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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS60004


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PURL: https://purl.expasy.org/prosite/signature/PS60004

Direct ScanProsite submission
General information about the entry

Entry name [info] OMEGA_CONOTOXIN
Accession [info] PS60004
Entry type [info] PATTERN
Date [info] 01-OCT-2004 CREATED;
01-OCT-2004 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC60004

Name and characterization of the entry

Description [info] Omega-conotoxin family signature.
Pattern [info] 
C-[SREYKLIMQVN]-x(2)-[DGWET]-x-[FYSPKV]-C-[GNDSRHTP]-x(1,5)-[NPGSMTAHF]-
[GWPNIYRSKLQ]-x-C-C-[STRHGD]-x(0,2)-[NFLWSRYIT]-C-x(0,3)-[VFGAITSNRKL]-
[FLIKRNGH]-[VWIARKF]-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 81 in 81 different sequences
Number of true positive hits 68 in 68 different sequences
Number of 'unknown' hits 0
Number of false positive hits 13 in 13 different sequences
Number of false negative sequences 3
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 83.95 %
Recall (true positives / (true positives + false negatives)) 95.77 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 7
Site [info] disulfide at position 13
Site [info] disulfide at position 14
Site [info] disulfide at position 18
Site [info] disulfide at position 23
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 68 sequences 

I166_CONTE  (P0DPM4), M7E_CONCN   (P0DKQ3), M7F_CONCN   (P0DKQ4), 

M7G_CONCN   (P0DKQ5), M7J_CONCN   (P0DKQ6), NEMA1_LINLO (P0DM24), 
NEMA2_LINLO (P0DM25), O1618_CONAE (Q9BP78), O161A_CONPL (Q9XYZ0), 
O161_CONST  (Q9XZL4), O162A_CONPL (Q9XYZ1), O162_CONAA  (A0A2L2P6T9), 
O162_CONAE  (Q9BH84), O162_CONIM  (Q5K0B9), O162_CONST  (Q5K0D8), 
O163_CONAA  (A0A3G3C7S6), O163_CONAE  (Q9BP99), O163_CONIM  (Q5K0C0), 
O163_CONTE  (Q9XZL0), O164_CONAH  (P0C8V8), O164_CONST  (Q9XZK3), 
O164_CONTE  (Q9XZL1), O164_CONVC  (P69761), O165_CONAA  (A0A3G3C7U7), 
O165_CONAH  (P0C8V9), O165_CONST  (Q9XZK4), O165_CONTE  (Q9XZL2), 
O1661_CONTE (Q3YEF3), O166_CONST  (P0C831), O167_CONMR  (Q3YED6), 
O168_CONBU  (P0CY66), O168_CONVE  (Q9BPA5), O16A2_CONST (Q9XZL5), 
O16A_CONCT  (P58917), O16A_CONFU  (P0DW83), O16A_CONGE  (P01522), 
O16A_CONMB  (A0A384E129), O16A_CONPE  (P56712), O16A_CONRA  (P58914), 
O16A_CONST  (P28880), O16A_CONTU  (P58915), O16B_CONCT  (P58918), 
O16B_CONPB  (P0DMA2), O16B_CONPE  (P56713), O16B_CONST  (P28881), 
O16C_CONCT  (P58919), O16C_CONST  (Q5K0D6), O16D_CONCT  (P58920), 
O16E_CONCT  (Q9N633), O16F_CONCT  (P0DQD4), O16F_CONST  (Q5K0D5), 
O16K_CONTE  (Q9U654), O16L6_CONST (Q5K0D3), O16L_CONTE  (Q9U645), 
O16M_CONTE  (Q9U648), O16O2_CONTE (Q9XZK9), O16O3_CONST (Q9XZK2), 
O16O6_CONTE (Q9XZL3), O17A_CONMA  (P05484), O17B_CONMA  (P05485), 
O17C_CONMA  (P37300), O17D_CONMA  (Q26350), O17H_CONCN  (P58916), 
O17_CONTE   (P56714), O194_CONTE  (Q9U647), O19_CONST   (Q5K0D2), 
O1X1_CONTE  (Q9XZK8), U7AB_CONGE  (P05483)
» more

UniProtKB/Swiss-Prot
False negative sequences		 3 sequences 

O161_CONTE  (Q9U651), O162_CONTE  (Q9U650), O167_CONST  (P0C832)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			13 sequences
			


			
NEMA1_LINLC (P0DQS1), NEMA1_LINRU (P0DQS2), NEMA2_LINRU (P0DQS3), 

			
NEMA4_LINSA (P0DQS6), NEMA8_RISOC (P0DQT0), O163_CONAH  (P0C8V7), 
O16A_CONCN  (P69750), O16A_CONMA  (P69753), O16A_CONSE  (P69757), 
O16B_CONMA  (P69754), O16C_CONMA  (P69755), O16D_CONMA  (P69756), 
O16E_CONST  (Q9XZK5)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			22 PDB
			


			pdb_00001cnn; pdb_00001dw4; pdb_00001dw5; pdb_00001f3k; pdb_00001feo; pdb_00001fyg; pdb_00001mvi; pdb_00001mvj; pdb_00001omc; pdb_00001omg; pdb_00001omn; pdb_00001tr6; 
			
				pdb_00001tt3; pdb_00001ttk; pdb_00001ttl; pdb_00002cco; pdb_00005znu; pdb_00006ceg; pdb_00006ena; pdb_00007mix; pdb_00007vfu; pdb_00008x91
			
			

			» more