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PROSITE entry PS60014


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General information about the entry

PURL [info] https://purl.expasy.org/prosite/signature/PS60014
Entry name [info] ALPHA_CONOTOXIN
Accession [info] PS60014
Entry type [info] PATTERN
Date [info] 01-MAR-2005 CREATED;
01-OCT-2005 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC60004

Name and characterization of the entry

Description [info] Alpha-conotoxin family signature.
Pattern [info] 
C-C-[SHYN]-x(0,1)-[PRG]-[RPATV]-C-[ARMFTNHG]-x(0,4)-[QWHDGENLFYVP]-
[RIVYLGSDW]-C.

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_02 which contains 573'230 sequence entries.


Total number of hits 72 in 72 different sequences
Number of true positive hits 67 in 67 different sequences
Number of 'unknown' hits 1
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 48
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 94.37 %
Recall (true positives / (true positives + false negatives)) 58.26 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 1
Site [info] disulfide at position 1
Site [info] disulfide at position 2
Site [info] disulfide at position 7
Site [info] disulfide at position 12
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 67 sequences 

CA11B_CONAH (P0CAQ5), CA11_CONAJ  (P0CB07), CA11_CONSE  (P0C8V1), 

CA11_CONTE  (Q9XZK6), CA12A_CONIM (Q9U619), CA12A_CONRE (P85013), 
CA12_CONAA  (A0A3G3C7S9), CA12_CONAJ  (P0CB08), CA12_CONGE  (P01520), 
CA12_CONIM  (Q8I6R5), CA12_CONMA  (P56636), CA12_CONPE  (P0DM23), 
CA12_CONVC  (E2DIH5), CA13_CONBN  (P0C1Y2), CA13_CONMR  (A0SE59), 
CA14_CONLI  (S4UJV1), CA14_CONMN  (P0C8U5), CA15_CONAA  (A0A3G3C7S0), 
CA16_CONAA  (A0A3G3C7U1), CA16_CONEB  (F2XFS9), CA16_CONQU  (A1X8D1), 
CA189_CONAJ (P0CB12), CA1AB_CONAN (P0C1V7), CA1AB_CONSP (P85886), 
CA1A_CONAE  (P0C8R2), CA1A_CONAL  (P56639), CA1A_CONBU  (P69657), 
CA1A_CONCN  (P56973), CA1A_CONCT  (D4HPD6), CA1A_CONEP  (P56638), 
CA1A_CONER  (P50982), CA1A_CONLG  (X1WB75), CA1A_CONLI  (L8BU87), 
CA1A_CONLM  (P0DL68), CA1A_CONOB  (P0DQY0), CA1A_CONOM  (P0C1R7), 
CA1A_CONPE  (P50984), CA1A_CONPU  (P69658), CA1A_CONRE  (P0C1D0), 
CA1A_CONST  (P28878), CA1A_CONVC  (P69747), CA1A_CONVR  (F5C0A0), 
CA1B_CONAL  (P56640), CA1B_CONOB  (P0DQY1), CA1B_CONPE  (P50985), 
CA1B_CONTE  (K4RNX9), CA1C_CONAL  (P56641), CA1C_CONAN  (P0C1V8), 
CA1C_CONCN  (P0C8U4), CA1C_CONGE  (Q86RB2), CA1D_CONGE  (P60274), 
CA1E_CONRE  (P85011), CA1L_CONCN  (P0DKP6), CA1Z_CONTE  (P0DPL9), 
CA1_CONGE   (X5I9Y2), CA1_CONIM   (P50983), CA1_CONMA   (P01521), 
CA1_CONST   (P15471), CA2_CONTE   (Q9XZK7), CA761_CONIN (P0DUR2), 
CA878_CONIN (P0DUR1), CA907_CONIN (P0DUR0), CAIA_CONGE  (P0DQR7), 
CAIB_CONGE  (X5IGW1), CAL12_CONPE (Q9BP56), CAS2_CONST  (P28879), 
O16A_CONVX  (Q86RA3)
» more

UniProtKB/Swiss-Prot
False negative sequences		 48 sequences 

CA11A_CONAH (P0CAQ4), CA11A_CONQU (Q6PTD7), CA11B_CONQU (Q6PPB3), 

CA11C_CONQU (A1X8C6), CA11_CONBN  (P0CE73), CA11_CONBU  (P0CY86), 
CA11_CONCB  (P0C1V9), CA11_CONLE  (Q6PTD5), CA11_CONLT  (Q2I2R8), 
CA11_CONMR  (Q6PTD1), CA11_CONPL  (A0SE60), CA11_CONST  (P0C1W4), 
CA12_CONBN  (P0CE74), CA12_CONCB  (P0C1W0), CA12_CONKI  (D4HRK7), 
CA12_CONLE  (Q6PTD4), CA12_CONLT  (Q2I2R7), CA12_CONMR  (A6M934), 
CA12_CONPL  (A1X8D8), CA12_CONQU  (Q6PTD6), CA13_CONLT  (Q2I2R6), 
CA14A_CONQU (P0CAQ8), CA14B_CONQU (P0CAQ9), CA14_CONBR  (P0C8U3), 
CA14_CONLE  (A1X8B6), CA14_CONPL  (P0C8U8), CA15_CONPL  (P0C8U9), 
CA15_CONQU  (A1X8D0), CA16A_CONLE (P0CAQ6), CA16B_CONLE (P0CAQ7), 
CA16_CONPL  (P0C8V0), CA17_CONLE  (A1X8C3), CA18_CONLE  (A1X8C2), 
CA1A_CONLE  (A6M938), CA1A_CONMA  (P0C1W1), CA1A_CONPR  (Q1L777), 
CA1A_CONTI  (P0CI05), CA1B_CONBR  (C0HLK1), CA1B_CONPU  (P0C351), 
CA1B_CONRE  (P85009), CA1C_CONTE  (P86261), CA1D_CONRE  (P85010), 
CA1F_CONRE  (P85012), CA1LB_CONRE (C0HJA8), CA1_CONQU   (A1X8B8), 
CA2_CONQU   (A1X8B9), CAE1_CONPL  (C6ZJQ2), CAEA_CONTS  (P86362)
» more

UniProtKB/Swiss-Prot
'Unknown' sequences		 1 sequence 

M34_CONMR   (P0C1N3)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			4 sequences
			


			
CM314_CONRE (A0A2I6EDN1), O165_CONCL  (D6C4L2), SJ380_SCHJA (Q5DBT1), 

			
SJ643_SCHJA (Q5DFA1)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			61 PDB
			


			1A0M; 1AKG; 1B45; 1CNL; 1DG2; 1E76; 1G2G; 1HJE; 1IM1; 1IMI; 1K64; 1M2C; 
			
				1MII; 1MTQ; 1MXN; 1MXP; 1NOT; 1PEN; 1QMW; 1UL2; 1XGA; 1XGB; 1XGC; 1ZLC; 
				2AJW; 2AK0; 2BYP; 2C9T; 2GCZ; 2H8S; 2I28; 2IGU; 2JUR; 2JUS; 2JUT; 2LZ5; 
				2MD6; 2MDQ; 2NS3; 4EZ1; 4TTL; 5CO5; 5UG3; 5UG5; 5XGL; 6HY7; 6M4X; 6M4Z; 
				6OTB; 6OVJ; 7EGR; 7N0T; 7N1Z; 7N20; 7N21; 7N22; 7N23; 7N24; 7N25; 7N26; 
				7N43
			
			

			» more