PROSITE logo
Black ribbon
We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Amos Bairoch

PROSITE entry PS00036


View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00036

Direct ScanProsite submission
General information about the entry

Entry name [info] BZIP_BASIC
Accession [info] PS00036
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-APR-2006 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00036

Name and characterization of the entry

Description [info] Basic-leucine zipper (bZIP) domain signature.
Pattern [info] 
[KR]-x(1,3)-[RKSAQ]-N-{VL}-x-[SAQ](2)-{L}-[RKTAENQ]-x-R-{S}-[RK].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 363 in 363 different sequences
Number of true positive hits 332 in 332 different sequences
Number of 'unknown' hits 0
Number of false positive hits 31 in 31 different sequences
Number of false negative sequences 120
Number of 'partial' sequences 1
Precision (true positives / (true positives + false positives)) 91.46 %
Recall (true positives / (true positives + false negatives)) 73.45 %

Comments [info]

Taxonomic range [info] Eukaryotes, Eukaryotic viruses
Maximum number of repetitions [info] 1
Version [info] 2

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 332 sequences 

ABI5_ARATH  (Q9SJN0), ABI5_ORYSJ  (Q8RZ35), ACA1_YEAST  (P39970), 

ACA2_YEAST  (P40535), AI5L1_ARATH (Q8RYD6), AI5L2_ARATH (Q9LES3), 
AI5L3_ARATH (Q9C5Q2), AI5L4_ARATH (Q9M7Q5), AI5L5_ARATH (Q9M7Q4), 
AI5L6_ARATH (Q9M7Q3), AI5L7_ARATH (Q9M7Q2), AI5L8_ARATH (Q9FMM7), 
AP1_ASPFN   (B8NNN3), AP1_ASPFU   (Q4WMH0), AP1_ASPOR   (Q2UMT9), 
AP1_CANAL   (Q5AJU7), AP1_CANGA   (Q6FRZ8), AP1_CRYNH   (J9VEC2), 
AP1_EMENI   (Q5AW17), AP1_KLULA   (P56095), AP1_SCHPO   (Q01663), 
AP1_YEAST   (P19880), AP2_YEAST   (P24813), ATF1_BOVIN  (Q08DA8), 
ATF1_HUMAN  (P18846), ATF1_MOUSE  (P81269), ATF21_SCHPO (P78962), 
ATF2_CHICK  (O93602), ATF2_HUMAN  (P15336), ATF2_MOUSE  (P16951), 
ATF2_RAT(Q00969), ATF31_SCHPO (Q09771), ATF3_BOVIN  (Q2KII1), 
ATF3_DROME  (Q9XZS8), ATF3_HUMAN  (P18847), ATF3_MOUSE  (Q60765), 
ATF3_RAT(P29596), ATF4H_CAEEL (Q22156), ATF4_BOVIN  (Q3ZCH6), 
ATF4_DANRE  (Q6NW59), ATF4_HUMAN  (P18848), ATF4_MOUSE  (Q06507), 
ATF4_RAT(Q9ES19), ATF6A_HUMAN (P18850), ATF6A_MOUSE (F6VAN0), 
ATF6A_RAT   (G3V909), ATF6B_HUMAN (Q99941), ATF6B_MOUSE (O35451), 
ATF7_HUMAN  (P17544), ATF7_MOUSE  (Q8R0S1), ATF7_PONAB  (Q5R9C9), 
ATFB_ASPFN  (B8NLU5), ATFB_ASPFU  (Q4WVQ7), ATFB_ASPOR  (Q2U616), 
ATFB_ASPPU  (A0A0F0IP79), ATFC_BOMMO  (Q9GPH3), BACH1_HUMAN (O14867), 
BACH1_MOUSE (P97302), BACH2_HUMAN (Q9BYV9), BACH2_MOUSE (P97303), 
BATF2_HUMAN (Q8N1L9), BATF2_MOUSE (Q8R1H8), BATF3_HUMAN (Q9NR55), 
BATF3_MOUSE (Q9D275), BATF3_RAT   (P97876), BATF_BOVIN  (E1BD44), 
BATF_DANRE  (F1QW76), BATF_HUMAN  (Q16520), BATF_MOUSE  (O35284), 
BATF_RAT(D4A7E1), BATF_XENLA  (A1L2X1), BATF_XENTR  (F7EMX9), 
BZIP1_ARATH (Q9FGX2), BZIP2_ARATH (Q9SI15), BZIP4_ARATH (Q9LQ65), 
BZIP8_ARATH (Q9CA46), BZIP9_ARATH (Q9FUD3), BZIP_PSEMZ  (P85926), 
BZLF1_EBVA8 (Q1HVG1), BZLF1_EBVB9 (P03206), BZLF1_EBVG  (Q3KSS8), 
BZP02_ORYSJ (Q5QNI5), BZP06_ORYSJ (Q5JMK6), BZP10_ARATH (O22763), 
BZP11_ARATH (O65683), BZP12_ORYSJ (Q0JHF1), BZP16_ARATH (Q501B2), 
BZP19_ORYSJ (Q6K3R9), BZP1A_WHEAT (A0A3B6KF13), BZP1B_WHEAT (B6E107), 
BZP1D_WHEAT (A0A3B6MPP5), BZP23_ORYSJ (Q6Z312), BZP25_ARATH (Q9M1G6), 
BZP34_ARATH (F4IN23), BZP43_ARATH (Q9FMC2), BZP44_ARATH (C0Z2L5), 
BZP46_ORYSJ (Q69TW5), BZP50_ORYSJ (Q69XV0), BZP53_ARATH (Q9LZP8), 
BZP60_ARATH (Q9C7S0), BZP60_ORYSJ (Q8LIB3), BZP61_ARATH (Q9M2K4), 
BZP63_ARATH (B9DGI8), BZP68_ARATH (Q84LG2), BZPC_DICDI  (Q54WU0), 
BZPH_DICDI  (Q86AF3), CNC_DROME   (P20482), CPC1_CRYPA  (P87090), 
CPC1_NEUCR  (P11115), CPCA_ASPNG  (Q00096), CPRF1_PETCR (Q99089), 
CPRF2_PETCR (Q99090), CPRF3_PETCR (Q99091), CR3L1_HUMAN (Q96BA8), 
CR3L1_MOUSE (Q9Z125), CR3L1_RAT   (Q66HA2), CR3L2_DANRE (A1L224), 
CR3L2_HUMAN (Q70SY1), CR3L2_MOUSE (Q8BH52), CR3L2_PONAB (Q5RCM9), 
CR3L2_RAT   (Q6QDP7), CR3L2_XENLA (A2VD01), CR3L3_BOVIN (Q3SYZ3), 
CR3L3_HUMAN (Q68CJ9), CR3L3_MOUSE (Q91XE9), CR3L3_RAT   (Q5FVM5), 
CR3LA_DANRE (Q502F0), CR3LB_DANRE (Q1LYG4), CREB1_BOVIN (P27925), 
CREB1_HUMAN (P16220), CREB1_MOUSE (Q01147), CREB1_RAT   (P15337), 
CREB3_BOVIN (Q8SQ19), CREB3_HUMAN (O43889), CREB3_MOUSE (Q61817), 
CREB5_HUMAN (Q02930), CREB5_MOUSE (Q8K1L0), CREBA_DROME (P29747), 
CREBB_DROME (Q9VWW0), CREBH_CAEEL (Q9U2I0), CREB_HYDVD  (P51984), 
CREB_HYDVU  (P51985), CREM_BOVIN  (Q1LZH5), CREM_CANLF  (P79145), 
CREM_HUMAN  (Q03060), CREM_MOUSE  (P27699), CREM_RAT(Q03061), 
CRERF_DROME (Q9VC61), CRERF_HUMAN (Q8IUR6), CRERF_MOUSE (Q8CDG5), 
CRH2_CAEEL  (Q4JFH9), CYS3_NEUCR  (P22697), EMBP1_WHEAT (P25032), 
FCR3_CANAX  (Q8X229), FDP_ARATH   (Q7PCC6), FD_ARATH(Q84JK2), 
FOS1_CAEEL  (G5ECG2), FOSB_CANLF  (Q9TUB3), FOSB_HUMAN  (P53539), 
FOSB_MOUSE  (P13346), FOSB_RAT(D3ZLB7), FOSL1_HUMAN (P15407), 
FOSL1_MOUSE (P48755), FOSL1_RAT   (P10158), FOSL2_CHICK (P18625), 
FOSL2_HUMAN (P15408), FOSL2_MOUSE (P47930), FOSL2_RAT   (P51145), 
FOSLA_DROME (P21525), FOSLD_DROME (A8MPH9), FOSL_DROAN  (B3MTI9), 
FOSL_DROER  (B3P5D2), FOSL_DROGR  (B4JYN3), FOSL_DROMO  (B4K617), 
FOSL_DROPE  (B4G652), FOSL_DROPS  (Q29AP1), FOSL_DROSE  (B4HZE8), 
FOSL_DROSI  (B4R090), FOSL_DROVI  (B4M5T7), FOSL_DROWI  (B4NBL5), 
FOSL_DROYA  (B4PPK2), FOSX_MSVFR  (P29176), FOS_AVINK   (P23050), 
FOS_BOVIN   (O77628), FOS_CHICK   (P11939), FOS_CYPCA   (P79702), 
FOS_DICFU   (Q91496), FOS_FELCA   (Q8HZP6), FOS_HUMAN   (P01100), 
FOS_MESAU   (O88479), FOS_MOUSE   (P01101), FOS_MSVFB   (P01102), 
FOS_PHOCM   (Q56TT7), FOS_PHORO   (Q56TN0), FOS_PIG (O97930), 
FOS_RAT (P12841), FOS_TAKRU   (P53450), GBF1_ARATH  (P42774), 
GBF2_ARATH  (P42775), GBF3_ARATH  (P42776), GBF4_ARATH  (P42777), 
GCN4_YEAST  (P03069), GIANT_DROME (P39572), HAC1_ASPOR  (Q1XGE2), 
HAC1_EMENI  (Q8TFU8), HAC1_YEAST  (P41546), HACA_ASPFU  (Q4WEY8), 
HAPX_ARTBC  (D4AQY2), HAPX_ASPFU  (Q4WER3), HBP1A_WHEAT (P23922), 
HBP1B_WHEAT (P23923), HBP1C_WHEAT (Q41558), HY5_ARATH   (O24646), 
HY5_SOLLC   (Q9SM50), HYH_ARATH   (Q8W191), JDP2_DANRE  (Q6DGM8), 
JDP2_HUMAN  (Q8WYK2), JDP2_MOUSE  (P97875), JDP2_RAT(Q78E65), 
JRA_DROME   (P18289), JUNB_BOVIN  (Q0VBZ5), JUNB_CYPCA  (P79703), 
JUNB_HUMAN  (P17275), JUNB_MOUSE  (P09450), JUNB_RAT(P24898), 
JUND_BOVIN  (A7YY54), JUND_CHICK  (P27921), JUND_HUMAN  (P17535), 
JUND_MOUSE  (P15066), JUND_RAT(P52909), JUN_AVIS1   (P05411), 
JUN_BOVIN   (O77627), JUN_CAEEL   (G5ECU7), JUN_CHICK   (P18870), 
JUN_COTJA   (P12981), JUN_HUMAN   (P05412), JUN_MOUSE   (P05627), 
JUN_PIG (P56432), JUN_RAT (P17325), JUN_SERCA   (P54864), 
KAPC_ASPCL  (A1C9M5), KAPC_ASPFU  (Q4WA21), KAPC_ASPNC  (A2R346), 
KAPC_ASPOR  (Q2UNX4), KAPC_ASPTN  (Q0CEI3), KAPC_EMENI  (P0C5H8), 
KAPC_NEOFI  (A1D9Z7), LE607_CAEEL (O44743), LG2_MAIZE   (O49067), 
LG2_ORYSJ   (Q5N7C7), MEQ_GAHVM   (Q9DGW5), MET28_YEAST (P40573), 
NF2L1_BOVIN (A5D7E9), NF2L1_CHICK (Q5ZL67), NF2L1_HUMAN (Q14494), 
NF2L1_MOUSE (Q61985), NF2L1_PONAB (Q5RA25), NF2L2_BOVIN (Q5NUA6), 
NF2L2_HUMAN (Q16236), NF2L2_MOUSE (Q60795), NF2L2_RAT   (O54968), 
NF2L3_HUMAN (Q9Y4A8), NF2L3_MOUSE (Q9WTM4), NFE2_BOVIN  (Q5EAD3), 
NFE2_HUMAN  (Q16621), NFE2_MOUSE  (Q07279), NFE2_RAT(Q6AYT2), 
NFIL3_BOVIN (Q08D88), NFIL3_CAEEL (Q21361), NFIL3_CHICK (Q90Z72), 
NFIL3_DANRE (Q68EL6), NFIL3_HUMAN (Q16649), NFIL3_MOUSE (O08750), 
NFIL3_RAT   (Q6IMZ0), NFIL3_XENLA (Q66J36), NFIL3_XENTR (Q5FW38), 
NFILZ_HUMAN (A0A5F9ZHS7), OCS1_MAIZE  (P24068), OP2_MAIZE   (P12959), 
OTAR1_ASPC5 (A0A1R3RGK4), OTAR1_ASPNC (A2R6G8), PAN_ARATH   (Q9SX27), 
PCR1_SCHPO  (Q09926), RADR_FLOCH  (C5H883), RSBZ3_ORYSJ (Q6ETX0), 
RSBZ4_ORYSJ (Q6H500), RSBZ5_ORYSJ (Q654B3), SKN1_CAEEL  (P34707), 
TAF1_TOBAC  (Q99142), TGA10_ARATH (E3VNM4), TGA10_TOBAC (Q52MZ2), 
TGA1A_TOBAC (P14232), TGA1_ARATH  (Q39237), TGA21_ORYSJ (Q7X993), 
TGA21_TOBAC (O24160), TGA22_ORYSJ (Q6IVC3), TGA23_ORYSJ (Q0JNL3), 
TGA2_ARATH  (P43273), TGA3_ARATH  (Q39234), TGA4_ARATH  (Q39162), 
TGA5_ARATH  (Q39163), TGA6_ARATH  (Q39140), TGA7_ARATH  (Q93ZE2), 
TGA9_ARATH  (Q93XM6), TGAL1_ORYSJ (Q6IVC2), TGAL3_ORYSJ (Q5Z6N9), 
TGAL4_ORYSJ (Q53Q70), TGAL5_ORYSJ (Q6F2N0), TGAL6_ORYSJ (A0A0P0WFC8), 
TGAL7_ORYSJ (Q6H434), TGAL8_ORYSJ (Q69T21), TGAL9_ORYSJ (Q0E342), 
TGL10_ORYSJ (Q6ZBS8), TGL11_ORYSJ (Q2QXL0), TOXE_COCCA  (O74205), 
TRAB1_ORYSJ (Q6ZDF3), XANC_ASPFU  (A4DA05), XBP1_BOVIN  (Q3SZZ2), 
XBP1_CAEEL  (G5EE07), XBP1_HUMAN  (P17861), XBP1_MOUSE  (O35426), 
XBP1_RAT(Q9R1S4), YAP3_YEAST  (P38749), YAP4_YEAST  (P40917), 
YAP5_YEAST  (P40574), YAP6_YEAST  (Q03935), YAP7_YEAST  (Q08182), 
ZEB2_GIBZE  (I1RFC6), ZIP11_CAEEL (Q9N5A8), ZIP1_SCHPO  (Q10424), 
ZIP2_CAEEL  (Q21148), ZIP3_CAEEL  (Q9XUK2)
» more

UniProtKB/Swiss-Prot
False negative sequences		 120 sequences 

ARR1_YEAST  (Q06596), ATF1_SCHPO  (P52890), ATF5_HUMAN  (Q9Y2D1), 

ATF5_MOUSE  (O70191), ATF5_RAT(Q6P788), BZIP8_CAEEL (P46505), 
BZP1_PHYIN  (Q5BUB4), BZP39_ORYSJ (Q6AU90), BZPD_DICDI  (Q54Y73), 
BZPE_DICDI  (Q55E93), BZPF_DICDI  (Q54WN7), BZPG_DICDI  (Q54RZ9), 
BZPI_DICDI  (Q54GG8), BZPJ_DICDI  (Q554P0), BZPK_DICDI  (Q54T16), 
BZPL_DICDI  (Q54Q90), BZPM_DICDI  (Q54T17), BZPO_DICDI  (Q54GH0), 
BZPP_DICDI  (Q54G94), BZPQ_DICDI  (Q54IJ9), BZPR_DICDI  (Q54GH2), 
BZPS_DICDI  (Q54GG9), CEBP2_CAEEL (Q8IG69), CEBPA_BOVIN (O02754), 
CEBPA_HUMAN (P49715), CEBPA_MOUSE (P53566), CEBPA_RAT   (P05554), 
CEBPB_BOVIN (O02755), CEBPB_CHICK (Q05826), CEBPB_HUMAN (P17676), 
CEBPB_MOUSE (P28033), CEBPB_RAT   (P21272), CEBPD_BOVIN (O02756), 
CEBPD_HUMAN (P49716), CEBPD_MOUSE (Q00322), CEBPD_RAT   (Q03484), 
CEBPD_SHEEP (Q9N0J3), CEBPE_HUMAN (Q15744), CEBPE_MOUSE (Q6PZD9), 
CEBPE_RAT   (P56261), CEBPE_SHEEP (O77728), CEBPG_BOVIN (Q3T0B9), 
CEBPG_HUMAN (P53567), CEBPG_MOUSE (P53568), CEBPG_RAT   (P26801), 
CEBP_DROME  (Q02637), CEBP_DROVI  (Q02638), CES2_CAEEL  (Q94126), 
CRBL2_BOVIN (Q0VD32), CRBL2_DANRE (Q642H2), CRBL2_HUMAN (O60519), 
CRBL2_MOUSE (Q32M00), CRBL2_RAT   (Q5BJU6), CRBL2_XENTR (A4IGK3), 
DBP_BOVIN   (Q32PF6), DBP_HUMAN   (Q10586), DBP_MOUSE   (Q60925), 
DBP_RAT (P16443), DDIT3_BOVIN (Q0IIB6), DDIT3_CRIGR (P14607), 
DDIT3_HUMAN (P35638), DDIT3_MOUSE (P35639), DDIT3_RAT   (Q62857), 
DIMA_DICDI  (Q54XG7), FOS_CRIGR   (Q9Z2Q8), HLF_HUMAN   (Q16534), 
HLF_MOUSE   (Q8BW74), HLF_RAT (Q64709), KK1F_CURCL  (A0A348AXX8), 
LCSF_PURLI  (A0A179H0U5), MAFA_CHICK  (O42290), MAFA_COTJA  (O57342), 
MAFA_DANRE  (A3KMR8), MAFA_HUMAN  (Q8NHW3), MAFA_MOUSE  (Q8CF90), 
MAFA_XENTR  (Q4U1U2), MAFB_CHICK  (Q90888), MAFB_COTJA  (Q90370), 
MAFB_DANRE  (Q98UK5), MAFB_HUMAN  (Q9Y5Q3), MAFB_MACFA  (Q2PFS4), 
MAFB_MOUSE  (P54841), MAFB_RAT(P54842), MAFB_XENLA  (Q6DE84), 
MAFB_XENTR  (Q504L8), MAFF_BOVIN  (A7YY73), MAFF_CHICK  (Q90595), 
MAFF_HUMAN  (Q9ULX9), MAFF_MOUSE  (O54791), MAFG_CHICK  (Q90889), 
MAFG_HUMAN  (O15525), MAFG_MOUSE  (O54790), MAFK_CHICK  (Q90596), 
MAFK_HUMAN  (O60675), MAFK_MOUSE  (Q61827), MAF_AVIS4   (P23091), 
MAF_BOVIN   (A7Z017), MAF_CHICK   (Q789F3), MAF_DANRE   (Q98UK4), 
MAF_HUMAN   (O75444), MAF_MOUSE   (P54843), MAF_RAT (P54844), 
MAF_XENTR   (Q0V9K1), MET4_YEAST  (P32389), NRL_HUMAN   (P54845), 
NRL_MOUSE   (P54846), POF21_ARATH (Q04088), RF2A_ORYSJ  (Q69IL4), 
RF2B_ORYSJ  (Q6S4P4), RSBZ1_ORYSJ (Q6ZLB0), RSBZ2_ORYSJ (Q7X9A8), 
SKO1_YEAST  (Q02100), TEF_CHICK   (Q92172), TEF_HUMAN   (Q10587), 
TEF_MOUSE   (Q9JLC6), TEF_PHOSU   (P97516), TEF_RAT (P41224), 
TGA1B_TOBAC (P14233), ZHANG_HUMAN (Q9NS37), ZHANG_MOUSE (Q91ZR3)
» more

UniProtKB/Swiss-Prot
'Partial' sequences		 1 sequence 

FOS_SHEEP   (O02761)


				
	

	

		UniProtKB/Swiss-Prot
False positive sequences		
		
			31 sequences
			


			
ADDA_ALKOO  (A8MJ41), APCB_SYNY4  (Q02924), APTIR_ACTS5 (G8SD34), 

			
BTBD8_RAT   (D4A0X3), CCR4_COCIM  (Q1EA11), CTTB2_ORNAN (Q07DZ5), 
DAN_AEDAE   (Q16IB4), DC2L1_BOVIN (Q32KV4), DC2L1_RAT   (Q6AY43), 
EIF3E_SCHPO (O94513), EXLYS_BPKMV (Q7Y2C9), KAL1L_MOUSE (Q5DTI6), 
KDM2B_XENLA (Q640I9), KNTC1_HUMAN (P50748), LRC63_MOUSE (A6H694), 
NOL11_XENLA (Q6INI5), NOP16_EMENI (Q5AVK6), OCTB2_DROME (Q4LBB9), 
PAST_ECOL6  (Q8FEY4), PG189_VACCC (P21001), PG189_VACCW (P24769), 
PG189_VAR67 (P0DSS9), PG189_VARV  (P0DST0), PLPL_YARLI  (Q6C8W4), 
RAD54_DROWI (B4MX21), RATA_ECOLI  (P0AGL5), RATA_SHIFL  (P0AGL6), 
RS11_PARXL  (Q13TJ4), Y4393_NOSS1 (Q05070), YYDD_BACSU  (Q45598), 
ZAPB_PHOPR  (Q6LVI6)


			
			» more
			


				
	

	

		PDB
[Detailed view]		
		
			46 PDB
			


			pdb_00001a02; pdb_00001ci6; pdb_00001dgc; pdb_00001dh3; pdb_00001fos; pdb_00001gd2; pdb_00001jnm; pdb_00001ld4; pdb_00001s9k; pdb_00001skn; pdb_00001t2k; pdb_00001ysa; 
			
				pdb_00002c9l; pdb_00002c9n; pdb_00002dgc; pdb_00002e42; pdb_00002h7h; pdb_00002kz5; pdb_00002lz1; pdb_00002wt7; pdb_00005szx; pdb_00005t01; pdb_00005vpa; pdb_00005vpb; 
				pdb_00005vpc; pdb_00005vpd; pdb_00005vpe; pdb_00005vpf; pdb_00005zk1; pdb_00005zko; pdb_00006mg3; pdb_00006uci; pdb_00006ucl; pdb_00006ucm; pdb_00007nx5; pdb_00007o7b; 
				pdb_00007tac; pdb_00007tad; pdb_00007ucc; pdb_00007ucd; pdb_00007x5e; pdb_00007x5f; pdb_00008gyz; pdb_00008k86; pdb_00008k89; pdb_00008k8a
			
			

			» more