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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00024


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PURL: https://purl.expasy.org/prosite/signature/PS00024

Direct ScanProsite submission
General information about the entry

Entry name [info] HEMOPEXIN
Accession [info] PS00024
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00023

Name and characterization of the entry

Description [info] Hemopexin domain signature.
Pattern [info] 
[LIFAT]-{IL}-x(2)-W-x(2,3)-[PE]-x-{VF}-[LIVMFY]-[DENQS]-[STA]-[AV]-
[LIVMFY].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 132 in 125 different sequences
Number of true positive hits 82 in 75 different sequences
Number of 'unknown' hits 0
Number of false positive hits 50 in 50 different sequences
Number of false negative sequences 23
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 62.12 %
Recall (true positives / (true positives + false negatives)) 78.10 %

Comments [info]

Taxonomic range [info] Eukaryotes
Maximum number of repetitions [info] 2
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 75 sequences 

HEMO_BOVIN  (Q3SZV7), HEMO_HUMAN  (P02790), HEMO_MOUSE  (Q91X72), 

HEMO_PIG(P50828), HEMO_PONAB  (Q5R543), HEMO_RABIT  (P20058), 
HEMO_RAT(P20059), HE_HEMPU(P91953), MMP10_HUMAN (P09238), 
MMP10_MOUSE (O55123), MMP10_RAT   (P07152), MMP11_HUMAN (P24347), 
MMP11_MOUSE (Q02853), MMP11_RAT   (Q499S5), MMP11_XENLA (Q11005), 
MMP12_HUMAN (P39900), MMP12_MOUSE (P34960), MMP12_RABIT (P79227), 
MMP12_RAT   (Q63341), MMP13_HORSE (O18927), MMP13_HUMAN (P45452), 
MMP13_MOUSE (P33435), MMP13_RABIT (O62806), MMP13_RAT   (P23097), 
MMP13_XENLA (Q10835), MMP14_BOVIN (Q9GLE4), MMP14_HUMAN (P50281), 
MMP14_MOUSE (P53690), MMP14_PIG   (Q9XT90), MMP14_PONAB (Q5RES1), 
MMP14_RABIT (Q95220), MMP14_RAT   (Q10739), MMP15_HUMAN (P51511), 
MMP15_MOUSE (O54732), MMP16_HUMAN (P51512), MMP16_MOUSE (Q9WTR0), 
MMP16_RAT   (O35548), MMP19_MOUSE (Q9JHI0), MMP1A_MOUSE (Q9EPL5), 
MMP1B_MOUSE (Q9EPL6), MMP1_BOVIN  (P28053), MMP1_HORSE  (Q9XSZ5), 
MMP1_HUMAN  (P03956), MMP1_PIG(P21692), MMP1_RABIT  (P13943), 
MMP24_HUMAN (Q9Y5R2), MMP24_MOUSE (Q9R0S2), MMP24_RAT   (Q99PW6), 
MMP27_HUMAN (Q9H306), MMP27_TUPBE (Q9GKE1), MMP2_BOVIN  (Q9GLE5), 
MMP2_CHICK  (Q90611), MMP2_HUMAN  (P08253), MMP2_MOUSE  (P33434), 
MMP2_RABIT  (P50757), MMP2_RAT(P33436), MMP3_CANLF  (Q6Y4Q5), 
MMP3_HORSE  (Q28397), MMP3_HUMAN  (P08254), MMP3_MOUSE  (P28862), 
MMP3_RABIT  (P28863), MMP3_RAT(P03957), MMP8_HUMAN  (P22894), 
MMP8_MOUSE  (O70138), MMP8_RAT(O88766), MMP9_HUMAN  (P14780), 
MMP9_MOUSE  (P41245), MMP9_RABIT  (P41246), MMP9_RAT(P50282), 
PRG4_HUMAN  (Q92954), PRG4_MOUSE  (Q9JM99), VTNC_HUMAN  (P04004), 
VTNC_MOUSE  (P29788), VTNC_PIG(P48819), VTNC_RABIT  (P22458)
» more

UniProtKB/Swiss-Prot
False negative sequences		 23 sequences 

D2MP_DROME  (Q8MPP3), HE_PARLI(P22757), MMP13_BOVIN (O77656), 

MMP17_HUMAN (Q9ULZ9), MMP17_MOUSE (Q9R0S3), MMP18_XENLA (O13065), 
MMP19_HUMAN (Q99542), MMP1_AQUCT  (Q11133), MMP20_BOVIN (O18767), 
MMP20_HUMAN (O60882), MMP20_MOUSE (P57748), MMP20_PIG   (P79287), 
MMP21_CYNPY (Q90YC2), MMP21_HUMAN (Q8N119), MMP21_MOUSE (Q8K3F2), 
MMP21_XENLA (O93470), MMP25_HUMAN (Q9NPA2), MMP25_MOUSE (Q3U435), 
MMP28_HUMAN (Q9H239), MMP9_BOVIN  (P52176), MMP9_CANLF  (O18733), 
MMPA_CAEEL  (G5EGM1), MMPC_CAEEL  (G5EBU3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

HEMO_CHICK  (P20057)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			50 sequences
			


			
ASTE_PARXL  (Q141D1), BPHA4_RHOJR (Q0S032), CPLN1_MOUSE (Q8CE72), 

			
DPP6_PANTR  (Q5IS50), GC_PSHV1(Q6UDI7), HISX_PROMM  (Q7V5N9), 
KATG_MYCGI  (A4TA35), LGRC_BREPA  (Q70LM5), LTD_ORYSI   (A2YLX7), 
LTD_ORYSJ   (A3BKF2), MPPE1_AILME (D2I2M6), MPPE1_CHICK (Q5ZK82), 
MPPE1_CRIGR (C7G3A0), MPPE1_HUMAN (Q53F39), MPPE1_MACFA (Q9GMS6), 
MPPE1_MOUSE (Q80XL7), MPPE1_PONAB (Q5RET5), MPPE1_RAT   (B1WC86), 
MPPE1_XENLA (Q0IHA5), MSLN_HUMAN  (Q13421), NIFJ_ECOLI  (P52647), 
OPGG2_SHEON (Q8EDL2), PMA6E_HUMAN (A0A0J9YXQ4), PORCN_CAEBR (A8WZ09), 
STEA4_HUMAN (Q687X5), STEA4_MOUSE (Q923B6), SYE1_RHIWR  (A5V932), 
SYT_HAEDU   (Q7VKR9), TFE_METTP   (A0B9P3), TMCA_CITK8  (A8ADB3), 
TRAK1_HUMAN (Q9UPV9), TRAK1_MOUSE (Q6PD31), TYSY_HALVO  (Q9UWQ5), 
UBID_BURL3  (Q39IR6), UBID_BURMA  (Q62HU9), UBID_BURO1  (Q1BYC0), 
UBID_BURP1  (Q3JPM4), UBID_BURPS  (Q63RP1), UBID_BURTA  (Q2SYC8), 
UBID_METCA  (Q602K0), UBID_NITEU  (Q82TP1), UBID_THIDA  (Q3SMI8), 
URE1_ACIAD  (Q6FD83), URE1_CORGL  (Q79VJ3), UTP20_SCHPO (O60055), 
Y022_ALKMQ  (A6TJ97), Y1488_MYCTO (P9WPR8), Y1488_MYCTU (P9WPR9), 
Y1524_MYCBO (P63694), Y3298_MAGMM (A0LCU4)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			24 PDB
			


			pdb_00001ck7; pdb_00001fbl; pdb_00001gen; pdb_00001gxd; pdb_00001hxn; pdb_00001itv; pdb_00001pex; pdb_00001qhu; pdb_00001qjs; pdb_00001rtg; pdb_00001su3; pdb_00002clt; 
			
				pdb_00002jxy; pdb_00002mqs; pdb_00003ba0; pdb_00003c7x; pdb_00004auo; pdb_00004fu4; pdb_00004fvl; pdb_00004g0d; pdb_00006clz; pdb_00006cm1; pdb_00006o5e; pdb_00007rj9
			
			

			» more