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PROSITE entry PS52096


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PURL: https://purl.expasy.org/prosite/signature/PS52096

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General information about the entry

Entry name [info] SACK1
Accession [info] PS52096
Entry type [info] MATRIX
Date [info] 02-SEP-2026 CREATED;
02-SEP-2026 DATA UPDATE;
02-SEP-2026 INFO UPDATE.
PROSITE Doc. [info] PDOC52096
Associated ProRule [info] PRU01440

Name and characterization of the entry

Description [info] Scaffold anchor of CK1 (SACK1) domain profile.
Matrix / Profile [info]
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=268;
/DISJOINT: DEFINITION=PROTECT; N1=6; N2=263;
/NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=3.0503893; R2=0.0070905; TEXT='-LogE';
/CUT_OFF: LEVEL=0; SCORE=1192; N_SCORE=11.5; MODE=1; TEXT='!';
/CUT_OFF: LEVEL=-1; SCORE=487; N_SCORE=6.5; MODE=1; TEXT='?';
/DEFAULT: M0=-49; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380;
...
                A    C    D    E    F    G    H    I    K    L    M    N    P    Q    R    S    T    V    W    Y
/I:         B1=0; BI=-380; BD=-380;
/M: SY='N';  M= -72,  55, -68,  10, -90, -77, -73, -89,  25, -13, -82,  71, -87, -67,  17,  65, -65, -86,-101, -85;
/M: SY='E';  M= -78, -99, -52, 109,-101, -93, -70,-101, -57, -94, -88, -74, -75,  28,  15, -74, -79, -94, -97, -89;
/M: SY='W';  M=  13, -91, -72,  45, -84,  -4, -75, -88, -64, -89, -83,  19, -85, -66,  53,  46, -72, -12,  55,  23;
/M: SY='Q';  M=  42, -94, -75,  17, -77, -83,  41, -88, -65, -84, -76, -75, -87,  84,  32, -70, -78, -85, -79,  69;
/M: SY='R';  M= -85,-101, -81, -70, -86, -95, -68, -98, -43, -91, -80, -75, -94, -59, 117, -79, -83, -93, -87,  27;
/M: SY='L';  M= -12, -87, -92,   6, -65, -96, -84, -20, -86,  79,   8, -92, -95, -81, -16,  -7, -77,  -7, -91, -74;
/M: SY='A';  M=  96, -80,  15, -74, -94, -67, -85, -84, -79, -86, -80, -76, -84, -75, -84,   8, -69, -72, -95, -88;
/M: SY='L';  M= -14, -86, -97, -92, -65, -98, -89,  32, -91,  70,  13, -92, -95, -87, -92, -83,  28,  26, -93, -74;
/M: SY='D';  M= -81, -97,  87,  80,  14, -89, -73, -89, -68, -89, -89, -65, -81, -64, -77, -75, -76,   0,-102, -82;
/M: SY='A';  M=  81,  16, -80,  23, -91,   0, -85, -27, -78, -83, -78, -78, -84, -15, -83,  -3, -25,   1, -95, -88;
/M: SY='L';  M= -84,  46,-102, -94, -60,-103, -87, -52, -96,  92, -48,-100,-102, -89, -93, -94, -81, -58, -90, -72;
/M: SY='L';  M=  14, -85, -99, -92, -64, -97, -90,   1, -92,  74, -52, -96, -97, -88, -92, -85, -35,  46, -93, -75;
/M: SY='E';  M=  25, -90,  32,  57, -97,  23, -75, -96, -67, -95, -88,  20, -82, -65,  20,  46, -70, -89, -99, -88;
/M: SY='G';  M= -74,  43,  39,  23, -95,  60,  29, -92, -18, -92, -86, -14, -86,  -1,  26, -22, -78,   0,-100, -86;
/M: SY='G';  M= -68, -95,  18, -88,-101, 103, -87,-108, -86,-104, -93, -66, -86, -84, -93, -67, -85,-102, -93, -95;
/M: SY='W';  M= -28, -94, -83,  34, -77, -92, -86, -23, -78,  37, -68, -88,  65, -77,  -2,  -9, -14,  23,  70, -79;
/M: SY='E';  M= -13,  46,  32,  86,-100,  19, -74,-100, -66, -94, -89,   9, -80,  38, -74, -71, -77, -93,-100, -90;
/M: SY='A';  M=  87, -83,   4, -76, -95,   5, -86, -86, -80, -89, -82, -76,  38, -77, -86, -13, -16, -76, -95, -90;
/M: SY='Y';  M= -88, -95, -94, -95,  82,  -1, -67, -72, -88, -67,  10, -89,-100, -87, -86, -85, -84, -77,  27, 111;
/M: SY='Y';  M= -21, -98, -81,  -5, -67, -89,  14, -83, -65, -20,  14, -30, -91,  65,  53, -19, -81, -85,  77,  81;
/M: SY='E';  M=   6, -91, -68,  54, -96,  34, -76, -94,   0, -92, -84, -12, -81,  41,  32,  -3,  37, -87, -96, -87;
/M: SY='F';  M=   6,  41, -87,  29,  78, -94, -83, -64, -20, -39, -70, -87, -94, -83, -15, -81, -77,  45, -77,  29;
/M: SY='L';  M= -80, -87,-100, -94, -63,  -2, -89,   1, -94,  81, -51, -96, -99, -89, -93, -90, -78,  36, -91, -74;
/M: SY='K';  M= -25, -92, -69,  36, -94, -82, -73, -35,  61, -88,   1,  13, -82,  55,   8,  44, -70, -32, -95, -83;
/M: SY='R';  M= -14, -93, -69,  42, -96, -27, -73, -93,  32, -91, -82, -12, -82,  56,  63, -36,  43, -87, -95, -84;
/M: SY='E';  M= -33, -96, -53, 105,  17, -90,  30, -97, -62, -90, -87,  19, -77, -56, -71, -74, -77, -92, -95, -81;
/M: SY='R';  M=  -2, -94,   3, -17, -96,  47, -72, -99, -59, -96, -86,  58, -88,   1,  79, -70, -78, -94, -97, -86;
/M: SY='E';  M=  -8, -89, -82,  54, -72, -98, -86,  37, -82,  46,  16, -89, -89, -77, -86, -83, -76,  43, -95, -78;
/M: SY='P';  M= -40, -93, -84,  -4, -85,   0, -86, -68, -74, -20, -75, -82,  69, -77,  38,  27, -73,  51,  37, -83;
/M: SY='D';  M= -28, -96,  95, -59, -97, -82, -75, -92, -72, -13, -88,  -2,  61, -73,   5,  12, -73, -91,-107, -88;
/M: SY='F';  M=  -4, -88,-104, -99, 121, -97, -85, -67, -95, -27, -68, -93,-102,-103, -93, -88, -83, -71, -61, -39;
/M: SY='L';  M= -85, -86,-102, -94, -58,-104, -86, -49, -96,  96, -46,-101,-102, -88, -92, -95, -81, -57, -89, -71;
/M: SY='S';  M=  13,  39, -74, -77, -92,   3, -78, -92, -76, -94, -87,  15, -84, -70, -81,  98, -58, -84,-100, -86;
/M: SY='E';  M=  39, -90,  15,  62, -97,  -9, -79, -93, -70, -93, -87, -72,  46, -67, -21,  38,   1, -85, -98, -90;
/M: SY='E';  M= -38, -93,  59,  68, -87, -88, -76, -80, -72,  30, -76, -15,  18, -15, -79,  10, -74, -29,-100, -85;
/M: SY='E';  M= -78, -99,   8, 110,-101, -92, -72,-101, -61, -95, -91, -74,  23, -54, -71, -75, -78, -95, -99, -92;
/I:         I=-5; MI=0; MD=-12; IM=0; DM=-12;
/M: SY='V';  M=   2, -95,-101, -41, -79,-103, -98,  42,   4,  24,  13, -97,-100, -90, -14, -90, -82,  48,-102, -84; D=-5;
/I:         I=-5; DM=-12;
/M: SY='Q';  M= -29,-103,  15,  32,-107, -90,  -6,-103,  15,-100, -90,  35, -91,  82,  13, -19, -82,-101,-104, -90; D=-5;
/I:         I=-5; DM=-12;
/M: SY='Y';  M=  11,-102, -90, -85,  17, -30,  61, -90, -80, -86, -80, -85, -31,  34,  19, -43, -87, -51, -76,  85; D=-5;
/I:         I=-5; DM=-12;
/M: SY='I';  M= -47, -98,-109,-104,  32,-110,-100,  70, -99,   6,  29,-101,-102, -98, -40, -96, -84,  33, -93, -25; D=-5;
/I:         I=-5; DM=-12;
/M: SY='L';  M=  -8,  35, -42, -87, -76, -95, -86,  -5, -87,  47,  -2, -89, -99,  41, -41,  17, -22, -39,  14,  16; D=-5;
/I:         I=-5; DM=-12;
/M: SY='R';  M=  18, -96, -78,  26,-101, -87, -81,-100,  42, -98, -90, -76, -35,   1,  51,  41, -18, -92,-101, -90; D=-5;
/I:         I=-5; DM=-12;
/M: SY='W';  M=  31, -94, -79, -81, -93, -26,  50, -95, -78, -96, -87,  62, -29,  15, -15, -26,  37, -91,  77, -82; D=-5;
/I:         I=-5; DM=-12;
/M: SY='W';  M=  41, -91, -97, -92, -80,  -3, -95,  35, -90,   2, -71, -89, -95, -88, -38,  12, -77,  37,  42, -21; D=-5;
/I:         I=-5; DM=-12;
/M: SY='Q';  M= -83,-102, -72,  56,-102, -94, -76, -98,  43, -95, -87, -76, -87,  64,  56, -17, -82, -26, -98, -88; D=-5;
/I:         I=-5; DM=-12;
/M: SY='D';  M= -31,-101,  53,  42, -97, -13, -85,   3,  -5, -90, -86, -77,  43, -75,   6, -27, -80,  14,-105, -92; D=-5;
/I:         I=-5; DM=-12;
/M: SY='P';  M= -46,-102, -88, -38, -10, -34,  63, -34, -85, -86,   8, -85,  81, -83, -89,   4, -22,  -6,  65,  37; D=-5;
/I:         I=-5; DM=-12;
/M: SY='Q';  M= -52,-100,   1, -14, -95,  -4,  50, -86, -17,  -5,  -4,  19,  51,  58, -39, -78, -16, -17,-103, -86; D=-5;
/I:         I=-5; DM=-12;
/M: SY='W';  M= -83,   9,  -8,  36, -84, -25, -85, -84,  -6, -89, -85, -83,  19,  20, -83, -20,  26,  18,  68,  38; D=-5;
/I:         I=-5; MI=0; MD=-12; IM=0; DM=-12;
/M: SY='V';  M=  19,-103,  11, -96, -98,-101,-105,   3,-100, -22, -87, -96,  13, -98,-105,   9,  -8,  30,-117,-100; D=-5;
/I:         I=-5; DM=-12;
/M: SY='S';  M=  -2,  14,  12, -87,-102, -21, -91, -97, -45,  -7, -93,  21,  33, -87, -95,  51, -34, -95,-113, -99; D=-5;
/I:         I=-5; DM=-12;
/M: SY='E';  M= -90,  14,  31,  52,-109, -16, -83, -24, -72,-102, -95,  -7, -36,  52,  34, -84, -89,-101,-110, -97; D=-5;
/I:         I=-5; DM=-12;
/M: SY='N';  M=  11,  11,  14,  -3,-115,  12,  11,-115, -93,-114,-106,  29,-105, -91, -32,   2, -22,-108,-122,-106; D=-5;
/I:         I=-5; DM=-12;
/M: SY='Q';  M=  33,  14, -97, -38,-110, -27, -95,-102, -84, -44, -95, -20,   8,  47,  27, -86, -42, -45,-112,-103; D=-5;
/I:         I=-5; DM=-12;
/M: SY='G';  M= -86,-110,   3, -99,-116,  70,-101,-119, -46,-117,-108, -84, -20, -96, -19,  -6,  -1,-113,-113,-109; D=-5;
/I:         I=-5; DM=-12;
/M: SY='D';  M=  -6,-107,  29,  18,-106, -13, -92,-101, -21,-105, -99, -16,  17,   8, -92, -11,  11, -19,-112, -13; D=-5;
/I:         I=-5; DM=-12;
/M: SY='E';  M=  22,-102,   5,  43,-107,  25, -93,-101, -87, -42, -97, -84, -19, -83, -95,  20, -32, -36,-110,-102; D=-5;
/I:         I=-5; DM=-12;
/M: SY='D';  M=  -9,-109,  31,  30,-112,   6,  14,-110,  22,-108, -99, -82,  31,  14, -31, -84, -29,-105,-111, -99; D=-5;
/I:         I=-5; MI=0; MD=-12; IM=0; DM=-12;
/M: SY='S';  M=  44,  34, -68,  53, -91, -75, -77, -87, -72, -17, -82,  42, -83, -67, -79,  57, -15, -80, -99, -87;
/M: SY='G';  M=  -8, -91, -10, -18, -94,  68,  13, -92,  -3, -44, -85, -69,  36, -76, -83,  32,  11, -36, -96, -88;
/M: SY='P';  M=  11,  15,  60, -26, -93,  -3,  29, -87, -76, -89,  10, -70,  67,  20, -82,   8, -17, -23, -99, -10;
/M: SY='A';  M=  51, -91,  46,  23, -91,  18,  29,  -8,  14, -89, -83, -70,   8, -71, -26, -15, -75, -81, -95,  -8;
/M: SY='E';  M=  33, -92,  29,  51, -94,  41,  43, -28,   6, -46, -83, -70, -83, -67,   8, -26, -77, -86, -97, -84;
/M: SY='S';  M= -73, -90,  38,   5, -92,  19, -75, -88, -30,  -7, -81,  29,  -6,  38,   0,  45,  30, -86,-100, -85;
/I:         I=-21; MD=-53;
/M: SY='E';  M=   4,-105,  46,  48, -97, -49, -88, -25, -86, -22, -93, -84, -34, -81, -92,  14, -86, -50,-106,  14; D=-21;
/I:         I=-21; MI=0; MD=-53; IM=0; DM=-53;
/M: SY='S';  M= -29,  15, -14,  -7, -32,  30,-100, -29, -96,-106,-102, -86, -31, -93,-103,  37,  25, -98,-114,-102; D=-21;
/I:         I=-21; DM=-53;
/M: SY='S';  M= -17,  31, -42,   3,  14, -96, -96, -30, -22, -43,  -3, -88,  10, -89, -94,  37,  25, -26,-107, -90; D=-21;
/I:         I=-21; DM=-53;
/M: SY='D';  M=   4, -98,  69,   8, -99,   6, -85, -95, -83,   2, -90, -73, -92,  -2, -89,  33, -34, -92,-109, -93; D=-21;
/I:         I=-21; DM=-53;
/M: SY='S';  M=  -9,   0,  21,  33,-100,   4,  34, -93, -77, -94,  11, -77, -92,  12,  10,  35, -80,  -5,-108, -90; D=-21;
/I:         I=-21; DM=-53;
/M: SY='D';  M= -76, -95,  74,  12,-100,  17, -75, -98, -68, -97, -90, -64,  44,  15,  27,  37,  -3, -94,-102, -88;
/M: SY='W';  M=  -4,  69, -82,  11,  16,  27, -85, -76, -82,  13, -75,  29, -91, -81, -87,  16, -29,   6,  70, -76;
/M: SY='S';  M= -71, -90, -74,   0, -83,  -4, -73, -86,  -2,  -4, -79,  20,   7,  35,  14,  66,   2, -84, -90,  27;
/M: SY='S';  M=   2, -83, -75, -74, -93, -68, -78, -91, -75, -95, -87, -64,  20, -68, -80, 106, -55, -83, -99, -85;
/M: SY='G';  M= -74, -91,  38,  -2, -77,  53, -81, -19, -83,  30, -72, -73, -88, -79, -87,   5,  13,   0, -90,  27;
/M: SY='T';  M=  19,   0,  16,  15, -90, -82,  40, -85, -71, -86, -80, -66, -80,  15, -14,   6,  87, -77,-103, -82;
/M: SY='Y';  M= -86, -97, -88, -90,  32, -93, -58, -74, -83, -71, -68, -87, -99, -79, -81,   4, -80, -79, -48, 131;
/M: SY='W';  M= -89,-101,-111, -98,  74, -95, -99, -70, -91, -72, -77,-103, -99, -94, -93, -94, -91,  25, 153,  23;
/M: SY='P';  M= -81,-107, -83, -73,-103, -84, -86, -91, -80,-101, -88, -88, 128, -82, -92,   6, -74, -95, -97, -99;
/M: SY='M';  M= -76, -91,  36,  37, -81,  12, -80,  -4, -77,   3,  73, -77, -87,  13, -19, -78, -14,  39, -98, -80;
/M: SY='R';  M=  12, -93, -20, -21, -92, -83,  61, -85,  -2, -87, -78,  30, -87,  56,  65,   6, -74,   8, -99, -78;
/I:         I=-31; MI=0; MD=-79; IM=0; DM=-79;
/M: SY='S';  M= -59, -82, -74, -75, -92,   3, -77, -92, -75, -95, -88, -62, -81, -67, -80, 108,  -8, -84, -99, -84;
/M: SY='D';  M= -82, -98, 106,  30,-104, -82, -73,-101, -72,-100, -97, -59,  49, -70, -81,   5, -73, -98,-112, -90;
/I:         I=-42; MI=0; MD=-106; IM=0; DM=-106;
/M: SY='T';  M= -75,  15, -81,   3, -79, -12,  40,   3, -31,  29, -67, -75, -87,  25,  -1,   7,  53,   8, -98, -78;
/M: SY='E';  M=  -7, -94,  45,  64, -99, -81, -76, -96, -67, -96, -89, -70,  59, -64,  11,  53, -70, -91,-100, -89;
/M: SY='C';  M=  49,  74, -87,  10, -84, -86, -91,  35, -84, -31, -72, -86,  59, -83, -90, -75, -74,  23, -98, -87;
/M: SY='P';  M= -83,-109, -81,   8,-103, -86, -86, -92, -78,-101, -88, -89, 128, -81, -91, -81, -77, -96, -97,-100;
/I:         I=-29; MD=-75;
/M: SY='D';  M= -12,-118,  13,  -7,-113, -40,-109, -27,-104, -22,-101,  -8,  -4,  -5,-110,-100, -22,   0,-127,-112; D=-29;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='L';  M= -89, -92,-104, -96, -65,-107, -89, -57, -92,  86, -53,-102,-105, -89,   9, -96, -30, -64, -94, -76; D=-29;
/I:         I=-29; DM=-75;
/M: SY='D';  M=  -3, -98,  83,  58, -97, -89, -76, -93, -70,   4, -86, -69, -86,   1,   8, -77, -80, -91,-107, -89; D=-29;
/I:         I=-29; DM=-75;
/M: SY='H';  M=  -5, -91, -93, -89, -68, -98,  80, -63, -91,  76, -56,  -7,-100, -84, -89, -88, -83, -68, -98, -72; D=-29;
/I:         I=-29; DM=-75;
/M: SY='G';  M= -71, -96, -81, -92,-101,  94,  42,-108, -87,-104, -93,  11, -89, -84, -93, -22, -29,-103, -98, -92; D=-29;
/I:         I=-29; DM=-75;
/M: SY='W';  M=  -4,-113,-114, -97, -65, -89,-115, -93, -91, -92, -93,-107, -97, -89, -94,   2, -98,-103, 171, -52; D=-29;
/I:         I=-29; DM=-75;
/M: SY='P';  M= -31, -99, -83, -75, -95, -83, -86, -85, -80, -11, -82, -84, 115, -81, -90,  27,  17, -87, -97, -93;
/M: SY='E';  M=  28,  44,  31,  50, -84, -84, -77, -81, -73, -17,   3, -72, -83,  14, -79,  -3,  46, -25, -95,  15;
/I:         I=-28; MI=0; MD=-70; IM=0; DM=-70;
/M: SY='T';  M= -28, -91,  10, -74, -86, -90, -81, -28,  38,  11,  27,  19, -88,  34, -12, -73,  55, -10,-101, -83; D=-28;
/I:         I=-28; DM=-70;
/M: SY='P';  M= -82,-100,   3,  22,  15,  31,  46, -10,   7, -91, -85, -22,  65, -77, -82, -21, -19, -90, -94, -10; D=-28;
/I:         I=-28; DM=-70;
/M: SY='Y';  M=  38, -91, -86, -83,  39,  17, -80, -87, -77, -85, -81, -78, -91,  14,  26,  30,  13, -83, -82,  46; D=-28;
/I:         I=-28; DM=-70;
/M: SY='W';  M= -15,  46, -99, -95,  46, -95, -80, -75, -91,  21, -72, -94,-102, -89, -91,   3, -84, -79, 101,  84; D=-28;
/I:         I=-28; DM=-70;
/M: SY='R';  M= -81, -94, -80,  -2, -82, -94,  41,  -6,  42,  28, -69, -76,  -7,  21,  66, -78,   0, -30, -94, -77;
/M: SY='G';  M= -71, -95,  23,  -3, -98,  87, -83, -98,   7, -95,  38, -69,  20, -78, -84, -70, -82, -95, -94, -91;
/I:         I=-45; MD=-115;
/M: SY='V';  M= -10,  46, -86,   6,   5, -35, -91,   3,  42, -76, -76, -84,  25, -81, -78, -32, -14,  52, -98, -83; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='T';  M= -66, -81, -74,  -3, -87, -25, -83, -77, -75, -83, -80, -66, -79, -74, -82,  62,  94,   3,-103, -84;
/M: SY='R';  M= -79, -96, -67,  51, -94, -86,  65, -99, -55, -93, -83,  36,   9, -60,  81,  22, -75, -94,-100, -80;
/M: SY='V';  M=  53, -82, -93, -87, -78, -87, -96,   0, -87, -65, -66, -87, -90, -87, -90, -72,  20,  83,-101, -82;
/M: SY='T';  M= -73,  44,  21,   2, -88, -85, -78, -77, -73, -81,  27,  20, -82,  46, -79,  -4,  83,   1,-104, -83;
/M: SY='V';  M=  19, -84, -94, -90, -71, -93, -92,  13, -88,  39,   7, -89, -92, -87, -91, -77,  36,  67, -98, -78;
/M: SY='Y';  M= -86, -95, -90, -89,  13, -96,  52, -65, -86,  41, -61, -89,  21, -82, -84, -86, -81,  -9, -63, 105;
/M: SY='F';  M= -80, -86, -97, -93,  83, -96, -86, -13, -89,  19,  59, -87, -94, -91, -90,  -7,  32,  35, -79, -57;
/M: SY='Q';  M= -79, -98, -70, -61, -89, -83,  82, -94, -62, -88, -76,  45, -87, 106,  15, -17, -77, -95, -91,  28;
/M: SY='P';  M= -30, -99, -84, -75,   4, -86, -86, -85, -80, -91,  -3, -84, 115, -83, -90, -74,  52, -86, -95, -89;
/M: SY='P';  M=   1,-100,  18,   8,-100, -83, -81, -89, -73, -96, -86, -79, 106,  15,   4,   4, -74, -32, -98, -93;
/I:         I=-38; MD=-97;
/M: SY='K';  M=  -2, -96, -84,  12, -14,  19, -85,  -7,  39, -11, -77, -82,  14, -76,  27, -80, -80,  20, -92,   2; D=-38;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='D';  M=   6, -95,  64,  61, -99, -83,  31, -96, -68, -95, -87,  20,  49,  28, -76, -70,   2, -92,-104, -87;
/M: SY='H';  M= -75,  18,  33, -22, -96,  48,  65, -99,  23, -96, -86,  38, -86,  15,  12,   6, -17, -95,-101, -82;
/I:         I=-33; MD=-84;
/M: SY='Q';  M=  44, -94, -89, -81, -90,   5, -85,   3, -81,   9,  27, -18,  21,  56, -23, -18, -80, -77, -97, -87; D=-33;
/I:         I=-33; MD=-84;
/M: SY='P';  M=   9,-106, -90, -80, -93, -90, -88, -90,  -6, -24, -86, -93, 110, -86, -90, -83, -81, -93, -93,  26; D=-33;
/I:         I=-33; MI=0; MD=-84; IM=0; DM=-84;
/M: SY='H';  M= -78, -93, -74, -79, -94,  22,  96, -97, -79, -95, -84,  47,  34, -75, -82,  28,  44, -94,-110, -79; D=-33;
/I:         I=-33; DM=-84;
/M: SY='I';  M= -85,  69,-106,-103, -71,-108,-103,  90, -99,  23, -59, -97, -99, -97,-102, -93, -80,  -1, -98, -80; D=-33;
/I:         I=-33; DM=-84;
/M: SY='K';  M= -82, -97, -75, -62, -95, -89,  41, -97,  96, -95, -82, -68,  22, -59,  54, -76, -77, -94, -92, -81;
/M: SY='E';  M= -79, -97,  78,  89,-101, -88, -71,-100, -64, -95, -92, -64, -77,  19, -73, -71,  13, -94,-104, -89;
/M: SY='V';  M=  37, -84, -86,   2, -77, -89, -88, -55, -81,  24, -64, -84, -89,  30, -85, -73,  27,  66, -98, -80;
/M: SY='I';  M=  47, -86, -97, -91, -73, -91, -96,  63, -90,  10, -60, -91, -92, -88, -93, -78, -72,  61, -96, -79;
/M: SY='R';  M= -82, -98, -81, -71, -89, -92,  10, -93, -46, -12, -78, -74, -92, -60, 112,   7, -80, -89, -94, -78;
/M: SY='R';  M= -82, -98,  14,  23,   4, -91, -71, -93,  46, -36, -80, -71, -87,  56,  82, -76, -80, -91, -91, -77;
/M: SY='M';  M= -80,  84, -91,   3,  17, -95, -80, -64, -83,  34, 104, -85, -92,  18, -85, -82,  10, -67, -92, -72;
/M: SY='I';  M= -82, -93,-101, -99,   8,-105, -99, 100, -94,  11, -54, -91, -92, -92, -97, -87,  13, -22, -89, -71;
/M: SY='R';  M= -75, -94, -73, -65, -96, -82,  -1, -95,  32, -92, -81,  18, -86,  70,  74,  46, -17, -91, -95, -81;
/M: SY='Q';  M=  -6, -93, -70,  -1, -98,   7, -71, -93,  21, -58, -81,  40, -84,  90,  17,  31, -72, -90, -94, -83;
/M: SY='A';  M=  99, -79, -84, -77, -92, -68, -87, -82, -80, -84, -78, -78, -83, -77, -85, -58,  19, -69, -94, -88;
/M: SY='Q';  M= -77, -96, -73,   9, -96,   0,  51, -95, -11, -90, -79, -68, -84,  87,  62,  -3,  27, -91, -95, -78;
/M: SY='Q';  M= -78, -94, -70,  32,  14, -88, -73, -90,  68, -87, -79, -68, -81,  89, -57, -69,  38, -87, -89, -77;
/M: SY='V';  M= -27, -84, -95, -90, -71, -94, -94, -45, -89,  35, -59, -90, -95, -87, -91,  31, -68,  86,-100, -78;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='I';  M= -80, -91,   0, -94, -67,-104, -97,  87, -94,  27, -54, -92, -94, -91, -96, -89, -75,  48, -95, -75;
/M: SY='A';  M=  91, -81, -86, -78, -89, -30, -88, -73,   5, -80, -76, -80, -85, -77, -81, -63, -70,  30, -95, -87;
/M: SY='V';  M= -75, -87,-102, -97, -68,-104,-101,  66, -94,  17, -55, -96, -95, -93, -96, -87, -72,  82, -98, -76;
/I:         I=-20; MI=0; MD=-51; IM=0; DM=-51;
/M: SY='V';  M= -72, -85, -97, -91, -72, -97, -96, -43, -90,  23, -60, -93,  21, -90, -92,   4, -69,  92,-101, -79;
/M: SY='M';  M= -14, -85, -95, -88, -70, -91, -75, -56, -83,  -2, 137, -84, -87, -76, -83, -80,  38, -61, -93, -70;
/M: SY='D';  M= -84, -97, 116, -53,  14,   0, -73,-100, -75, -97, -97, -55, -86, -74, -83, -74, -76, -98,-109, -82;
/M: SY='M';  M= -78, -91, -86,  -3, -75, -94,  57,  24, -78,  13,  68, -11,  22, -77,  19, -19, -75,  46, -98, -75;
/M: SY='F';  M= -92, -90,-106,-100, 117,-100, -87, -65, -95,   2,  15, -96,-102,-102, -93, -92, -85, -71,  71, -40;
/M: SY='T';  M= -67, -79, -75, -77, -86, -82, -84, -78, -75, -83, -79, -64, -77, -77, -82,  40, 112, -70,-105, -83;
/M: SY='D';  M= -85, -99, 120, -50,-105, -83, -71,-103, -69,-101, -99, -54, -85, -70,  13, -73, -75,-100,-118, -87;
/M: SY='V';  M=   2, -89, -91, -88, -78,   8, -91,  39, -87, -26,  29, -11,  47, -86, -91,  -6, -72,  63, -98, -82;
/M: SY='D';  M= -27, -94,  96,  56,  14, -84, -73, -96, -70, -93, -92, -61, -82, -68, -79,   8,   1, -91,-103, -82;
/M: SY='I';  M= -82, -93,-102, -99, -62,-106, -93,  92, -95,  36, -53, -95, -95, -91, -96, -91, -77,  14, -86,  30;
/M: SY='F';  M= -89, -91,-101, -96,  96,-100, -84,  15, -94,  43, -60, -95,  21, -96, -93, -91, -82, -64, -68,  31;
/M: SY='C';  M= -14,  94, -78, -76, -91, -12,  15, -91,  21, -37, -81,  35, -90,  17,  43,  15,  13, -85,-101, -85;
/M: SY='D';  M=  -5,  46, 110,  28,-103, -83, -73,-101, -72, -98, -97, -58, -84, -71, -81, -73, -75, -95,-115, -89;
/M: SY='L';  M= -83, -89,-103, -96,  20,-104, -90,  56, -95,  71,  12, -98, -98, -91, -94, -92, -78,  14, -87, -68;
/M: SY='L';  M= -79,  44, -94, -86, -70, -98,  48, -54, -82,  58,  30, -88, -97,  18,  11, -85, -77,  50, -97, -73;
/M: SY='E';  M= -77, -94,  63,  91, -99, -86, -72, -98, -64, -94, -91,  10, -77, -59, -74,  -4,  28, -91,-104, -89;
/M: SY='A';  M=  97, -80, -85, -79, -92,   3, -87, -20, -81, -84, -78, -79, -84, -77, -86, -25, -70, -70, -93, -89;
/M: SY='A';  M=  82,  64, -84, -80, -93,   8, -86, -87, -81, -88, -82, -75, -86, -77, -86,  45, -68, -75, -97, -89;
/M: SY='C';  M=  -6,  70, -77, -78,  23, -80, -77, -84,   6, -83,  27,  46, -88, -74,  22,  48,  42, -80, -96, -78;
/I:         I=-29; MI=0; MD=-75; IM=0; DM=-75;
/M: SY='K';  M=  -4,-107, -87, -78,-110, -98, -88,-110,  77,-109, -97,  18, -99, -74,  43, -86, -89,-104,-107, -98; D=-29;
/I:         I=-29; DM=-75;
/M: SY='R';  M=  -5, -99, -80, -69, -93, -91,  43, -99, -45, -91, -80, -73, -92,   4, 112, -76, -82, -92, -95, -78;
/M: SY='W';  M= -78, -95, -80, -80,  15,  57,   5, -91,  14, -12, -81,  36, -90, -72,  64, -75, -82, -91,  65, -75;
/M: SY='V';  M= -71, -85,-101, -95, -71,-103,-103,  35, -93, -56, -59, -96, -96, -95, -95, -85, -69, 101,-103, -78;
/I:         I=-9; MD=-23;
/M: SY='P';  M=  28, -96, -88, -81,  33, -85, -90, -83, -85, -89, -84, -86,  96, -86, -92,  13,  11, -12, -94, -84; D=-9;
/I:         I=-9; MD=-23;
/M: SY='V';  M= -74, -88,-102, -95, -77,-103,-105, -42, -94, -62, -65, -99,  21, -97, -97, -87, -72, 101,-108, -84; D=-9;
/I:         I=-9; MD=-23;
/M: SY='Y';  M= -91,  32,  12, -89, -44, -97, -60, -80, -86, -76, -73, -88,-103, -82, -84, -86, -85, -84, -53, 130; D=-9;
/I:         I=-9; MD=-23;
/M: SY='I';  M= -84, -96,-104, -99, -71,-107,-101,  87, -97,  26, -57, -98,  21, -95,-100, -93, -79,  30, -96, -79; D=-9;
/I:         I=-9; MD=-23;
/M: SY='L';  M= -87, -93,-104, -97, -65,-107, -92,  56, -91,  74, -53, -99,-101, -89,  12, -96, -83, -55, -93, -75; D=-9;
/I:         I=-9; MD=-23;
/M: SY='L';  M= -87, -91,-103, -95, -64,-105, -90, -54, -97,  86, -52,-103,  21, -91, -96, -96, -83,  -8, -93, -76; D=-9;
/I:         I=-9; MD=-23;
/M: SY='D';  M= -15,  46, 107, -58,-105, -83, -75,-103, -76,-102, -99,  42, -90, -76, -85, -74, -76, -99,-121, -92; D=-9;
/I:         I=-9; MD=-23;
/M: SY='Q';  M=  18, -98, -68,  67,-102, -87,   9, -98, -14, -94, -85, -74, -83,  79,  20,   7, -78, -93, -98, -86; D=-9;
/I:         I=-9; MD=-23;
/M: SY='Q';  M=  -3, -92, -77,  -2, -95,   1, -77, -90, -67, -89,  33,  11, -87,  55,  44,  32,  43, -86,-100, -86; D=-9;
/I:         I=-9; MD=-23;
/M: SY='N';  M= -79, -95, -11, -74, -96,  36,  48, -95,  -3, -19, -84,  70,   8,  52, -76,   7, -76, -96,-103, -86; D=-9;
/I:         I=-9; MD=-23;
/M: SY='V';  M=  29,   5, -98, -92,   5, -95,  42, -55, -92,  36, -63, -92, -98, -90, -93, -83, -77,  66, -99, -76; D=-9;
/I:         I=-9; MD=-23;
/M: SY='H';  M= -26, -97,  14, -67, -98, -84,  78, -99,  51, -96, -85, -11,  29,  45, -17,  38, -75, -96,-103, -81; D=-9;
/I:         I=-9; MD=-23;
/M: SY='H';  M=  -9,-102, -89, -84, -74, -96,  89, -87,   4,  13, -76, -83,  21,   0, -81, -19, -86, -89, -87,  70; D=-9;
/I:         I=-9; MD=-23;
/M: SY='F';  M=-101, -96,-113,-109, 119,-108, -93, -74,-104, -65, -76,-102,-111,-115,-101, -99, -92, -79, -65, -44; D=-9;
/I:         I=-9; MD=-23;
/M: SY='L';  M= -89, -95,-106, -97, -69,-109, -93, -16, -98,  77, -57,-103,-106,  13, -97, -97, -30,   7, -98, -80; D=-9;
/I:         I=-9; MD=-23;
/M: SY='Q';  M= -33,-102,  36,  61,-107, -91,  28,-103, -71,-100, -92,  37, -88,  68, -77, -75,   1,-100,-109, -91; D=-9;
/I:         I=-9; MD=-23;
/M: SY='M';  M=  -3, -93,-107, -97, -76, -98, -81, -62, -91,  -7, 136, -95, -96, -83, -90, -92, -84, -68, -99, -76; D=-9;
/I:         I=-9; MD=-23;
/M: SY='C';  M=  18, 121,-100, -98, -91, -94,-100, -84, -96, -12, -84, -89,-105, -97,-101,   6,  -1,   4,-115, -97; D=-9;
/I:         I=-9; MI=0; MD=-23; IM=0; DM=-23;
/M: SY='Q';  M= -13, -99,  51,  47, -90,  -2, -73, -94, -15, -90,  32, -71, -86,  67, -74,  -5, -79, -92, -92,  35; D=-9;
/I:         I=-9; DM=-23;
/M: SY='K';  M=  -2, -94,  26, -66,-100, -40, -75, -98,  74, -99, -88,  56, -87,  23,   3,   2, -74, -94,-100, -88; D=-9;
/I:         I=-9; DM=-23;
/M: SY='C';  M=  27,  76, -93, -89, -75, -91, -85, -67, -88,  53,  29,  18, -99,  12, -90, -82, -79,  -8, -97, -10; D=-9;
/I:         I=-9; DM=-23;
/M: SY='Q';  M= -77,  43,   3, -30,-100,  43, -80,-100,   4, -96, -87, -71, -89,  63,  43,   8,  19, -94, -99, -89; D=-9;
/I:         I=-9; DM=-23;
/M: SY='V';  M= -77,  31,-102, -95, -74,-101, -96,   2, -94,  26,  48, -96,   7, -93, -95, -22, -75,  76,-103, -81; D=-9;
/I:         I=-9; DM=-23;
/M: SY='H';  M= -41, -93, -73, -77, -89, -83,  80,   3,  -4, -10, -78,  72,  -7, -14,   3,  24, -13, -84,-107, -79; D=-9;
/I:         I=-9; DM=-23;
/M: SY='P';  M= -87,-101,  47, -81, -86,   5, -90,  26, -21,  30, -74, -84,  55, -86,  -1, -87, -84, -29,-102, -88; D=-9;
/I:         I=-9; DM=-23;
/M: SY='W';  M= -85,-101, -11,  36,   7,  14, -14, -33, -83,  32, -77, -18,  19,  25, -88, -26, -85, -85,  65, -79; D=-9;
/I:         I=-9; DM=-23;
/M: SY='H';  M= -87,-102, -74,  29, -94, -93,  99,-100,  -4, -93,   3,  19,  22,   8,  28, -79,   6, -98,-106,  -9; D=-9;
/I:         I=-9; DM=-23;
/M: SY='H';  M= -83,  46, -89,  16, -75,-101,  49,  13, -83,  46,  31, -87, -95, -81,  10, -85,   7,  13,-100, -78; D=-9;
/I:         I=-9; DM=-23;
/M: SY='K';  M= -79, -95, -10,  44, -89, -92,   5, -77,  52, -32, -77, -75,  39, -65,  49, -77, -17,  33, -97, -83;
/M: SY='N';  M= -79, -87, -61, -74,  10, -74,  12, -86,  15, -18,   3, 110, -90,   2, -71,  -4, -68, -88,-101, -79;
/M: SY='M';  M= -82, -90,-103, -97,  18,-102, -89,  72, -93,  41,  85, -94, -94, -88, -93, -91, -77,  13, -88, -68;
/M: SY='R';  M= -75,  43,  10, -69, -94, -84, -74, -96, -10, -92, -84, -68, -88,  15,  89,  52,   5, -89, -98, -83;
/M: SY='V';  M= -72, -86, -98, -90, -72,-101, -99,  36, -89, -57, -60, -93, -95,  24, -91, -83, -70,  97,-102, -78;
/M: SY='R';  M= -83, -98, -78, -71, -86, -90, -68, -97, -46, -91, -81,  19, -93, -60, 111,  -6, -79, -92, -89,  27;
/M: SY='S';  M= -66, -83, -78, -78, -85, -77, -83,  13, -77, -36, -77, -67,   9, -74, -83,  83,  70, -22,-100, -83;
/M: SY='V';  M= -71,  32, -93, -91, -74,  -3, -94,  20, -89,  11, -63, -85, -93, -88, -92,  27,   2,  77,-100, -80;
/M: SY='T';  M= -24,  33, -73,  29, -93,  48, -82, -91,  -4, -91, -84, -68, -81,  -5, -15,  22,  71, -83, -98, -88;
/M: SY='G';  M= -66, -93, -81, -92,-100, 104, -88,-107, -86,-103, -93, -67, -85, -84, -94,  -4, -83,-100, -92, -95;
/M: SY='Q';  M= -77,  14,  31,  -1, -82, -84,   9, -36, -17, -85, -79,  30,  45,  47, -76,   6,  33,  -5, -91,  44;
/I:         I=-42; MD=-106;
/M: SY='T';  M= -76, -90,   3,  39, -89, -11, -17,  13, -75, -82, -80, -29, -84, -76,  -1, -18,  78,   5,-105, -86; D=-42;
/I:         I=-42; MI=-106; MD=-106; IM=-106; DM=-106;
/M: SY='Y';  M= -94, -98, -98, -98,  90,-101, -69, -74, -92, -68, -71, -95,-105, -92, -89, -90, -87, -79, -53, 110; D=-42;
/I:         I=-42; DM=-106;
/M: SY='Y';  M= -15,  79, -89, -85,  55, -91,  29, -78, -81, -19, -71, -83, -97,  21, -15,   4, -79, -79, -67,  91;
/M: SY='S';  M=  44,  54, -79, -77, -89, -75, -79, -81, -76, -81,  51,   9, -84,  25, -81,  57,  51, -75,-100, -84;
/I:         I=-24; MD=-60;
/M: SY='R';  M= -84,-100, -80, -68, -97, -92, -75,-100,  62, -96, -85, -73,  11, -61,  95,  -6, -80, -95, -95, -84; D=-24;
/I:         I=-24; MD=-60;
/M: SY='S';  M= -12, -88,  22, -74, -12, -79, -81, -87,  18, -87,  30, -68, -85, -73, -18,  71,  50, -82,  37, -80; D=-24;
/I:         I=-24; MD=-60;
/M: SY='G';  M=  18, -93, -84, -89,-100,  88, -88,-102, -82,-100, -91, -71, -87, -82,   7, -17,  10, -94, -95, -94; D=-24;
/I:         I=-24; MD=-60;
/M: SY='T';  M=   4, -94, -82, -76, -97,  -3, -84, -95,  55, -95, -86, -73, -88, -72,  55, -26,  61, -87,-100, -89; D=-24;
/I:         I=-24; MI=-60; MD=-60; IM=-60; DM=-60;
/M: SY='K';  M=  -4, -95, -78, -65, -97, -87, -77, -94,  90, -92,  11, -70, -85,  24,  36,   2, -23, -90, -94, -84; D=-24;
/I:         I=-24; DM=-60;
/M: SY='F';  M= -86, -90,-103,-100,  94,-103, -93,  38, -96,  -6, -64, -94,-100,-100, -96, -88,  10,  36, -76, -54; D=-24;
/I:         I=-24; DM=-60;
/M: SY='K';  M=  13, -89, -83, -75, -87, -85,  28,  -6,  64, -78,  62, -74, -86, -71, -67,  30,  21,   2, -98, -81; D=-24;
/I:         I=-24; DM=-60;
/M: SY='G';  M= -69, -97, -84, -96,-103, 104, -91,-111, -90,-106, -95, -70, -88, -87, -97, -69, -88,-104, -94, -98; D=-24;
/I:         I=-24; DM=-60;
/M: SY='Q';  M=  11, -94, -74,  17, -95, -86,  39,   3,  43, -86, -78, -15, -85,  79, -66, -18,  20, -43, -97, -82; D=-24;
/I:         I=-24; DM=-60;
/M: SY='L';  M=  17, -88,-102, -94, -69, -98, -93,  25, -94,  60,  29, -97, -98, -90, -94, -87, -77,  49, -96, -77; D=-24;
/I:         I=-24; DM=-60;
/M: SY='H';  M=  17, -93, -77,  -3, -91, -26,  82, -92,  28, -22,   3,  -8, -88,  13,  35,  28, -76, -88,-100, -78; D=-24;
/I:         I=-24; DM=-60;
/M: SY='E';  M= -75, -97, -12,  98,-101, -87, -70, -99, -60, -93, -87, -70, -76,  71, -67,  22, -75, -93, -97, -87;
/M: SY='K';  M= -80, -93, -71, -62, -95, -86, -74, -95, 101, -95, -83,  29, -82, -59,  29, -72,  11, -90, -93, -83;
/M: SY='F';  M= -93, -89,-105,-101, 124,-101, -85, -65, -96, -14, -67, -95,-103,-106, -93, -92, -85, -71, -59, -37;
/M: SY='M';  M= -79, -87,-100, -94, -65,-101, -88,  53, -91,  51,  82, -93, -94, -87, -91, -87,   5,  36, -93, -73;
/M: SY='L';  M= -85, -89,-103, -97,  61,-103, -89,  59, -95,  63,  33, -97, -98, -92, -94, -93, -80, -53, -81, -61;
/I:         I=-33; MD=-84;
/M: SY='V';  M= -74,  44, -96, -93, -76, -97, -98,  36, -91, -10, -65, -88, -95, -91, -94,  21,  24,  74,-104, -82; D=-33;
/I:         I=-33; MI=-84; MD=-84; IM=-84; DM=-84;
/M: SY='D';  M= -88,-101, 121, -51,-108, -84, -73,-106, -75,-104,-104, -55, -87, -74, -83, -75, -77,-103,-123, -90; D=-33;
/I:         I=-33; DM=-84;
/M: SY='W';  M= -75,  87, -87,   5, -87,  69, -92, -95, -88,  -5, -86, -79, -93, -85, -94,   5, -84, -92,  87, -85; D=-33;
/I:         I=-33; DM=-84;
/M: SY='D';  M= -27, -95,  64,  44, -96, -87, -77,  -4, -67, -90, -86,  -3, -85,  15,  37,   5,  23, -28,-105, -87; D=-33;
/I:         I=-33; DM=-84;
/M: SY='R';  M=  -8,  -1, -80,   8,  23, -92, -79, -86,  50, -85,   1, -75, -88,  15,  62, -75,  32, -25, -92, -78; D=-33;
/I:         I=-33; DM=-84;
/M: SY='V';  M=  53, -82, -94, -88, -78, -87, -97, -48, -87, -65, -66, -88, -91, -88, -90, -73,   1,  89,-102, -82;
/M: SY='M';  M=  33, -86, -98, -91, -69, -93, -90,  47, -90,  41,  63, -92, -93, -86, -91, -82, -74,  48, -94, -76;
/M: SY='C';  M=  18,  78, -84, -84,   5, -81, -84,   4, -82, -20, -75, -75, -88, -80, -87,  57,  50, -21, -92,  16;
/M: SY='G';  M= -66, -93, -81, -92,-100, 104, -88,-107, -86,-103, -93, -67, -85, -84, -94,  -4, -83,-100, -92, -95;
/M: SY='S';  M= -61, -82, -73, -75, -89, -69, -76, -87, -75, -23, -84,  15, -82, -68, -79, 105,   8, -81,-100, -83;
/M: SY='Y';  M= -87, -97, -88, -91,  32, -94, -57, -74, -84, -70, -68, -88,-100, -79, -81,  -7, -81, -79, -47, 132;
/I:         I=-4; MI=0; MD=-11; IM=0; DM=-11;
/M: SY='S';  M= -62, -83, -72, -75, -92,  -9, -75, -93, -71, -96, -88,  21, -83, -66,  12, 104, -57, -86,-100, -84;
/M: SY='F';  M= -92, -90,-103, -99, 116,-100, -80, -65, -94,   2, -66, -94,-103,-101, -91, -91, -84, -71, -58,  53;
/M: SY='T';  M= -70, -81, -77, -80, -82, -84, -80, -72, -76, -73,  81,  -3, -79, -77, -82,  18, 103, -68,-102, -80;
/M: SY='W';  M= -92,  43,-119, -98, -60, -91,-119, -91, -90, -88, -91,-111, -98, -90, -94, -98,-103,-104, 179, -47;
/M: SY='S';  M= -23, -83, -80, -80, -79, -77, -81,  -5, -80,  35, -71, -71, -85, -74, -83,  88,  36, -70, -97, -80;
/M: SY='D';  M=  42,  62,  69, -71,  56, -80, -81, -85, -81, -82, -83, -69, -89, -80, -86,  23,  11, -80, -92, -72;
/M: SY='W';  M=  44, -88, -73,  47, -92,  47, -82, -94, -76, -93, -87, -72, -82, -70, -82,  55, -71, -86,  68, -84;
/M: SY='H';  M= -82, -97, -76, -65, -89, -89,  93, -93,  67, -85,  39, -68, -86,  44,  59, -76, -80, -92, -95, -14;
/M: SY='I';  M=  11, -86, -96, -91, -69, -96, -94,  55, -90,  44, -57, -89, -92, -88, -92, -79,  33,  49, -95, -77;
/M: SY='H';  M= -85, -95,  59, -65, -91, -82, 130,-102, -73, -92, -79,  62, -87, -67, -73, -72, -78,-101,-119, -65;
/M: SY='R';  M= -79, -96, -80, -71, -90, -90, -72, -93, -47, -23, -79, -73, -91, -61, 109,  28,   0, -88, -94, -80;
/M: SY='N';  M= -69,  49, -65,   8, -94, -23, -70, -94, -70, -96, -87,  82, -86,  35, -76,  74, -63, -90,-104, -87;
/M: SY='N';  M= -82, -87, -87, -90,  40, -93, -81,  23, -86,  50,  57,  61, -96, -85, -88, -83, -75,  23, -89, -68;
/M: SY='V';  M=  39, -85, -98, -91, -70, -92, -93,  39, -90,  41,  12, -93, -94, -88, -92, -80, -73,  62, -95, -77;
/M: SY='H';  M= -75, -88, -83, -81,  17, -88,  70,  21, -81,  16, -67, -74, -88,  13, -82,  41,  50,  -4, -90,  19;
/M: SY='V';  M= -78, -89, -92, -17, -70,-100, -89,  49,  22,  43,  14, -89, -93,  14, -81, -85, -75,  55, -94, -76;
/M: SY='L';  M= -85, -88,-103, -97,  68,-103, -89,  28, -96,  71, -52, -98,-100, -93, -94, -93, -80,   4, -80, -60;
/M: SY='S';  M= -67, -85, -75, -71, -88, -78, -77, -83,   7,  -7, -78, -66, -82,  51,   2,  78,  58, -79, -97, -81;
/M: SY='G';  M= -67, -95, -78,   5,-101, 103, -87,-108, -84,-103, -93, -68, -85, -81, -92, -67, -85,-101, -92, -95;
/I:         I=-38; MI=0; MD=-97; IM=0; DM=-97;
/M: SY='Q';  M= -77,-100, -12,  39,-101, -85,  26, -92, -63, -91, -80, -71,  53, 105, -17,   6, -76, -41, -95, -82;
/M: SY='V';  M=  31, -86, -94, -91, -71, -92, -93,  52, -89,  29, -59,  10, -93, -88, -92, -80, -72,  63, -97, -78;
/M: SY='V';  M= -28, -84, -99, -93, -72,-100,-101,  12, -91, -57,  -2, -93, -95, -93, -93, -82, -10, 100,-104, -79;
/M: SY='E';  M=   2, -92,  14,  92, -98, -84, -74, -96,   8, -93, -88, -69, -76, -58, -70,  34,  11, -88, -99, -88;
/M: SY='M';  M=  -6,  16,   3, -75, -81, -84,  34, -74,   5,  26,  63, -73,  11,  25, -77,  37,  30, -74, -97, -78;
/M: SY='F';  M= -92, -89,-104,-100, 121,-100, -83, -65, -96,  -5, -66, -95,-103,-103, -93, -91, -85, -71, -59,  23;
/M: SY='D';  M= -84, -96, 113, -54, -95, -83, -73,   2, -75, -13, -88,  -6, -86, -74, -82, -20, -74, -87,-114, -85;
/M: SY='E';  M= -80, -97,  15,  78, -90, -93, -73, -38, -58,  10, -78, -74, -83,  25,  65, -76, -14, -84, -96, -83;
/M: SY='E';  M= -77, -99, -52, 107,-102, -92, -70,-100, -58, -93, -87, -73, -75,  67, -66, -72, -78, -94, -96, -88;
/M: SY='F';  M= -93, -89,-105,-101, 123,-101, -85, -65, -96,  -5, -66, -95,-103,-106, -93, -92, -85, -70, -60, -38;
/M: SY='R';  M= -81, -99, -76,   9, -95, -92, -70, -97, -46, -91, -81, -72, -88,  59, 105, -74,  10, -92, -94, -81;
/M: SY='I';  M= -80,  32, -12,  44, -81, -96,  29,  65, -70, -70, -70, -10, -87, -72,  44, -78,  18,   1, -99, -79;
/M: SY='L';  M= -85, -86,-102, -94, -58,-104, -86, -49, -96,  96, -46,-101,-102, -88, -92, -95, -81, -57, -89, -71;
/I:         I=-38; MD=-97;
/M: SY='Y';  M= -89, -99, -92, -94,  47, -96, -62, -77, -87, -73, -72, -91,-103, -84, -85,   3, -83, -81, -52, 125; D=-38;
/I:         I=-38; MI=-97; MD=-97; IM=-97; DM=-97;
/M: SY='A';  M=  86, -84, -90, -83, -88, -35, -89, -79, -85,  20, -75, -84, -89, -81, -89,   6, -73, -72, -96, -88; D=-38;
/I:         I=-38; DM=-97;
/M: SY='Q';  M=  15,  43, -81,  16, -91, -87, -78,  -4, -72, -33,  63, -78, -89,  81,   0,  22, -77, -79, -97, -83; D=-38;
/I:         I=-38; DM=-97;
/M: SY='S';  M= -60, -83, -73, -72, -93, -68, -75, -91, -73, -94, -87, -62, -81,  26, -77, 110, -54, -84, -99, -83;
/M: SY='H';  M= -78,  39, -18,  46, -91, -88,  58, -89,  43, -11, -78,  -8, -83,  57, -14, -29,  32, -86, -99, -79;
/I:         I=-45; MD=-115;
/M: SY='P';  M= -79,-103, -81,   0,-103, -26, -86, -95, -80,-102, -91, -83, 113, -79, -90,  44, -73, -96,-100, -98; D=-45;
/I:         I=-45; MI=-115; IM=-115; DM=-115;
/M: SY='V';  M= -75,  44,-101, -95, -68,-102, -98,  31, -94,  42, -56, -96, -98, -93, -95, -87, -73,  81, -99, -77;
/M: SY='P';  M= -73, -91, -12,  -3, -85, -28, -82,  33, -79, -75,  57, -22,  65, -76, -86,  55,  12,  -2, -98, -83;
/I:         E1=0; IE=-380; DE=-380;
» more

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2026_03 which contains 575'748 sequence entries.


Total number of hits 25 in 25 different sequences
Number of true positive hits 25 in 25 different sequences
Number of 'unknown' hits 0
Number of false positive hits 0
Number of false negative sequences 0
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 100.00 %
Recall (true positives / (true positives + false negatives)) 100.00 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Matrix type [info] protein_domain
Scaling database [info] reversed
Author [info] CJA_Sigrist
Feature key [info] DOMAIN
Feature description [info] SACK1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences
25 sequences

SCK1A_HUMAN (Q86UY5), SCK1A_MOUSE (Q8K2P2), SCK1A_XENLA (Q6PF42), 
SCK1A_XENTR (Q66JF7), SCK1B_HUMAN (Q5T0W9), SCK1B_MOUSE (Q0VBM2), 
SCK1C_HUMAN (Q9BQN1), SCK1C_MOUSE (A2ARK0), SCK1D_BOVIN (A3KN19), 
SCK1D_DANRE (A4QP72), SCK1D_HUMAN (Q9H4H8), SCK1D_MOUSE (Q9D7I8), 
SCK1D_XENLA (Q5XGY0), SCK1E_HUMAN (Q2M2I3), SCK1E_MOUSE (Q80XS7), 
SCK1F_HUMAN (Q8NEG4), SCK1F_MOUSE (Q3UKU4), SCK1G_HUMAN (A6ND36), 
SCK1G_MOUSE (Q5SWY7), SCK1G_XENLA (Q5XK72), SCK1H_DANRE (Q1LVV0), 
SCK1H_HUMAN (Q6ZRV2), SCK1H_MOUSE (Q148V8), SCK1H_XENTR (A9JRM0), 
SCKDL_XENLA (A1L1G9)
» more

PDB
[Detailed view]
13 PDB

pdb_00004urj; pdb_00005lzk; pdb_00005qhi; pdb_00005qhj; pdb_00005qhk; pdb_00005qhl; pdb_00005qhm; pdb_00005qhn; pdb_00005qho; pdb_00005qhp; pdb_00005qhq; pdb_00005qhr; pdb_00005qhs
» more