We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.

PROSITE entry PS00063

View entry in original PROSITE format
View entry in raw text format (no links)
View entry auxiliary file in raw text format (no links)
PURL: https://purl.expasy.org/prosite/signature/PS00063

Direct ScanProsite submission

General information about the entry

Entry name [info]	ALDOKETO_REDUCTASE_3
Accession [info]	PS00063
Entry type [info]	PATTERN
Date [info]	01-APR-1990 CREATED; 01-APR-2006 DATA UPDATE; 29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info]	PDOC00061

Name and characterization of the entry

Description [info]	Aldo/keto reductase family putative active site signature.
Pattern [info]	[LIVM]-[PAIV]-[KR]-[ST]-{EPQG}-{RFI}-x(2)-R-{SVAF}-x-[GSTAEQK]-[NSL]-x- {LVRI}-[LIVMFA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.

Total number of hits	194 in 194 different sequences
Number of true positive hits	131 in 131 different sequences
Number of 'unknown' hits	0
Number of false positive hits	63 in 63 different sequences
Number of false negative sequences	73
Number of 'partial' sequences	2

Precision (true positives / (true positives + false positives))	67.53 %
Recall (true positives / (true positives + false negatives))	64.22 %

Comments [info]

Taxonomic range [info]	Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info]	1
Site [info]	active_site(?) at position 8
Version [info]	2

Cross-references [info]

UniProtKB/Swiss-Prot True positive sequences	131 sequences 6DCS_SOYBN (P26690), A1A1A_DANRE (Q6AZW2), A1A1B_DANRE (Q568L5), AK1A1_BOVIN (Q3ZCJ2), AK1A1_CHICK (Q5ZK84), AK1A1_CRIGR (O70473), AK1A1_HUMAN (P14550), AK1A1_MOUSE (Q9JII6), AK1A1_PIG (P50578), AK1A1_PONAB (Q5R5D5), AK1A1_RAT (P51635), AK1A1_XENLA (Q6GMC7), AK1A1_XENTR (Q28FD1), AK1BA_HUMAN (O60218), AK1C1_HUMAN (Q04828), AK1C1_MACFA (Q95JH7), AK1C1_MACFU (Q95JH6), AK1C1_PONAB (Q5REQ0), AK1C2_HUMAN (P52895), AK1C3_HUMAN (P42330), AK1C3_PONAB (Q5R7C9), AK1C4_HUMAN (P17516), AK1C4_MACFA (Q95JH5), AK1C4_MACFU (Q95JH4), AK1CA_RAT (D3ZF77), AK1CN_HORSE (Q1XAA8), AK1CO_HORSE (Q6W8P9), AK1D1_HUMAN (P51857), AK1D1_MOUSE (Q8VCX1), AK1D1_RABIT (Q9TV64), AK1D1_RAT (P31210), AK2E4_BOMMO (H9JTG9), AKC1H_MOUSE (Q8K023), AKC1H_RAT (P51652), AKCL1_HUMAN (Q5T2L2), AKCL2_MOUSE (Q9DCT1), AKCL2_PIG (P82125), AKCL2_RAT (Q5U1Y4), AKRC8_ARATH (O80944), AKRC9_ARATH (Q0PGJ6), AKRCA_ARATH (Q84TF0), AKRCB_ARATH (Q9M338), AKR_CITSI (P0DXG9), AKR_MELAZ (P0DXH7), ALD1_MOUSE (P21300), ALD2_CRIGR (O08782), ALD2_MOUSE (P45377), ALDR_BOVIN (P16116), ALDR_DROME (M9PF61), ALDR_HORVU (P23901), ALDR_HUMAN (P15121), ALDR_MOUSE (P45376), ALDR_PIG(P80276), ALDR_RABIT (P15122), ALDR_RAT(P07943), ALRB_DICDI (Q54NZ7), ARA1_YEAST (P38115), COR11_PAPSO (Q9SQ70), COR12_PAPSO (Q9SQ69), COR13_PAPSO (Q9SQ68), COR14_PAPSO (Q9SQ67), COR15_PAPSO (B9VRJ2), COR2_PAPSO (Q9SQ64), CRO_AQUCT (P17264), CRO_RANTE (P02532), DDBX_BOVIN (P52898), DHB5_MOUSE (P70694), DIDH_RAT(P23457), DKGA_ECO57 (Q8XBT6), DKGA_ECOLI (Q46857), DKGA_SALTI (P58744), DKGA_SALTY (Q8ZM06), DKGA_YERPE (Q8ZI40), DKGB_CORSS (P15339), DMAS1_HORVU (Q0PCF4), DMAS1_MAIZE (B4F9A4), DMAS1_ORYSJ (Q10PE7), DMS1A_WHEAT (W5DYE3), DMS1B_WHEAT (A0A1D5XGW0), DMS1D_WHEAT (A0A1X9QHJ0), DTDH_MUCMU (Q01213), GAR1_HYPJE (Q3ZFI7), GCY1_YEAST (P14065), GLD2_HYPJE (Q0GYU4), GRE3_YEAST (P38715), GR_BACSU(O32210), MER_ERYCB (E7C196), MIOX_MOUSE (Q9QXN5), MIOX_RAT(Q9QXN4), MORA_PSEPU (Q02198), MRP1_RAT(Q8CG09), NADO1_ORYSJ (Q7G764), NADO2_ORYSJ (Q7G765), PE2R_RABIT (P80508), PGFS1_BOVIN (P05980), PGFS2_BOVIN (P52897), PGFS_LEIMA (P22045), PGFS_TRYCC (Q4DJ07), S6PD_MALDO (P28475), STORR_PAPSO (P0DKI7), XYL1_ARTOC (C5FFQ7), XYL1_ASPCL (A1CRI1), XYL1_ASPFC (B0XNR0), XYL1_ASPFN (B8N195), XYL1_ASPFU (Q4WJT9), XYL1_ASPNC (A2Q8B5), XYL1_ASPNG (Q9P8R5), XYL1_ASPOR (Q2UKD0), XYL1_ASPTN (Q0CUL0), XYL1_CANBO (Q8X195), XYL1_CANPA (Q6Y0Z3), XYL1_CANTE (O74237), XYL1_CANTR (O13283), XYL1_EMENI (Q5BGA7), XYL1_NEOFI (A1D4E3), XYL1_PICGU (O94735), XYL1_PICST (P31867), XYL1_SCHSH (Q9P430), XYL2_CANTR (P87039), Y1918_MYCSJ (A3PXS9), Y1919_MYCSJ (A3PXT0), Y1938_MYCSS (Q1BAN7), Y1984_MYCSK (A1UEC5), Y1985_MYCSK (A1UEC6), Y2408_MYCS2 (A0QV10), Y4205_MYCGI (A4TE41), YER5_SCHPO (O14088), YJ66_YEAST (P47137), YOF5_CAEEL (Q09632), YPR1_YEAST (Q12458), YTBE_BACSU (O34678) » more Retrieve an alignment of UniProtKB/Swiss-Prot true positive hits: [Clustal format, color, condensed view] [Clustal format, color] [Clustal format, plain text] [Fasta format] Retrieve the sequence logo from the alignment
UniProtKB/Swiss-Prot False negative sequences	73 sequences AK1BF_HUMAN (C9JRZ8), AK1CD_MESAU (P82809), AK1CD_MOUSE (Q8VC28), AK1CL_MOUSE (Q91WR5), AK1CL_RAT (Q6AYQ2), AKCL2_HUMAN (Q96JD6), AKCL2_MACFA (Q4R802), AKR1_ORYSI (B8ASB2), AKR1_ORYSJ (Q0JE32), AKR1_SOYBN (C6TBN2), AKR2_ORYSI (A2XRZ0), AKR2_ORYSJ (Q7XT99), AKR3_ORYSI (A2XRZ6), AKR3_ORYSJ (Q7XQ45), AKRMG_ECOLI (P77256), AKR_SYNY3 (P74308), ALDX_SPOSA (P27800), ALKR1_ARATH (Q9C5B9), ALKR2_ARATH (Q84M96), ALKR3_ARATH (O22707), ALKR4_ARATH (Q93ZN2), ALKR5_ARATH (Q9ASZ9), ALKR6_ARATH (F4HPY8), ALRA_DICDI (Q6IMN8), ALRC_DICDI (Q55FL3), ARA2_YEAST (Q04212), DHGRD_AGRFC (A9CEY6), DHGRD_NOVAD (Q2G5J3), DKGA_CORSC (P06632), DKGB_ECO57 (Q8X7Z7), DKGB_ECOLI (P30863), DKGB_SALTI (Q8Z988), DKGB_SALTY (Q8ZRM7), DKGB_YERPE (Q8ZH36), FCDH_PSESP (Q52472), GALDH_ARATH (O81884), GLD1_HYPJE (Q0GYU5), GS69_BACSU (P80874), I3ACR_SCHPO (O13848), IOLS_BACSU (P46336), KAR_YEAST (Q07551), MORA_RABIT (P82810), PERR_RAUSE (Q3L181), PGFS_TRYBB (Q9GV41), PLR1_SCHPO (O14295), PLR1_YEAST (Q06494), PLR2_SCHPO (O94521), PRD1_PYRO7 (G4MZI3), XYL1_HYPJE (Q876L8), XYL1_KLULA (P49378), XYL1_PACTA (P78736), XYL1_PYRO7 (G4N708), Y1669_MYCLB (B8ZS00), Y1669_MYCLE (O69462), Y1744_MYCMM (B2HIJ9), Y1987_MYCUA (A0PQ11), Y2161_MYCVP (A1T726), Y2407_MYCS2 (A0QV09), Y2971_MYCTO (P9WQA4), Y2971_MYCTU (P9WQA5), Y2993_MYCBP (A1KMW6), Y2996_MYCBO (Q7TXI6), Y2999_MYCTA (A5U6Y1), Y3007_MYCPA (Q73VK6), Y3816_MYCA1 (A0QJ99), Y4149_MYCPA (Q73SC5), Y4483_MYCA1 (A0QL30), YBN4_SCHPO (O42888), YDG7_SCHPO (Q10494), YEAE_ECOLI (P76234), YEZB_SCHPO (O14125), YH5B_SCHPO (O94315), YKW2_SCHPO (Q9C1X5) » more
UniProtKB/Swiss-Prot 'Partial' sequences	2 sequences CROB_LEPLU (P49261), DHGP_ASPNG (P55804)
UniProtKB/Swiss-Prot False positive sequences	63 sequences AAP1_ARATH (Q42400), AAP6_ARATH (P92934), ATPFD_MYCA9 (B1MLV9), BST1_EREGS (Q752Q2), CK024_HUMAN (Q96F05), DEXH4_ARATH (Q9C6G0), EIF3C_ASPOR (Q2U0Q9), EIF3C_ASPTN (Q0CVT0), EIF3C_BOMMO (Q0ZB76), FAD3_RICPR (Q9ZCZ1), FGFP3_MOUSE (Q1HCM0), H34_TETTS (Q22RG7), HMUV_PHOLL (Q7N3S7), LPIN2_MOUSE (Q99PI5), MACBH_PSEPF (Q3KE48), MEIKN_HUMAN (A0A087WXM9), MURC_BART1 (A9IWA4), MUTS_AGRFC (Q8UIF2), MUTS_AZOC5 (A8I275), MUTS_BARHE (Q6G542), MUTS_BARQU (Q6G0X1), MUTS_BART1 (A9ILT1), MUTS_BRUA2 (Q2YNZ0), MUTS_BRUA4 (A6WV86), MUTS_BRUAB (Q57FM9), MUTS_BRUC2 (A9M792), MUTS_BRUME (Q8YES6), MUTS_BRUO2 (A5VN83), MUTS_BRUSI (B0CIQ5), MUTS_BRUSU (Q8G310), MUTS_CHESB (Q11B27), MUTS_RHIEC (Q2KD76), MUTS_RHIJ3 (Q1MMA5), NAGS_NEUCR (Q1K8F6), NAGS_PODAN (B2B2C5), NIGP_LACP7 (A9KT32), NTND_NECSZ (A0A455LLW5), NUP85_ARATH (Q8RXH2), OFOB2_AERPE (Q9YBX8), PB1_CHICK (Q90941), PB1_HUMAN (Q86U86), PI4KA_BOVIN (O02811), PI4KA_HUMAN (P42356), PI4KA_MOUSE (E9Q3L2), PI4KA_RAT (O08662), PTA_DEIGD (Q1J2D0), RL13_SACS2 (P95991), RR18_GRATL (Q6B8S1), RR18_TETOB (Q1KVT1), RS18_THET2 (P62659), RS18_THET8 (Q5SLQ0), RS18_THETH (P80382), SECA_PHATC (A0T0G5), SYE_LACGA (Q045X9), SYE_LACJO (Q74L27), TRMB_CAMFF (A0RQ93), U507_KLULA (Q6CSG8), VLMS_LECSP (A0A024F910), XERC_RICPR (Q9ZCE0), XERC_RICTY (Q68VT2), Y109_OSHVF (Q6R7C1), Y2014_VIBVU (Q8DB14), Y2402_VIBVY (Q7MIW1) » more
PDB [Detailed view]	342 PDB pdb_00001abn; pdb_00001ads; pdb_00001ae4; pdb_00001afs; pdb_00001ah0; pdb_00001ah3; pdb_00001ah4; pdb_00001az1; pdb_00001az2; pdb_00001c9w; pdb_00001cwn; pdb_00001dla; pdb_00001ef3; pdb_00001eko; pdb_00001el3; pdb_00001frb; pdb_00001hqt; pdb_00001iei; pdb_00001ihi; pdb_00001j96; pdb_00001jez; pdb_00001k8c; pdb_00001lwi; pdb_00001mar; pdb_00001mi3; pdb_00001mrq; pdb_00001mzr; pdb_00001pwl; pdb_00001pwm; pdb_00001q13; pdb_00001q5m; pdb_00001r38; pdb_00001ral; pdb_00001ry0; pdb_00001ry8; pdb_00001s1p; pdb_00001s1r; pdb_00001s2a; pdb_00001s2c; pdb_00001sm9; pdb_00001t40; pdb_00001t41; pdb_00001us0; pdb_00001x96; pdb_00001x97; pdb_00001x98; pdb_00001xf0; pdb_00001xjb; pdb_00001ye4; pdb_00001ye6; pdb_00001z3n; pdb_00001z89; pdb_00001z8a; pdb_00001z9a; pdb_00001zq5; pdb_00001zua; pdb_00002acq; pdb_00002acr; pdb_00002acs; pdb_00002acu; pdb_00002agt; pdb_00002alr; pdb_00002bgq; pdb_00002bgs; pdb_00002dux; pdb_00002duz; pdb_00002dv0; pdb_00002f2k; pdb_00002f38; pdb_00002fgb; pdb_00002fvl; pdb_00002fz8; pdb_00002fz9; pdb_00002fzb; pdb_00002fzd; pdb_00002hdj; pdb_00002huo; pdb_00002hv5; pdb_00002hvn; pdb_00002hvo; pdb_00002i16; pdb_00002i17; pdb_00002ikg; pdb_00002ikh; pdb_00002iki; pdb_00002ikj; pdb_00002ine; pdb_00002inz; pdb_00002ipj; pdb_00002ipw; pdb_00002iq0; pdb_00002iqd; pdb_00002is7; pdb_00002isf; pdb_00002j8t; pdb_00002nvc; pdb_00002nvd; pdb_00002pd5; pdb_00002pd9; pdb_00002pdb; pdb_00002pdc; pdb_00002pdf; pdb_00002pdg; pdb_00002pdh; pdb_00002pdi; pdb_00002pdj; pdb_00002pdk; pdb_00002pdl; pdb_00002pdm; pdb_00002pdn; pdb_00002pdp; pdb_00002pdq; pdb_00002pdu; pdb_00002pdw; pdb_00002pdx; pdb_00002pdy; pdb_00002pev; pdb_00002pf8; pdb_00002pfh; pdb_00002pzn; pdb_00002qxw; pdb_00002r24; pdb_00002vdg; pdb_00003b3d; pdb_00003bcj; pdb_00003bur; pdb_00003buv; pdb_00003bv7; pdb_00003bxd; pdb_00003c3u; pdb_00003caq; pdb_00003cas; pdb_00003cav; pdb_00003cmf; pdb_00003cot; pdb_00003cv7; pdb_00003d3f; pdb_00003dn5; pdb_00003dop; pdb_00003f7j; pdb_00003fx4; pdb_00003g1r; pdb_00003g5e; pdb_00003ghr; pdb_00003ghs; pdb_00003ght; pdb_00003ghu; pdb_00003gug; pdb_00003h4g; pdb_00003h7r; pdb_00003h7u; pdb_00003lbo; pdb_00003ld5; pdb_00003len; pdb_00003lep; pdb_00003lqg; pdb_00003lql; pdb_00003lz3; pdb_00003lz5; pdb_00003m0i; pdb_00003m4h; pdb_00003m64; pdb_00003mb9; pdb_00003mc5; pdb_00003nty; pdb_00003onb; pdb_00003onc; pdb_00003p2v; pdb_00003q65; pdb_00003q67; pdb_00003r43; pdb_00003r58; pdb_00003r6i; pdb_00003r7m; pdb_00003r8g; pdb_00003r8h; pdb_00003r94; pdb_00003rx2; pdb_00003rx3; pdb_00003rx4; pdb_00003s3g; pdb_00003t42; pdb_00003u2c; pdb_00003ufy; pdb_00003ug8; pdb_00003ugr; pdb_00003uwe; pdb_00003uzw; pdb_00003uzx; pdb_00003uzy; pdb_00003uzz; pdb_00003v35; pdb_00003v36; pdb_00003wcz; pdb_00004dbs; pdb_00004dbu; pdb_00004dbw; pdb_00004dz5; pdb_00004f40; pdb_00004fa3; pdb_00004fal; pdb_00004fam; pdb_00004fzi; pdb_00004g5d; pdb_00004ga8; pdb_00004gab; pdb_00004gac; pdb_00004gca; pdb_00004gie; pdb_00004gq0; pdb_00004gqg; pdb_00004h7c; pdb_00004hmn; pdb_00004i5x; pdb_00004icc; pdb_00004igs; pdb_00004ijc; pdb_00004ijr; pdb_00004jih; pdb_00004jii; pdb_00004jir; pdb_00004jq1; pdb_00004jq2; pdb_00004jq3; pdb_00004jq4; pdb_00004jqa; pdb_00004jtq; pdb_00004jtr; pdb_00004l1w; pdb_00004l1x; pdb_00004lau; pdb_00004laz; pdb_00004lb3; pdb_00004lb4; pdb_00004lbr; pdb_00004lbs; pdb_00004nkc; pdb_00004pr4; pdb_00004prr; pdb_00004prt; pdb_00004puu; pdb_00004puw; pdb_00004q7b; pdb_00004qbx; pdb_00004qr6; pdb_00004qx4; pdb_00004qxi; pdb_00004rpq; pdb_00004wdt; pdb_00004wdu; pdb_00004wdw; pdb_00004wdx; pdb_00004wev; pdb_00004wrh; pdb_00004xo6; pdb_00004xo7; pdb_00004xvd; pdb_00004xve; pdb_00004xzh; pdb_00004xzi; pdb_00004xzl; pdb_00004xzm; pdb_00004xzn; pdb_00004ys1; pdb_00004yu1; pdb_00004yvp; pdb_00004yvv; pdb_00004yvx; pdb_00004zfc; pdb_00005ha7; pdb_00005hnt; pdb_00005hnu; pdb_00005lik; pdb_00005liu; pdb_00005liw; pdb_00005lix; pdb_00005liy; pdb_00005m2f; pdb_00005ou0; pdb_00005ouj; pdb_00005ouk; pdb_00005y7n; pdb_00005z6t; pdb_00005z6u; pdb_00006a7a; pdb_00006a7b; pdb_00006f2u; pdb_00006f78; pdb_00006f7r; pdb_00006f81; pdb_00006f82; pdb_00006f84; pdb_00006f8o; pdb_00006gxk; pdb_00006ijx; pdb_00006syw; pdb_00006t27; pdb_00006t3p; pdb_00006t5g; pdb_00006t7q; pdb_00006td8; pdb_00006tuc; pdb_00006tuf; pdb_00006txp; pdb_00006xum; pdb_00006y03; pdb_00006y1p; pdb_00007c7f; pdb_00007c7g; pdb_00007c7h; pdb_00007mbf; pdb_00007wqm; pdb_00007wqr; pdb_00007wqs; pdb_00007x3l; pdb_00007x3m; pdb_00007x3o; pdb_00008a4n; pdb_00008ae9; pdb_00008aqg; pdb_00008aqp; pdb_00008auu; pdb_00008b34; pdb_00008b3n; pdb_00008b3r; pdb_00008b66; pdb_00008bbs; pdb_00008bjl; pdb_00008cnf; pdb_00008cnp; pdb_00008fh5; pdb_00008fh6; pdb_00008fh7; pdb_00008fh8; pdb_00008fh9; pdb_00008i0c; pdb_00008jp1; pdb_00008jp2; pdb_00008oz2; pdb_00008p2r; pdb_00008rb6; pdb_00009ffd » more