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PROSITE entry PS52095


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PURL: https://purl.expasy.org/prosite/signature/PS52095

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General information about the entry

Entry name [info] FAF
Accession [info] PS52095
Entry type [info] MATRIX
Date [info] 10-JUN-2026 CREATED;
10-JUN-2026 DATA UPDATE;
10-JUN-2026 INFO UPDATE.
PROSITE Doc. [info] PDOC52095
Associated ProRule [info] PRU01439

Name and characterization of the entry

Description [info] FANTASTIC FOUR (FAF) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=54;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=49;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.7001603; R2=0.0066236; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1027; N_SCORE=9.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=574; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-29; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='P';  M= -66, -90, -67, -56, -84, -68, -70, -72, -63, -58, -69, -72, 126, -66, -75, -63, -22, -77, -79, -82;
/M: SY='P';  M= -66, -91, -65, -23, -85, -68, -69, -74, -62, -84, -70, -72, 126, -65, -74, -63, -26, -78, -79, -83;
/M: SY='P';  M=   1, -83, -67, -58, -78, -67, -68, -28, -62, -29,  10, -69, 114, -64, -32, -13, -14, -67, -79, -76;
/M: SY='L';  M= -37,  -5, -84, -78, -45, -84, -72,  58, -77,  71,  38, -78, -79, -70, -76, -41, -61, -33, -73, -55;
/M: SY='P';  M= -54, -73, -61, -58, -13, -18, -64, -67, -57, -71,   1, -29,  77, -21,   5,  53,  53, -39, -79, -67;
/I:         I=-19; MD=-49;
/M: SY='S';  M= -53,  46, -66, -65,  -8, -39,  14, -21, -62,  -5, -61, -56, -34, -59, -14,  72,  29, -24,  61, -59; D=-19;
/I:         I=-19; MD=-49;
/M: SY='L';  M= -67, -74, -81, -15, -17, -45, -71,  30, -75,  66,  49, -79, -81, -22, -75, -48, -64,  -7,  -3, -56; D=-19;
/I:         I=-19; MD=-49;
/M: SY='R';  M=  31, -73, -23, -62, -78,  16, -64, -74, -25, -52, -20,  34, -73, -57,  42,  35,   8, -39, -84, -72; D=-19;
/I:         I=-19; MD=-49;
/M: SY='G';  M=  -4, -79, -30,  11, -78,  48, -66, -76,  -7, -26, -20, -58, -72,   6,  42,  14, -32, -34,   9, -71; D=-19;
/I:         I=-19; MD=-49;
/M: SY='T';  M= -33, -94, -13, -77, -99,   4, -83, -93,   9, -96, -89,  16, -90,  -1,  -6, -20,  26, -44,-105, -91; D=-19;
/I:         I=-19; MI=0; MD=-49; IM=0; DM=-49;
/M: SY='G';  M= -42, -16,  -3, -15, -95,  57, -27, -96, -81, -66, -22, -27, -87, -29, -51, -27, -48, -53,  15, -88; D=-19;
/I:         I=-19; DM=-49;
/M: SY='R';  M=  -7, -82,  -1, -37, -77, -16, -65, -72,  12, -34,  38, -19,  21,   1,  54,  11, -63, -27,  12, -70; D=-19;
/I:         I=-19; DM=-49;
/M: SY='P';  M=   6, -83, -12, -33, -77,  -1, -21, -69, -41, -43,  18, -22,  81, -31,  15, -39, -17, -14,  38, -72; D=-19;
/I:         I=-19; DM=-49;
/M: SY='W';  M= -59,  46, -67, -14, -67,  30, -68, -23, -12, -22,  -5, -31,  11, -30,  24,  31,  -7, -35,  76, -14; D=-19;
/I:         I=-19; DM=-49;
/M: SY='W';  M=  -2, -71, -26, -69,  49, -41, -70,  -2, -18,   7,   6, -69, -24, -67,  16, -36,  -2,  45,  58, -18;
/M: SY='Q';  M= -14, -19, -17,  -3,  17, -70,   9, -32, -11,  14,  43, -18, -72,  53,  20,  18, -57,  -8, -70,   8;
/M: SY='M';  M= -37, -71,  -9, -37,  29, -79, -65,  -6,  -3,  40,  71, -69, -76, -63,  17, -46, -36,  31,   9, -51;
/M: SY='R';  M= -35, -20, -25,  -6, -72, -72,  20, -24,  44, -66,  10, -25, -69,  20,  72, -16,   6,   5, -79, -62;
/M: SY='S';  M=  23,  -6, -60,  -2, -24, -31,   9, -27, -24, -45, -62, -56,  46, -25,  22,  48,  27, -62, -75,   2;
/M: SY='H';  M= -63,  -7,  -6,  27, -18, -74,  83, -34, -33, -60, -13, -17, -72, -22,  32, -16, -60,  21, -66,  67;
/M: SY='R';  M= -64, -21, -16, -12, -72, -74, -54, -77,  10, -73, -64, -30, -24, -44,  98, -32,  33, -71, -75,  -2;
/M: SY='E';  M= -35, -77,   8,  65, -77,   4, -55, -77,  25, -75, -68,  10, -64,  28,  29,  15, -32, -32, -78, -20;
/M: SY='D';  M= -62, -14,  90,  21, -84,  35,  -9, -85, -55, -83, -77,  56, -67, -53, -63, -52, -57, -81, -92, -72;
/M: SY='G';  M= -50, -77, -36, -16, -83,  98, -69, -90, -64, -85, -75, -50, -68, -63,   0, -50, -68, -83, -74, -77;
/M: SY='R';  M= -66, -82, -63, -51, -75, -76, -53, -81,  -3, -54, -63, -56, -75, -40, 114, -29, -64, -75, -76, -62;
/M: SY='L';  M= -68, -69, -85, -78,  50, -86, -69, -18, -78,  83, -32, -82, -84, -74, -75, -77, -63, -24, -64, -45;
/M: SY='V';  M= -58, -71, -77, -24, -16, -83, -76,  47, -68,  13, -41, -74, -76,  20, -20, -66, -34,  76, -79, -58;
/M: SY='L';  M= -63, -70, -85, -78, -45, -86, -72,  47, -76,  66,  51, -80, -80, -71, -75, -74, -59,  34, -74, -55;
/M: SY='T';  M= -14, -72, -31,  37, -21, -42, -58, -40,  38, -69, -63, -15, -64,  29,  31,  10,  51, -33, -76, -24;
/M: SY='E';  M=  58, -70, -53,  63, -73, -38, -63, -11, -34, -26, -60, -60, -27,   7, -17,  -9, -26,  -9, -78, -69;
/M: SY='V';  M=  -9, -19, -68,  29, -28, -78, -74,  11, -29, -24,  15, -70, -72,  -8, -67, -61,  -7,  79, -82, -62;
/M: SY='P';  M= -43, -17, -26, -21, -77, -41, -61, -70,  39, -74, -65, -29,  69, -22,  62,  -8,  17, -10, -79, -69;
/M: SY='V';  M=  -5, -70, -71, -38, -57, -50, -71,  43, -67,   1,  16,  20,  15, -39, -38, -34,   2,  58, -79, -23;
/M: SY='P';  M= -28, -20, -11,  18, -74, -14,  17, -67,   0,  -8,  -5,  10,  76, -12,   2,  15, -29, -27, -80, -68;
/M: SY='R';  M=  -5, -73, -22, -56,  -8, -17,   2, -39, -15, -33, -61,  -2,  29,  11,  50,  41,  16, -15, -75, -10;
/I:         I=-22; MD=-55;
/M: SY='P';  M= -28,  17, -64, -32, -25, -29,  46, -74, -13, -54, -64, -29,  68,  36,  49,   5, -61, -31, -78,  -8; D=-22;
/I:         I=-22; MD=-55;
/M: SY='E';  M= -46, -79,  -2,  68,  -6, -26,  34, -79,  18, -50, -68,  16, -11,  18,  11,  -6, -14, -75, -80, -65; D=-22;
/I:         I=-22; MI=0; MD=-55; IM=0; DM=-55;
/M: SY='Y';  M= -66,  59, -72, -73,  24, -78,  19,  27, -44, -18, -10,   8, -30, -67,  -5, -30,  -4,   7, -60,  73; D=-22;
/I:         I=-22; DM=-55;
/M: SY='F';  M= -36,  -7, -83, -76,  80, -42, -68,   0, -72,  48,  23, -76, -24, -74,  -6, -71, -63,   3, -59, -39;
/M: SY='H';  M= -42,  22, -32,  30, -67, -74,  66, -65,  -7,  16, -55, -24, -13,  41,  54, -59,  -8, -28, -79, -26;
/M: SY='A';  M=  81, -13, -66, -60, -73, -53, -68, -60, -62, -66, -61, -59,  -6, -19, -66,  34,   0,   7, -78, -70;
/M: SY='H';  M= -33,  33, -23,  43, -37, -41,  56, -42,   0, -69,  -6, -53, -15,  37,  30,  29,   7, -69, -12, -10;
/M: SY='R';  M= -38,  14, -61, -17, -77, -48, -54, -82,   7, -75, -64, -56, -73,  14, 106, -27, -63, -75, -76, -64;
/M: SY='E';  M= -11,  28,   8,  55, -76,  -7,  -9, -44, -49, -53, -65, -16, -65,  53,   9,  35,  -2, -39, -79, -25;
/M: SY='D';  M= -34, -76,  76,   2, -78,  31,  57, -83, -31, -80, -72,  57, -68, -52, -27, -13, -57, -80, -88, -19;
/M: SY='G';  M= -50, -77, -66, -76, -79,  99, -72, -82, -69, -82, -73, -52, -69, -67, -40, -51, -67, -16,  14, -75;
/M: SY='R';  M= -66,  19, -63, -53, -75, -41,   9, -82,  -9, -75, -64, -55, -75, -42, 110, -39, -34, -75, -77, -62;
/M: SY='L';  M= -36, -69, -34, -75,  -3, -42, -69, -33, -77,  83, -32, -80, -83, -71, -75, -74, -62,  13, -71, -53;
/M: SY='R';  M= -60, -19, -64, -26, -66, -38, -62,   3,  31, -14, -15, -57, -70, -20,  71, -23,  41,  18, -78, -63;
/M: SY='L';  M= -66, -70, -82, -34, -43, -85, -68,  26, -75,  80,  54, -80, -80, -68, -74, -75, -62, -21, -72, -54;
/M: SY='H';  M= -35,  17,   7, -20,   5, -16,  52, -72,  12, -32, -62,  -5, -69,  44,  34,  32,  21, -69, -77, -23;
/M: SY='F';  M= -70,  10, -85, -80,  88, -42, -18,   9, -77,  50,  27, -77, -83, -77, -75, -74, -65, -46,  11, -35;
/M: SY='V';  M=  27, -15, -27, -68, -17, -73,  16,  32, -16,   6,  -5, -36, -75, -65, -14, -24, -55,  55,  -4,   0;
/M: SY='E';  M= -45, -78,  37,  45,  -3, -41,  43, -22,  -8, -45, -64,  -1,  41,  29,  -4,   6, -14, -43, -78, -21;
/I:         E1=0; IE=-380; DE=-380;
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Comments [info]

Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] FAF
Version [info] 1