -60, -49, -80, -72, 32, -79, 59, -76, -65, -12, -71, 53, 66, 1, -24, -37, -80, -64; /M: SY='C'; M= -67, 53, -88, -82, 49, -86, -76, 2, -80, 45, -44, -82, -86, -79, -79, -75, -64, 41, 44, 8; /M: SY='V'; M= -60, -74, -86, -83, -21, -25, -87, 65, -79, -13, -43, -79, -80, -79, -82, -72, -58, 74, -82, -61; /M: SY='L'; M= -69, -73, -88, -80, 18, -87, -69, -4, -79, 74, 74, -83, -84, -72, -76, -79, -66, -43, -71, -52; /M: SY='V'; M= 47, -70, -79, -73, -61, -71, -79, 39, -73, -1, -49, -72, -76, -71, -76, 5, -55, 57, -82, -66; /M: SY='G'; M= -52, -80, -67, -79, -86, 100, -74, -94, -73, -89, -78, -53, -71, -70, -80, -52, -71, -87, -77, -81; /M: SY='D'; M= -71, -83, 113, -35, -90, -66, -55, -89, -57, -88, -86, 16, -70, -57, -66, -58, -60, -86,-106, -74; /M: SY='H'; M= -69, -86, -60, -22, -77, -73, 112, -20, -61, -74, -62, -11, 78, 17, -62, -61, -10, -78, -92, -56; /M: SY='K'; M= -68, -2, -62, -55, -62, -74, 44, -71, 64, -66, 54, 15, -73, 16, 33, -62, -63, -71, -69, 51; /M: SY='Q'; M= -63, -87, -59, -39, -87, -71, -51, -74, -44, -17, -58, -54, -70, 125, -45, -53, -65, -77, -75, -63; /M: SY='L'; M= -68, -71, -85, -78, -45, -88, -72, -36, -79, 84, -33, -83, -85, -73, -77, -76, 3, -14, -76, -57; /M: SY='P'; M= -60, -83, -65, -58, -84, 9, -67, -79, -11, -83, -72, -61, 92, -8, 27, 39, -13, -78, -82, -77; /M: SY='P'; M= -21, -89, -69, -61, -87, 12, -72, -78, -66, -86, -74, -70, 114, -68, -77, -5, -61, -80, -82, -84; /M: SY='T'; M= -59, -70, -66, -70, 8, -28, -67, -18, -65, 4, -54, 35, -74, -67, -16, 4, 57, 38, -79, 5; /I: I=-28; MD=-70; /M: SY='V'; M= -32, 42, -88, -86, -67, -90, -89, 36, -83, -12, -55, -7, -14, -84, -87, -75, -21, 60, -95, -74; D=-28; /I: I=-28; MD=-70; /M: SY='K'; M= -32, -86, -76, -15, 16, -85, -72, 2, 35, -2, -5, -16, -83, 10, -23, -24, -23, -29, -77, 16; D=-28; /I: I=-28; MD=-70; /M: SY='S'; M= -62, -2, -65, -15, -9, -30, -71, -77, -69, -82, -78, 44, -80, -66, -75, 65, 5, -10, -94, -76; D=-28; /I: I=-28; MI=0; MD=-70; IM=0; DM=-70; /M: SY='D'; M= -25, -91, 29, 13, -90, -7, 3, -87, 1, -40, 2, -66, 1, 2, 23, -30, -10, -84, -95, -80; D=-28; /I: I=-28; DM=-70; /M: SY='K'; M= 13, -80, -24, -5, 14, -79, -70, -24, 36, 16, -59, -68, -78, 16, 14, -66, -26, -10, -79, -64; D=-28; /I: I=-28; DM=-70; /M: SY='A'; M= 65, -70, 26, -57, -76, -23, -66, -67, -60, -16, -63, -12, -71, 24, -9, 9, -1, -31, -82, -71; /M: SY='Q'; M= 18, -77, -13, 18, -76, -70, 4, 7, 22, -67, -5, -14, -70, 44, 38, 8, -59, -6, -81, -67; /M: SY='N'; M= 13, -75, 8, 35, -70, -67, -60, -7, 31, -19, -63, 49, -10, -53, -57, 2, -57, -16, -80, 4; /M: SY='Y'; M= -15, -77, -22, -25, 44, -31, 28, -64, -26, -2, 3, 34, -18, -60, 26, -2, -62, -66, -63, 55; /M: SY='G'; M= -23, -77, -5, -24, -83, 70, -63, -85, 13, -84, -74, 53, -71, -10, -24, -51, 3, -80, -82, -76; /M: SY='L'; M= -27, -75, -81, -75, -9, -80, -64, -7, -74, 57, 48, -77, 16, -69, -74, -4, -62, -12, -65, 52; /M: SY='E'; M= -59, -77, 31, 48, -77, 21, 9, -80, -22, -28, -71, 34, -68, -51, -15, 43, -56, -76, -84, -15; /M: SY='Q'; M= -63, -79, -61, 18, -69, -9, 11, 28, -5, -18, -56, -2, -71, 73, -23, -58, 11, 5, -78, -11; /M: SY='S'; M= -46, -67, -58, -11, -76, -56, -63, -74, -59, -78, -72, -48, -65, -53, -64, 95, 41, -66, -86, -69; /M: SY='M'; M= -70, -73, -86, -78, 27, -86, -66, -39, -74, 70, 74, -81, -84, -70, -8, -78, -66, -46, -69, -7; /M: SY='F'; M= -74, -75, -81, 8, 101, -85, -67, -50, -76, 22, 30, -78, -84, -77, -75, -76, -69, -55, -51, 0; /M: SY='E'; M= -28, -81, 36, 69, -81, -75, 43, -75, 31, -75, -69, -54, -66, -11, 9, -59, -9, -6, -86, -68; /M: SY='R'; M= -22, -82, -67, -57, -77, -22, -58, -80, -32, -43, -66, -59, -76, -47, 104, -60, 9, -74, -79, -66; /M: SY='L'; M= -70, -73, -84, -80, 30, -86, -70, 15, -78, 71, 26, -6, -85, -74, -77, -77, -65, -19, -69, -10; /M: SY='C'; M= -30, 50, -73, -6, 21, -80, -6, 18, -14, -3, -2, -69, -78, 14, 3, -10, -60, 41, -75, -2; /M: SY='E'; M= -63, -80, -48, 71, -71, -75, -57, -73, 43, -17, -66, 2, -66, -4, 13, -8, -22, -37, -75, 18; /I: I=-17; MD=-42; /M: SY='C'; M= -47, 33, -90, -30, -89,-100, 5, -35, 5, -45, -88, -5,-103, -20, -5, -39, -89, -93, -99, 22; D=-17; /I: I=-17; MI=0; MD=-42; IM=0; DM=-42; /M: SY='H'; M= 5, -78, 0, -20, -31, -13, 52, -65, 3, -6, 2, 34, -77, -61, -16, -21, -22, -3, -80, 25; D=-17; /I: I=-17; DM=-42; /M: SY='P'; M= -6, -82, 3, -24, -16, 24, -64, -77, 20, -77, 13, 20, 64, -59, 20, -35, -63, -76, -78, -11; D=-17; /I: I=-17; DM=-42; /M: SY='Q'; M= -65, -78, -17, 20, -5, -75, 4, -6, -23, 12, 7, 26, -11, 29, 11, 9, -60, 4, -79, -17; D=-17; /I: I=-17; DM=-42; /M: SY='P'; M= -2, 10, -24, 9, 2, -70, 17, -65, -22, -41, 2, -16, 58, -22, 15, 26, -58, 2, -78, -12; /M: SY='V'; M= -17, -75, -77, -71, 9, -78, -74, 30, -30, -28, -11, -71, 39, -69, 6, 1, -8, 52, -76, -3; /M: SY='C'; M= -29, 58, -71, -69, -62, -76, 46, 29, -9, 0, -53, -62, -74, -65, -21, 9, 48, 12, -84, -11; /M: SY='M'; M= -64, -76, 24, -20, 3, -76, -64, -22, 18, 10, 45, -60, -73, 32, 16, -14, 19, 13, -79, -60; /M: SY='L'; M= -70, -72, -88, -80, -3, -89, -71, -35, -81, 87, -32, -87, -87, -74, -78, -80, -66, -43, -73, -54; /M: SY='N'; M= -63, 11, 30, -21, -73, -70, 12, -66, 4, -2, -62, 44, -72, 9, 31, -12, 41, -15, -88, -67; /M: SY='T'; M= -20, -74, -65, 3, -58, -76, 17, 14, -9, -16, 8, 13, -73, -5, -23, -58, 43, 30, -75, 39; /M: SY='Q'; M= -63, -82, -55, -44, -9, -68, 23, -73, -47, -72, -61, 51, -72, 112, -48, -53, -62, -23, -78, -61; /M: SY='Y'; M= -73, -84, -73, -75, 10, -23, 34, -61, -67, -23, -53, -71, -85, -64, -17, -68, -69, -65, -37, 120; /M: SY='R'; M= -70, -85, -64, -54, -79, -78, -55, -85, 1, -79, -67, 12, -78, -44, 109, -63, -67, -79, -80, -66; /M: SY='M'; M= -4, 78, -78, -74, -61, -72, -63, -48, -69, -44, 117, -4, -76, -64, -70, 7, -59, -4, -84, -62; /M: SY='H'; M= -69, 46, -56, -59, -73, -71, 118, -82, -54, -39, -61, 50, -76, -53, 36, -59, -15, -80, -98, -52; /M: SY='P'; M= -21, -85, -10, 47, -84, -30, -65, -77, -57, -39, -71, -64, 90, 16, -26, 12, -60, -77, -82, -78; /M: SY='S'; M= 27, -73, 26, 19, -78, -15, -63, -74, 32, -28, -67, -53, -67, -2, -6, 33, 23, -68, -83, -71; /M: SY='I'; M= -68, -80, -87, -86, -52, -92, -86, 99, -81, 5, -38, -78, -77, -77, -84, -75, -9, -24, -77, -60; /M: SY='M'; M= -27, 53, -72, -70, -1, -70, -66, -18, -64, 7, 69, -17, -76, -62, 10, 52, -7, -3, -81, -61; /M: SY='S'; M= 6, -75, 19, 33, -78, -65, -11, -75, -4, -37, -6, 20, -68, 9, 27, 42, 10, -70, -85, -69; /M: SY='F'; M= -73, -76, -87, -80, 75, -87, -69, 12, -26, 54, -42, -81, -86, -77, -75, -77, -68, -48, 31, 32; /M: SY='P'; M= -12, 34, -73, -67, -1, -72, -70, 1, -70, 4, -59, -71, 84, -69, -76, 17, -15, -23, -73, 24; /M: SY='S'; M= -51, -69, -55, -59, -76, -56, -59, -30, 12, -77, -70, 58, -69, -52, -59, 84, -12, -27, -87, -70; /I: I=-45; MD=-115; /M: SY='K'; M= -40, -89, 33, 18, -22, -80, 4, -87, 43, -86, -79, 7, -16, -11, 25, -30, -69, -43, -91, -75; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='L'; M= -36, -74, -73, -28, 13, -76, 44, -24, -14, 52, 4, -68, -77, -19, -67, 22, -2, -54, 43, -1; /M: SY='F'; M= -70, -76, -83, -79, 85, -84, 16, 41, -73, -45, 29, -73, -82, -76, -11, -24, -21, -1, -56, 29; /M: SY='Y'; M= -75, -85, -74, -77, 5, -81, -41, -59, -69, -56, -53, -75, -87, -65, -66, -69, -69, -65, -30, 130; /M: SY='D'; M= -19, -80, 44, 37, -77, -14, -2, -75, 15, -40, -69, 43, 12, 26, -7, -57, -61, -27, -83, -5; /I: I=-45; MD=-115; /M: SY='G'; M= -23, -78, 48, -61, -81, 60, -65, -82, -62, -20, -73, 30, -73, -62, -2, 25, -61, -78, -86, -75; D=-45; /I: I=-45; MI=-115; IM=-115; DM=-115; /M: SY='K'; M= 3, -78, 35, 29, -77, -69, -59, -74, 59, -4, -66, 26, -69, -4, 11, -27, -60, -72, -82, -70; /M: SY='L'; M= -65, -73, -7, -75, -50, -2, -71, 4, -77, 74, -39, -75, -82, -71, -77, 2, -63, -17, -77, -60; /M: SY='M'; M= -21, -1, -13, 24, -69, -74, -63, -22, 47, -8, 51, 20, -71, 10, -53, -60, 4, 16, -82, -66; /M: SY='C'; M= 26, 58, 44, -7, -74, -65, -63, -70, -62, -29, -68, 37, 26, -62, -69, -11, 27, -34, -86, -5; /M: SY='G'; M= -10, 53, 2, -21, -74, 56, 28, -21, -69, -29, -66, -10, -2, -66, -74, -3, -63, 5, 18, -70; /M: SY='H'; M= 15, -76, 15, 11, -73, -26, 40, 4, -26, -36, -62, -12, 31, -15, -18, 24, -57, 17, -85, -67; /M: SY='T'; M= 8, -71, 24, -5, -78, -13, -62, -71, -2, -75, -69, 39, -68, -4, -61, 45, 45, -19, -88, -71; /M: SY='V'; M= -33, -75, 1, 33, -6, -74, -66, -11, -1, -36, 33, -61, -20, 24, -13, 17, 2, 35, -81, -64; /M: SY='P'; M= 6, -76, -22, 8, -65, -5, -70, 15, 7, 5, -56, -65, 36, -62, -27, -27, 17, 14, -78, -4; /I: I=-11; MI=0; MD=-29; IM=0; DM=-29; /M: SY='M'; M= -16, -99, -30, -33, -87, -96, -88, -82, -38, 4, 12, 7,-101, -85, -31, -15, -26, -42,-104, -14; D=-11; /I: I=-11; DM=-29; /M: SY='S'; M= -23, -93, -78, 2, -92, -87, -82, -10, 8, -85, -8, -17, -4, -71, 12, 14, 3, -34,-100, -87; D=-11; /I: I=-11; DM=-29; /M: SY='R'; M= -77, 3, 15, 15, -94, -43, -79, -87, -4, -49, -84, -72, -26, -21, 27, 12, -29, -19,-102, -87; D=-11; /I: I=-11; DM=-29; /M: SY='L'; M= -38, 7, -89, -86, 21, -93, -84, -29, -30, 22, -67, 3, -28, -83, 1, -36, 1, -31, -91, -72; D=-11; /I: I=-11; DM=-29; /M: SY='D'; M= -22, 0, 39, -28, -24, -81, -3, -90, -31, -51, -84, -67, 21, 21, -77, 20, -6, -87,-100, -81; D=-11; /I: I=-11; DM=-29; /M: SY='W'; M= -77, -95, -10, 9, -26, -17, -77, -86, -27, -86, -82, -23, -17, -26, 18, -7, 1, -44, 82, 18; D=-11; /I: I=-11; DM=-29; /M: SY='W'; M= -8, -84, -3, -72, -7, -10, -10, -61, -2, 16, -63, -73, 3, -18, -23, -6, -69, 16, 49, -67; D=-11; /I: I=-11; DM=-29; /M: SY='W'; M= -16, -88, -21, 27, -63, -38, -71, -30, -30, -77, -74, 45, -80, -64, -71, -27, -71, -28, 117, 31; D=-11; /I: I=-11; DM=-29; /M: SY='P'; M= 5, -85, 4, -4, -26, -33, 62, -83, 16, -82, -73, -2, 68, -60, -21, -2, -64, -80, -88, -70; D=-11; /I: I=-11; DM=-29; /M: SY='D'; M= 15, -79, 29, -27, -76, 19, -71, -26, -10, 7, -65, -2, -9, -14, -71, -6, -2, -20, -88, -75; D=-11; /I: I=-11; DM=-29; /M: SY='H'; M= -75, -86, 22, -6, 22, -42, 35, 27, -71, 14, -58, -7, 18, -71, -12, -74, -70, -23, -81, -17; D=-11; /I: I=-11; DM=-29; /M: SY='P'; M= -11, -84, -16, 37, -79, -75, -64, -1, 20, -16, -66, 26, 49, 14, 19, -63, -64, -69, -84, -74; D=-11; /I: I=-11; DM=-29; /M: SY='P'; M= -66, -8, -15, -27, 3, 6, 31, -14, 1, -70, -64, -15, 58, 26, -14, -60, 13, -32, 28, 31; /M: SY='M'; M= -30, -76, 20, 22, 22, 0, 11, -12, 4, -7, 32, 16, -72, 15, -61, -9, -1, -27, -78, -59; /M: SY='F'; M= -11, -3, -69, -68, 44, 8, 42, -5, -28, -62, -60, 16, 10, -64, 21, -7, -32, 6, -69, 24; /M: SY='P'; M= -64, -86, -63, 8, -80, -31, -66, -34, -22, -79, -69, -65, 98, 42, -66, -5, 15, -74, -79, -7; /M: SY='M'; M= -63, -70, -77, -75, 22, -80, -64, 14, -72, 53, 69, 9, -79, -68, -71, -69, -19, 29, -67, 24; /M: SY='I'; M= -62, 44, -74, -72, 19, -5, -69, 54, -27, 2, 39, 0, -76, -12, 10, -64, -15, 23, -72, -10; /M: SY='F'; M= -73, -73, -76, -76, 106, -77, -62, -53, -70, -16, -52, 29, 0, -76, -18, -69, -64, -58, 32, 31; /M: SY='Y'; M= -65, 14, -19, -74, 63, -41, 23, 9, -72, 13, 18, -71, -80, -71, -71, -69, -61, 37, -54, 68; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='H'; M= -9, 4, 49, -19, -13, 11, 61, -13, -59, -68, -63, 55, -70, -58, -64, -52, 24, -11, 32, -5; /M: SY='V'; M= -25, -70, 2, -66, 28, -29, 40, 38, -15, -13, -49, -2, -72, -66, -67, -19, 31, 46, -77, -53; /M: SY='Q'; M= 9, -74, 34, -3, -73, -66, 30, -26, 24, -9, -1, 12, -67, 61, 13, -7, 11, -64, -80, -62; /M: SY='G'; M= -51, 6, -66, -74, -19, 90, 7, -73, -69, -73, -5, -53, -69, -67, -75, -51, 9, -3, 16, -68; /M: SY='S'; M= 2, 30, -16, 2, -71, -63, -4, -27, 2, -21, -61, -16, 36, -12, 21, 55, -19, -3, -81, -67; /M: SY='E'; M= -28, -78, 42, 70, -78, 22, -55, -79, -48, -75, 5, -10, -5, 32, 3, -11, -26, -75, -79, -15; /M: SY='E'; M= -4, -76, -9, 54, -18, -70, -59, -3, -8, -33, 35, -58, 20, 29, 31, 5, -8, -23, -77, -63; /M: SY='Q'; M= -60, -76, -55, 33, 16, -72, -58, 6, 37, -65, -60, -54, -66, 59, 43, 2, 35, -62, -73, -59; /M: SY='E'; M= -33, -76, 41, 67, -3, -69, -6, -25, -26, -40, 14, 9, 19, -5, -59, 6, -21, -4, -80, -64; /I: I=-25; MD=-63; /M: SY='P'; M= -17, -79, -22, -60, -8, -1, -62, -70, -1, -23, 8, 51, 54, 15, 22, -27, -19, -32, -82, -69; D=-25; /I: I=-25; MD=-63; /M: SY='N'; M= -32, -84, 22, 22, -85, -21, -68, -19, -9, -81, -76, 50, -79, -62, -6, 19, -63, 1, -96, -80; D=-25; /I: I=-25; MI=0; MD=-63; IM=0; DM=-63; /M: SY='S'; M= -54, -73, -15, 12, -15, 39, -60, -72, -2, -38, 8, 23, -1, 33, -59, 46, 6, -70, 43, -63; /M: SY='G'; M= -5, -74, 18, -58, -20, 49, -61, -69, -4, -71, 15, 30, 41, -8, -9, -52, 20, -27, -75, 5; /M: SY='S'; M= -6, -66, -58, -60, -5, -24, -58, -29, -59, -69, -64, 18, -67, -53, -63, 91, -12, -15, -74, 19; /M: SY='W'; M= -66, -78, -69, -63, 24, -75, 5, 15, 42, -18, -54, -3, -74, -58, 20, -63, 1, -11, 95, 61; /M: SY='H'; M= -34, -74, -63, -4, 36, -31, 51, 0, -58, 13, -51, -18, -73, 46, -8, 13, 0, -32, -62, 49; /M: SY='N'; M= -62, -67, -35, -57, -77, -50, -43, -76, -48, -84, -70, 125, -73, -50, -56, -44, -47, -78, -96, -72; /M: SY='P'; M= -63, -76, -65, -5, -61, -74, 41, -2, -1, 38, 2, -10, 59, 24, -3, -15, -59, 6, -78, -60; /M: SY='H'; M= 14, -74, 10, 31, -14, 34, 55, -30, -58, -11, 2, -54, -67, 36, -62, -11, -4, -33, 21, -59; /M: SY='E'; M= -60, -81, -31, 112, -84, -76, -53, -85, -41, -77, -73, -57, -55, -34, -51, -57, -61, -77, -80, -74; /M: SY='A'; M= 77, 26, -72, -65, -66, -60, -74, 38, -15, -54, -53, -66, -70, -64, -68, -50, -53, 28, -78, -67; /M: SY='E'; M= 19, -73, 0, 56, 5, -66, 5, -70, 12, -69, -64, -54, -65, 17, 31, 30, -17, -14, -76, -62; /M: SY='Y'; M= -64, -74, -7, 21, 29, -76, -58, 22, 15, 15, 44, -19, -71, 15, -59, -61, 20, -24, -63, 46; /M: SY='V'; M= 11, -67, -79, -74, -55, -78, -81, 40, -72, -12, -43, -73, -75, -73, -75, -61, 18, 82, -83, -62; /M: SY='V'; M= 6, -68, -73, -9, -13, -22, -72, 2, -26, 28, 26, -70, -74, -66, -69, -7, -19, 65, -78, -59; /M: SY='E'; M= 34, -74, -50, 67, -18, -67, -56, -68, 10, 1, -59, -26, -65, 46, -2, -23, -58, -64, -71, 8; /M: SY='W'; M= -34, 6, -77, -71, -7, -80, 43, 53, -19, 42, 22, -70, -77, -64, 10, -69, -24, -42, 65, 14; /M: SY='V'; M= -26, 29, -80, -76, 36, -81, -74, 43, -74, 26, -42, -73, -77, -74, -75, -64, 22, 53, -69, 10; /M: SY='Q'; M= -58, -2, -3, 41, -74, -71, -6, -23, 42, -63, 15, -54, -66, 71, -47, 7, -22, 25, -79, -64; /M: SY='Y'; M= 16, -74, -59, 21, -53, -12, 10, -25, -5, 14, -53, 16, -71, 20, 10, -5, -58, -27, -63, 64; /M: SY='L'; M= -26, -70, -81, -74, 30, -81, 37, -10, -74, 70, 62, -76, -80, -68, -71, -72, -62, -7, -69, -47; /M: SY='I'; M= -34, 20, -70, -66, -15, -77, -64, 33, 17, 28, 4, 1, -74, -61, 30, -61, 25, 14, -71, 21; /M: SY='N'; M= -1, 6, 35, -3, -71, -65, -1, -66, 28, 6, 29, 46, -69, 40, 18, -20, -26, -65, -81, -64; /M: SY='D'; M= 18, 1, 37, -53, -17, -33, -59, -63, 19, 1, -8, 23, -17, 18, -20, 9, 29, -34, -77, -9; /I: I=-29; MD=-75; /M: SY='W'; M= -63, -81, -23, -25, -5, 58, -68, 10, -26, -26, -66, 25, -3, -65, -2, -26, -67, -68, 63, 8; D=-29; /I: I=-29; MD=-75; /M: SY='Y'; M= -9, 28, -26, 3, -69, -84, -72, -79, -5, -46, -75, -77, 32, -71, -12, -12, -30, -31, -77, 57; D=-29; /I: I=-29; MI=0; MD=-75; IM=0; DM=-75; /M: SY='V'; M= -7, -78, -70, 17, -64, -28, -72, -3, 8, -8, -57, 12, -80, -67, -69, -67, -63, 54, -81, 22; D=-29; /I: I=-29; DM=-75; /M: SY='P'; M= -30, -81, 0, 30, -80, -68, -62, -73, 17, -37, -67, -26, 94, -10, 5, -4, 4, -72, -80, -73; /M: SY='Y'; M= 21, 7, 15, 14, 16, -30, -61, -6, -61, 9, -54, -59, -21, 15, -65, 17, 19, -15, -68, 33; /I: I=-33; MD=-84; /M: SY='Q'; M= -66, -82, 35, 28, -77, -69, -56, -83, -6, -81, -73, 49, -73, 50, 5, 23, -31, -80, -82, 23; D=-33; /I: I=-33; MI=0; MD=-84; IM=0; DM=-84; /M: SY='D'; M= -58, -75, 65, 17, -78, -65, -56, -69, 26, -72, 0, -6, -15, 37, 13, 32, -4, -3, -84, -67; /M: SY='I'; M= -63, 13, -85, -82, -50, -89, -84, 98, -78, -3, -37, -75, -75, -75, -81, -71, -20, 20, -76, -58; /M: SY='G'; M= 21, -71, -65, -71, -75, 82, -71, -21, -67, -72, -66, -12, -68, -65, -74, -9, 4, 7, -77, -73; /M: SY='V'; M= -57, 39, -84, -80, -53, -86, -86, 71, -77, -38, -41, -77, -78, -77, -79, -69, -54, 78, -82, -61; /M: SY='I'; M= -62, 35, -85, -81, -49, -87, -81, 84, -77, 22, 9, -77, -77, -75, -79, -72, -58, 44, -77, -58; /M: SY='T'; M= -6, 50, -60, -61, -69, -63, -67, -61, -59, -65, -62, -49, -63, -60, -66, 46, 94, -19, -87, -67; /M: SY='P'; M= -63, -79, -68, -61, 31, -70, 6, -27, -65, 6, -58, -67, 101, -66, -72, 8, 22, -63, -73, -61; /M: SY='Y'; M= -71, -80, -69, -72, 24, -76, 16, -57, -65, -53, -50, -4, -83, -61, -63, -65, -65, -62, -30, 128; /M: SY='N'; M= -6, -73, -14, 14, -77, -22, -54, -77, 39, -77, -67, 55, -67, -3, 53, 36, -16, -72, -80, -67; /M: SY='A'; M= 60, -67, -13, -22, -74, 10, -61, -70, 8, -38, -64, 0, -66, 25, -58, 47, -50, -62, -76, -19; /M: SY='Q'; M= -59, -85, -54, -34, -90, -67, -47, -76, -39, -71, -57, -50, -66, 131, -40, -48, -62, -77, -72, -61; /M: SY='V'; M= 4, -68, -75, -66, -57, -76, -72, -33, 28, 18, 27, -69, -74, -64, -2, -62, -7, 74, -80, -61; /M: SY='S'; M= -31, -73, 21, 25, 8, -63, 31, -71, 9, -43, -3, 32, -67, 35, 3, 48, -14, -69, -76, -6; /M: SY='L'; M= 15, 7, -67, -13, -53, -73, 5, -9, 25, 50, 31, 1, -74, -12, -14, -61, -27, -22, -71, 13; /M: SY='I'; M= -66, -73, -85, -80, 15, -87, -74, 72, -78, 61, 32, -79, -79, -73, -77, -75, -61, -30, -69, -51; /M: SY='R'; M= -61, 5, -57, 9, -71, -70, -55, -14, 40, -70, -62, 13, -69, 16, 76, 17, -8, -34, -75, -3; /M: SY='K'; M= -26, -77, 31, 34, -69, -68, 27, -34, 42, -67, 35, -51, -66, 41, 27, 15, -57, -68, -73, 23; /M: SY='I'; M= -8, 2, -15, 26, -56, -73, 17, 38, -62, 38, 37, -18, -72, -12, -29, 15, -57, -22, -75, -12; /I: I=-22; MI=0; MD=-55; IM=0; DM=-55; /M: SY='L'; M= -67, -72, -83, -76, 48, -85, -68, 48, -75, 63, 30, -78, -80, 4, -73, -74, -63, -37, -63, 2; /M: SY='R'; M= 2, -76, 33, -17, -78, -28, 27, -75, 22, -75, -66, 32, 7, 35, 54, 13, -56, -32, -82, -65; /M: SY='R'; M= -10, -75, -14, 8, -76, -20, 6, -69, 45, -71, -63, 21, -67, 37, 56, -23, 12, 0, -79, -65; /M: SY='K'; M= -61, -75, -15, 38, -20, -72, 3, -61, 43, -1, -7, -11, -68, 7, 43, 3, -23, 4, -73, 10; /M: SY='C'; M= -62, 56, 28, 6, 30, 4, 5, -11, -20, -7, -58, 16, 1, -61, -17, -23, 0, -8, -71, 24; /I: I=-13; MD=-33; /M: SY='G'; M= -63, -77, 3, -28, 7, 32, 8, 29, -25, 12, 0, -2, -15, -65, -25, -3, -62, -6, -73, 14; D=-13; /I: I=-13; MD=-33; /M: SY='H'; M= -14, -77, 4, 9, -16, 15, 46, -75, -34, -39, 22, 34, -2, -13, -18, 27, -6, -73, -86, -66; D=-13; /I: I=-13; MD=-33; /M: SY='N'; M= -89,-101, -8, -41, -95, -7, -1, -14, -29, -19, -7, 28, -98, -86, -90, -46, -1, -86,-112, -92; D=-13; /I: I=-13; MI=0; MD=-33; IM=0; DM=-33; /M: SY='P'; M= -71, -88, 27, -9, -85, 23, -4, -75, -72, -15, -1, 0, 42, -5, -78, -29, -9, -15, -94, -80; D=-13; /I: I=-13; DM=-33; /M: SY='V'; M= 5, -69, -79, -75, -52, -79, -76, 50, -73, 36, -39, -5, -15, -72, -75, -66, -55, 63, -79, -60; /M: SY='E'; M= -34, -75, 22, 57, 26, -68, 3, -74, 47, -71, -66, 22, -8, -4, -13, -3, 9, -71, -75, -60; /M: SY='V'; M= -57, 20, -84, -79, -15, -85, -83, 56, -76, -11, 3, -77, -78, -77, -78, -69, -54, 83, -81, -58; /M: SY='G'; M= 2, -72, 3, 3, -77, 57, 41, -78, 4, -40, -67, 40, -67, -20, -60, 25, -7, -73, -81, -67; /M: SY='T'; M= -50, -63, -56, -59, -69, -63, -64, -61, -55, -66, -62, 2, -61, -57, -16, 50, 98, -24, -87, -66; /M: SY='V'; M= -26, -68, -83, -77, -7, -84, -84, 38, -75, -39, -42, -78, -78, -77, -77, -66, -52, 93, -83, -59; /M: SY='D'; M= -65, -80, 101, 54, -82, -68, 38, -82, -52, -38, -75, -41, -64, -48, -60, -56, -25, -78, -95, -67; /M: SY='G'; M= 16, -73, -55, 10, -77, 41, -60, -24, 35, -75, -66, 20, -66, 14, 21, 37, -54, -68, -77, -69; /M: SY='F'; M= -20, -71, -82, -78, 96, -79, -63, -44, -75, 22, -46, -75, -83, -77, -73, -33, -63, 12, -47, 54; /M: SY='Q'; M= -60, -85, -55, -35, -89, -67, -49, -75, -41, -72, -58, -51, 30, 127, -42, -50, -62, -78, -73, -62; /M: SY='G'; M= -48, -76, -64, -75, -82, 101, -70, -90, -69, -86, -75, -50, -68, -66, -76, 1, -65, -83, -74, -77; /M: SY='R'; M= 7, -79, 40, 6, -80, -67, 4, -79, 8, -75, -65, -50, -68, 66, 72, 1, -59, -74, -79, -64; /M: SY='E'; M= -61, -81, 31, 97, -84, -73, -53, -83, 4, -77, -71, -52, -58, 51, -48, -55, -60, -77, -80, -71; /M: SY='K'; M= -65, -77, -57, -50, 31, -70, -55, -74, 76, -71, -64, 40, -70, -45, 64, -58, -59, -73, 20, -11; /M: SY='D'; M= -4, -76, 81, 45, -79, -66, -56, -72, 3, -44, -70, -46, -65, -8, 19, 9, -56, -9, -87, -68; /M: SY='I'; M= -1, 48, -77, -77, 5, -79, -74, 75, -73, -42, -44, 9, -77, -73, -76, -65, -56, 44, -71, 22; /M: SY='I'; M= -36, -73, -85, -81, 11, -87, -84, 85, -77, -16, -38, -77, -76, -76, -80, -70, -56, 59, -75, -55; /M: SY='I'; M= -64, -73, -85, -81, 6, -88, -79, 79, -78, 47, -34, -79, -78, -75, -79, -74, -59, 31, -72, -53; /M: SY='F'; M= -66, -71, -86, -80, 63, -86, -74, 55, -77, 47, 20, -79, -80, -76, -77, -74, -61, 27, -64, -43; /M: SY='S'; M= -44, 50, -59, -60, 7, -53, -61, -72, -59, -73, -69, -47, -66, -53, -64, 100, -8, -65, -80, -62; /M: SY='C'; M= -61, 88, -73, -71, 38, -75, -70, -52, -69, 39, 5, -65, 17, -71, -73, -13, 57, -52, -75, -55; /M: SY='V'; M= -51, -66, -77, -74, -57, -23, -81, -24, -71, -44, -46, -71, -75, -73, -74, -10, 23, 95, -87, -63; /M: SY='R'; M= -66, -81, -62, -53, -63, -75, 13, -71, -16, -69, -60, -1, -75, 11, 101, -60, -63, -9, -68, 43; /M: SY='S'; M= 16, -66, -4, 19, -73, -57, -60, -13, -54, -70, -65, 13, -63, -51, -19, 73, 46, -60, -83, -67; /M: SY='N'; M= -60, 33, -15, -54, -74, -59, 11, -77, 18, -78, -67, 85, -23, -48, 51, 29, -19, -74, -84, -23; /M: SY='H'; M= -6, -75, 19, 40, -74, -65, 53, -2, 2, -68, -3, 19, -65, 43, 7, 30, -19, -35, -82, -62; /I: I=-14; MI=0; MD=-35; IM=0; DM=-35; /M: SY='K'; M= -13, -91, 18, -3, -93, -43, -5, -84, 30, -87, -80, 5, -83, 16, 25, -31, -73, -9, -97, -81; D=-14; /I: I=-14; DM=-35; /M: SY='G'; M= -42, -87, -77, -81, 18, 26, -16, -79, -35, -4, -72, 25, -88, -19, -30, -11, 3, -79, -83, 9; D=-14; /I: I=-14; DM=-35; /M: SY='E'; M= -25, 0, -12, 52, -5, 15, -67, -83, -4, -45, -76, 7, -73, -17, -66, 30, -21, -78, -86, -74; D=-14; /I: I=-14; DM=-35; /M: SY='V'; M= 1, -73, 9, -71, -14, -33, -72, 43, -73, 18, -46, -71, -9, -71, -75, -16, -58, 49, -73, 26; D=-14; /I: I=-14; DM=-35; /M: SY='G'; M= -51, -78, -7, -20, -84, 94, -70, -91, -68, -87, -77, -51, -69, -65, -76, 11, -65, -84, -78, -78; D=-14; /I: I=-14; DM=-35; /M: SY='F'; M= -33, -74, 4, -6, 106, -77, 17, -56, -65, -49, -55, -67, -3, -71, 8, -31, -64, -60, -50, -28; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='L'; M= -65, -71, 9, -67, -5, -81, 31, -13, -71, 73, 20, -70, -79, 2, -70, -69, -6, -5, -74, -52; /M: SY='W'; M= 14, -73, -17, -53, -71, -4, -60, -70, 36, -26, -63, -15, -68, 34, 36, 47, -11, -35, 59, -62; /M: SY='N'; M= -61, 6, 74, 24, -76, -17, -53, -28, -54, -30, -69, 75, -69, -52, -62, 14, -52, -28, -92, -70; /M: SY='W'; M= -5, -76, -17, 18, -4, -66, -65, -60, -7, 4, -60, -63, 66, -57, -64, 44, -54, -6, 69, -2; /M: SY='R'; M= -64, -76, -53, -50, -76, -67, 44, -79, 45, -76, -64, 60, -70, 0, 80, -54, 9, -75, -81, -62; /M: SY='R'; M= -65, -80, -65, -54, -71, -78, -56, 1, -30, -33, -58, -58, -74, -9, 106, -60, 3, -23, -76, -62; /M: SY='L'; M= -66, -70, -85, -78, 51, -85, -69, 25, -77, 67, 49, -80, -81, -73, -75, -75, -62, 10, -65, -45; /M: SY='N'; M= -62, 53, -41, -60, -69, -54, -46, -70, -52, -77, -67, 116, -75, -53, -59, -47, -49, -21, -87, 18; /M: SY='V'; M= -52, -66, -79, -72, -56, -82, -82, -23, -3, -42, -44, -73, -76, -73, -70, -63, 9, 98, -87, -62; /M: SY='A'; M= 94, -62, -67, -61, -75, -28, -69, -63, -63, -66, -61, -61, -66, -59, -67, -12, -13, -18, -76, -71; /M: SY='M'; M= -63, -71, -85, -79, 12, -85, -73, 59, -76, 49, 64, -78, -78, -72, -76, -73, -59, 36, -72, -52; /M: SY='T'; M= -48, -62, -57, -59, -70, -60, -64, -64, -57, -68, -63, -46, -61, -56, -64, 68, 96, -56, -86, -66; /M: SY='R'; M= -10, -82, -64, -52, -76, -75, -53, -81, -25, -74, -64, -57, -75, -41, 114, -60, -65, -74, -76, -63; /M: SY='A'; M= 90, 36, -68, -61, -76, -22, -70, -67, -63, -69, -63, -63, 30, -61, -69, -44, -54, -55, -77, -73; /M: SY='K'; M= -61, -78, -57, -44, -78, -70, -56, -34, 87, -74, -63, -50, -66, 45, 56, -1, -58, -72, -73, -64; /M: SY='S'; M= 0, -74, 12, -23, -62, -64, 46, -69, -2, -27, -60, -52, -69, 29, 43, 51, -19, -32, -70, 44; /M: SY='G'; M= -53, -73, -63, -59, -69, 48, 43, -62, 27, 2, 3, -53, -69, 19, -7, 44, -55, 5, -78, -62; /M: SY='L'; M= -64, 3, -83, -76, 18, -84, -69, 9, -76, 72, 47, -78, -81, -71, -74, -72, -9, 17, -71, -51; /M: SY='Y'; M= -10, 24, -77, -16, 33, -81, -66, 59, -72, 20, -43, -75, -78, -70, -73, -68, -61, 12, 26, 64; /M: SY='I'; M= -60, 7, -85, -80, -50, -86, -81, 75, -77, 13, 26, -77, -77, -75, -78, -71, -56, 64, -79, -58; /M: SY='F'; M= -63, -71, -84, -79, 62, -85, -77, 56, -76, 28, -40, -76, -79, -77, -77, -70, -5, 50, -66, -45; /M: SY='G'; M= -15, 51, -66, -74, -80, 93, -72, -81, -15, -80, -72, -53, -70, -67, -73, -51, -65, -19, -76, -76; /M: SY='N'; M= -61, 6, 55, -50, -77, -57, 51, -78, -51, -80, -70, 91, 2, -52, -7, 17, -6, -77, -95, -66; /M: SY='P'; M= 3, -74, -65, -23, -66, -26, -4, -21, -3, 9, 55, -2, 60, 10, 4, 6, -25, -1, -78, -64; /M: SY='D'; M= 0, -75, 46, -5, -72, -66, 41, 5, 6, -23, -60, 21, -14, 19, 38, 15, -56, -23, -83, -63; /M: SY='T'; M= 23, 7, -5, -66, -56, -20, -67, -20, -67, 43, 6, -62, -19, -65, -70, -4, 48, 5, -76, -3; /M: SY='L'; M= -64, -70, -82, -75, 30, -83, -71, 35, -14, 69, -35, -77, -80, -70, -71, -17, -60, 11, -69, -50; /I: I=-29; MI=0; MD=-75; IM=0; DM=-75; /M: SY='R'; M= 31, 1, -60, 8, -75, 6, -62, -72, 15, -71, 25, 12, -70, -5, 38, 34, -56, -35, 20, -68; D=-29; /I: I=-29; DM=-75; /M: SY='R'; M= -32, 33, -61, -18, 13, -31, 1, -35, 27, -28, -63, 13, -72, 12, 45, 43, -29, -29, -77, -61; D=-29; /I: I=-29; DM=-75; /M: SY='N'; M= -18, 48, 51, -22, -71, -21, 6, -67, -57, -71, -66, 58, -69, -13, -63, 38, 24, 2, -87, -9; /M: SY='P'; M= -29, -82, -5, 14, -81, -28, -60, -75, 21, -78, -4, 15, 92, 17, 20, -12, -57, -75, -79, -73; /I: I=-42; MI=0; MD=-106; IM=0; DM=-106; /M: SY='L'; M= -21, 29, -5, -25, 23, 9, 7, -4, -71, 56, -43, -19, -16, -67, -72, -66, -62, -23, -67, 25; /M: SY='W'; M= -70, -83, -91, -78, 47, -77, -81, -20, -74, 34, -52, -85, -81, -73, -75, -18, -72, -29, 148, 2; /M: SY='K'; M= -3, -74, -51, 28, -72, -2, 0, -76, 52, -75, -5, 49, -66, -46, 26, 28, -54, -72, 33, -12; /M: SY='K'; M= -32, -74, 35, -2, -74, -66, 24, -69, 51, -15, -62, -17, -66, 45, 8, 33, 10, -33, -80, -63; /M: SY='L'; M= -28, -72, -84, -77, 37, -82, -67, 21, -75, 64, 7, -80, -81, -72, -74, -73, -63, 6, 54, 39; /M: SY='I'; M= -62, -73, -82, -78, -46, -84, -76, 66, -75, 39, -38, -76, -77, -72, -76, -27, -8, 42, 59, 11; /M: SY='N'; M= -3, -74, 12, 56, 12, -64, 7, -73, -2, -38, -65, 69, -67, 29, -10, -52, -19, -71, 23, -61; /M: SY='W'; M= -63, -75, 24, 17, 28, -70, 42, -64, 2, -4, -58, -8, -70, -54, 8, 12, 24, -65, 56, 53; /I: I=-36; MD=-90; /M: SY='C'; M= 20, 89, -81, -76, -13, -77, -75, 17, -76, 43, -48, -75, -4, -74, -78, -31, -27, -25, -78, -14; D=-36; /I: I=-36; MI=0; MD=-90; IM=0; DM=-90; /M: SY='E'; M= -59, -75, -50, 65, -69, -72, 42, -29, 25, 1, 7, -12, -65, 15, 7, 4, -18, 6, -80, -62; /M: SY='E'; M= -34, -77, 34, 62, -75, -30, 19, -79, 42, -75, -68, 9, -63, 34, -10, -9, -4, -74, -77, 5; /M: SY='N'; M= -62, 20, -8, 0, -74, -62, 41, -74, -43, -30, -63, 83, -71, 35, 51, -16, 5, -73, -86, -64; /I: I=-38; MI=0; MD=-97; IM=0; DM=-97; /M: SY='N'; M= 10, -73, 22, 19, -78, 33, 41, -77, 15, -77, -68, 62, -67, 7, -55, 11, -55, -38, -84, -67; /M: SY='W'; M= 20, 2, -18, -22, -56, -12, -63, 1, 11, 8, -54, -2, -14, -17, -27, 3, 1, 2, 54, 39; /M: SY='I'; M= -62, -71, -81, -75, -10, -83, -73, 55, -73, 49, 48, -75, -76, -15, -74, -69, 9, 32, 22, -53; /M: SY='Q'; M= -6, 13, -68, -6, 16, 10, 9, 19, -58, 7, -1, -64, -2, 46, 14, -60, -61, 7, -67, 27; /M: SY='C'; M= -62, 56, 15, -26, 33, -6, 5, -65, -6, -15, -60, 32, 22, -10, -19, -32, 37, -65, -69, 33; /M: SY='E'; M= 21, -72, 16, 33, -66, -15, -63, -4, 5, 18, 4, 19, 19, -55, -61, -55, 19, -15, -80, -66; /M: SY='C'; M= -62, 61, -24, -66, 35, 5, -13, -11, -66, 17, -56, 38, 28, 2, -70, -10, 26, -59, -76, -58; /M: SY='P'; M= -16, 6, 26, -1, 15, 10, -62, -13, 4, -18, -62, -58, 50, 43, -61, -5, -21, -66, -72, 9; /M: SY='W'; M= -14, -78, 24, 36, -70, 1, 9, -73, 18, -36, -66, 37, 25, 16, -56, -16, -23, -38, 42, 16; /M: SY='M'; M= -14, -74, 16, 0, -19, -69, -56, -2, 0, -5, 44, 23, -70, 37, 20, -2, 17, -59, -73, 23; /M: SY='Y'; M= -65, 10, -18, 8, 2, -76, 29, -2, -63, 24, -52, -24, 23, 39, -65, -11, -9, -10, -68, 46; /M: SY='D'; M= -34, -4, 50, 11, -73, -7, -60, -27, 10, -8, -64, 13, 27, 30, 21, -60, -61, -27, -81, -8; /M: SY='F'; M= -8, -77, -65, 6, 33, -73, 7, -24, 22, 8, -59, 6, 4, 3, -9, 19, -22, -23, -76, -59; /M: SY='Q'; M= -18, -79, -16, -16, -28, -73, 8, 11, -25, -12, -60, 16, -76, 45, 17, 18, 4, -10, -81, -7; /M: SY='H'; M= -5, -81, -67, -25, 2, -2, 57, 7, 21, -19, -62, -16, 5, 29, -8, 12, -63, -67, -81, -62; /M: SY='N'; M= -5, -77, 20, 33, -19, -8, 3, -35, -1, -11, -6, 37, -72, -59, -65, -26, 24, -27, -87, -69; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 67 in 65 different sequences |
| Number of true positive hits | 67 in 65 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria), Eukaryotic viruses |
| Maximum number of repetitions [info] | 2 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | UPF1-type SF1B helicase ATP-binding |
| Feature key [info] | DOMAIN |
| Feature description [info] | UPF1-type SF1B helicase C-terminal |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
65 sequences
AQR_HUMAN (O60306), AQR_MOUSE (Q8CFQ3), ARMI_DROME (Q6J5K9), CWF11_SCHPO (O94508), DNA2_BOVIN (E1BMP7), DNA2_CHICK (Q5ZKG3), DNA2_HUMAN (P51530), DNA2_MOUSE (Q6ZQJ5), DNA2_RAT(D3ZG52), DNA2_SCHPO (Q9URU2), DNA2_XENLA (Q8QHA5), DNA2_XENTR (F6QXW0), DNA2_YEAST (P38859), ECM32_YEAST (P32644), HCS1_SCHPO (O94247), HCS1_YEAST (P34243), HELZ2_HUMAN (Q9BYK8), HELZ2_MOUSE (E9QAM5), HELZ_DANRE (Q6NYU2), HELZ_HUMAN (P42694), HELZ_MOUSE (Q6DFV5), HRR1_SCHPO (O74465), JHS1_ARATH (A0A1P8ASY1), M10B1_DANRE (Q1LXK4), M10B2_DANRE (Q1LXK5), M10L1_HUMAN (Q9BXT6), M10L1_MOUSE (Q99MV5), MAA3_ARATH (B6SFA4), MOV10_BOVIN (Q0V8H6), MOV10_CHICK (Q5ZKD7), MOV10_HUMAN (Q9HCE1), MOV10_MOUSE (P23249), R1AB_AMV79 (F8RL29), RENT1_ARATH (Q9FJR0), RENT1_CAEEL (O76512), RENT1_DANRE (F1RCY6), RENT1_DICDI (Q54I89), RENT1_DROME (Q9VYS3), RENT1_HUMAN (Q92900), RENT1_MOUSE (Q9EPU0), RENT1_NEUCR (Q9HEH1), RENT1_SCHPO (Q09820), RENT1_TAKRU (Q98TR3), RENT1_YEAST (P30771), SDE3_ARATH (Q8GYD9), SEN1_SCHPO (Q92355), SEN1_YEAST (Q00416), SETX_HUMAN (Q7Z333), SETX_MOUSE (A2AKX3), SMBP2_HUMAN (P38935), SMBP2_MESAU (Q60560), SMBP2_MOUSE (P40694), SMBP2_RAT (Q9EQN5), Y104_METJA (Q57568), Y140_MYCGE (P47386), Y153_MYCPN (P75033), Y4399_DICDI (Q86AS0), YGSA_SCHPO (O94387), YJHR_ECOLI (P39369), YQ12_CAEEL (Q09449), ZGRF1_HUMAN (Q86YA3), ZGRF1_MOUSE (Q0VGT4), ZNFX1_CAEEL (E9P860), ZNFX1_HUMAN (Q9P2E3), ZNFX1_MOUSE (Q8R151)» more
|
| PDB [Detailed view] |
54 PDB
pdb_00002gjk; pdb_00002gk6; pdb_00002gk7; pdb_00002wjv; pdb_00002wjy; pdb_00002xzl; pdb_00002xzo; pdb_00002xzp; pdb_00003jb9; pdb_00004b3f; pdb_00004b3g; pdb_00004pj3; pdb_00005ean; pdb_00005eaw; pdb_00005eax; pdb_00005mqf; pdb_00005mzn; pdb_00005xjc; pdb_00005yzg; pdb_00005z56; pdb_00005z57; pdb_00006ej5; pdb_00006ff7; pdb_00006i59; pdb_00006icz; pdb_00006id0; pdb_00006id1; pdb_00006qdv; pdb_00007a5p; pdb_00007abi; pdb_00007w59; pdb_00007w5a; pdb_00007w5b; pdb_00008c6j; pdb_00008ch6; pdb_00008i0p; pdb_00008i0r; pdb_00008i0s; pdb_00008i0t; pdb_00008i0u; pdb_00008i0v; pdb_00008i0w; pdb_00008ram; pdb_00008ran; pdb_00008rao; pdb_00008rap; pdb_00008rd3; pdb_00008ro2; pdb_00009esh; pdb_00009esi; pdb_00009fmd; pdb_00009q9z; pdb_00009qdq; pdb_00009qwn » more |