We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
Our deepest condolences go out to his family and friends, and to all those who had the privilege of working with him. Rest in peace, Amos. Your work will live on long after you are gone.
PROSITE entry PS00065
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PURL: https://purl.expasy.org/prosite/signature/PS00065
Direct ScanProsite submission
General information about the entry
| Entry name [info] | D_2_HYDROXYACID_DH_1 |
| Accession [info] | PS00065 |
| Entry type [info] | PATTERN |
| Date [info] |
01-APR-1990 CREATED;
01-DEC-2004 DATA UPDATE; 29-MAY-2024 INFO UPDATE. |
| PROSITE Doc. [info] | PDOC00063 |
Name and characterization of the entry
| Description [info] | D-isomer specific 2-hydroxyacid dehydrogenases NAD-binding signature. |
| Pattern [info] |
[LIVMA]-[AG]-[IVT]-[LIVMFY]-[AG]-x-G-[NHKRQGSAC]-[LIV]-G-x(13,14)-
[LIVMFT]-{A}-x-[FYWCTH]-[DNSTK].
|
Numerical results [info]
| Total number of hits | 249 in 249 different sequences |
| Number of true positive hits | 195 in 195 different sequences |
| Number of 'unknown' hits | 0 |
| Number of false positive hits | 54 in 54 different sequences |
| Number of false negative sequences | 215 |
| Number of 'partial' sequences | 1 |
| Precision (true positives / (true positives + false positives)) | 78.31 % |
| Recall (true positives / (true positives + false negatives)) | 47.56 % |
Comments [info]
| Taxonomic range [info] | Archaea, Eukaryotes, Prokaryotes (Bacteria) |
| Maximum number of repetitions [info] | 1 |
| Version [info] | 1 |
Cross-references [info]
| UniProtKB/Swiss-Prot True positive sequences |
195 sequences
2KGR_VITVI (A5CAL1), CTBP1_CAEEL (Q20595), CTBP1_HUMAN (Q13363), CTBP1_MOUSE (O88712), CTBP1_RAT (Q9Z2F5), CTBP1_XENLA (Q9YHU0), CTBP2_XENLA (Q9W758), DDH2_SCHPO (Q9P7Q1), DDH_HAEIN (P44501), DDH_ZYMMO (P30799), DHD2_LACPA (P17584), DHGY_CUCSA (P13443), DHGY_HYPME (P36234), DHGY_METEA (Q59516), EFUE_HORCR (A0A2Z4HPZ6), FDH1_ORYSJ (Q9SXP2), FDH2_ORYSJ (Q67U69), FDH_ARATH (Q9S7E4), FDH_CANBO (O13437), FDH_CHATD (G0SGU4), FDH_EMENI (Q03134), FDH_NEUCR (Q07103), FDH_PICAN (P33677), FDH_PSESR (P33160), FDH_SOLTU (Q07511), FLDH_CLOS1 (J7SHB8), FLDH_CLOS3 (G9EZR6), GHRB_YERE8 (A1JT62), GHRB_YERP3 (A7FPA2), GHRB_YERPA (Q1C3K4), GHRB_YERPB (B2K7F1), GHRB_YERPE (Q0W9V5), GHRB_YERPG (A9R4G6), GHRB_YERPN (Q1CD80), GHRB_YERPP (A4TGN1), GHRB_YERPS (Q663W4), GHRB_YERPY (B1JH01), GOR1_YEAST (P53839), GYAR_AERPE (Q9YAW4), GYAR_KORCO (B1L765), GYAR_PYRAB (Q9UYR1), GYAR_PYRFU (Q8U3Y2), GYAR_PYRHO (O58320), GYAR_THEGJ (C5A1V0), GYAR_THEKO (Q5JEZ2), GYAR_THELN (Q9C4M5), HADHA_ASPOR (Q2UH56), HPPR_PLESU (Q65CJ7), HPR1_ARATH (Q9C9W5), HPR2_ARATH (Q9CA90), HPR_BLAHS (C0CMQ8), KK1H_CURCL (A0A348AXY0), LDHA_CLODI (Q5U922), LDHD_ECOLI (P52643), LDHD_LACDA (P26297), LDHD_LACHE (P30901), LDHD_LACPE (P26298), LDHD_LACPL (Q88VJ2), LDHD_LEUMC (P51011), LDHD_PEDAC (Q59642), LDHD_STAAC (Q5HD29), LDHD_STAAM (P63940), LDHD_STAAN (P99116), LDHD_STAAR (Q6GDS2), LDHD_STAAS (Q6G6F1), LDHD_STAAU (P72357), LDHD_STAAW (Q8NUT2), LDHD_STAEQ (Q5HLA0), LDHD_STAES (Q8CN22), LDHD_STRA3 (Q8E6A9), LDHD_STRA5 (Q8E0N5), LDHD_STRP1 (Q99ZM2), LDHD_TREPA (O83080), MORA_ASPOR (Q2U0N3), PDXB_ACIAD (Q6F943), PDXB_ACIB3 (B7GY62), PDXB_ACIB5 (B7I5Z2), PDXB_ACIBC (B2HX89), PDXB_ACIBS (B0VT23), PDXB_ACIBT (A3M810), PDXB_ACIBY (B0VDM7), PDXB_ALCBS (Q0VQC3), PDXB_BAUCH (Q1LTA7), PDXB_BLOFL (Q7VRU9), PDXB_BLOPB (Q492H2), PDXB_CITK8 (A8ADQ9), PDXB_CROS8 (A7MH63), PDXB_ECO24 (A7ZPD6), PDXB_ECO27 (B7UFX8), PDXB_ECO45 (B7MG84), PDXB_ECO55 (B7LBH4), PDXB_ECO57 (Q8XCR0), PDXB_ECO5E (B5YXW1), PDXB_ECO7I (B7NP01), PDXB_ECO81 (B7MXZ7), PDXB_ECO8A (B7M6K1), PDXB_ECOBW (C4ZVL3), PDXB_ECODH (B1X931), PDXB_ECOHS (A8A2I9), PDXB_ECOK1 (A1ADG9), PDXB_ECOL5 (Q0TFC6), PDXB_ECOL6 (Q8FFH2), PDXB_ECOLC (B1IXM2), PDXB_ECOLI (P05459), PDXB_ECOLU (B7N5T2), PDXB_ECOSE (B6I4U8), PDXB_ECOSM (B1LLS6), PDXB_ECOUT (Q1R992), PDXB_EDWI9 (C5B8N0), PDXB_ENT38 (A4WCV4), PDXB_ESCF3 (B7LLF0), PDXB_KLEP3 (B5XNR7), PDXB_LEGPA (Q5X6I6), PDXB_LEGPH (Q5ZX15), PDXB_LEGPL (Q5WXZ0), PDXB_MARMS (A6VXM3), PDXB_MARN8 (A1U1I8), PDXB_PECAS (Q6D2N5), PDXB_PECCP (C6DA76), PDXB_PHOLL (Q7N2B2), PDXB_PORGI (Q7MV70), PDXB_PROMH (B4EZF9), PDXB_PSET1 (Q3IF36), PDXB_PSYA2 (Q4FV16), PDXB_PSYCK (Q1QE21), PDXB_PSYWF (A5WHK7), PDXB_SALA4 (B5EZQ4), PDXB_SALAR (A9MJ55), PDXB_SALCH (Q57LY4), PDXB_SALDC (B5FPL4), PDXB_SALEP (B5R3Q1), PDXB_SALG2 (B5RCJ5), PDXB_SALHS (B4TBN9), PDXB_SALNS (B4SZP2), PDXB_SALPA (Q5PCV8), PDXB_SALPB (A9N474), PDXB_SALPC (C0PZZ3), PDXB_SALPK (B5BCH6), PDXB_SALSV (B4TQA6), PDXB_SALTI (P60801), PDXB_SALTY (P60802), PDXB_SERP5 (A8GH44), PDXB_SHIB3 (B2TWA2), PDXB_SHIBS (Q31YD8), PDXB_SHIDS (Q32DL6), PDXB_SHIF8 (Q0T2G5), PDXB_SHIFL (Q83QR1), PDXB_SHISS (Q3YZP1), PDXB_SODGM (Q2NSH9), PDXB_WIGBR (Q8D2P6), PDXB_YERE8 (A1JL55), PDXB_YERP3 (A7FGL9), PDXB_YERPA (Q1C676), PDXB_YERPB (B2K8H7), PDXB_YERPE (Q8D0U3), PDXB_YERPG (A9R7V0), PDXB_YERPN (Q1CHL8), PDXB_YERPP (A4TM66), PDXB_YERPS (Q668W7), PDXB_YERPY (B1JGI0), SER33_YEAST (P40510), SERA1_ARATH (O49485), SERA2_ARATH (O04130), SERA3_ARATH (Q9LT69), SERA_ARCFU (O29445), SERA_BACSU (P35136), SERA_BOVIN (Q5EAD2), SERA_DICDI (Q54UH8), SERA_ECO57 (P0A9T2), SERA_ECOL6 (P0A9T1), SERA_ECOLI (P0A9T0), SERA_HAEIN (P43885), SERA_HUMAN (O43175), SERA_MACFA (Q60HD7), SERA_METJA (Q58424), SERA_METTH (O27051), SERA_MOUSE (Q61753), SERA_MYCBO (P0A545), SERA_MYCLE (O33116), SERA_MYCTO (P9WNX2), SERA_MYCTU (P9WNX3), SERA_PANTR (A5A6P1), SERA_PIG(A5GFY8), SERA_PONAB (Q5R7M2), SERA_RAT(O08651), SERA_SCHPO (P87228), SERA_SHIFL (P0A9T3), SERA_SYNY3 (P73821), SERA_YEAST (P40054), TKRA_BACSU (O32264), UBA5_DANRE (X1WER2), VANH_ENTFA (Q47748), VANH_ENTFC (Q05709), YEAA_SCHPO (O14075), YGDH_SCHPO (O94574)» more
|
| UniProtKB/Swiss-Prot False negative sequences |
215 sequences
2KGR_GLUOX (Q5FTU6), CTBP2_BOVIN (Q0VCQ1), CTBP2_HUMAN (P56545), CTBP2_MOUSE (P56546), CTBP2_RAT (Q9EQH5), CTBP_ARATH (O23702), CTBP_DROME (O46036), DDH1_SCHPO (Q9P7P8), DDH_HALMT (Q2VEQ7), FDH1_YEAS7 (A6ZN46), FDH1_YEAS8 (C8ZHD6), FDH1_YEASC (N1P3Y5), FDH1_YEAST (Q08911), FDH2_YEASC (P0CT22), FDH2_YEAST (P0CF35), FDH_HORVU (Q9ZRI8), GHRA_CITK8 (A8AI49), GHRA_CROS8 (A7MFZ8), GHRA_ECO27 (B7UP47), GHRA_ECO45 (B7MIH3), GHRA_ECO55 (B7LFE3), GHRA_ECO57 (Q8X9K1), GHRA_ECO5E (B5YVQ3), GHRA_ECO7I (B7NLA1), GHRA_ECO81 (B7MTG4), GHRA_ECO8A (B7M907), GHRA_ECOBW (C4ZRX4), GHRA_ECODH (B1X9E7), GHRA_ECOHS (A7ZYY6), GHRA_ECOK1 (A1A9T1), GHRA_ECOL5 (Q0TJ41), GHRA_ECOL6 (Q8FIT1), GHRA_ECOLC (B1IV68), GHRA_ECOLI (P75913), GHRA_ECOLU (B7N3I0), GHRA_ECOSE (B6I9A9), GHRA_ECOSM (B1LIY1), GHRA_ECOUT (Q1RDC8), GHRA_ENT38 (A4W948), GHRA_ESCF3 (B7LTA2), GHRA_KLEP3 (B5XXL3), GHRA_KLEP7 (A6T7B8), GHRA_PHOLL (Q7N571), GHRA_SALA4 (B5F974), GHRA_SALAR (A9MH27), GHRA_SALCH (Q57QM2), GHRA_SALDC (B5FL30), GHRA_SALEP (B5QY30), GHRA_SALG2 (B5RBG3), GHRA_SALHS (B4TEQ6), GHRA_SALNS (B4T2W6), GHRA_SALPA (Q5PGZ3), GHRA_SALPB (A9N5T3), GHRA_SALPC (C0Q872), GHRA_SALPK (B5BBF3), GHRA_SALSV (B4TSP5), GHRA_SALTI (Q8Z7M6), GHRA_SALTY (Q8ZQ30), GHRA_SERP5 (A8GD46), GHRA_SHIB3 (B2TTN6), GHRA_SHIBS (Q31Z89), GHRA_SHIDS (Q32HN5), GHRA_SHISS (Q3Z393), GHRA_YERE8 (A1JRR3), GHRB_CITK8 (A8ARD9), GHRB_CROS8 (A7MKR1), GHRB_ECO24 (A7ZTA0), GHRB_ECO27 (B7ULB4), GHRB_ECO45 (B7MER0), GHRB_ECO55 (B7L6W9), GHRB_ECO57 (P58220), GHRB_ECO5E (B5YVK6), GHRB_ECO7I (B7NP49), GHRB_ECO81 (B7N1K7), GHRB_ECO8A (B7M3H6), GHRB_ECOBW (C4ZXE2), GHRB_ECODH (B1X8G8), GHRB_ECOHS (A8A609), GHRB_ECOK1 (A1AH96), GHRB_ECOL5 (Q0TBP9), GHRB_ECOL6 (Q8FCF1), GHRB_ECOLC (B1IZP1), GHRB_ECOLI (P37666), GHRB_ECOLU (B7NEK6), GHRB_ECOSE (B6I3C3), GHRB_ECOSM (B1LJB3), GHRB_ECOUT (Q1R543), GHRB_ENT38 (A4W577), GHRB_ENTAG (P58000), GHRB_ERWT9 (B2VCD1), GHRB_ESCF3 (B7LTG7), GHRB_KLEP3 (B5XMZ4), GHRB_KLEP7 (A6TFG7), GHRB_PECAS (Q6DB24), GHRB_PECCP (C6DJ88), GHRB_SALA4 (B5EX58), GHRB_SALCH (Q57IH8), GHRB_SALDC (B5FLC2), GHRB_SALEP (B5R4N3), GHRB_SALG2 (B5RGN1), GHRB_SALHS (B4T938), GHRB_SALNS (B4SWJ5), GHRB_SALPA (Q5PLL9), GHRB_SALPB (A9MUT4), GHRB_SALPC (C0Q1A7), GHRB_SALPK (B5BHT3), GHRB_SALSV (B4TZ41), GHRB_SALTI (Q8Z2A8), GHRB_SALTY (Q8ZLA1), GHRB_SERP5 (A8G7S7), GHRB_SHIB3 (B2U573), GHRB_SHIBS (Q31V71), GHRB_SHIDS (Q328L4), GHRB_SHIF8 (Q0SZE5), GHRB_SHIFL (Q83PR3), GHRB_SHISS (Q3YVT5), GLYR1_ARATH (Q9LSV0), GLYR2_ARATH (F4I907), GRHPR_HUMAN (Q9UBQ7), GRHPR_MOUSE (Q91Z53), GYAR_THEON (B6YWH0), GYAR_THEPD (A1RYE4), HGDH_ACIFV (D2RJU7), HPR_THEMA (Q9X1C1), LDHD_DICDI (Q54UF7), PDXB_AERHH (A0KLP0), PDXB_AERS4 (A4SNU1), PDXB_ALIF1 (Q5E452), PDXB_ALIFM (B5FFP0), PDXB_ALISL (B6EIW3), PDXB_AZOVD (C1DM66), PDXB_BACFN (Q5LIR8), PDXB_BACFR (Q64ZV5), PDXB_BACTN (Q8A2E4), PDXB_CELJU (B3PK14), PDXB_CHRSD (Q1QXV7), PDXB_COLP3 (Q47XK1), PDXB_COXBN (A9KEY5), PDXB_COXBR (A9NAQ7), PDXB_COXBU (Q83AR8), PDXB_ECTM1 (A4XTK4), PDXB_HAHCH (Q2SJQ9), PDXB_HYDCU (Q31IH6), PDXB_IDILO (Q5QUE2), PDXB_PHOPR (Q6LNU2), PDXB_PSE14 (Q48KQ3), PDXB_PSEA6 (Q15QG8), PDXB_PSEA8 (B7UVK4), PDXB_PSEAB (Q02JM2), PDXB_PSEAE (Q9I3W9), PDXB_PSEE4 (Q1I7B3), PDXB_PSEF5 (Q4KFD1), PDXB_PSEFS (C3K5G7), PDXB_PSEP1 (A5W6I8), PDXB_PSEP7 (A6V8H9), PDXB_PSEPF (Q3K9D1), PDXB_PSEPG (B0KGD9), PDXB_PSEPK (Q88L20), PDXB_PSEPW (B1J5D7), PDXB_PSESM (Q884R9), PDXB_PSEU2 (Q4ZVE7), PDXB_PSYIN (A1SW94), PDXB_RUTMC (A1AWW7), PDXB_SACD2 (Q21LK8), PDXB_SALRD (Q2S0U3), PDXB_SHEAM (A1S7K2), PDXB_SHEB2 (B8EEB4), PDXB_SHEB5 (A3D669), PDXB_SHEB8 (A6WQ07), PDXB_SHEB9 (A9KTV0), PDXB_SHEDO (Q12P58), PDXB_SHEFN (Q084S1), PDXB_SHEHH (B0TKZ7), PDXB_SHELP (A3QFC7), PDXB_SHEON (Q8ECR2), PDXB_SHEPC (A4Y882), PDXB_SHESA (A0KV91), PDXB_SHESH (A8FTT7), PDXB_SHESM (Q0HKB6), PDXB_SHESP (Q56731), PDXB_SHESR (Q0HWL8), PDXB_SHESW (A1RIA7), PDXB_SHEVD (Q56733), PDXB_SHEWM (B1KKP1), PDXB_STUS1 (A4VKJ1), PDXB_TERTT (C5BR49), PDXB_TOLAT (C4LF16), PDXB_VESOH (A5CWD1), PDXB_VIBA3 (B7VL81), PDXB_VIBCH (Q9KQ92), PDXB_VIBPA (Q87MN8), PDXB_VIBVU (Q8DB36), PDXB_VIBVY (Q7MIT6), PTXD_STUST (O69054), SLCC_CHRSD (Q1QWN6), TKRA_DICDI (Q54DP1), Y1556_HAEIN (P45250), Y1879_STAES (Q8CNB8), Y1888_STAEQ (Q5HLU4), Y2098_STAAN (Q7A417), Y2178_STAAB (Q2YYT9), Y2196_STAAS (Q6G716), Y2224_STAAW (Q8NV80), Y2254_STAA3 (Q2FEI9), Y2296_STAAC (Q5HDQ4), Y2305_STAAM (Q99RW8), Y2355_CORGL (P0C1E8), Y2389_STAAR (Q6GEC9), Y2577_STAA8 (Q2FVW4), Y606_STAS1 (Q49ZM5), Y752_STAHJ (Q4L8G4), YGT5_YEAST (P53100), YOAD_BACSU (O34815), YP113_YEAST (Q02961), YPRB2_CORML (P0C1E9)» more |
| UniProtKB/Swiss-Prot 'Partial' sequences |
1 sequence
YMP5_STRCH (P43169) |
| UniProtKB/Swiss-Prot False positive sequences |
54 sequences
ADH7_YEAST (P25377), ADHA_SYNY3 (P74721), ADH_STAA3 (Q2FJ31), ADH_STAA8 (Q2G0G1), ADH_STAAB (Q2YSX0), ADH_STAAC (Q5HI63), ADH_STAAM (Q99W07), ADH_STAAN (Q7A742), ADH_STAAR (Q6GJ63), ADH_STAAS (Q6GBM4), ADH_STAAW (Q8NXU1), ADH_STAEQ (Q5HRD6), ADH_STAES (Q8CQ56), AHR_ECOLI (P27250), CADH1_ARATH (Q9CAI3), CADH4_ORYSJ (Q2R114), CARB_SULAC (Q4J8E8), DOIAD_MICEC (Q70KF0), GLNE_AGRFC (Q8UGQ4), GLNE_BARHE (Q6G488), GLNE_BARQU (Q6G0B0), GLNE_RHIME (Q92R86), MDH1_AQUAE (O67655), PC2DH_METJA (Q57605), RAPB_DICDI (Q86L51), UBA5_AEDAE (Q17DT0), UBA5_ARATH (O23034), UBA5_BOMMO (B9VJ80), UBA5_BOVIN (A7MAZ3), UBA5_BRAFL (C3YZ51), UBA5_CAEBR (A8XEQ8), UBA5_CAEEL (P91430), UBA5_CHICK (Q6IVA4), UBA5_CULQU (B0WQV1), UBA5_DROAN (D1GY43), UBA5_DROER (B3NUC9), UBA5_DROGR (B4JIY0), UBA5_DROME (Q9VYY3), UBA5_DROMO (B4L1K2), UBA5_DROPE (B4GYC7), UBA5_DROPS (Q29HT0), UBA5_DROSE (B4IK21), UBA5_DROSI (B4R345), UBA5_DROVI (B4M357), UBA5_DROWI (B4NDE5), UBA5_DROYA (B4PYA4), UBA5_HUMAN (Q9GZZ9), UBA5_MOUSE (Q8VE47), UBA5_ORYSJ (Q6K6K7), UBA5_PONAB (Q5R8X4), UBA5_RAT(Q5M7A4), UBA5_XENLA (Q3KQ23), UBA5_XENTR (Q6GLG7), YAHK_ECOLI (P75691)» more |
| PDB [Detailed view] |
79 PDB
pdb_00001dxy; pdb_00001gdh; pdb_00001hku; pdb_00001hl3; pdb_00001j49; pdb_00001j4a; pdb_00001mx3; pdb_00001psd; pdb_00001sc6; pdb_00001yba; pdb_00001ygy; pdb_00002dbq; pdb_00002dbr; pdb_00002dbz; pdb_00002dld; pdb_00002fss; pdb_00002g76; pdb_00002go1; pdb_00002gug; pdb_00002hu2; pdb_00002j6i; pdb_00002nac; pdb_00002nad; pdb_00002p9c; pdb_00002p9e; pdb_00002p9g; pdb_00002pa3; pdb_00003ba1; pdb_00003baz; pdb_00003dc2; pdb_00003ddn; pdb_00003jtm; pdb_00003n7u; pdb_00003naq; pdb_00003oet; pdb_00004lce; pdb_00004u6q; pdb_00004u6s; pdb_00005aov; pdb_00005n53; pdb_00005n6c; pdb_00005nzo; pdb_00005nzp; pdb_00005nzq; pdb_00005ofm; pdb_00005ofv; pdb_00005ofw; pdb_00005z1z; pdb_00006cdf; pdb_00006cdr; pdb_00006cwa; pdb_00006juj; pdb_00006juk; pdb_00006jwg; pdb_00006jx1; pdb_00006pex; pdb_00006plf; pdb_00006plg; pdb_00006rih; pdb_00006rj2; pdb_00006rj3; pdb_00006rj5; pdb_00006rj6; pdb_00006t8y; pdb_00006t8z; pdb_00006t92; pdb_00006t94; pdb_00006v89; pdb_00007cvp; pdb_00007dkm; pdb_00007ewh; pdb_00007jp2; pdb_00007va1; pdb_00008ari; pdb_00008pin; pdb_00008pio; pdb_00008pir; pdb_00008pis; pdb_00008q2i » more |