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	PROSITE documentation PDOC00054 [for PROSITE entry PS00055]

Ribosomal protein S12 signature

Ribosomal protein S12 is one of the proteins from the small ribosomal subunit. In Escherichia coli, S12 is known to be involved in the translation initiation step. It is a very basic protein of 120 to 150 amino-acid residues. S12 belongs to a family of ribosomal proteins which, on the basis of sequence similarities [1], groups:

• Eubacterial S12.
• Archaebacterial S12.
• Algal and plant chloroplast S12.
• Cyanelle S12.
• Protozoa and plant mitochondrial S12.
• Yeast S28.
• Drosophila mitochondrial protein tko (Technical KnockOut).
• Mammalian S23.

As a signature pattern, we selected the best conserved regions in these proteins, located in the center of each sequence.

Last update:

November 1995 / Text revised.

PROSITE method (with tools and information) covered by this documentation:

RIBOSOMAL_S12, PS00055; Ribosomal protein S12 signature  (PATTERN)

• Consensus pattern:
  [RK]-x-P-N-S-[AR]-x-R
• Sequences in UniProtKB/Swiss-Prot known to belong to this class: 1027
  • detected by PS00055: 1011 (true positives)
  • undetected by PS00055: 16 (15 false negatives and 1 'partial')
• Other sequence(s) in UniProtKB/Swiss-Prot detected by PS00055:
  7 false positives.
• Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits:
  Clustal format, color, condensed view  /  Clustal format, color  /  Clustal format, plain text  /  Fasta format
• Retrieve the sequence logo from the alignment
• Taxonomic distribution of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00055
• Retrieve a list of all UniProtKB (Swiss-Prot + TrEMBL) entries matching PS00055
• Scan UniProtKB (Swiss-Prot and/or TrEMBL) entries against PS00055
• View ligand binding statistics of PS00055
• Matching PDB structures: 1FJG 1HNW 1HNX 1HNZ ... [ALL]

1	Authors	Otaka E., Hashimoto T., Mizuta K.
	Source	Protein Seq. Data Anal. 5:285-300(1993).

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