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We are deeply saddened by the passing of Amos Bairoch (1957–2025), the creator of PROSITE. We wish to dedicate our latest paper, published shortly before his death, to him. He will always be a source of inspiration to us.
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Amos Bairoch

PROSITE entry PS00072


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PURL: https://purl.expasy.org/prosite/signature/PS00072

Direct ScanProsite submission
General information about the entry

Entry name [info] ACYL_COA_DH_1
Accession [info] PS00072
Entry type [info] PATTERN
Date [info] 01-APR-1990 CREATED;
01-NOV-1997 DATA UPDATE;
29-MAY-2024 INFO UPDATE.
PROSITE Doc. [info] PDOC00070

Name and characterization of the entry

Description [info] Acyl-CoA dehydrogenases signature 1.
Pattern [info] 
[GAC]-[LIVM]-[ST]-E-x(2)-[GSAN]-G-[ST]-D-x(2)-[GSA].

Numerical results [info]

Numerical results for UniProtKB/Swiss-Prot release 2025_04 which contains 573'661 sequence entries.


Total number of hits 122 in 122 different sequences
Number of true positive hits 118 in 118 different sequences
Number of 'unknown' hits 0
Number of false positive hits 4 in 4 different sequences
Number of false negative sequences 51
Number of 'partial' sequences 0
Precision (true positives / (true positives + false positives)) 96.72 %
Recall (true positives / (true positives + false negatives)) 69.82 %

Comments [info]

Taxonomic range [info] Eukaryotes, Prokaryotes (Bacteria)
Maximum number of repetitions [info] 1
Version [info] 1

Cross-references [info]

UniProtKB/Swiss-Prot
True positive sequences		 118 sequences 

ACAD1_CAEBR (A8XNF0), ACAD2_CAEBR (A8WP91), ACAD8_BOVIN (Q0NXR6), 

ACAD8_DICDI (Q54IM8), ACAD8_HUMAN (Q9UKU7), ACAD8_MOUSE (Q9D7B6), 
ACAD9_HUMAN (Q9H845), ACAD9_MOUSE (Q8JZN5), ACAD9_RAT   (B1WC61), 
ACADL_HUMAN (P28330), ACADL_MACFA (Q60HI0), ACADL_MOUSE (P51174), 
ACADL_PIG   (P79274), ACADL_RAT   (P15650), ACADM_BOVIN (Q3SZB4), 
ACADM_CAEEL (Q22347), ACADM_DROME (Q9VSA3), ACADM_HUMAN (P11310), 
ACADM_MACFA (Q8HXY8), ACADM_MOUSE (P45952), ACADM_PANTR (A5A6I0), 
ACADM_PIG   (P41367), ACADM_RAT   (P08503), ACADS_BOVIN (Q3ZBF6), 
ACADS_HUMAN (P16219), ACADS_MOUSE (Q07417), ACADS_PIG   (P79273), 
ACADS_PONAB (Q5RAS0), ACADS_RAT   (P15651), ACADV_BOVIN (P48818), 
ACADV_HUMAN (P49748), ACADV_MACFA (Q8HXY7), ACADV_MOUSE (P50544), 
ACADV_RAT   (P45953), ACDA_BACSU  (P45867), ACDA_CLOS1  (J7TF92), 
ACDB_BACSU  (P45857), ACDC_BACSU  (O34421), ACDP_MYCBO  (P63428), 
ACDP_MYCLE  (P46703), ACDP_MYCTO  (P9WQG0), ACDP_MYCTU  (P9WQG1), 
ACDSB_BOVIN (Q5EAD4), ACDSB_DICDI (Q54RR5), ACDSB_HUMAN (P45954), 
ACDSB_MOUSE (Q9DBL1), ACDSB_PONAB (Q5RF40), ACDSB_RAT   (P70584), 
ACDS_CLOAB  (P52042), ACDS_MEGEL  (Q06319), ACD_DESML   (C3UVB0), 
ACOX4_ARATH (Q96329), ACRC_ANAPI  (G3KIM8), AIDB_ECOLI  (P33224), 
APDG_EMENI  (Q5ATG5), CAIA_CITK8  (A8ALR4), CAIA_ECO24  (A7ZHD0), 
CAIA_ECO27  (B7UI85), CAIA_ECO45  (B7MAG2), CAIA_ECO55  (B7L4G2), 
CAIA_ECO57  (P60586), CAIA_ECO5E  (B5YYD3), CAIA_ECO7I  (B7NHE3), 
CAIA_ECO81  (B7MNP6), CAIA_ECO8A  (B7M0D6), CAIA_ECOBW  (C4ZPW5), 
CAIA_ECODH  (B1XBG4), CAIA_ECOHS  (A7ZVY9), CAIA_ECOK1  (A1A789), 
CAIA_ECOL5  (Q0TLV0), CAIA_ECOL6  (P60585), CAIA_ECOLC  (B1IRD7), 
CAIA_ECOLI  (P60584), CAIA_ECOLU  (B7N7R4), CAIA_ECOSE  (B6HYZ0), 
CAIA_ECOSM  (B1LFX2), CAIA_ECOUT  (Q1RGF9), CAIA_ESCF3  (B7LWN0), 
CAIA_PROMH  (B4EY23), CAIA_PROSL  (Q8GB20), CAIA_SALA4  (B5F752), 
CAIA_SALAR  (A9MQH5), CAIA_SALCH  (Q57TI8), CAIA_SALDC  (B5FHG7), 
CAIA_SALEP  (B5R1R2), CAIA_SALG2  (B5RGA6), CAIA_SALHS  (B4TIH2), 
CAIA_SALNS  (B4T6J8), CAIA_SALPA  (Q5PIN6), CAIA_SALPB  (A9MYJ9), 
CAIA_SALPC  (C0Q4L5), CAIA_SALPK  (B5BL57), CAIA_SALSV  (B4TWR6), 
CAIA_SALTI  (Q8Z9L2), CAIA_SALTY  (Q8ZRX2), CAIA_SHIDS  (Q32K58), 
CAIA_SHIF8  (Q0T8F5), CAIA_SHIFL  (P60587), CAIA_SHISS  (Q3Z5W9), 
CARC_ACEWD  (H6LGM6), FADE_BACSU  (O32176), GCDH_DICDI  (Q54R47), 
GCDH_HUMAN  (Q92947), GCDH_MACFA  (Q8HXX8), IAAF_AROAE  (Q5P5Z9), 
IVD_ARATH   (Q9SWG0), IVD_BOVIN   (Q3SZI8), IVD_CAEEL   (P34275), 
IVD_HUMAN   (P26440), IVD_MOUSE   (Q9JHI5), IVD_ORYSJ   (Q75IM9), 
IVD_PONAB   (Q5RBD5), IVD_RAT (P12007), IVD_SOLTU   (Q9FS87), 
MBCD_SOLTU  (Q9FS88), YDIO_ECO57  (P0A9V0), YDIO_ECOL6  (P0A9U9), 
YDIO_ECOLI  (P0A9U8)
» more

UniProtKB/Swiss-Prot
False negative sequences		 51 sequences 

ACD10_HUMAN (Q6JQN1), ACD10_MOUSE (Q8K370), ACD17_MYCTU (P95280), 

ACD2_MYCTU  (P96831), ACDC_MYCBO  (Q7U0Y2), ACDC_MYCTO  (P9WQG2), 
ACDC_MYCTU  (P9WQG3), BBSG_THAAR  (Q9KJE8), CH1CO_GEOMG (Q39QF5), 
CH1CO_SYNAS (Q2LQN9), CHCOA_GEOMG (Q39QF4), CHCOA_SYNAS (Q2LQP0), 
CHSE1_MYCTU (P71857), CHSE2_MYCTU (P71858), CHSE3_MYCTU (P96855), 
CHSE4_MYCTU (I6YCA3), CHSE5_MYCTU (I6Y3Q0), FADE5_MYCS2 (Q3L887), 
FADE5_MYCTU (O53666), FADE_ECO57  (Q8X7R2), FADE_ECOLI  (Q47146), 
FADE_SALTI  (Q8Z937), FADE_SALTY  (Q8ZRJ7), FADE_YERPE  (Q8ZBY6), 
GCDH_BOVIN  (Q2KHZ9), GCDH_CAEEL  (Q20772), GCDH_MOUSE  (Q60759), 
GCDH_PIG(P81140), IPDE1_MYCS2 (A0R4Z9), IPDE1_MYCTU (I6Y3V5), 
IPDE2_MYCS2 (A0R502), IPDE2_MYCTU (I6YCF5), MBTN_MYCBO  (P63432), 
MBTN_MYCPA  (Q73ZP8), MBTN_MYCSS  (Q1BBA3), MBTN_MYCTO  (P9WQF8), 
MBTN_MYCTU  (P9WQF9), MCD_CERSP   (D3JV03), NAO_FUSOX   (Q8X1D8), 
NITSS_MICS3 (C4RPA1), NITSS_STRPE (A0A0R4I990), NITSS_STRRR (Q2PC69), 
PIGA_SERS3  (Q5W271), SPCAD_ADVMD (K4L7X3), SPCAD_CUPNN (F8GVD3), 
SPCAD_PARXL (Q13PC1), SPCAD_VARPD (B9U6P5), Y873_MYCTO  (P9WQF6), 
Y873_MYCTU  (P9WQF7), Y897_MYCBO  (P63430), YDBM_BACSU  (P96608)
» more

UniProtKB/Swiss-Prot
False positive sequences		 4 sequences 

ABCI_ASPFU  (Q4WUS1), IWS1_MOUSE  (Q8C1D8), LEA19_ORYSI (A2Y720), 

LEA19_ORYSJ (P0C5A4)
» more

PDB
[Detailed view]		 41 PDB

pdb_00001buc; pdb_00001egc; pdb_00001egd; pdb_00001ege; pdb_00001ivh; pdb_00001jqi; pdb_00001rx0; pdb_00001siq; pdb_00001sir; pdb_00001t9g; pdb_00001udy; pdb_00002a1t; pdb_00002ix5; pdb_00002ix6; pdb_00002jif; pdb_00002r0m; pdb_00002r0n; pdb_00002uxw; pdb_00002vig; pdb_00003b96; pdb_00003djl; pdb_00003mdd; pdb_00003mde; pdb_00003mpi; pdb_00003mpj; pdb_00003u33; pdb_00004p13; pdb_00005lnx; pdb_00006fah; pdb_00007s7g; pdb_00007y0a; pdb_00007y0b; pdb_00008ca1; pdb_00008phe; pdb_00008phf; pdb_00008sgp; pdb_00008sgr; pdb_00008sgs; pdb_00008w0t; pdb_00008w0u; pdb_00008w0z
» more