PROSITE entry PS52112
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PURL: https://purl.expasy.org/prosite/signature/PS52112
Direct ScanProsite submission
General information about the entry
| Entry name [info] | UDR |
| Accession [info] | PS52112 |
| Entry type [info] | MATRIX |
| Date [info] |
04-NOV-2026 CREATED;
04-NOV-2026 DATA UPDATE; 04-NOV-2026 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC52112 |
| Associated ProRule [info] | PRU01456 |
Name and characterization of the entry
| Description [info] | DNMT3A1 ubiquitin-dependent recruitment (UDR) domain profile. |
| Matrix / Profile [info] |
/GENERAL_SPEC: ALPHABET='ACDEFGHIKLMNPQRSTVWY'; LENGTH=70; /DISJOINT: DEFINITION=PROTECT; N1=6; N2=65; /NORMALIZATION: MODE=1; FUNCTION=LINEAR; R1=2.3755283; R2=0.0057591; TEXT='-LogE'; /CUT_OFF: LEVEL=0; SCORE=1411; N_SCORE=10.5; MODE=1; TEXT='!'; /CUT_OFF: LEVEL=-1; SCORE=717; N_SCORE=6.5; MODE=1; TEXT='?'; /DEFAULT: M0=-23; D=-150; I=-150; B1=-1000; E1=-1000; MI=-380; MD=-380; IM=-380; DM=-380; ... A C D E F G H I K L M N P Q R S T V W Y /I: B1=0; BI=-380; BD=-380; /M: SY='R'; M=-15, -3, 5, -6,-55,-24,-27,-44, 3,-18,-14,-20, 13,-19, 40, 17, -5,-32,-62,-51; /M: SY='W'; M= -5,-28,-11, 2,-46,-19,-38,-31, -5,-20,-28,-15,-20, -1, 20, 21, 0, -1, 27,-36; /M: SY='W'; M=-32, 2,-15,-32,-28,-30,-11,-21, 27,-28, 8, 4, 13,-16, 31, 1,-10,-42, 34,-39; /M: SY='K'; M=-47,-47,-42, -8,-54,-22,-45,-48, 39, -2,-18,-30, 8, -1, 29, -1, -4,-23, 15, -7; /M: SY='C'; M=-16, 30, 9,-12,-43,-15,-30,-52, 19,-17,-10,-19,-30,-28, 22, 18, 7,-39,-45,-15; /M: SY='S'; M=-23, 2, 11, 25,-30,-21,-46,-32,-36, -3,-25,-26, 11,-14, -3, 26,-18,-10,-25,-34; /M: SY='E'; M= -7, 15, -8, 28,-22, 1,-58,-33,-22,-22,-48,-33,-13, -1,-42, 20,-14, 10, 19,-48; /M: SY='E'; M=-31,-73, 0, 38,-26,-16, -6,-62, 23,-40,-10,-21, 11, 29,-14, 14,-15,-49,-62,-41; /M: SY='E'; M=-58,-33,-12, 62,-64,-16,-42,-63, -9,-63,-18,-22, -2, 53, 0, -1,-16,-53,-84,-38; /M: SY='E'; M=-20,-73, 16, 50,-40, 40,-61,-38,-27,-43, 2,-61,-50,-38,-18,-10,-45, -7,-22,-64; /M: SY='R'; M=-25, 11,-49,-61,-56,-33,-37,-45, 16,-40,-64, 14, -4, 16, 48, 17, 20,-28,-84,-21; /M: SY='T'; M=-25,-46,-22,-63,-42,-12,-13, -6,-14, -7,-31,-10, 26,-10,-29, 18, 30, 8, 27,-68; /M: SY='W'; M=-53, 12,-43,-32,-63,-39,-69,-83,-19,-49,-55,-69,-17,-50, 83,-27,-40,-74,104,-57; /M: SY='G'; M=-35,-65, 43,-37,-77, 74,-52,-74,-52,-65,-79,-26,-13,-54,-17,-35,-58,-41,-37,-80; /M: SY='S'; M=-22, 3,-58,-57,-59, 13,-18, 3,-55, -8, 18, 0,-27,-27, 2, 55, -4,-39,-85,-70; /I: I=-22; MD=-55; /M: SY='Y'; M= 12, 22,-26,-46, 14, -4, 10,-62,-47,-21,-61,-43,-21, -7,-15, 6,-24, -4,-48, 52; D=-22; /I: I=-22; MI=0; MD=-55; IM=0; DM=-55; /M: SY='G'; M=-40,-62,-50,-35,-83, 83,-68,-86,-72,-30,-75,-31,-10,-19,-78, 3,-47,-73, 3,-79; /M: SY='W'; M=-30, 15,-78, 15,-59,-20,-63,-78,-59,-43,-74,-78,-28, -7, 7,-10,-45,-66,143,-21; /M: SY='E'; M=-47,-85, 7, 91,-87, 3,-52,-78,-45,-68,-78,-60,-34,-37,-39, -5,-41,-70,-86,-78; /I: I=-15; MD=-38; /M: SY='S'; M=-41,-34, 8,-47,-79, -7,-67, -8, -4,-64,-57, 2,-61, 19,-40, 65, 9,-14,-88,-73; D=-15; /I: I=-15; MI=0; MD=-38; IM=0; DM=-38; /M: SY='S'; M=-50,-59,-64,-62,-81, 17,-67,-64,-60,-84,-76,-46,-71,-57, -7, 91,-11,-74,-87,-74; D=-15; /I: I=-15; MI=0; MD=-38; IM=0; DM=-38; /M: SY='L'; M=-73,-76,-91,-82,-44,-92,-75,-35,-83, 84,-24,-90,-90,-76,-60,-83,-70,-46, 5,-59; D=-15; /I: I=-15; DM=-38; /M: SY='R'; M=-73,-89,-60,-52,-82,-83,-58,-89,-30,-78,-70,-62,-81,-37,110,-67,-72,-82,-82,-68; D=-15; /I: I=-15; DM=-38; /M: SY='Q'; M=-61,-89,-61,-34,-91,-74,-40,-82,-16,-72,-65,-46,-18,112, 39,-34,-67,-82,-79,-67; D=-15; /I: I=-15; DM=-38; /M: SY='R'; M=-45,-82,-65,-54,-79,-77,-61,-71, 64,-76, -4,-45,-58,-38, 81,-61, 18,-60,-80,-68; D=-15; /I: I=-15; DM=-38; /M: SY='P'; M=-70,-95,-71,-60,-89,-72,-74,-77,-67,-63,-74,-77,121,-59,-79,-40,-47,-82,-84,-87; D=-15; /I: I=-15; DM=-38; /M: SY='Q'; M=-42,-76,-66,-40,-74,-73,-61,-32, 11,-49, 50,-61, 38, 73, 36, -9,-18, 20,-79,-65; D=-15; /I: I=-15; DM=-38; /M: SY='P'; M= 28,-18,-65, 1,-80,-67,-68,-69, -4,-44, -8,-50, 95, 2,-21,-45,-14,-29,-80,-76; /M: SY='R'; M=-44, 9,-65,-54,-74,-77,-33,-74,-28,-71,-63,-58,-76,-44,109,-61,-19, -6,-78,-63; /M: SY='T'; M=-24,-67,-56, 7,-41,-73,-40, 17,-20, -2,-11,-28,-66,-24,-55,-33, 82, 26,-83,-63; /M: SY='I'; M=-55,-71,-74,-71,-45,-80,-35, 58,-26,-10,-15,-66, -1,-69,-22,-54, 55, 50, 6,-60; /M: SY='F'; M=-75,-73,-84,-37,116,-83,-63,-50,-76,-34,-51,-76,-85,-84,-74,-73,-67,-55,-40, 46; /M: SY='Q'; M=-60,-85,-55,-35,-90,-68,-29,-76,-40,-71,-58,-51,-21,130,-41,-49,-62,-78,-73,-61; /M: SY='A'; M= 93,-63,-69,-61,-74,-52,-71,-21,-63,-64,-59,-64, 2,-60,-68,-43,-52, -9,-76,-71; /M: SY='G'; M=-45,-76,-62,-18,-82, 98,-69,-89,-38,-84,-74,-26,-67,-64,-30,-49,-26,-82,-74,-77; /I: I=-24; MD=-60; /M: SY='D'; M= 8,-74, 64, -2,-60,-50,-62,-48,-29, 32,-54,-55, 20, 5,-13,-15, 6,-15,-83,-66; D=-24; /I: I=-24; MI=0; MD=-60; IM=0; DM=-60; /M: SY='P'; M=-23,-37,-37,-59,-78, 23, 25,-73,-16,-77,-51, 21, 81,-50,-34, 20, 41,-56,-83,-71; D=-24; /I: I=-24; DM=-60; /M: SY='Y'; M= 12,-18,-45,-59, 21,-65, 28,-53,-51,-27,-56, 2, 25,-55, -8, 0, 55,-23,-62, 65; /M: SY='W'; M=-68,-56,-65,-56,-47,-42, 84,-72,-19,-51,-59, 5,-31, 29, 25,-53,-17,-75,113, 71; /M: SY='S'; M= 12, 28,-39, 18,-40,-24,-49, 49,-27,-58,-29,-10,-59,-41,-51, 55, 8,-27,-79,-43; /M: SY='K'; M=-37,-72,-37,-32,-73,-62, 16,-61, 75,-63, 29,-19,-25,-21, -5, 59,-21,-68,-77,-38; /M: SY='P'; M=-26,-82,-29,-51,-79,-44,-38,-74, 52,-59,-66, -3, 86,-17, 50,-43,-31,-41,-77,-61; /M: SY='R'; M=-41,-33,-61,-28,-68,-77,-41, 10, 33,-30,-14,-58,-45, 10, 83,-47,-54, 28,-77,-62; /M: SY='K'; M=-27,-75, 24, 7,-78, 9,-39,-66, 40,-74,-40, 33, 0, 32, 28, -7, 23,-25,-81,-68; /M: SY='R'; M=-43,-45, -4, 13,-50,-65, 8,-52, 27, 0,-32,-36, 29, 29, 71,-24,-43,-35,-77,-63; /M: SY='D'; M=-31,-78, 71, 64,-82,-55,-55,-61,-14,-74,-73, 11, 5, -7, 8, 6, -7,-71,-86,-70; /M: SY='E'; M=-39,-77,-19, 61,-77,-40,-12,-53, 41,-55,-38, 26,-23, 25, 42,-19,-28,-22,-79,-67; /I: I=-20; MI=0; MD=-51; IM=0; DM=-51; /M: SY='W'; M=-60,-14, 47,-18,-69,-27, -8,-77, 19,-23,-72, 10,-20,-26, -2, 17,-57,-55,109,-58; D=-20; /I: I=-20; DM=-51; /M: SY='S'; M=-38,-61,-66,-20,-57, -7,-32,-24, 24, 46,-21,-45,-66,-11, 19, 47,-34,-46,-76,-62; D=-20; /I: I=-20; DM=-51; /M: SY='K'; M= 31,-57,-31, 21,-65,-37, -7,-57, 47,-46, 13, -3, -9, 19,-30, 24, -8, -9,-79,-66; D=-20; /I: I=-20; DM=-51; /M: SY='P'; M=-41,-18, -2, 33,-80, -6, 1,-53, 42,-76,-42, 0, 44, 15, 35, 2, -4,-62,-80,-69; D=-20; /I: I=-20; DM=-51; /M: SY='W'; M=-10,-19, 0, 35,-39, -1, 16,-44, -9,-61,-54,-49, 2, 28,-19,-10,-10,-26,116,-53; D=-20; /I: I=-20; DM=-51; /M: SY='K'; M= 14,-62, 17, 5,-30,-53, 19,-45, 52, 11,-31,-30,-48, 26,-13, -9,-25, -8,-78,-62; D=-20; /I: I=-20; DM=-51; /M: SY='M'; M=-38, -3, -6, 31,-49,-30,-54,-28, 19,-17, 77, -2, -8,-51, 31, 6,-19, 0,-78,-33; /M: SY='E'; M=-17,-15, -2, 65,-59,-51,-50,-54,-15, -8,-62, -8, 4, 20,-12, 32,-13,-13,-77, 0; /M: SY='V'; M= 21,-15, -6,-12,-58,-30,-29, -9,-10, 10, 2,-14,-30, 27, -7, 12, -7, 35,-69,-49; /M: SY='E'; M=-12, 20, 17, 43,-71, 19,-20,-51, 9,-55,-36,-17, 32,-18, 17, 16,-29,-12,-81,-62; /M: SY='P'; M=-15,-35,-21, 18,-54, -2,-14, -3, 26,-47,-18,-18, 40, -6, 24, 17, 11, -5,-78,-47; /M: SY='K'; M=-31,-63, -8, -8,-51, -9,-31,-32, 34, 7, 28,-23, 31,-11, 16, 17, 19, -5,-78,-64; /M: SY='A'; M= 33,-54,-43,-19,-50, 2,-37,-46, -3,-15, 2, 5, 9, 0, 2, 32, -5, 20,-70,-37; /M: SY='K'; M= 2,-28,-33, -9,-30,-11, 24,-51, 29,-48, -8,-23, 27, -1, 26, 5, 17, 4,-63, 20; /M: SY='S'; M=-13,-40, -4, 11,-42,-10,-15, -7,-24, -7,-43,-31, 36, 0, 15, 37, 17, -8,-51,-10; /M: SY='S'; M=-10, 9,-38, -7, -8, 6,-18,-19,-19,-13, 5,-20, 2, 10, -6, 37, 25, 17,-78,-52; /M: SY='R'; M= 17, 19,-26,-15,-62,-24,-39,-32,-18,-26, 6, 11, 26, -8, 41, 36, 13,-28,-28,-61; /M: SY='P'; M= -2,-63,-25,-10,-41,-18,-24, 17,-27, 5,-24,-57, 41, 13, 30, 5, -5, 17,-39,-29; /M: SY='M'; M=-13,-56, -1,-34,-40, -8,-33,-11,-17,-16, 51,-15, 47,-33, 26, 33, -7, -4,-78,-37; /M: SY='N'; M=-15,-17,-31, 5, -4,-11,-25, -2, 1, -6, -1, 31, 17,-39, -6, 29, 16, -1,-53,-46; /M: SY='Q'; M= 13,-32,-25, 2,-31, -9, -4,-11, -1, -4, 7, 2, 16, 25,-16, 14, 14, 5,-78,-39; /M: SY='M'; M=-16,-35, 17,-19, 11,-28, 16,-25,-17,-16, 57,-41, 18, 15,-14, 20, 15, 10,-32,-43; /M: SY='P'; M=-14,-66, 5, 27,-46, -9,-43,-46, 3, -8, 9,-11, 45, 2,-11, 26, 7,-40, 11, 4; /I: E1=0; IE=-380; DE=-380;» more |
Numerical results [info]
| Total number of hits | 4 in 4 different sequences |
| Number of true positive hits | 4 in 4 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 0 |
| Number of false negative sequences | 0 |
| Number of 'partial' sequences | 0 |
| Precision (true positives / (true positives + false positives)) | 100.00 % |
| Recall (true positives / (true positives + false negatives)) | 100.00 % |
Comments [info]
| Taxonomic range [info] | Eukaryotes |
| Maximum number of repetitions [info] | 1 |
| Matrix type [info] | protein_domain |
| Scaling database [info] | reversed |
| Author [info] | CJA_Sigrist |
| Feature key [info] | DOMAIN |
| Feature description [info] | UDR |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
4 sequences
DNM3A_CHICK (Q4W5Z4), DNM3A_HUMAN (Q9Y6K1), DNM3A_MOUSE (O88508), DNM3A_RAT (Q1LZ53)» more
|
| PDB [Detailed view] |
4 PDB
pdb_00008qzm; pdb_00008u5h; pdb_00008uw1; pdb_00009lq1 |