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PROSITE documentation PDOC00019 [for PROSITE entry PS00019] |
α-actinin is a F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures [1]. The actin-binding domain of α-actinin seems to reside in the first 250 residues of the protein. A similar actin-binding domain has been found in the N-terminal region of many different actin-binding proteins [2,3]:
We selected two conserved regions as signature patterns for this type of domain. The first of this region is located at the beginning of the domain, while the second one is located in the central section and has been shown to be essential for the binding of actin.
Last update:April 2006 / Patterns revised.
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PROSITE methods (with tools and information) covered by this documentation:
1 | Authors | Schleicher M. Andre E. Hartmann H. Noegel A.A. |
Title | Actin-binding proteins are conserved from slime molds to man. | |
Source | Dev. Genet. 9:521-530(1988). | |
PubMed ID | 3243032 |
2 | Authors | Matsudaira P. |
Title | Modular organization of actin crosslinking proteins. | |
Source | Trends Biochem. Sci. 16:87-92(1991). | |
PubMed ID | 2058002 |
3 | Authors | Dubreuil R.R. |
Title | Structure and evolution of the actin crosslinking proteins. | |
Source | BioEssays 13:219-226(1991). | |
PubMed ID | 1892474 |